Inhibitors of tryptase for the treatment of mast cell-mediated diseases

Current Pharmaceutical Design

Volumn 4, Issue 5, 1998, Pages 381-396

  Rice, Kenneth D ^a   Tanaka, Riqhard D ^b   Katz, Bradley A ^a   Numerof, Robert P ^a   Moore, William R ^a  

^a Axys Pharmaceuticals Inc   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,1',3,1'' TERPHENYL 3,3'' DICARBAMIDINIUM; 2,5 BIS(3 AMIDINOBENZYLIDENE)CYCLOPENTANONE; ANTIINFLAMMATORY AGENT; BIS(5 AMIDINO 2 BENZIMIDAZOLYL)METHANE; CHYMASE; ENZYME INHIBITOR; HEPARIN ANTAGONIST; IMMUNOGLOBULIN E; LACTOFERRIN; N (1 HYDROXY 2 NAPHTHOYL)ARGINYLPROLINAMIDE; PENTAMIDINE; SERINE PROTEINASE INHIBITOR; TRYPTASE; UNCLASSIFIED DRUG;

AIRWAY DYNAMICS; ALLERGY; ANIMAL EXPERIMENT; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; DIAGNOSTIC APPROACH ROUTE; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG TARGETING; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; INFLAMMATORY DISEASE; INHALATIONAL DRUG ADMINISTRATION; INTERMETHOD COMPARISON; MAST CELL DEGRANULATION; NONHUMAN; PATHOPHYSIOLOGY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; REVIEW; SHEEP; STRUCTURE ACTIVITY RELATION; TISSUE SPECIFICITY;

ANIMALS; CHYMASES; DRUG DESIGN; HUMANS; IMMUNE SYSTEM DISEASES; INFLAMMATION; INFLAMMATION MEDIATORS; MAST CELLS; MODELS, MOLECULAR; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; TRYPTASES;

EID: 0031721008     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (122)

1. Welle, M. J. Leukoc. Biol. 1997, 61, 233-245.
2. Yong, L. C. J. Exp. Toxic Pathol. 1997, 49, 409-424.
3. Irani, A. A.; Schechter, N. M.; Craig, S. S.; Deblois, G., Shwartz, L.B. Proc Natl. Acad Sci. USA 1986, 83, 4464-4468.
4. Shwartz, L.B.; Irani, A A ; Roller, K.; Castells, M. C.; Schechter, N. M J. Immunol. 1987, 138, 2611-2615.
5. Shwartz, L.B. In Neutral Proteases of Mast Cells. Monogr. Allergy; Shwartz, L.B., Ed.; Karger: Basel, 1990, pp. 90-113.
6. Miller, J. S.; Westin, E. H.; Shwartz, L.B J. Clin Invest. 1989, 84, 1188-1195.
7. Miller, J. S.; Moxley, G.; Shwartz, L B. J. Clin. Invest 1990, 86, 864-870.
8. Vanderslice, P. S.; Ballinger, S M.; Tam, E. K.; Goldstein, S. M , Craik, C. S.; Caughey, G H. Proc. Natl. Acad. Sci USA 1990, 87, 3811-3815.
9. Shwartz, L B.; Lewis, R. A.; Austen K. F. J. Biol. Chem. 1981, 256, 11939-11943.
10. Smith, T J ; Hougland, M. W.; Johnson, D. A. J. Biol. Chem. 1984, 259, 11046-11051.
11. Shwartz, L.B.; Bradford, T. R. J. Biol. Chem. 1986, 261, 7372-7379.
12. Harvima, I. T.; Schechter, N M., Harvima, R. J.; Fräki, J. E Biochim Biophys. Acta 1988, 957, 71-80.
13. Cromlish, J A , Siedah, N.G ; Marcinkiewicz, M.; Hamelinin, J., Johnson, D. A.; Chretein, M. J. Biol. Chem 1987, 262, 1363-1373.
14. Butterfield, J. H.; Weiler, D. A.; Hunt, L. W.; Wynn, S. R.; Roche, P. C. J Leukoc Biol 1990, 47, 409-419.
15. Shwartz, L.B.; Bradford, T. R , Lee, D. C.; Chlebowski, J F. J. Immunol. 1990, 144, 2304-2311
16. Alter, S C ; Metcalfe, D. D ; Bradford, T. R.; Shwartz, L B. Biochem. J. 1987, 248, 821-827.
17. Schechter, N. M.; Eng, G. Y.; McCaslin, D. R. Biochemistry 1993, 32, 2617-2625.
18. Addington, A. K.; Johnson, D. A Biochemistry 1996, 35, 13511-13518
19. Wenzel, S., Irani, A. A.; Sanders, J. M.; Bradford, T. R.; Schwartz, L. B J Immunol. Methods 1986, 86, 139-142.
20. Enander, I.; Matsson, P.; Nystrand, J et. al. J. Immunol Methods 1991, 138, 39-46.
21. Schwartz, L.B.; Metcalfe, D. D , Miller, J. S., Earl, H.; Sullivan, T. New Engl J. Med. 1987, 316, 1622-1626.
22. Wenzel, S. E., Fowler, A. A. III; Schwartz, L. B. Am. Rev. Respir. Dis. 1988, 137, 1002-1008.
23. Butrus, S. I.; Ochsner, K. I.; Abelson, M. B ; Schwartz, L. B. Ophthalmology 1990, 97, 1678-1683.
24. Rozniecki, J. J.; Hauser, S L.; Stein, M.; Lincoln, R.; Theoharides, T. C Ann. Neurol 1995, 37, 63-66.
25. Sabbah, A ; Drouet, M.; Guittot, M. Allerg. Immunol. (Paris) 1997, 29, 239-241.
26. Barbosa Pereira, P. J.; Bergner, A.; Macedo-Ribeiro, S.; Huber, R.; Matschiner, G., Fritz, H ; Sommerhoff, C. S ; Bode, W. Nature 1998, 392, 306-311.
27. Tam, E. K.; Caughey, G. H. Am. J. Respir. Cell Mol. Biol. 1990, 3, 27-32.
28. Lilly, C M.; Martins, M A.; Drazen, J. M. J. Clin. Invest. 1993, 91, 235-243.
29. Franconi, G. M.; Graf, P. D.; Lazarus, S. C.; Nadel, J. A.; Caughy, G H. J. Pharmacol. Exp. Ther. 1989, 24, 133-137.
30. Church, M. K ; Lowman, M. A.; Rees, P. H.; Benyon, R. C. Agents Actions 1989, 27, 8-16.
31. Walls, A. F ; Brain, S. D.; Desai, A. et. al. Biochem. Pharmacol. 1992, 43, 1243-1248.
32. Rosenfeld, M. G.; Mermod, J. J.; Amara, S. G.; Swanson, L. W.; Sawchenko, P. E., Rivier, J.; Vala, W. W ; Evans, R. M. Nature 1983, 30-4, 129-135
33. Haak-Frendscho, M.; Okragly, A ; Niles, A ; Schmidt, D.; Moon, T. D.; Jarrard, D. F ; Uehling, D. T.; Saban, R. FASEB J. 1998, 12, A596.
34. Gray, J. L.; Bunnett, N. W.; Orloff, S. L.; Mulvihill, S. J ; Debas, H. T. Ann. Surgery 1994, 279, 58-64.
35. Tache, Y.; Pappas, T.; Lauffenburger, M.; Goto, Y.; Watsh, J. H ; Debas, H. Gastroenterology 1984, 87, 344-349.
36. Bauerfeind, P.; Hoff, A. et. al. Amer. J. Physiol. 1989, 256, G145-149.
37. Beil, W.J.; Schulz, M.; McEuen, A. R.; Buckley, M. G.; Walls, A. F. Histochemical. 1997, 29, 759-773.
38. Goldstern, S M.; Leong, J., Bunnett, N. W. Peptides 1991, 12, 995-1000.
39. Schwartz, L. B.; Bradford, T R.; Littman, B. H.; Wintroub, B. U. J. Immunol. 1985, 135, 2762-2767.
40. Ren, S.; Lawson, A E.; Carr, M.; Baumgarten, C. M.; Schwartz, L. B. J. Immunol. 1997, 159, 3540-3548
41. Thomas, V. A.; Wheeless, C. J.; Stack, M. S.; Johnson, D. A. Biochemistry 1998, 37, 2291-2298.
42. Hsieh, K. H. Biochemistry 1997, 36, 9381-9387
43. Blair, R. J.; Meng, H.; Marchese, M. J.; Ren, S.; Schwartz, L. B.; Tonnesen, M G.; Gruber, B. L. J. Clin. Invest. 1997, 99, 2691-2700.
44. Lohi, J.; Harvima, I.; Keski-Oja, J. J. Cell. Biochem. 1992, 50, 337-349
45. Kielty, C. M.; Lees, M.; Shuttleworth, A.; Woolley, D. Biochem Biophys. Res. Commun. 1993, 191, 1230-1236.
46. Gruber, B L.; Marchese, M. J.; Suzuki, K ; Schwartz, L B.; Okada, Y.; Nagase, H.; Ramamurthy, N. S. J. Clin. Invest. 1989, 84, 1657-1662
47. Gruber, B. L.; Schwartz, L. B.; Ramamurthy, N. S ; Irani, A.; Marchese, M. J. J Immunol 1988, 740, 3936-3942.
48. Sepper, R , Konttinen, Y. T.; Buo, L.; Eklund, K. K., Lauhio, A.; Sorsa, T.; Tschesche, H.; Aasen, A. O ; Sillastu, H. Eur. Respir. J. 1997, 70, 2788-2793.
49. Stack, M. S.; Johnson, D. A. J. Biol. Chem. 1994, 269, 9416-9419.
50. Maier, M.; Spragg, J.; Schwartz, L. B. J. Immunol. 1983, 130, 2352-2356.
51. Schwartz, L. B.; Bradford, T R.; Griffin, J. H. Biochem. Biophys. Res. Commun. 1985, 729, 76-81.
52. Alter, S. C.; Yates, P.; Margolius, H. S ; Schwartz, L. B. Int. Archs. Allergy Appl. Immunol. 1987, 83, 321-324.
53. Proud, D.; Siekierski, E. S.; Bailey, G. S. Biochem. Pharmacol. 1988, 37, 1473-1480.
54. Walls, A. F ; Bennert, A. R ; Sueiras-Dias, J.; Olsson, H. Biochem. Soc. Trans. 1992, 22, 260S.
55. Imamura, T.; Dubin, A.; Moore, W.; Tanaka, R.; Travis, J. Lab. Invest. 1996, 74, 861-870
56. Abraham, W. M.; Burch, R. M.; Farmer, S. G. et. al. Am. Rev. Respir. Dis. 1991, 143, 787-796
57. Nystedt, S.; Emilsson, K.; Wahlestedt, C Sundelin, J. Proc. Natl. Acad. Sci. USA 1994, 97, 9208-9212
58. Mirza, H.; Yatsula, V.; Bahou, W. F J. Clin. Invest. 1996, 97, 1705.
59. Santulli, R. J.; Derian, C. K.; Darrow, A. L ; Tomko, K. A.; Eckardt, A. J.; Seilbarg, M ; Scarborough, R. M.; Andrade-Gordon, P. Proc. Natl Acad. Sci. USA 1995, 92, 9151.
60. Bohm, S K.; Kong, W. Y.; Bromme, D.; Smeekens, S. P.; Anderson, D. C.; Connolly, A.; Kahn, M.; Nelken, N. A.; Coughlin, R. S.; Payan, D. G.; Bunnett, N. W. Biochem. J. 1996, 314, 1009.
61. Corvera, C. U.; Dery, O.; McConalogue, K.; Khitin, L.; Böhrn S, K., W.; Kong, W ; Raymond, W.; Caughy, G.H.; Bunnett, N. W. Gastroenterology 1997, 112, A1140.
62. Fox, M T ; Harriott, P.; Walker, B., Stone, S. R. FEBS Letters 1997, 417, 267-269.
63. Mirza, H.; Schmidt, V. A.; Derian, C. K.; Jesty, J.; Bahou, W. F. Blood 1991, 90, 3914-2922.
64. Molino, M.; Barnathan, E. S.; Numerof, R.; Clark, J.; Dreyer, M.; Cumashi, A.; Hoxie, J. A.; Schechter, N.; Woolkalis, M.; Brass, L. F J Biol. Chem. 1997, 272, 4043-4049.
65. Wender, P. A.; Cribbs, C. M. Adv. Med. Chem. 1992, 1, 1.
66. Nishizuka, Y. Nature 1988, 334, 661.
67. Protein Kinase C Current Concepts and Future Perspectives; Lester, D. S., Ed.; Ellis Harwood, Ltd.: West Sussex, 1992.
68. Arnaout, R. K.; Ren, S.; Schwartz, L. B. J Allergy Clin. Immunol. 1998, 101, S110.
69. Gruber, B. A.; Kew, R R.; Jelaska, A.; Marchese, M. J.; Garlick, J ; Ren, S ; Schwartz, L. B.; Korn, J. H. J. Immunol 1997, 158, 2310-2317.
70. Cairns, J. A.; Walls, A. F. J. Clin. Invest 1997, 99, 1313-1321.
71. Cairns, J. A.; Walls, A. F. J Allergy Clin. Immunol. 1997, 101, S370
72. Cairns, J. A ; Walls, A. F J. Allergy Clin. Immunol. 1997, 101, S213.
73. Akers, I. A ; Laurent, G. J.; Sanjar, S.; McAnulty, R. J. FASEB J. 1998, 12, A434.
74. Kovacs, E J. Immmunol. Today 1991, 12, 17-23.
75. Patella, V ; Marino, I.; Arbustini, E.; Lamparter-Schummert, B.; Verga, L.; Adt, M.; Marone, G. Circulation 1998, 97, 971-978.
76. Jeziorska, M.; McCollum, C.; Woolley, D. E. J. Pathol. 1997, 182, 115-122
77. Biasucci, L. M.; Schiavino, D.; Luizzo, G ; Cuculo, A.; Meo, A.; Caligiuri, G., Summaria, F.; Rebuzzi, A. G.; Patriarca, G ; Maseri, A. J. Am. Coll. Cardiology 1997, 29, 271A.
78. He, S.; Peng, Q.; Walls, A. F. J. Immunol 1997, 159, 6216-6225.
79. Jung, K-S.; Shute, J. K.; Caims, J. A. et. al. Am. J. Respir. Crit. Care Med. 1995, 151, A530
80. Numerof, R.; Moore, W.; Tanaka, R. Am. J. Respir. Crit. Care Med. 1996, 153, A202.
81. Numerof, R P.; Simpson, P. J.; Tanaka, R. Exp. Opin. Invest. Drugs 1997, 6, 811-817.
82. Rossi, G. L.; Olivieri, D. Chest 1997, 112, 523-529.
83. Zhang, M-Q.; Timmerman, H. Mediators of Inflammation 1997, 6, 311-317.
84. Clark, J M ; Moore, W. R.; Tanaka, R. D Drugs of the Future 1996, 21, 811-816.
85. Buckley, M. G.; Teran, L M ; Walls, A. F. J. Allergy Clin. Immunol. 1997, 99, S235.
86. Elrod, K. C.; Moore, W. R.; Abraham, W. M.; Tanaka, R. D. Am. J. Respir. Crit. Care Med. 1997, 156, 375-381.
87. Kennedy, J. A.; Wright, C. D FASEB J. 1998, 12, A175
88. Louis, R.; Shute, J.; Biagi, S.; Stanciu, L ; Marrelli, F.; Tenor, H ; Hidi, R.; Djukanovic, R Am. J. Respir. Crit. Care Med. 1997, 155, 466-472.
89. Cairns, J. A ; Walls, A F. J. Immunol. 1996, 156, 275-283.
90. He, S.; Walls, A. F. Eur J Pharmacol. 1997, 328, 89-97.
91. Schwartz, L B. Meth Enzymol. 1994, 244, 88-100.
92. Cha, S. Biochem.Pharmacol. 1975, 24, 2177-2185.
93. Stubbs, M. T., Morenweiser, R.; Stürzebecher, J.; Bauer, M , Bode, W.; Huber, R.; Piechottka, G P.; Matschiner, G., Sommerhof, C. P.; Fritz, H.; Auerswald, E A. J. Biol. Chem. 1997, 272, 19931-19937.
94. Kam, C-M.; Fujikawa, K.; Powers, J. C. Biochemistry 1988, 27, 2547-2557.
95. Stürzebecher, J.; Prasa, D.; Sommerhof, C. P. Biol Chem. Hoppe-Seyler 1992, 373, 1025-1030.
96. Caughy, G. H.; Raymond, W. W.; Bacci, E.; Lombardy, R J.; Tidwell, R. R. J. Pharmacol. Exp. Ther. 1993, 264, 676-682.
97. Sommerhof, C. P.; Söllner, C.; Mentele, R.; Piechottka, G. P.; Auerswald, E A ; Fritz, H. Biol. Chem. Hoppe-Seyler 1994, 375, 685-694.
98. Drake, B.; Patek, M.; Lebl, M. Synthesis 1994, 579-582.
99. Bannard, R. A. B.; Casselman, A. A.; Cockburn, W. F.; Brown, G. M. Can. J. Chem. 1958, 36, 1541.
100. Short, J. H.; Biermacher, U.; Dunnigan, D. A ; Leth, T. D. J Med. Chem. 1963, 6, 275.
101. Tabushi, I., Kimura, Y.; Yamamura, K. J Am. Chem. Soc. 1981, 103, 6486-6492.
102. Dyer, Scott J. Am. Chem. Soc. 1957, 79, 672-674..
103. Coste, J ; Dufour, M-N.; Pantaloni, A.; Castro, B. Tetrahedron Lett. 1990, 31, 669-672.
104. Richter, R.; Tucker, B. J. Org Chem. 1983, 48, 2625-2627.
105. Safier, Kushner, Brancone, Subbarrow J. Org. Chem. 1948, 13, 924-930.
106. Callahan, J. F.; Ashton-Shue, D.; Heidemarie, G. B. et al. J Med Chem. 1989, 32, 391-396.
107. Katz, B. A.; Clark, J. M.; Finer-Moore J. S ; Jenkins, T E; Johnson, C. R.; Ross, M. J.; Luong, C.; Moore, W. R.; Stroud, R. M Nature 1998, 391, 608-612.
108. Elrod, K.C., Moore, W R., Abraham, W.M., Tanaka, R.D , (1995). Presented at the Joint Meeting of the American Thoracic Society and American Academy of Allergy and Immunology, Chicago, Illinois
109. Elrod, K.C., Moore, W.R., Cregar, L M., Abraham, W.M , Tanaka, R.D , (1996). Presented at the Federation of Immunological Societies of Asia-Oceania, Adelaide, Australia
110. Abraham, W M, Burch, R. M., Farmer, S. G et. al Am. Rev. Respir. Dis. 1991, 143, 787-796
111. Abraham, W M., Delehunt, J. C., Yerger, L., Marchette, B Am. Rev. Respir. Dis. 1983, 128, 839-844.
112. Abraham, W M., Sielczak, M. W., Ahmed, A. et. al J. Clin. Invest. 1994, 93, 776-787
113. Molinari, J F., Scuri, M., Moore, W R. et. al. Am. J. Resp. Crit. Care Med. 1996, 154, 649-653.
114. Clark, J. M.; Abraham, W. M.; Fishman, C. E.; Forteza, R.; Ahmed, A., Cortes, A.; Warne, R. L.; Moore, W. R ; Tanaka, R D. Am. J. Respir. Crit Care Med. 1995, 152, 2076-2083.
115. Molinari, J. F , Moore, W. R., Clark, J., et. al. J. Appl. Physiol. 1995, 79, 1966-1970
116. Fisher, M M.; Baldo, B. A. Brit. J. Anaesthesia 1998, 80, 26-29.
117. Jacobi, H. H.; Skov, P. S.; Kampen, G. T.; Poulsen, L. K.; Reimert, C. M.; Bindslev-Jensen, C ; Praetorius, C.; Malling, H. J.; Mygind, N. Clin. Exp. Allergy 1998, 28, 83-91.
118. Turner, G.; Stevenson, E. C.; Taylor, R.; Shields, M. D.; Ennis, M. Inflamm. Res. 1997, 46, S69-S70.
119. Ordoqui, E ; Zubeldia, J. M.; Aranzabal, A.; Rubio, M ; Herrero, T.; Tornero, P.; Rodriguez, V. M.; Prieto, A.; Baeza, M. L.; Allergy 1997, 52, 1102-1105.
120. Wilson, S. J.; Lau, L., Howarth, P. H. Clin. Exp. Allergy 1998, 28, 220-227
121. Di Lorenzo, G.; Mansueto, P.; Melluso, M.; Candore, G.; Colombo, A.; Pellitteri, M. E.; Drago, A.; Potestio, M.; Caruso, C. J. Allergy Clin. Immunol. 1997, 100, 832-836.
122. Bonini, S.; Schiavone, M.; Bonini, S.; Magrini, L.; Lischetti, P.; Lambiase, A.; Bucci, M.G. Opthalmology 1997, 104, 849-853.