Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells

Journal of Neurochemistry

Volumn 96, Issue 2, 2006, Pages 541-549

  Yi, Hong ^a   Akao, Yukihiro ^a   Maruyama, Wakako ^b   Chen, Kavin ^c   Shih, Jean ^c   Naoi, Makoto ^a  

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Apoptosis; Dopamine neuron; Mitochondria; Neurotoxin; Parkinson's disease; RNA interference

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; N METHYLSALSOLINOL; NEUROTOXIN; SALSOLINOL; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); DNA; MONOAMINE OXIDASE INHIBITOR; SALSOLINE; SALSOLINE DERIVATIVE; SMALL INTERFERING RNA; TETRAHYDROISOQUINOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; HUMAN; HUMAN CELL; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RNA INTERFERENCE; BINDING SITE; CELL MEMBRANE POTENTIAL; DRUG EFFECT; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; KINETICS; METABOLISM; MITOCHONDRION; NEUROBLASTOMA; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; DNA; GENE SILENCING; HUMANS; KINETICS; MEMBRANE POTENTIALS; MITOCHONDRIA; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEUROBLASTOMA; NEUROTOXINS; RNA, SMALL INTERFERING; SALSOLINE ALKALOIDS; TETRAHYDROISOQUINOLINES; TRANSFECTION;

EID: 33644874108     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03573.x     Document Type: Article

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