Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines

Journal of Neural Transmission

Volumn 109, Issue 5-6, 2002, Pages 607-621

  Naoi, M ^a   Maruyama, W ^b   Akao, Y ^c   Yi, H ^a,c  

^a Institute of Physical and Chemical Research   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c Aichi Institute of Technology   (Japan)

Author keywords

Apoptosis; Mitochondrial permeability transition; N methyl(R)salsolinol; Neuroprotection; Rasagiline

Indexed keywords

3 (2 HEPTYLAMINE) N METHYLPROPIONIC ACID; AMINE; N (2 HEPTYL) N METHYLPROPARGYLAMINE; N (2 HEPTYL)PROPARGYLAMINE; NEUROTOXIN; NORSELEGILINE; PROTEIN BCL 2; RASAGILINE; SALSOLINOL; SELEGILINE; TV 1022; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ALKYNES; ANIMALS; APOPTOSIS; CELL SURVIVAL; HUMANS; INDANS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIA, LIVER; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED STRAINS; SALSOLINE ALKALOIDS; SIGNAL TRANSDUCTION; TETRAHYDROISOQUINOLINES; TUMOR CELLS, CULTURED;

EID: 0036329996     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020200050     Document Type: Article

References (56)

1. Apoptosis induced by endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3
2. +-induced dopaminergic neural cell death: Role of caspases, ROS, and JNK
3. Apoptosis and DNA degradation by 1-methyl-4-phenypyridinium in neurons
4. Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor
5. Pharmacology of rasagiline (N-propargyl-1R-aminoindan)
6. The neuronal survival effects of rasagiline and deprenyl on fetal human and rat ventral mesencephalic neurons in culture
7. Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: Effect of R-apomorphine
8. Caspase 3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
9. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors
10. Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury
11. Cell death mechanisms in Parkinson's disease
12. Efficiency and safety of rasagiline as monotherapy in early Parkinson's disease
13. Selegiline is neuroprotective in primary brain cultures treated with 1-methyl-4-phenylpyridinium
14. The proto-oncogene Bcl-2 and its role in regulating apoptosis
15. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
16. The mitochondrion in cell death control: Certainties and incognita
17. Neuroprotection by (-)-deprenyl and related compounds
18. A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in parkinsonian cerebrospinal fluid
19. An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells
20. (-)-Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide
21. Neurotoxins induced apoptosis in dopamine neurons: Protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022
22. Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: Suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine
23. Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehydes-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol
24. Antiapoptotic properties of rasagiline, N-propargylamin-1(R)-aminoindan, and its optical (S)-isomer, TV1022
25. Glyceraldehyde-3-phospate dehydrogenase is translocated into nuclei through Golgi apparatus in apoptosis induced by 6-hydroxydopamine
26. The permeability transition pore complex: A target for apoptosis regulation by caspases and Bcl-2-related proteins
27. Histochemical detection of apoptosis in Parkinson's disease
28. bcl-2 Protein is increased in the brain from parkinsonian patients
29. Caspase activities and tumor necrosis factor receptor R1 (p55) are elevated in the substantia nigra from Parkinsonian brain
30. Deprenyl protects dopaminergic neurons from neurotoxic effects of 1-methyl-4-phenylpyridiniun ion
31. Changes in cytokines and neurotrophins in Parkinson's disease
32. Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: Biochemical, pathological and behavioral studies
33. A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol
34. +-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains
35. (R)Salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes
36. Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons
37. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
38. Transgenic mice expressing human bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrdine neurotoxicity
39. DATATOP: A multicenter controlled clinical trial in early Parkinson's disease
40. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
41. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
42. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
43. Immunocytochemical evidence for apoptosis in Alzheimer's disease
44. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease
45. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labeling and acridine orange staining
46. Rescue of dying neurons: A new action for deprenyl in MPTP parkinsonism
47. Alkaloids in mammalian tissues. 2. Synthesis of (+) and (-)-substituted 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines
48. Apoptosis in the pathogenesis and treatment of diseases
49. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma
50. Bcl-2 family: Life-or-death switch
51. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity is attenuated in mice overexpressing Bcl-2
52. The anti-parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo
53. Aliphatic propargylamines: Potent, selective, irreversible monoamine oxidase B inhibitors
54. Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines; new MAO-B inhibitors without amphetamine properties
55. Loss of mitochondrial membrane potential is dependent on the apoptotic program activated: Prevention by R-HMP