P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells

Biochemical Pharmacology

Volumn 58, Issue 6, 1999, Pages 951-957

  Letrent, Stephen P ^a   Polli, Joseph W ^b   Humphreys, Joan E ^b   Pollack, Gary M ^a   Brouwer, Kenneth R ^b   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Blood brain barrier; Cell culture; Morphine; P glycoprotein; Rhodamine; Transport

Indexed keywords

CYCLOSPORIN A; ELACRIDAR; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; MORPHINE; N [4 [2 (1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 ISOQUINOLINYL)ETHYL]PHENYL]9,10 DIHYDRO 5 METHOXY 9 OXO 4 ACRIDINE CARBOXAMIDE; PROPRANOLOL; PROTEIN INHIBITOR; RHODAMINE 123; SUCROSE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CATTLE; CELL CULTURE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG TRANSPORT; ENDOTHELIUM CELL; ENERGY; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE;

ANALGESICS, OPIOID; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARIES; CATTLE; CELLS, CULTURED; DIFFUSION; ENDOTHELIUM, VASCULAR; MORPHINE; MORPHINE DERIVATIVES; P-GLYCOPROTEIN;

EID: 0032798013     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00180-X     Document Type: Article

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