Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers

Journal of Clinical Pharmacology

Volumn 42, Issue 5, 2002, Pages 569-576

  Murthy, Bindu P ^a   Pollack, Gary M ^b   Brouwer, Kim L R ^b  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; MORPHINE 6 GLUCURONIDE; MORPHINE SULFATE; ONDANSETRON; PLACEBO;

ANALGESIA; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG GLUCURONIDATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NONLINEAR REGRESSION ANALYSIS; NORMAL HUMAN; PAIN THRESHOLD; PHARMACODYNAMICS; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; STEADY STATE; VOMITING;

ADULT; ANALGESICS, OPIOID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MORPHINE; MORPHINE DERIVATIVES; PAIN; SEX CHARACTERISTICS; TEMPERATURE;

EID: 0036224193     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700222011508     Document Type: Article

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