Mitochondrial pathology in human schizophrenic striatum: A postmortem ultrastructural study

Synapse

Volumn 31, Issue 1, 1999, Pages 67-75

  Kung, Lili ^a,b   Roberts, Rosalinda C ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

^b LUTHERAN MEDICAL CENTER   (United States)

Author keywords

Basal ganglia; Electron microscopy; Metabolism

Indexed keywords

ARTICLE; AUTOPSY; BASAL GANGLION; BRAIN METABOLISM; CORPUS STRIATUM; ELECTRON MICROSCOPY; ENERGY METABOLISM; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION; ULTRASTRUCTURE;

EID: 0032953266     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-2396(199901)31:1<67::aid-syn9>3.0.co;2-%23     Document Type: Article

References (64)

1. Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Ponto LLB, Hichwa RD. 1997. Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients. Lancet 349:1730-1734.
2. Bartlett EJ, Wolkin A, Brodie JD, Laska EM, Wolf AP. 1991. Importance of pharmacologic control in PET studies: Effects of thiothixene and haloperidol on cerebral glucose utilization in chronic schizophrenia. Psychiatry Res Neuroimaging 40:115-124.
3. Benecke R, Strumper P, Weiss H. 1992. Electron transfer complex I defect in idiopathic dystonia. Ann Neurol 32:683-686.
4. Bereiter-Hahn J, Voth M. 1994. Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria. Microsc Res Tech 27:198-219.
5. Bilder RM, Wu H, Chakos MH, Bogerts B, Pollock S, Aronowitz J, Ashtari M, Degreef G, Kane JM, Lieberman JA. 1994. Cerebral morphometry and clozapine treatment in schizophrenia. J Clin Psychiatry 55(Suppl. B):53-60.
6. Bogerts B, Meertz E, Schönfeldt-Bausch R. 1985. Basal ganglia and limbic system pathology in schizophrenia. Arch Gen Psychiatry 42:784-790.
7. Breier A, Buchanan RW, Elkashef A, Munson RC, Kirkpatrick B, Gellad F. 1992. Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Arch Gen Psychiatry 49:921-926.
8. Brown GC. 1992. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J 284:1-13.
9. Buchanan RW, Breier A, Kirkpatrick B, Elkashef A, Munson RC, Gellad F, Carpenter WT. 1993. Structural abnormalities in deficit and nondeficit schizophrenia. Am J Psychiatry 150:59-65.
10. Buchsbaum MS. 1990. The frontal lobes, basal ganglia and temporal lobes as sites for schizophrenia. Schizophr Bull 16:379-390.
11. Buchsbaum MS, Wu JC, DeLisi LE, Holcomb HH, Hazlett E, Cooper-Langston K, Kessler R. 1987. Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: Differences between normal controls and schizophrenic patients. Biol Psychiatry 22:479-494.
12. Buchsbaum MS, Haier RJ, Potkin SG, Nuechterlein K, Bracha HS, Katz M, Lohr J, Wu J, Lottenberg S, Jerabek PA, Trenary M, Tafalla R, Reynolds C, Bunney WE. 1992a. Frontstriatal disorder of cerebral metabolism in never-medicated schizophrenics. Arch Gen Psychiatry 49:935-942.
13. Buchsbaum MS, Potkin SG, Siegel BV Jr, Lohr J, Katz M, Gottschalk A, Gulasekaram B, Marshall JF, Lottenberg S, Teng CY, Abel L, Plon L, Bunney WE Jr. 1992b. Striatal metabolic rate and clinical response to neuroleptics in schizophrenia. Arch Gen Psychiatry 49:966-974.
14. Burkhardt C, Kelly JP, Lim Y-H, Filley CM, Parker WD Jr. 1993. Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol 33:512-517.
15. Byczkowski JZ, Borysewicz R. 1979. The action of chlorpromazine and imipramine on rat brain mitochondria. Gen Pharmacol 10:369-372.
16. Chakos MH, Lieberman JA, Bilder RM, Borenstein M, Lerner G, Bogerts B, Wu H, Kinon B, Ashtari M. 1994. Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs. Am J Psychiatry 151:1430-1436.
17. Cleghorn JM, Franco S, Szechtman B, Kaplan RD, Szechtman H, Brown GM, Nahmias C, Garnett ES. 1992. Toward a brain map of auditory hallucinations. Am J Psychiatry 149:1062-1069.
18. Cohen RM, Semple WE, Gross M, Norhadl TE, Holcomb HH, Dowling S, Pickar D. 1988. The effect of neuroleptics on dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sci 43:1141-1150.
19. DeLisi LE, Holcomb HH, Cohen RM, Pickar D, Carpenter W, Morihisa JM, King AC, Kessler R, Buchsbaum MS. 1985. Positron emission tomography in schizophrenic patients with and without neuroleptic medication. J Cereb Blood Flow Metab 5:201-206.
20. Elkashef A, Buchanan RW, Gellad F, Munson RC, Breier A. 1994. Basal ganglia pathology in schizophrenia and tardive dyskinesia: An MRI quantitative study. Am J Psychiatry 151:752.
21. Gallagher CH, Koch JH, Mann DM. 1965. The effect of phenothiazine on the metabolism of liver mitochondria. Biochem Pharmacol 14: 789-797.
22. Goff DC, Tsai G, Beal MF, Coyle JT. 1995. Tardive dyskinesia and substrates of energy metabolism in CSF. Am J Psychiatry 152:1730-1736.
23. Gu M, Gash MT, Mann VM, Javoy-Agid F, Cooper JM, Schapira AHV. 1996. Mitochondrial defect in Huntington's disease caudate nucleus. Ann Neurol 39:385-389.
24. Gunter TE, Gunter KK, Sheu S-S, Gavin CE. 1994. Mitochondrial calcium transport: Physiological and pathological relevance. Am J Physiol 267:C313-C339.
25. Guth PS, Spirtes MA. 1964. The phenothiazine tranquilizers: Biochemical and biophysical actions. Int Rev Neurobiol 7:231-278.
26. Hatefi Y. 1993. ATP synthesis in mitochondria. Eur J Biochem 218:759-767.
27. Heckers S, Heinsen H, Heinsen Y, Beckman H. 1991. Cortex, white matter, and basal ganglia in schizophrenia: A volumetric postmortem study. Biol Psychiatry 29:556-566.
28. Holcomb HH, Cascella NG, Thaker GK, Medoff DR, Dannals RF, Tamminga CA. 1996. Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol. Am J Psychiatry 153:41-49.
29. Holt DJ, Graybiel AM, Hyde TM, Herman MM, Kleinman JE, German DC, Saper CB. 1994. Decreased density of cholinergic interneurons in the striatum of schizophrenics. Soc Neurosci Abstr 20:784.
30. Ichiki T, Tanaka M, Nishikimi M, Suzuki H, Ozawa T, Kobayashi M, Wada Y. 1988. Deficiency of subunits of complex I and mitochondrial encephalomyopathy. Ann Neurol 23:287-294.
31. Jernigan TL, Zisook S, Heaton RK, Moranville JT, Hesselink JR, Braff DL. 1991. Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Arch Gen Psychiatry 48:881-890.
32. Kadekaro M, Crane AM, Sokoloff L. 1985. Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat. Proc Natl Acad Sci USA 82:6010-6013.
33. Kelley JJ, Kung L, Roberts RC. 1997. Ultrastructural changes in dopaminergic neurons in the substantia nigra pars compacta of rats treated chronically with haloperidol. Soc Neurosci Abstr 23:191.
34. Kemp JM, and Powell TPS. 1971a. The site of termination of afferent fibres in the caudate nucleus. Phil Trans R Soc Lond (Biol) 262: 413-427.
35. Kemp JM, Powell TPS. 1971b. The termination of fibres from the cerebral cortex and thalamus upon dendritic spines in the caudate nucleus: Astudy with the Golgi method. Phil Trans R Soc Lond (Biol) 262:429-439.
36. Keshavan MS, Bagwell WW, Haas GL, Sweeney JA, Schooler NR, Pettegrew JW. 1994. Changes in caudate volume with neuroleptic treatment (Letter). Lancet 344:1434.
37. Kleinman JE, Hong J, Iadarola M, Govoni S, Gillin CJ. 1985. Neuropeptides in human brain - Postmortem studies. Prog Neuropsychopharmacol Biol Psychiatry 9:91-95.
38. Korpi ER, Kleinman JE, Goodman SI, Phillips I, DeLisi LE, Linnoila M, Wyatt RJ. 1986. Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death. Arch Gen Psychiatry 43:594-600.
39. Kung L, Conley R, Chute DJ, Smialek J, Roberts RC. 1998. Synaptic changes in the striatum of schizophrenic cases: A controlled postmortem ultrastructural study. Synapse 28:125-239.
40. Leterrier JF. Rusakov DA, Nelson BD, Linden M. 1994. Interactions between brain mitochondria and cytoskeleton: Evidence for specialized outer membrane domains involved in the association of cytoskeleton-associated proteins to mitochondria in situ and in vitro. Microsc Res Tech 27:233-261.
41. Mjaatvedt AE, Wong-Riley MTT. 1988. Relationship between synaptogenesis and cytochrome oxidase activity in purkinje cells of the developing rat cerebellum. J Comp Neurol 277:155-182.
42. Mjaatvedt AE, Wong-Riley MTT. 1991. Effects of unilateral climbing fibre deafferentation on cytochrome oxidase activity in the developing rat cerebellum. J Neurocytol 20:2-16.
43. Orlovskaya DD, Denisov DV, Uranova NA. 1997. The ultrastructural pathology of myelinated fibers and oligodendroglial cells in autopsied caudate nucleus of schizophrenics. Schizophr Res 24(1,2): 39-40.
44. Parker WD Jr, Boyson SJ, Parks JK. 1989a. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-723.
45. Parker WD, Olet CA, Parks JK. 1989b. A defect in mitochondrial electron-transport activity (NADH-coenzyme Q oxidoreductase) in Leber's hereditary optic neuropathy. N Engl J Med 320:1331-1333.
46. Parker WD Jr, Boyson SJ, Luder AS, Parks JK. 1990. Evidence for a defect in NADH: Ubiquinone oxidoreductase (complex I) in Huntington's disease. Neurology 40:1231-1234.
47. Resnick SM, Gur RE, Alavi A, Gur RC, Reivich M. 1988. Positron emission tomography and subcortical glucose metabolism in schizophrenia. Psychiatry Res 24:1-11.
48. Roberts RC, Gaither LA, Gao X-M, Kashyap SM, Tamminga CA. 1995a. Ultrastructural correlates of haloperidol-induced oral dyskinesias in rat striatum. Synapse 20:234-243.
49. Roberts RC, Gaither LA, Peretti F, Conley R, Lapidus B. 1995b. Striatal pathology in schizophrenia: A postmortem ultrastructural study. Soc Neurosci Abstr 21:237.
50. Roberts RC, Conley R, Kung L, Peretti FJ, Chute DJ. 1996a. Reduced striatal spine size in schizophrenia: A postmortem ultrastructural study. NeuroReport 7:1214-1218.
51. Roberts RC, Gaither LA, Peretti FJ, Lapidus B, Chute DJ. 1996b. The synaptic organization of the human striatum: A postmortem ultrastructural study. J Comp Neurol 374:523-534.
52. Roberts RC, McKim RA, Crosby K, Force M, Kung L. 1997. Ultrastructural changes in dopaminergic neurons in the substantia nigra pars compacta of schizophrenics. Soc Neurosci Abstr 23:2199.
53. Salzman S, Endicott J, Clayton P, Winokur G. 1983. Diagnostic Evaluation After Death (DEAD). Rockville, MD: National Institute of Mental Health, Neuroscience Research Branch.
54. Saper CB. 1996. Any way you cut it: A new journal policy for the use of unbiased counting methods. J Comp Neurol 364:5.
55. Senior AE. 1988. ATP synthesis by oxidative phosphorylation. Physiol Rev 68:177-231.
56. Simpson MD, Slater P, Royston MC, Deakin JF. 1992. Regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia in schizophrenia. Psychiatry Res 42:273.
57. Swayze VW II, Andreasen NC, Alliger RJ, Yuh WT, Ehrhardt JC. 1992. Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biol Psychiatry 31:221-240.
58. Uranova NA, Orlovskaya DD. 1996. Ultrastructural pathology of neuronal connectivity in postmortem brains of schizophrenia patients. Ann Psych 6:55-72.
59. Uranova NA, Casanova MF, DeVaughn NM, Orlovskaya DD, Denisov DV. 1996. Ultrastructural alterations of synaptic contacts and astrocytes in postmortem caudate nucleus of schizophrenic patients. Schizophr Res 22:81-83.
60. Uranova NA, Orlovskaya DD, Kolomeets NS, Vikchreva OV, Zimina IS, Denisov DV. 1997. Morphometric study of synaptic size in autopsied prefrontal cortex, caudate nucleus and substantia nigra of schizophrenics. Schizophr Res 24(1,2):41-42.
61. Wik G, Wiesel FA, Sjorgen I, Blomqvist G, Greitz T, Stone-Elander S. 1989. Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography. Psychopharmacology (Berl) 97: 309-318.
62. Williamson P. 1987. Hypofrontality in schizophrenia: A review of the evidence. Can J Psychiatry 32:399-404.
63. Wong-Riley MTT. 1989. Cytochrome oxidase: An endogenous metabolic marker for neuronal activity. Trends Neurosci 12:94-101.
64. Young AH, Blackwood DHR, Roxborough H, McQueen JK, Martin MJ, Kean D. 1991. A magnetic resonance imaging study of schizophrenia: Brain structure and clinical symptoms. Br J Psychiatry 158: 158-164.