Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 20, 2000, Pages 2357-2360

  Rice, Kenneth D ^b   Gangloff, Anthony R ^a   Kuo, Elaine Y L ^a   Dener, Jeffrey M ^c   Wang, Vivian R ^a   Lum, Robert ^d   Newcomb, William S ^e   Havel, Chris ^a   Putnam, Daun ^a   Cregar, Lynne ^a   Wong, Martin ^a   Warne, Robert L ^f  

^a Axys Pharmaceuticals Inc   (United States)

^b EXELIXIS INC   (United States)

^c ChemRx Advanced Technologies   (United States)

^d CV THERAPEUTICS INC   (United States)

^e Argonaut Technologies   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; TRYPTASE;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION;

ANGIOGENESIS FACTOR; BINDING SITES; BINDING, COMPETITIVE; DIAMINES; DRUG DESIGN; HUMAN; NYLONS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; XYLENES;

EID: 0034675805     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00484-4     Document Type: Article

References (23)