Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: Suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine

Journal of Neural Transmission

Volumn 108, Issue 1, 2001, Pages 11-24

  Maruyama, W ^a   Boulton, A A ^b   Davis, B A ^b   Dostert, P ^c   Naoi, M ^d  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c Biotrial SA   (France)

^d Institute of Physical and Chemical Research   (Japan)

Author keywords

Apoptosis; Mitochondrial membrane potential; N methyl(R)salsolinol; Neuroprotection; Parkinson's disease; Propargylamines

Indexed keywords

AMINE; N (2 HEPTYL) N METHYLPROPARGYLAMINE; N METHYLSALSOLINOL; NEUROTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; MEMBRANE POTENTIAL; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY;

ALKYNES; APOPTOSIS; DOPAMINE; DRUG INTERACTIONS; FLUORESCENT DYES; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; MONOAMINE OXIDASE INHIBITORS; NEUROBLASTOMA; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PARKINSONIAN DISORDERS; SALSOLINE ALKALOIDS; SIGNAL TRANSDUCTION; STEREOISOMERISM; SUBSTANTIA NIGRA; TETRAHYDROISOQUINOLINES; TUMOR CELLS, CULTURED;

EID: 0034928655     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020170093     Document Type: Article

References (42)

1. Apoptosis induced by endogenous neurotoxin,N-methyl(R)salsolinol, is mediated by activation of caspase 3
2. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
3. Application of combined treatment with 'Madopar' and l-deprenyl in Parkinson's disease
4. Aliphatic N-methylpropargylamines: MAO-B inhibitors and antiapoptotic drugs
5. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons
6. Deprenyl (selegiline), a selective MAO-B inhibitor with active metabolites
7. Mitochondria and apoptosis
8. Stereoselective analyses of selegiline metabolites: Possible urinary markers for selegiline therapy
9. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis
10. Is there apoptosis in Lewy body disease
11. Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl
12. Deprenyl's effect at slowing progression of parkinsonian disability: The DATATOP study
13. Some new mechanisms underlying the actions of (-)deprenyl: Possible relevance to neurodegeneration
14. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
15. A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in parkinsonian CSF
16. Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, N-methyl(R)salsolinol, in the human intraventricular fluid
17. An endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells
18. A dopaminergic neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroiso-quinoline, and its oxidized product, 1,2(N)-dimethyl-dimethyl-6,7-dihydroxyiso-quinolinium ion, accumulate in the nigro-striatal system in the human brain
19. A neurotoxin N-methyl(R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells
20. (-)Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide
21. Histochemical detection of apoptosis in Parkinson's disease
22. N-Methyl(R)salsolinol, a dopamine neurotoxin, in Parkinson's disease
23. Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol induced parkinsonism in rat: Biochemical, pathological and behavioral studies
24. A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol
25. +-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains
26. (R)Salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes
27. Selegiline: Current perspectives on issues related to neuroprotection and mortality
28. DATATOP: A multicenter controlled clinical trial in early Parkinson's disease
29. The impact of extended deprenyl and tocopherol treatment in Parkinson's disease patients requiring levodopa
30. R-Deprenyl andR-2-heptyl-N-methylpropargylamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium
31. Nuclear translocation of GAPDH-GFP fusion protein during apoptosis
32. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis
33. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-Deprenyl-related compounds in controlling neurodegeneration
34. Alkaloids in mammalian tissues. 2. Synthesis of (+) and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines
35. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by (-)deprenyl
36. Aliphatic propargylamines: Potent, selective, irreversible monoamine oxidase B inhibitors
37. Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity
38. Neurochemical and neuroprotective effects of some aliphalic propargylamine MAO-B inhibitors
39. Neuroprotective effect of some monoamine oxidase-B inhibitors against DSP-4 induced noradrenaline depletion in the mouse hippocampus
40. Neurochemical, neuroprotective and neurorescue effects of aliphalic N-methylpropargylamines; New MAO-B inhibitors without amphetamine-like properties
41. Mitochondrial control of nuclear apoptosis
42. Loss of mitochondrial membrane potential is dependent on the apoptotic program activated: Prevention by R-HMP