Identification of serum factor inducing ectodomain shedding of proHB-EGF and studies of noncleavable mutants of proHB-EGF

Biochemical and Biophysical Research Communications

Volumn 283, Issue 4, 2001, Pages 915-922

  Hirata, Michinari ^a   Umata, Toshiyuki ^b   Takahashi, Tsuyoshi ^a   Ohnuma, Masaaki ^b   Miura, Yoshiki ^b   Iwamoto, Ryo ^a   Mekada, Eisuke ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KURUME UNIVERSITY   (Japan)

Author keywords

Ectodomain shedding; HB EGF; Lysophosphatidic acid; Mitogenic activity; Phospholipase B; Serum factor

Indexed keywords

EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; SERUM FACTOR; VERO CELL;

EID: 0034811076     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4879     Document Type: Article

References (37)

1. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
2. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: Conversion from juxtacrine to paracrine growth factor activity
3. Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity
4. Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin α3β1 at cell-cell contact sites
5. The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor
6. Contact-dependent growth inhibition and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by the membrane-anchored form of heparin-binding EGF-like growth factor
7. Related articles membrane-anchored growth factors
8. Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation
9. Shedding of the lymphocyte L-selectin adhesion molecule is inhibited by a hydroxamic acid-based protease inhibitor. Identification with an L-selectin-alkaline phosphatase reporter
10. Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation
11. ECM and cell surface proteolysis: Regulating cellular ecology
12. Cleavage of amyloid beta peptide during constitutive processing of its precursor
13. Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process
14. Fas ligand in human serum
15. Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing
16. A metalloprotease-disintegrin, MDC9/meltrin-γ/ADAM9 and PKCδ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
17. Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells
18. The selective loss of lysophospholipids in some commonly used lipid-extraction procedures
19. A comparison of extraction methods for the isolation of phospholipids from biological sources
20. Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma
21. Diphtheria toxin binds to the EGF-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity
22. Bioactive lysophospholipids and their G protein-coupled receptors
23. Transport of lysolecithin by albumin in human and rat plasma
24. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
25. The bioactive phospholipid lysophosphatidic acid is released from activated platelets
26. Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid
27. A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid
28. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
29. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid
30. Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein
31. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site
32. Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase
33. Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury
34. Production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at sites of thermal injury in pediatric patients
35. Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes
36. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing
37. Heparin-binding EGF-like growth factor: A juxtacrine growth factor