Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

Journal of Neurochemistry

Volumn 78, Issue 4, 2001, Pages 727-735

  Maruyama, Wakako ^a   Akao, Yukihiro ^b   Youdim, Moussa B H ^c   Davis, Bruce A ^d   Naoi, Makoto ^e,f  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

^e Institute of Physical and Chemical Research   (Japan)

^f Institute of Applied Biochemistry   (Japan)

Author keywords

Apoptosis; Bcl 2; Glyceraldehyde 3 phosphate dehydrogenase; N methyl(R)salsolinol; Parkinson's disease; Rasagiline

Indexed keywords

CASPASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NEUROTOXIN; PROTEIN BCL 2; RASAGILINE; SALSOLINOL;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NEUROTOXICITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL LINE; CELL NUCLEUS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INDANS; MEMBRANE POTENTIALS; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PARKINSON DISEASE; PROTO-ONCOGENE PROTEINS C-BCL-2; SALSOLINE ALKALOIDS; SIGNAL TRANSDUCTION; TETRAHYDROISOQUINOLINES; TRANSFECTION;

EID: 0034884148     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00448.x     Document Type: Article

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