Ischemia opens neuronal gap junction hemichannels

Science

Volumn 312, Issue 5775, 2006, Pages 924-927

  Thompson, Roger J ^a   Zhou, Ning ^a   MacVicar, Brian A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CALCIUM COMPOUNDS; ENZYME INHIBITION; FLUORESCENCE; NEUROLOGY; TOXICITY;

IONIC DYSREGULATION; ISCHEMIA; LARGE-CONDUCTANCE; NEURONAL GAP JUNCTION HEMICHANNELS;

HEMODYNAMICS;

CALCEIN; CARBENOXOLONE; CARRIER PROTEIN; DYE; GLUCOSE; HEMICHANNEL; OXYGEN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

FLUORESCENCE; GLUCOSE; INHIBITOR; IONIC COMPOSITION; MORTALITY RISK; NEUROLOGY; STROKE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CALCIUM TRANSPORT; CONTROLLED STUDY; CULTURE MEDIUM; FLUORESCENCE; GAP JUNCTION; HIPPOCAMPUS; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN ISCHEMIA; CARBENOXOLONE; CELL HYPOXIA; CELL MEMBRANE PERMEABILITY; CEREBROVASCULAR ACCIDENT; FLUORESCEINS; GAP JUNCTIONS; GLUCOSE; HIPPOCAMPUS; ION CHANNELS; LANTHANUM; MEMBRANE POTENTIALS; MICE; NECROSIS; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RHODAMINES;

EID: 33646584876     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1126241     Document Type: Article

References (25)

1. A. J. Hansen, Physiol. Rev. 65, 101 (1985).
2. P. Lipton, Physiol. Rev. 79, 1431 (1999).
3. M. Kamermans et al., Science 292, 1178 (2001).
4. J. E. Contreras et al., Proc. Natl Acad. Sci. U.S.A. 99, 495 (2002).
5. R. P. Kondo, S. Y. Wang, S. A. John, J. N. Weiss, J. I. Goldhaber, J. Mol. Cell. Cardiol. 32, 1859 (2000).
6. H. Li et al., J. Cell Biol. 134, 1019 (1996).
7. L. Bao, S. Locovei, G. Dahl, FEBS Lett. 572, 65 (2004).
8. R. Bruzzone, M. T. Barbe, N. J. Jakob, H. Monyer, J. Neurochem. 92, 1033 (2005).
9. R. Bruzzone, S. G. Hormuzdi, M. T. Barbe, A. Herb, H. Monyer, Proc. Natl. Acad. Sci. U.S.A. 100, 13644 (2003).
10. See supporting material on Science Online.
11. J. Gao et al., Neuron 48, 635 (2005).
12. M. Aarts et al., Cell 115, 863 (2003).
13. C. Tomasetto, M. J. Neveu, J. Daley, P. K. Horan, R. Sager, J. Cell Biol. 122, 157 (1993).
14. G. Feng et al., Neuron 28, 41 (2000).
15. A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, F. Helmchen, Nat. Methods 1, 31 (2004).
16. G. Sohl, S. Maxeiner, K. Willecke, Nat. Rev. Neurosci. 6, 191 (2005).
17. J. C. Saez, M. A. Retamal, D. Basilio, F. F. Bukauskas, M. V. Bennett, Biochim. Biophys. Acta 1711, 215 (2005).
18. R. J. Thompson, M. H. Nordeen, K. E. Howell, J. H. Caldwell, Biophys. J. 83, 278 (2002).
19. M. L. Fung, G. G. Haddad, Brain Res. 762, 97 (1997).
20. H. Benveniste, J. Drejer, A. Schousboe, N. H. Diemer, J. Neurochem. 43, 1369 (1984).
21. C. E. Stout, J. L. Costantin, C. C. Naus, A. C. Charles, J. Biol. Chem. 277, 10482 (2002).
22. H. B. Zhao, N. Yu, C. R. Fleming, Proc. Natl. Acad. Sci. U.S.A. 102, 18724 (2005).
23. T. R. Anderson, C. R. Jarvis, A. J. Biedermann, C. Molnar, R. D. Andrew, J. Neurophysiol. 93, 963 (2005).
24. G. G. Somjen, Physiol. Rev. 81, 1065 (2001).
25. Supported by the Canadian Institutes for Health Research and the Canadian Stroke Network. B.A.W. has a Tier 1 Canada Research Chair in Neuroscience and a Michael Smith Foundation for Health Research distinguished scholar award. We thank Y.-T. Wang, C. C. Naus, and T. Snutch for critical reading of the manuscript.