Ectodomain shedding of the receptor for advanced glycation end products: A novel therapeutic target for Alzheimer's disease

Cellular and Molecular Life Sciences

Volumn 66, Issue 24, 2009, Pages 3923-3935

  Zhang, Ling ^a   Postina, Rolf ^b   Wang, Yingqun ^c  

^a AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

ADAM10; Alzheimer's disease; Amyloid peptide; Ectodomain shedding; MMP9; Receptor for advanced glycation end products

Indexed keywords

ADAM PROTEIN; ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; BRYOSTATIN; GAMMA SECRETASE; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PF 4494700; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; BIOTINYLATION; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CELL MIGRATION; CLINICAL TRIAL; DISEASE MARKER; DRUG TARGETING; ENZYME ACTIVITY; GLYCATION; HUMAN; MICROGLIA; NEGATIVE FEEDBACK; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN VARIANT; REVIEW; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BINDING SITES; HUMANS; MATRIX METALLOPROTEINASE 9; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC;

EID: 70849087805     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0121-4     Document Type: Review

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