Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

Journal of Neurochemistry

Volumn 82, Issue 4, 2002, Pages 913-923

  Akao, Yukihiro ^a   Maruyama, Wakako ^c   Shimizu, Shigeomi ^d   Yi, Hong ^a   Nakagawa, Yoshihito ^a   Shamoto Nagai, Masayo ^a,c   Youdim, Moussa B H ^e   Tsujimoto, Yoshihide ^d   Naoi, Makoto ^b,f  

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b Department of Brain Sciences ^*  (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^f Institute of Applied Biochemistry   (Japan)

Author keywords

Apoptosis; Bcl 2; Mitochondrial permeability transition; N methyl(R)salsolinol; Parkinson's disease; Rasagiline

Indexed keywords

CASPASE INHIBITOR; CYCLOSPORIN A; CYTOCHROME C; NEUROTOXIN; PROTEIN BCL 2; RASAGILINE; SALSOLINOL;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GENE OVEREXPRESSION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REDUCTION;

ANIMALS; APOPTOSIS; CYCLOSPORINE; ENZYME INHIBITORS; HUMANS; INDANS; ION CHANNELS; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEUROBLASTOMA; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PERMEABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SALSOLINE ALKALOIDS; TETRAHYDROISOQUINOLINES; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036677312     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01047.x     Document Type: Article

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