메뉴 건너뛰기




Volumn 15, Issue 12, 2009, Pages 562-570

One-carbon metabolism and schizophrenia: current challenges and future directions

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CARBON; CYANOCOBALAMIN; DOPAMINE; FOLIC ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; HOMOCYSTEINE; METABOTROPIC RECEPTOR AGONIST; METHIONINE; METHYL GROUP; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; S ADENOSYLMETHIONINE;

EID: 70949085092     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2009.10.001     Document Type: Article
Times cited : (73)

References (97)
  • 1
    • 2942648152 scopus 로고    scopus 로고
    • Schizophrenia
    • Mueser K.T., and McGurk S.R. Schizophrenia. Lancet 363 (2004) 2063-2072
    • (2004) Lancet , vol.363 , pp. 2063-2072
    • Mueser, K.T.1    McGurk, S.R.2
  • 2
    • 34748864737 scopus 로고    scopus 로고
    • The pipeline and future of drug development in schizophrenia
    • Gray J.A., and Roth B.L. The pipeline and future of drug development in schizophrenia. Mol. Psychiatry 12 (2007) 904-922
    • (2007) Mol. Psychiatry , vol.12 , pp. 904-922
    • Gray, J.A.1    Roth, B.L.2
  • 3
    • 33749074397 scopus 로고    scopus 로고
    • Glutamate and schizophrenia: beyond the dopamine hypothesis
    • Coyle J.T. Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol. Neurobiol. 26 (2006) 365-384
    • (2006) Cell Mol. Neurobiol. , vol.26 , pp. 365-384
    • Coyle, J.T.1
  • 4
    • 38049177900 scopus 로고    scopus 로고
    • Back to the future: predicting and reshaping the course of psychotic disorder
    • McGorry P.D., et al. Back to the future: predicting and reshaping the course of psychotic disorder. Arch. Gen. Psychiatry 65 (2008) 25-27
    • (2008) Arch. Gen. Psychiatry , vol.65 , pp. 25-27
    • McGorry, P.D.1
  • 5
    • 61349159852 scopus 로고    scopus 로고
    • Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation
    • Wood S.J., et al. Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation. Neurobiol. Dis. 33 (2009) 354-357
    • (2009) Neurobiol. Dis. , vol.33 , pp. 354-357
    • Wood, S.J.1
  • 6
    • 65349088024 scopus 로고    scopus 로고
    • What we know: findings that every theory of schizophrenia should explain
    • MacDonald A.W., and Schulz S.C. What we know: findings that every theory of schizophrenia should explain. Schizophr. Bull. 35 (2009) 493-508
    • (2009) Schizophr. Bull. , vol.35 , pp. 493-508
    • MacDonald, A.W.1    Schulz, S.C.2
  • 7
    • 46449113977 scopus 로고    scopus 로고
    • Schizophrenia, "just the facts": what we know in 2008. 2. Epidemiology and etiology
    • Tandon R., et al. Schizophrenia, "just the facts": what we know in 2008. 2. Epidemiology and etiology. Schizophr. Res. 102 (2008) 1-18
    • (2008) Schizophr. Res. , vol.102 , pp. 1-18
    • Tandon, R.1
  • 8
    • 18444385647 scopus 로고    scopus 로고
    • The neurodevelopmental model of schizophrenia: update 2005
    • Rapoport J.L., et al. The neurodevelopmental model of schizophrenia: update 2005. Mol. Psychiatry 10 (2005) 434-449
    • (2005) Mol. Psychiatry , vol.10 , pp. 434-449
    • Rapoport, J.L.1
  • 9
    • 54249162304 scopus 로고    scopus 로고
    • Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications
    • Mittal V.A., et al. Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications. Schizophr. Bull. 34 (2008) 1083-1094
    • (2008) Schizophr. Bull. , vol.34 , pp. 1083-1094
    • Mittal, V.A.1
  • 10
    • 26444447578 scopus 로고    scopus 로고
    • Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia?
    • Picker J.D., and Coyle J.T. Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia?. Harv. Rev. Psychiatry 13 (2005) 197-205
    • (2005) Harv. Rev. Psychiatry , vol.13 , pp. 197-205
    • Picker, J.D.1    Coyle, J.T.2
  • 11
    • 2142814375 scopus 로고    scopus 로고
    • Methylomics in psychiatry: modulation of gene-environment interactions might be through DNA methylation
    • Abdolmaleky H.M., et al. Methylomics in psychiatry: modulation of gene-environment interactions might be through DNA methylation. Am. J. Med. Gen. Part B: Neuropsychiatric Genet. 127 (2004) 51-59
    • (2004) Am. J. Med. Gen. Part B: Neuropsychiatric Genet. , vol.127 , pp. 51-59
    • Abdolmaleky, H.M.1
  • 12
    • 34247509796 scopus 로고    scopus 로고
    • Epigenetic regulation in psychiatric disorders
    • Tsankova N., et al. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8 (2007) 355-367
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 355-367
    • Tsankova, N.1
  • 13
    • 41149140859 scopus 로고    scopus 로고
    • Epigenomic profiling reveals DNA methylation changes associated with major psychosis
    • Mill J., et al. Epigenomic profiling reveals DNA methylation changes associated with major psychosis. Am. J. Hum. Genet. 82 (2008) 696-711
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 696-711
    • Mill, J.1
  • 14
    • 12344327212 scopus 로고    scopus 로고
    • Schizophrenia genes, gene expression and neuropathology: on the matter of their convergence
    • Image 45
    • Harrison P.J., and Weinberger D.R. Schizophrenia genes, gene expression and neuropathology: on the matter of their convergence. Mol. Psychiatry 10 (2005) 40-68 Image 45
    • (2005) Mol. Psychiatry , vol.10 , pp. 40-68
    • Harrison, P.J.1    Weinberger, D.R.2
  • 15
    • 33847355523 scopus 로고    scopus 로고
    • Glutamate and schizophrenia: phencyclidine, N-methyl-d-Aspartate receptors and dopamine-glutamate interactions
    • Javitt D.C. Glutamate and schizophrenia: phencyclidine, N-methyl-d-Aspartate receptors and dopamine-glutamate interactions. Int. Rev. Neurobiol. 78 (2007) 69-108
    • (2007) Int. Rev. Neurobiol. , vol.78 , pp. 69-108
    • Javitt, D.C.1
  • 16
    • 2342562466 scopus 로고    scopus 로고
    • Mitochondria, synaptic plasticity and schizophrenia
    • Ben-Shachar D., and Laifenfeld D. Mitochondria, synaptic plasticity and schizophrenia. Int. Rev. Neurobiol. 59 (2004) 273-296
    • (2004) Int. Rev. Neurobiol. , vol.59 , pp. 273-296
    • Ben-Shachar, D.1    Laifenfeld, D.2
  • 17
    • 56649111125 scopus 로고    scopus 로고
    • Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression
    • Ben-Shachar D., and Karry R. Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression. PLoS ONE 3 (2008) e3676
    • (2008) PLoS ONE , vol.3
    • Ben-Shachar, D.1    Karry, R.2
  • 18
    • 62849119061 scopus 로고    scopus 로고
    • Mitochondrial variants in schizophrenia, bipolar disorder and major depressive disorder
    • Rollins B., et al. Mitochondrial variants in schizophrenia, bipolar disorder and major depressive disorder. PLoS ONE 4 (2009) e4913
    • (2009) PLoS ONE , vol.4
    • Rollins, B.1
  • 19
    • 0031057859 scopus 로고    scopus 로고
    • Disturbances of one-carbon metabolism in neuropsychiatric disorders: a review
    • Smythies J.R., et al. Disturbances of one-carbon metabolism in neuropsychiatric disorders: a review. Biol. Psychiatry 41 (1997) 230-233
    • (1997) Biol. Psychiatry , vol.41 , pp. 230-233
    • Smythies, J.R.1
  • 20
    • 33645999355 scopus 로고    scopus 로고
    • S-adenosylmethionine: jack of all trades and master of everything?
    • Loenen W.A. S-adenosylmethionine: jack of all trades and master of everything?. Biochem. Soc. Trans. 34 (2006) 330-333
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 330-333
    • Loenen, W.A.1
  • 21
    • 0016260034 scopus 로고
    • The administration of methionine to chronic schizophrenic patients: a review of 10 studies
    • Cohen S.M., et al. The administration of methionine to chronic schizophrenic patients: a review of 10 studies. Biol. Psychiatry 8 (1974) 209-225
    • (1974) Biol. Psychiatry , vol.8 , pp. 209-225
    • Cohen, S.M.1
  • 22
    • 0037168650 scopus 로고    scopus 로고
    • An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
    • Tremolizzo L., et al. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 17095-17100
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 17095-17100
    • Tremolizzo, L.1
  • 23
    • 0033759439 scopus 로고    scopus 로고
    • Decrease in reelin and glutamic acid decarboxylase 67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
    • Guidotti A., et al. Decrease in reelin and glutamic acid decarboxylase 67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry 57 (2000) 1061-1069
    • (2000) Arch. Gen. Psychiatry , vol.57 , pp. 1061-1069
    • Guidotti, A.1
  • 24
    • 16344372645 scopus 로고    scopus 로고
    • Cortical inhibitory neurons and schizophrenia
    • Lewis D.A., et al. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 6 (2005) 312-324
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 312-324
    • Lewis, D.A.1
  • 25
    • 33947671401 scopus 로고    scopus 로고
    • Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection
    • Ruzicka W.B., et al. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol. Psychiatry 12 (2007) 385-397
    • (2007) Mol. Psychiatry , vol.12 , pp. 385-397
    • Ruzicka, W.B.1
  • 26
    • 38949150121 scopus 로고    scopus 로고
    • Methylation status of the reelin promoter region in the brain of schizophrenic patients
    • Tochigi M., et al. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol. Psychiatry 63 (2008) 530-533
    • (2008) Biol. Psychiatry , vol.63 , pp. 530-533
    • Tochigi, M.1
  • 27
    • 38649094308 scopus 로고    scopus 로고
    • GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia
    • Huang H.S., and Akbarian S. GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PLoS ONE 2 (2007) e809
    • (2007) PLoS ONE , vol.2
    • Huang, H.S.1    Akbarian, S.2
  • 28
    • 34548130797 scopus 로고    scopus 로고
    • Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia
    • Shimabukuro M., et al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia. J. Psychiatr. Res. 41 (2006) 1042-1046
    • (2006) J. Psychiatr. Res. , vol.41 , pp. 1042-1046
    • Shimabukuro, M.1
  • 29
    • 33750244045 scopus 로고    scopus 로고
    • Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    • Abdolmaleky H.M., et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum. Mol. Genet. 15 (2006) 3132-3145
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 3132-3145
    • Abdolmaleky, H.M.1
  • 30
    • 33745597874 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection
    • Pamplona R., and Barja G. Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim. Biophys. Acta 1757 (2006) 496-508
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 496-508
    • Pamplona, R.1    Barja, G.2
  • 31
    • 0034836896 scopus 로고    scopus 로고
    • Assessment of nutritional folate status and selected vitamin status of women of childbearing age
    • Wartanowicz M., et al. Assessment of nutritional folate status and selected vitamin status of women of childbearing age. Eur. J. Clin. Nutr. 55 (2001) 743-747
    • (2001) Eur. J. Clin. Nutr. , vol.55 , pp. 743-747
    • Wartanowicz, M.1
  • 33
    • 34447626495 scopus 로고    scopus 로고
    • Plasma homocysteine, folate and B12 in chronic schizophrenia
    • Haidemenos A., et al. Plasma homocysteine, folate and B12 in chronic schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (2007) 1289-1296
    • (2007) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.31 , pp. 1289-1296
    • Haidemenos, A.1
  • 34
    • 56549107657 scopus 로고    scopus 로고
    • Plasma homocysteine levels in young male patients in the exacerbation and remission phase of schizophrenia
    • Petronijevic N.D., et al. Plasma homocysteine levels in young male patients in the exacerbation and remission phase of schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (2008) 1921-1926
    • (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.32 , pp. 1921-1926
    • Petronijevic, N.D.1
  • 35
    • 0142188577 scopus 로고    scopus 로고
    • Homocysteine metabolism and B vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia
    • Muntjewerff J.W., et al. Homocysteine metabolism and B vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia. Psychiatry Res. 121 (2003) 1-9
    • (2003) Psychiatry Res. , vol.121 , pp. 1-9
    • Muntjewerff, J.W.1
  • 36
    • 16844374176 scopus 로고    scopus 로고
    • Nutritional and lifestyle determinants of plasma homocysteine in schizophrenia patients
    • Stahl Z., et al. Nutritional and lifestyle determinants of plasma homocysteine in schizophrenia patients. Eur. Neuropsychopharmacol. 15 (2005) 291-295
    • (2005) Eur. Neuropsychopharmacol. , vol.15 , pp. 291-295
    • Stahl, Z.1
  • 37
    • 24944581659 scopus 로고    scopus 로고
    • Relation of plasma glycine, serine and homocysteine levels to schizophrenia symptoms and medication type
    • Neeman G., et al. Relation of plasma glycine, serine and homocysteine levels to schizophrenia symptoms and medication type. Am. J. Psychiatry 162 (2005) 1738-1740
    • (2005) Am. J. Psychiatry , vol.162 , pp. 1738-1740
    • Neeman, G.1
  • 38
    • 17744400085 scopus 로고    scopus 로고
    • Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype and the risk for schizophrenia: a Dutch population based case-control study
    • Muntjewerff J.W., et al. Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype and the risk for schizophrenia: a Dutch population based case-control study. Am. J. Med. Gen. Part B: Neuropsychiatric Genet. 135 (2005) 69-72
    • (2005) Am. J. Med. Gen. Part B: Neuropsychiatric Genet. , vol.135 , pp. 69-72
    • Muntjewerff, J.W.1
  • 39
    • 31544442693 scopus 로고    scopus 로고
    • Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis
    • Muntjewerff J.W., et al. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol. Psychiatry 11 (2006) 143-149
    • (2006) Mol. Psychiatry , vol.11 , pp. 143-149
    • Muntjewerff, J.W.1
  • 40
    • 45549083182 scopus 로고    scopus 로고
    • Prenatal nutritional deficiency and risk of adult schizophrenia
    • Brown A.S., and Susser E.S. Prenatal nutritional deficiency and risk of adult schizophrenia. Schizophr. Bull. 34 (2008) 1054-1063
    • (2008) Schizophr. Bull. , vol.34 , pp. 1054-1063
    • Brown, A.S.1    Susser, E.S.2
  • 41
    • 34547683246 scopus 로고    scopus 로고
    • Schizophrenia and neural tube defects: comparisons from an epidemiological perspective
    • Zammit S., et al. Schizophrenia and neural tube defects: comparisons from an epidemiological perspective. Schizophr. Bull. 33 (2007) 853-858
    • (2007) Schizophr. Bull. , vol.33 , pp. 853-858
    • Zammit, S.1
  • 42
    • 0035124196 scopus 로고    scopus 로고
    • Genes, folate and homocysteine in embryonic development
    • Rosenquist T.H., and Finnell R.H. Genes, folate and homocysteine in embryonic development. Proc. Nutr. Soc. 60 (2001) 53-61
    • (2001) Proc. Nutr. Soc. , vol.60 , pp. 53-61
    • Rosenquist, T.H.1    Finnell, R.H.2
  • 43
    • 33845993973 scopus 로고    scopus 로고
    • Elevated prenatal homocysteine levels as a risk factor for schizophrenia
    • Brown A.S., et al. Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Arch. Gen. Psychiatry 64 (2007) 31-39
    • (2007) Arch. Gen. Psychiatry , vol.64 , pp. 31-39
    • Brown, A.S.1
  • 44
    • 0141683745 scopus 로고    scopus 로고
    • Homocysteine induces trophoblast cell death with apoptotic features
    • Di Simone N., et al. Homocysteine induces trophoblast cell death with apoptotic features. Biol. Reprod. 69 (2003) 1129-1134
    • (2003) Biol. Reprod. , vol.69 , pp. 1129-1134
    • Di Simone, N.1
  • 45
    • 34047258298 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    • Burdge G.C., et al. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br. J. Nutr. 97 (2007) 435-439
    • (2007) Br. J. Nutr. , vol.97 , pp. 435-439
    • Burdge, G.C.1
  • 46
    • 33749026098 scopus 로고    scopus 로고
    • Maternal methyl supplements increase offspring DNA methylation at Axin fused
    • Waterland R.A., et al. Maternal methyl supplements increase offspring DNA methylation at Axin fused. Genesis 44 (2006) 401-406
    • (2006) Genesis , vol.44 , pp. 401-406
    • Waterland, R.A.1
  • 47
    • 0035909980 scopus 로고    scopus 로고
    • Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase
    • Yamada K., et al. Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 14853-14858
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 14853-14858
    • Yamada, K.1
  • 48
    • 33749494516 scopus 로고    scopus 로고
    • A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism
    • Reed M.C., et al. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J. Nutr. 136 (2006) 2653-2661
    • (2006) J. Nutr. , vol.136 , pp. 2653-2661
    • Reed, M.C.1
  • 49
    • 46249104490 scopus 로고    scopus 로고
    • Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
    • Allen N.C., et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat. Genet. 40 (2008) 827-834
    • (2008) Nat. Genet. , vol.40 , pp. 827-834
    • Allen, N.C.1
  • 50
    • 50249135384 scopus 로고    scopus 로고
    • Genetic associations with schizophrenia: meta-analyses of 12 candidate genes
    • Shi J., et al. Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr. Res. 104 (2008) 96-107
    • (2008) Schizophr. Res. , vol.104 , pp. 96-107
    • Shi, J.1
  • 51
    • 22544476559 scopus 로고    scopus 로고
    • Folate deficiency inhibits proliferation of adult hippocampal progenitors
    • Kruman I.I., et al. Folate deficiency inhibits proliferation of adult hippocampal progenitors. Neuroreport 16 (2005) 1055-1059
    • (2005) Neuroreport , vol.16 , pp. 1055-1059
    • Kruman, I.I.1
  • 52
    • 70349655079 scopus 로고    scopus 로고
    • Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study
    • Sun D., et al. Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Mol. Psychiatry (2008)
    • (2008) Mol. Psychiatry
    • Sun, D.1
  • 53
    • 33846297362 scopus 로고    scopus 로고
    • Excitotoxic neuronal injury in chronic homocysteine neurotoxicity studied in vitro: the role of NMDA and group I metabotropic glutamate receptors
    • Zieminska E., and Lazarewicz J.W. Excitotoxic neuronal injury in chronic homocysteine neurotoxicity studied in vitro: the role of NMDA and group I metabotropic glutamate receptors. Acta. Neurobiol. Exp. (Wars) 66 (2006) 301-309
    • (2006) Acta. Neurobiol. Exp. (Wars) , vol.66 , pp. 301-309
    • Zieminska, E.1    Lazarewicz, J.W.2
  • 54
    • 0030915272 scopus 로고    scopus 로고
    • Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor
    • Lipton S.A., et al. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 5923-5928
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 5923-5928
    • Lipton, S.A.1
  • 55
    • 33744900653 scopus 로고    scopus 로고
    • Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors
    • Kartvelishvily E., et al. Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors. J. Biol. Chem. 281 (2006) 14151-14162
    • (2006) J. Biol. Chem. , vol.281 , pp. 14151-14162
    • Kartvelishvily, E.1
  • 56
    • 0027400406 scopus 로고
    • Abnormal serine-glycine metabolism in the brains of schizophrenics
    • Waziri R., et al. Abnormal serine-glycine metabolism in the brains of schizophrenics. Schizophr. Res. 8 (1993) 233-243
    • (1993) Schizophr. Res. , vol.8 , pp. 233-243
    • Waziri, R.1
  • 57
    • 0033594947 scopus 로고    scopus 로고
    • A hyperglycinergic rat model for the pathogenesis of schizophrenia: preliminary findings
    • Waziri R., and Baruah S. A hyperglycinergic rat model for the pathogenesis of schizophrenia: preliminary findings. Schizophr. Res. 37 (1999) 205-215
    • (1999) Schizophr. Res. , vol.37 , pp. 205-215
    • Waziri, R.1    Baruah, S.2
  • 59
    • 34249099711 scopus 로고    scopus 로고
    • NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
    • Lau C.G., and Zukin R.S. NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat. Rev. Neurosci. 8 (2007) 413-426
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 413-426
    • Lau, C.G.1    Zukin, R.S.2
  • 60
    • 10244229166 scopus 로고    scopus 로고
    • Mitochondrial impairment in the developing brain after hypoxia-ischemia
    • Hagberg H. Mitochondrial impairment in the developing brain after hypoxia-ischemia. J. Bioenerg. Biomembr. 36 (2004) 369-373
    • (2004) J. Bioenerg. Biomembr. , vol.36 , pp. 369-373
    • Hagberg, H.1
  • 61
    • 0035878141 scopus 로고    scopus 로고
    • Electron microscopy of oligodendroglia in severe mental illness
    • Uranova N., et al. Electron microscopy of oligodendroglia in severe mental illness. Brain Res. Bull. 55 (2001) 597-610
    • (2001) Brain Res. Bull. , vol.55 , pp. 597-610
    • Uranova, N.1
  • 62
    • 0032953266 scopus 로고    scopus 로고
    • Mitochondrial pathology in human schizophrenic striatum: a postmortem ultrastructural study
    • Kung L., and Roberts R.C. Mitochondrial pathology in human schizophrenic striatum: a postmortem ultrastructural study. Synapse 31 (1999) 67-75
    • (1999) Synapse , vol.31 , pp. 67-75
    • Kung, L.1    Roberts, R.C.2
  • 63
    • 70449527034 scopus 로고    scopus 로고
    • Ultrastructural abnormalities of astrocytes in the hippocampus in schizophrenia and duration of illness: a postortem morphometric study
    • Kolomeets N.S., and Uranova N. Ultrastructural abnormalities of astrocytes in the hippocampus in schizophrenia and duration of illness: a postortem morphometric study. World J. Biol. Psychiatry (2009) 1-11
    • (2009) World J. Biol. Psychiatry , pp. 1-11
    • Kolomeets, N.S.1    Uranova, N.2
  • 64
    • 2942604863 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress
    • 643
    • Prabakaran S., et al. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol. Psychiatry 9 (2004) 684-697 643
    • (2004) Mol. Psychiatry , vol.9 , pp. 684-697
    • Prabakaran, S.1
  • 65
    • 60349098146 scopus 로고    scopus 로고
    • Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis
    • Regenold W.T., et al. Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis. Biol. Psychiatry 65 (2009) 489-494
    • (2009) Biol. Psychiatry , vol.65 , pp. 489-494
    • Regenold, W.T.1
  • 66
    • 2342573633 scopus 로고    scopus 로고
    • Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders
    • Ben-Shachar D., et al. Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders. Biochem. Pharmacol. 67 (2004) 1965-1974
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 1965-1974
    • Ben-Shachar, D.1
  • 67
    • 0041833480 scopus 로고    scopus 로고
    • Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine
    • Ho P.I., et al. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol. Dis. 14 (2003) 32-42
    • (2003) Neurobiol. Dis. , vol.14 , pp. 32-42
    • Ho, P.I.1
  • 68
    • 7444239650 scopus 로고    scopus 로고
    • Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation
    • Tjiattas L., et al. Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell 3 (2004) 71-76
    • (2004) Aging Cell , vol.3 , pp. 71-76
    • Tjiattas, L.1
  • 69
    • 0037289759 scopus 로고    scopus 로고
    • Homocysteine-evoked 45Ca release in the rabbit hippocampus is mediated by both NMDA and group I metabotropic glutamate receptors: in vivo microdialysis study
    • Lazarewicz J.W., et al. Homocysteine-evoked 45Ca release in the rabbit hippocampus is mediated by both NMDA and group I metabotropic glutamate receptors: in vivo microdialysis study. Neurochem. Res. 28 (2003) 259-269
    • (2003) Neurochem. Res. , vol.28 , pp. 259-269
    • Lazarewicz, J.W.1
  • 70
    • 33645845744 scopus 로고    scopus 로고
    • Excitotoxic neuronal injury in acute homocysteine neurotoxicity: role of calcium and mitochondrial alterations
    • Zieminska E., et al. Excitotoxic neuronal injury in acute homocysteine neurotoxicity: role of calcium and mitochondrial alterations. Neurochem. Int. 48 (2006) 491-497
    • (2006) Neurochem. Int. , vol.48 , pp. 491-497
    • Zieminska, E.1
  • 71
    • 0036270262 scopus 로고    scopus 로고
    • Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
    • Duan W., et al. Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J. Neurochem. 80 (2002) 101-110
    • (2002) J. Neurochem. , vol.80 , pp. 101-110
    • Duan, W.1
  • 72
    • 0032515179 scopus 로고    scopus 로고
    • Homocysteine-dependent alterations in mitochondrial gene expression, function and structure
    • Austin R.C., et al. Homocysteine-dependent alterations in mitochondrial gene expression, function and structure. J. Biol. Chem. 273 (1998) 30808-30817
    • (1998) J. Biol. Chem. , vol.273 , pp. 30808-30817
    • Austin, R.C.1
  • 73
    • 33646075145 scopus 로고    scopus 로고
    • New variants in the mitochondrial genomes of schizophrenic patients
    • Martorell L., et al. New variants in the mitochondrial genomes of schizophrenic patients. Eur. J. Hum. Genet. 14 (2006) 520-528
    • (2006) Eur. J. Hum. Genet. , vol.14 , pp. 520-528
    • Martorell, L.1
  • 74
    • 0242667149 scopus 로고    scopus 로고
    • A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress
    • Marchbanks R.M., et al. A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophr. Res. 65 (2003) 33-38
    • (2003) Schizophr. Res. , vol.65 , pp. 33-38
    • Marchbanks, R.M.1
  • 75
    • 27644581655 scopus 로고    scopus 로고
    • Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia
    • Tyagi N., et al. Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia. J. Cell. Biochem. 96 (2005) 665-671
    • (2005) J. Cell. Biochem. , vol.96 , pp. 665-671
    • Tyagi, N.1
  • 76
    • 49049116608 scopus 로고    scopus 로고
    • Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene
    • Bamne M.N., et al. Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene. Schizophr. Bull. 34 (2008) 458-465
    • (2008) Schizophr. Bull. , vol.34 , pp. 458-465
    • Bamne, M.N.1
  • 77
    • 1542359567 scopus 로고    scopus 로고
    • Folic acid rescues nitric oxide-induced neural tube closure defects
    • Weil M., et al. Folic acid rescues nitric oxide-induced neural tube closure defects. Cell Death Differ. 11 (2004) 361-363
    • (2004) Cell Death Differ. , vol.11 , pp. 361-363
    • Weil, M.1
  • 78
    • 34249825521 scopus 로고    scopus 로고
    • Nitric oxide and mitochondria
    • Brown G.C. Nitric oxide and mitochondria. Front. Biosci. 12 (2007) 1024-1033
    • (2007) Front. Biosci. , vol.12 , pp. 1024-1033
    • Brown, G.C.1
  • 79
    • 0029101854 scopus 로고
    • Decreased cytochrome c oxidase activity and lack of age-related accumulation of mitochondrial DNA deletions in the brains of schizophrenics
    • Cavelier L., et al. Decreased cytochrome c oxidase activity and lack of age-related accumulation of mitochondrial DNA deletions in the brains of schizophrenics. Genomics 29 (1995) 217-224
    • (1995) Genomics , vol.29 , pp. 217-224
    • Cavelier, L.1
  • 80
    • 0033974589 scopus 로고    scopus 로고
    • Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics
    • Prince J.A., et al. Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics. Neuropsychopharmacol. 22 (2000) 284-292
    • (2000) Neuropsychopharmacol. , vol.22 , pp. 284-292
    • Prince, J.A.1
  • 81
    • 0027394523 scopus 로고
    • Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development
    • Akbarian S., et al. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch. Gen. Psychiatry 50 (1993) 169-177
    • (1993) Arch. Gen. Psychiatry , vol.50 , pp. 169-177
    • Akbarian, S.1
  • 82
    • 34447521395 scopus 로고    scopus 로고
    • NO synthase-positive striatal interneurons are decreased in schizophrenia
    • Fritzen S., et al. NO synthase-positive striatal interneurons are decreased in schizophrenia. Eur. Neuropsychopharmacol. 17 (2007) 595-599
    • (2007) Eur. Neuropsychopharmacol. , vol.17 , pp. 595-599
    • Fritzen, S.1
  • 83
    • 0032484549 scopus 로고    scopus 로고
    • Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics
    • Bernstein H.G., et al. Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 83 (1998) 867-875
    • (1998) Neuroscience , vol.83 , pp. 867-875
    • Bernstein, H.G.1
  • 84
    • 1842556339 scopus 로고    scopus 로고
    • Expression of nNOS and soluble guanylate cyclase in schizophrenic brain
    • Baba H., et al. Expression of nNOS and soluble guanylate cyclase in schizophrenic brain. Neuroreport 15 (2004) 677-680
    • (2004) Neuroreport , vol.15 , pp. 677-680
    • Baba, H.1
  • 85
    • 0030582418 scopus 로고    scopus 로고
    • Elevated endogenous nitric oxide synthase inhibitor in schizophrenic plasma might reflect abnormalities in brain nitric oxide production
    • Das I., et al. Elevated endogenous nitric oxide synthase inhibitor in schizophrenic plasma might reflect abnormalities in brain nitric oxide production. Neurosci. Lett. 215 (1996) 209-211
    • (1996) Neurosci. Lett. , vol.215 , pp. 209-211
    • Das, I.1
  • 86
    • 0036430378 scopus 로고    scopus 로고
    • State-dependent alterations in mitochondrial complex I activity in platelets: a potential peripheral marker for schizophrenia
    • Dror N., et al. State-dependent alterations in mitochondrial complex I activity in platelets: a potential peripheral marker for schizophrenia. Mol. Psychiatry 7 (2002) 995-1001
    • (2002) Mol. Psychiatry , vol.7 , pp. 995-1001
    • Dror, N.1
  • 87
    • 30144435733 scopus 로고    scopus 로고
    • Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia
    • Steullet P., et al. Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia. Neuroscience 137 (2006) 807-819
    • (2006) Neuroscience , vol.137 , pp. 807-819
    • Steullet, P.1
  • 88
    • 48749112603 scopus 로고    scopus 로고
    • N-acetyl cysteine as a glutathione precursor for schizophrenia - a double-blind, randomized, placebo-controlled trial
    • Berk M., et al. N-acetyl cysteine as a glutathione precursor for schizophrenia - a double-blind, randomized, placebo-controlled trial. Biol. Psychiatry 64 (2008) 361-368
    • (2008) Biol. Psychiatry , vol.64 , pp. 361-368
    • Berk, M.1
  • 89
    • 34948858402 scopus 로고    scopus 로고
    • Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized phase 2 clinical trial
    • Patil S.T., et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized phase 2 clinical trial. Nat. Med. 13 (2007) 1102-1107
    • (2007) Nat. Med. , vol.13 , pp. 1102-1107
    • Patil, S.T.1
  • 90
    • 17644384824 scopus 로고    scopus 로고
    • The role of cystathionine beta-synthase in homocysteine metabolism
    • Jhee K.H., and Kruger W.D. The role of cystathionine beta-synthase in homocysteine metabolism. Antioxid. Redox Signal 7 (2005) 813-822
    • (2005) Antioxid. Redox Signal , vol.7 , pp. 813-822
    • Jhee, K.H.1    Kruger, W.D.2
  • 91
    • 0033787297 scopus 로고    scopus 로고
    • Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
    • Do K.Q., et al. Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur. J.Neurosci. 12 (2000) 3721-3728
    • (2000) Eur. J.Neurosci. , vol.12 , pp. 3721-3728
    • Do, K.Q.1
  • 92
    • 29244464827 scopus 로고    scopus 로고
    • Altered glutathione redox state in schizophrenia
    • Yao J.K., et al. Altered glutathione redox state in schizophrenia. Dis. Markers 22 (2006) 83-93
    • (2006) Dis. Markers , vol.22 , pp. 83-93
    • Yao, J.K.1
  • 93
    • 39049193486 scopus 로고    scopus 로고
    • Imbalanced free radicals and antioxidant defense systems in schizophrenia: a comparative study
    • Li H.C., et al. Imbalanced free radicals and antioxidant defense systems in schizophrenia: a comparative study. J. Zhejiang Univ. Sci. B 7 (2006) 981-986
    • (2006) J. Zhejiang Univ. Sci. B , vol.7 , pp. 981-986
    • Li, H.C.1
  • 94
    • 36749104268 scopus 로고    scopus 로고
    • Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence
    • Gysin R., et al. Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 16621-16626
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 16621-16626
    • Gysin, R.1
  • 95
    • 4644307783 scopus 로고    scopus 로고
    • Glutathione S-transferase M1 polymorphism might contribute to schizophrenia in the Korean population
    • Pae C.U., et al. Glutathione S-transferase M1 polymorphism might contribute to schizophrenia in the Korean population. Psychiatr. Genet. 14 (2004) 147-150
    • (2004) Psychiatr. Genet. , vol.14 , pp. 147-150
    • Pae, C.U.1
  • 96
    • 0034803190 scopus 로고    scopus 로고
    • Glutathione S-transferase M1 gene deletion might be associated with susceptibility to certain forms of schizophrenia
    • Harada S., et al. Glutathione S-transferase M1 gene deletion might be associated with susceptibility to certain forms of schizophrenia. Biochem. Biophys. Res. Commun. 281 (2001) 267-271
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 267-271
    • Harada, S.1
  • 97
    • 33846018435 scopus 로고    scopus 로고
    • A functional transsulfuration pathway in the brain links to glutathione homeostasis
    • Vitvitsky V., et al. A functional transsulfuration pathway in the brain links to glutathione homeostasis. J. Biol. Chem. 281 (2006) 35785-35793
    • (2006) J. Biol. Chem. , vol.281 , pp. 35785-35793
    • Vitvitsky, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.