-
1
-
-
0036896304
-
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs
-
Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW. 2002. Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther 303:1029-1037.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 1029-1037
-
-
Mahar Doan, K.M.1
Humphreys, J.E.2
Webster, L.O.3
Wring, S.A.4
Shampine, L.J.5
Serabjit-Singh, C.J.6
Adkison, K.K.7
Polli, J.W.8
-
2
-
-
0033756459
-
Transporter-mediated permeation of drugs across the blood-brain barrier
-
DOI 10.1002/1520-6017(200011)89:11<1371::AID-JPS1>3.0.CO;2-D
-
Tamai I, Tsuji A. 2000. Transporter-mediated permeation of drugs across the blood-brain barrier. J Pharm Sci 89:1371-1388. (Pubitemid 30805244)
-
(2000)
Journal of Pharmaceutical Sciences
, vol.89
, Issue.11
, pp. 1371-1388
-
-
Tamai, I.1
Tsuji, A.2
-
3
-
-
4243801613
-
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
-
DOI 10.1073/pnas.94.8.4028
-
Schinkel AH, Mayer U, Wagenaar E, Mol CA, van Deemter L, Smit JJ, van der Valk MA, Voordouw AC, Spits H, van Tellingen O, Zijlmans JM, Fibbe WE, Borst P. 1997. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci USA 94:4028-4033. (Pubitemid 27180493)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.8
, pp. 4028-4033
-
-
Schinkel, A.H.1
Mayer, U.2
Wagenaar, E.3
Mol, C.A.A.M.4
Van Deemter, L.5
Smit, J.J.M.6
Van Der Valk, M.A.7
Voordouw, A.C.8
Spits, H.9
Van Tellingen, O.10
Zijlmans, J.M.J.M.11
Fibbe, W.E.12
Borst, P.13
-
4
-
-
0028825399
-
Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
-
Schinkel AH, Wagenaar E, van Deemter L, Mol CA, Borst P. 1995. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96:1698-1705.
-
(1995)
J Clin Invest
, vol.96
, pp. 1698-1705
-
-
Schinkel, A.H.1
Wagenaar, E.2
Van Deemter, L.3
Mol, C.A.4
Borst, P.5
-
5
-
-
0030817935
-
The functional role of P-glycoprotein in the blood-brain barrier
-
DOI 10.1021/js9701364
-
van Asperen J, Mayer U, van Tellingen O, Beijnen JH. 1997. The functional role of P-glycoprotein in the blood-brain barrier. J Pharm Sci 86:881-884. (Pubitemid 27344043)
-
(1997)
Journal of Pharmaceutical Sciences
, vol.86
, Issue.8
, pp. 881-884
-
-
Van Asperen, J.1
Mayer, U.2
Van Tellingen, O.3
Beijnen, J.H.4
-
6
-
-
0041837255
-
Blood-brain barrier efflux transport
-
Golden PL, Pollack GM. 2003. Blood-brain barrier efflux transport. J Pharm Sci 92:1739-1753.
-
(2003)
J Pharm Sci
, vol.92
, pp. 1739-1753
-
-
Golden, P.L.1
Pollack, G.M.2
-
7
-
-
21344446092
-
The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice
-
DOI 10.1002/jps.20344
-
Salama NN, Kelly EJ, Bui T, Ho RJ. 2005. The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice. J Pharm Sci 94:1216-1225. (Pubitemid 40904186)
-
(2005)
Journal of Pharmaceutical Sciences
, vol.94
, Issue.6
, pp. 1216-1225
-
-
Salama, N.N.1
Kelly, E.J.2
Bui, T.3
Ho, R.J.Y.4
-
8
-
-
0037229942
-
Role of P-glycoprotein in pharmacokinetics: Clinical implications
-
DOI 10.2165/00003088-200342010-00003
-
Lin JH, Yamazaki M. 2003. Role of P-glycoprotein in pharmacokinetics: Clinical implications. Clin Pharmacokinet 42:59-98. (Pubitemid 36092258)
-
(2003)
Clinical Pharmacokinetics
, vol.42
, Issue.1
, pp. 59-98
-
-
Lin, J.H.1
Yamazaki, M.2
-
9
-
-
1642579542
-
Variable modulation of opioid brain uptake by P-glycoprotein in mice
-
DOI 10.1016/j.bcp.2003.08.027
-
Dagenais C, Graff CL, Pollack GM. 2004. Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol 67:269-276. (Pubitemid 38112757)
-
(2004)
Biochemical Pharmacology
, vol.67
, Issue.2
, pp. 269-276
-
-
Dagenais, C.1
Graff, C.L.2
Pollack, G.M.3
-
10
-
-
34748829961
-
Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in sprague dawley rats
-
DOI 10.1002/jps.20893
-
Hassan HE, Myers AL, Lee IJ, Coop A, Eddington ND. 2007. Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. J Pharm Sci 96:2494-2506. (Pubitemid 47477902)
-
(2007)
Journal of Pharmaceutical Sciences
, vol.96
, Issue.9
, pp. 2494-2506
-
-
Hassan, H.E.1
Myers, A.L.2
Lee, I.J.3
Coop, A.4
Eddington, N.D.5
-
11
-
-
0037457793
-
Drug-drug interaction mediated by inhibition and induction of P-glycoprotein
-
DOI 10.1016/S0169-409X(02)00171-0, PII S0169409X02001710
-
Lin JH. 2003. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Adv Drug Deliv Rev 55:53-81. (Pubitemid 36082882)
-
(2003)
Advanced Drug Delivery Reviews
, vol.55
, Issue.1
, pp. 53-81
-
-
Lin, J.H.1
-
12
-
-
0027285344
-
Dose-ranging study of oxycodone for chronic pain in advanced cancer
-
Glare PA, Walsh TD. 1993. Dose-ranging study of oxycodone for chronic pain in advanced cancer. J Clin Oncol 11:973-978.
-
(1993)
J Clin Oncol
, vol.11
, pp. 973-978
-
-
Glare, P.A.1
Walsh, T.D.2
-
13
-
-
0036224193
-
Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers
-
Murthy BR, Pollack GM, Brouwer KL. 2002. Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers. J Clin Pharmacol 42:569-576.
-
(2002)
J Clin Pharmacol
, vol.42
, pp. 569-576
-
-
Murthy, B.R.1
Pollack, G.M.2
Brouwer, K.L.3
-
15
-
-
0032798013
-
P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells
-
DOI 10.1016/S0006-2952(99)00180-X, PII S000629529900180X
-
Letrent SP, Polli JW, Humphreys JE, Pollack GM, Brouwer KR, Brouwer KL. 1999. P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells. Biochem Pharmacol 58:951-957. (Pubitemid 29361461)
-
(1999)
Biochemical Pharmacology
, vol.58
, Issue.6
, pp. 951-957
-
-
Letrent, S.P.1
Polli, J.W.2
Humphreys, J.E.3
Pollack, G.M.4
Brouwer, K.R.5
Brouwer, K.L.R.6
-
16
-
-
0033060742
-
Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat
-
Letrent SP, Pollack GM, Brouwer KR, Brouwer KL. 1999. Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat. Drug Metab Dispos 27:827-834.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 827-834
-
-
Letrent, S.P.1
Pollack, G.M.2
Brouwer, K.R.3
Brouwer, K.L.4
-
17
-
-
0031946026
-
Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat
-
Letrent SP, Pollack GM, Brouwer KR, Brouwer KL. 1998. Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat. Pharm Res 15:599-605.
-
(1998)
Pharm Res
, vol.15
, pp. 599-605
-
-
Letrent, S.P.1
Pollack, G.M.2
Brouwer, K.R.3
Brouwer, K.L.4
-
18
-
-
33846902630
-
Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine
-
Mercer SL, Hassan HE, Cunningham CW, Eddington ND, Coop A. 2007. Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine. Bioorg Med Chem Lett 17:1160-1162.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 1160-1162
-
-
Mercer, S.L.1
Hassan, H.E.2
Cunningham, C.W.3
Eddington, N.D.4
Coop, A.5
-
19
-
-
0036143616
-
Interaction of nonpeptidic delta agonists with P-glycoprotein by in situ mouse brain perfusion: Liquid chromatography-mass spectrometry analysis and internal standard strategy
-
DOI 10.1002/jps.1175
-
Dagenais C, Ducharme J, Pollack GM. 2002. Interaction of nonpeptidic delta agonists with P-glycoprotein by in situ mouse brain perfusion: Liquid chromatography-mass spectrometry analysis and internal standard strategy. J Pharm Sci 91:244-252. (Pubitemid 34074482)
-
(2002)
Journal of Pharmaceutical Sciences
, vol.91
, Issue.1
, pp. 244-252
-
-
Dagenais, C.1
Ducharme, J.2
Pollack, G.M.3
-
20
-
-
0033844780
-
Morphine antinociception is enhanced in mdr1a gene-deficient mice
-
DOI 10.1023/A:1007546719287
-
Zong J, Pollack GM. 2000. Morphine antinociception is enhanced in mdr1a gene-deficient mice. Pharm Res 17:749-753. (Pubitemid 30670642)
-
(2000)
Pharmaceutical Research
, vol.17
, Issue.6
, pp. 749-753
-
-
Zong, J.1
Pollack, G.M.2
-
21
-
-
0034016617
-
Opiate-induced analgesia is increased and prolonged in mice lacking P- Glycoprotein
-
Thompson SJ, Koszdin K, Bernards CM. 2000. Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein. Anesthesiology 92:1392-1399. (Pubitemid 30257201)
-
(2000)
Anesthesiology
, vol.92
, Issue.5
, pp. 1392-1399
-
-
Thompson, S.J.1
Koszdin, K.2
Bernards, C.M.3
-
22
-
-
33846650369
-
Buprenorphine for the treatment of opioid dependence
-
Boothby LA, Doering PL. 2007. Buprenorphine for the treatment of opioid dependence. Am J Health Syst Pharm 64:266-272.
-
(2007)
Am J Health Syst Pharm
, vol.64
, pp. 266-272
-
-
Boothby, L.A.1
Doering, P.L.2
-
23
-
-
0036206856
-
Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein
-
DOI 10.1097/00000542-200204000-00019
-
Wandel C, Kim R, Wood M, Wood A. 2002. Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology 96:913-920. (Pubitemid 34266685)
-
(2002)
Anesthesiology
, vol.96
, Issue.4
, pp. 913-920
-
-
Wandel, C.1
Kim, R.2
Wood, M.3
Wood, A.4
-
24
-
-
0027221177
-
Synthetic and natural opiates interact with P-glycoprotein in multidrug- Resistant cells
-
Callaghan R, Riordan JR. 1993. Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells. J Biol Chem 268:16059-16064. (Pubitemid 23222114)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.21
, pp. 16059-16064
-
-
Callaghan, R.1
Riordan, J.R.2
-
25
-
-
0030926727
-
Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets
-
Polli JE, Rekhi GS, Augsburger LL, Shah VP. 1997. Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets. J Pharm Sci 86:690-700.
-
(1997)
J Pharm Sci
, vol.86
, pp. 690-700
-
-
Polli, J.E.1
Rekhi, G.S.2
Augsburger, L.L.3
Shah, V.P.4
-
26
-
-
14744285705
-
Simultaneous determination of buprenorphine and its prodrug, buprenorphine propionate, by high-performance liquid chromatography with fluorescence detection: Application to pharmacokinetic studies in rabbits
-
DOI 10.1016/j.jchromb.2005.01.002, PII S1570023205000152
-
Liu SY, Liu KS, Kuei CH, Tzeng JI, Ho ST, Wang JJ. 2005. Simultaneous determination of buprenorphine and its prodrug, buprenorphine propionate, by high-performance liquid chromatography with fluorescence detection: Application to pharmacokinetic studies in rabbits. J Chromatogr B Analyt Technol Biomed Life Sci 818:233-239. (Pubitemid 40331829)
-
(2005)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.818
, Issue.2
, pp. 233-239
-
-
Liu, S.-Y.1
Liu, K.-S.2
Kuei, C.-H.3
Tzeng, J.-I.4
Ho, S.-T.5
Wang, J.-J.6
-
27
-
-
0000811019
-
The evaluation of the analgesic action of pethidine hydrochloride (demerol)
-
Woofle G, Macdonald A. 1944. The evaluation of the analgesic action of pethidine hydrochloride (demerol). J Pharmcol Exp Ther 80:300-307.
-
(1944)
J Pharmcol Exp Ther
, vol.80
, pp. 300-307
-
-
Woofle, G.1
Macdonald, A.2
-
28
-
-
0033810893
-
Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat
-
Nielsen CK, Ross FB, Smith MT. 2000. Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. J Pharmacol Exp Ther 295:91-99.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 91-99
-
-
Nielsen, C.K.1
Ross, F.B.2
Smith, M.T.3
-
29
-
-
0033968760
-
Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats
-
Ross FB, Wallis SC, Smith MT. 2000. Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain 84:421-428.
-
(2000)
Pain
, vol.84
, pp. 421-428
-
-
Ross, F.B.1
Wallis, S.C.2
Smith, M.T.3
-
30
-
-
33645214393
-
Determination of p-glycoprotein ATPase activity using luciferase
-
Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S. 2006. Determination of p-glycoprotein ATPase activity using luciferase. Biol Pharm Bull 29:560-564.
-
(2006)
Biol Pharm Bull
, vol.29
, pp. 560-564
-
-
Matsunaga, T.1
Kose, E.2
Yasuda, S.3
Ise, H.4
Ikeda, U.5
Ohmori, S.6
-
31
-
-
0030791978
-
Structure-activity relationships of P-glycoprotein interacting drugs: Kinetic characterization of their effects on ATPase activity
-
DOI 10.1016/S0925-4439(97)00026-4, PII S0925443997000264
-
Litman T, Zeuthen T, Skovsgaard T, Stein WD. 1997. Structure-activity relationships of P-glycoprotein interacting drugs: Kinetic characterization of their effects on ATPase activity. Biochim Biophys Acta 1361:159-168. (Pubitemid 27362089)
-
(1997)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1361
, Issue.2
, pp. 159-168
-
-
Litman, T.1
Zeuthen, T.2
Skovsgaard, T.3
Stein, W.D.4
-
32
-
-
0034763005
-
Rational use of in vitro P-glycoprotein assays in drug discovery
-
Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS. 2001. Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther 299:620-628. (Pubitemid 32979675)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.299
, Issue.2
, pp. 620-628
-
-
Polli, J.W.1
Wring, S.A.2
Humphreys, J.E.3
Huang, L.4
Morgan, J.B.5
Webster, L.O.6
Serabjit-Singh, C.S.7
-
33
-
-
0033279844
-
The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: In vitro studies using the rat everted intestinal sac
-
Bouer R, Barthe L, Philibert C, Tournaire C, Woodley J, Houin G. 1999. The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: In vitro studies using the rat everted intestinal sac. Fundam Clin Pharmacol 13:494-500.
-
(1999)
Fundam Clin Pharmacol
, vol.13
, pp. 494-500
-
-
Bouer, R.1
Barthe, L.2
Philibert, C.3
Tournaire, C.4
Woodley, J.5
Houin, G.6
-
34
-
-
0343526837
-
Methadone: A review of its pharmacokinetic/pharmacodynamic properties
-
Garrido MJ, Troconiz IF. 1999. Methadone: A review of its pharmacokinetic/pharmacodynamic properties. J Pharmacol Toxicol Methods 42:61-66.
-
(1999)
J Pharmacol Toxicol Methods
, vol.42
, pp. 61-66
-
-
Garrido, M.J.1
Troconiz, I.F.2
-
35
-
-
0031455482
-
The P-glycoprotein efflux pump: How does it transport drugs?
-
Sharom FJ. 1997. The P-glycoprotein efflux pump: How does it transport drugs? J Membr Biol 160:161-175.
-
(1997)
J Membr Biol
, vol.160
, pp. 161-175
-
-
Sharom, F.J.1
-
36
-
-
17544365536
-
The role of passive transbilayer drug movement in multidrug resistance and its modulation
-
DOI 10.1074/jbc.271.22.12897
-
Eytan GD, Regev R, Oren G, Assaraf YG. 1996. The role of passive transbilayer drug movement in multidrug resistance and its modulation. J Biol Chem 271:12897-12902. (Pubitemid 26175862)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.22
, pp. 12897-12902
-
-
Eytan, G.D.1
Regev, R.2
Oren, G.3
Assaraf, Y.G.4
-
37
-
-
0034058897
-
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein
-
Pauli-Magnus C, von Richter O, Burk O, Ziegler A, Mettang T, Eichelbaum M, Fromm MF. 2000. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther 293:376-382. (Pubitemid 30244084)
-
(2000)
Journal of Pharmacology and Experimental Therapeutics
, vol.293
, Issue.2
, pp. 376-382
-
-
Pauli-Magnus, C.1
Von Richter, O.2
Burk, O.3
Ziegler, A.4
Mettang, T.5
Eichelbaum, M.6
Fromm, M.F.7
-
38
-
-
0033526176
-
P-Glycoprotein, a gatekeeper in the blood-brain barrier
-
Schinkel AH. 1999. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 36:179-194.
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 179-194
-
-
Schinkel, A.H.1
-
39
-
-
33750317876
-
Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-alpha-acetylmethadol, and paclitaxel
-
Nekhayeva IA, Nanovskaya TN, Hankins GD, Ahmed MS. 2006. Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-alpha-acetylmethadol, and paclitaxel. Am J Perinatol 23:423-430.
-
(2006)
Am J Perinatol
, vol.23
, pp. 423-430
-
-
Nekhayeva, I.A.1
Nanovskaya, T.N.2
Hankins, G.D.3
Ahmed, M.S.4
-
40
-
-
34248196921
-
P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood-brain barrier
-
DOI 10.1080/10611860601141606, PII 772691204
-
Suzuki T, Zaima C, Moriki Y, Fukami T, Tomono K. 2007. P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood-brain barrier. J Drug Target 15:67-74. (Pubitemid 47161333)
-
(2007)
Journal of Drug Targeting
, vol.15
, Issue.1
, pp. 67-74
-
-
Suzuki, T.1
Zaima, C.2
Moriki, Y.3
Fukami, T.4
Tomono, K.5
-
41
-
-
19944429408
-
11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: Clinical and preclinical studies
-
DOI 10.1124/jpet.104.072686
-
Melichar JK, Hume SP, Williams TM, Daglish MR, Taylor LG, Ahmad R, Malizia AL, Brooks DJ, Myles JS, Lingford-Hughes A, Nutt DJ. 2005. Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: Clinical and preclinical studies. J Pharmacol Exp Ther 312:309-315. (Pubitemid 40096483)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.312
, Issue.1
, pp. 309-315
-
-
Melichar, J.K.1
Hume, S.P.2
Williams, T.M.3
Daglish, M.R.C.4
Taylor, L.G.5
Ahmad, R.6
Malizia, A.L.7
Brooks, D.J.8
Myles, J.S.9
Lingford-Hughes, A.10
Nutt, D.J.11
-
42
-
-
0015821183
-
Opiate agonists and antagonists discriminated by receptor binding in brain
-
Pert CB, Pasternak G, Snyder SH. 1973. Opiate agonists and antagonists discriminated by receptor binding in brain. Science 182:1359-1361.
-
(1973)
Science
, vol.182
, pp. 1359-1361
-
-
Pert, C.B.1
Pasternak, G.2
Snyder, S.H.3
-
44
-
-
0036827956
-
Investigation of transport mechanism of pentazocine across the blood-brain barrier using the in situ rat brain perfusion technique
-
DOI 10.1002/jps.10224
-
Suzuki T, Oshimi M, Tomono K, Hanano M, Watanabe J. 2002. Investigation of transport mechanism of pentazocine across the blood-brain barrier using the in situ rat brain perfusion technique. J Pharm Sci 91:2346-2353. (Pubitemid 35231197)
-
(2002)
Journal of Pharmaceutical Sciences
, vol.91
, Issue.11
, pp. 2346-2353
-
-
Suzuki, T.1
Oshimi, M.2
Tomono, K.3
Hanano, M.4
Watanabe, J.5
-
45
-
-
0347504918
-
Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine
-
DOI 10.1016/j.clpt.2003.08.011
-
Kharasch ED, Hoffer C, Whittington D, Sheffels P. 2003. Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. Clin Pharmacol Ther 74:543-554. (Pubitemid 37521998)
-
(2003)
Clinical Pharmacology and Therapeutics
, vol.74
, Issue.6
, pp. 543-554
-
-
Kharasch, E.D.1
Hoffer, C.2
Whittington, D.3
Sheffels, P.4
-
46
-
-
0038637177
-
Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin
-
DOI 10.1124/jpet.103.049452
-
Zong J, Pollack GM. 2003. Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin. J Pharmacol Exp Ther 306:556-562. (Pubitemid 36886154)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.306
, Issue.2
, pp. 556-562
-
-
Zong, J.1
Pollack, G.M.2
-
47
-
-
0037392850
-
Morphine blood-brain barrier transport is influenced by probenecid co-administration
-
DOI 10.1023/A:1023250900462
-
Tunblad K, Jonsson EN, Hammarlund-Udenaes M. 2003. Morphine blood-brain barrier transport is influenced by probenecid co-administration. Pharm Res 20:618-623. (Pubitemid 36438906)
-
(2003)
Pharmaceutical Research
, vol.20
, Issue.4
, pp. 618-623
-
-
Tunblad, K.1
Jonsson, E.N.2
Hammarlund-Udenaes, M.3
-
48
-
-
0037023533
-
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel
-
DOI 10.1016/S0014-2999(02)01366-3, PII S0014299902013663
-
Crowe A. 2002. The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel. Eur J Pharmacol 440:7-16. (Pubitemid 34312033)
-
(2002)
European Journal of Pharmacology
, vol.440
, Issue.1
, pp. 7-16
-
-
Crowe, A.1
-
49
-
-
0034874453
-
Effect of mdr1a p-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds
-
DOI 10.1023/A:1010984110732
-
Dagenais C, Zong J, Ducharme J, Pollack GM. 2001. Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds. Pharm Res 18:957-963. (Pubitemid 32799940)
-
(2001)
Pharmaceutical Research
, vol.18
, Issue.7
, pp. 957-963
-
-
Dagenais, C.1
Zong, J.2
Ducharme, J.3
Pollack, G.M.4
-
50
-
-
0033812879
-
Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine
-
DOI 10.1046/j.1365-2125.2000.00226.x
-
Drewe J, Ball HA, Beglinger C, Peng B, Kemmler A, Schachinger H, Haefeli WE. 2000. Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine. Br J Clin Pharmacol 50:237-246. (Pubitemid 30701419)
-
(2000)
British Journal of Clinical Pharmacology
, vol.50
, Issue.3
, pp. 237-246
-
-
Drewe, J.1
Ball, H.A.2
Beglinger, C.3
Peng, B.4
Kemmler, A.5
Schachinger, H.6
Haefeli, W.E.7
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