Dibasic inhibitors of human mast cell tryptase. Part 2: Structure-activity relationships and requirements for potent activity

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 20, 2000, Pages 2361-2366

  Rice, Kenneth D ^b   Wang, Vivian R ^a   Gangloff, Anthony R ^a   Kuo, Elaine Y L ^a   Dener, Jeffrey M ^c   Newcomb, William S ^d   Young, Wendy B ^a   Putnam, Daun ^a   Cregar, Lynne ^a   Wong, Martin ^a   Simpson, Paul J ^e  

^a Axys Pharmaceuticals Inc   (United States)

^b EXELIXIS INC   (United States)

^c ChemRx Advanced Technologies   (United States)

^d Argonaut Technologies   (United States)

^e GeneSoft Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; APC 1390; APC 2059; ASCARIS ANTIGEN; ENZYME INHIBITOR; N (1 HYDROXY 2 NAPHTHOYL)ARGINYLPROLINAMIDE; TRYPTASE; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

AEROSOL; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAST CELL; NONHUMAN; PROVOCATION TEST; PSORIASIS; SHEEP; STRUCTURE ACTIVITY RELATION; ULCERATIVE COLITIS;

ANIMAL; ANTI-ASTHMATIC AGENTS; ASTHMA; DIAMINES; DISEASE MODELS, ANIMAL; HUMAN; KINETICS; MOLECULAR STRUCTURE; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0034675757     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00485-6     Document Type: Article

References (10)