Generation of transgenic and knockdown mice with lentiviral vectors and RNAi techniques

RNAi

Volumn , Issue , 2008, Pages 91-112

  Huusko, Jenni ^a   Mäkinen, Petri I ^a   Alhonen, Leena ^a   Ylä Herttuala, Seppo ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70449402941     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (40)

1. Bot, I., Guo, J., Van Eck, M., Van Santbrink, P.J., Groot, P.H., Hildebrand, R.B., Seppen, J., Van Berkel, T.J. and Biessen, E.A. (2005) Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo. Blood 106: 1147-1153.
2. Bridge, A.J., Pebernard, S., Ducraux, A., Nicoulaz, A.L. and Iggo, R. (2003). Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 34:263-264.
3. Carmell, M.A., Zhang, L., Conklin, D.S., Hannon, G.J. and Rosenquist, T.A. (2003) Germline transmission of RNAi in mice. Nat Struct Biol 10: 91-92.
4. Coumoul, X., Shukla, V., Li, C., Wang, R.H. and Deng, C.X. (2005) Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res 33: e102.
5. Fleury, S., Simeoni, E., Zuppinger, C., Deglon, N., von Segesser, L.K., Kappenberger, L. and Vassalli, G. (2003) Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo. Circulation 107: 2375-2382.
6. Follenzi, A., Ailles, L.E., Bakovic, S., Geuna, M. and Naldini, L. (2000) Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet 25: 217-222.
7. Gordon, J.W., Scangos, G.A., Plotkin, D.J., Barbosa, J.A. and Ruddle, F.H. (1980) Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77: 7380-7384.
8. Grimm, D., Streetz, K.L., Jopling, C.L., Storm, T.A., Pandey, K., Davis, C.R., Marion, P., Salazar, F. and Kay, M.A. (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 445: 537-541.
9. Gupta, S., Schoer, R.A., Egan, J.E., Hannon, G.J. and Mittal, V. (2004) Inducible, reversible, and stable RNA interference in mammalian cells. Proc Natl Acad Sci USA 101: 1927-1932.
10. Haraguchi, S., Saga, Y., Naito, K., Inoue, H. and Seto, A. (2004) Specific gene silencing in the pre-implantation stage mouse embryo by an siRNA expression vector system. Mol Reprod Dev 68: 17-24.
11. Hogan, B., Beddington, R., Costantini, F. and Lacy, E. (eds) (1994) Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Plainview, New York.
12. Kankkonen, H.M., Vähäkangas, E., Marr, R.A., Pakkanen, T., Laurema, A., Leppänen, P., Jalkanen, J., Verma, I.M. and Ylä-Herttuala, S. (2004) Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Mol Ther 9: 548-556.
13. Kordower, J.H., Emborg, M.E., Bloch, J., et al. (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson’s disease. Science 290: 767-773.
14. Lee, Y., Kim, M., Han, J., Yeom, K.H., Lee, S., Baek, S.H. and Kim, V.N. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23: 4051-4060.
15. Lois, C., Hong, E.J., Pease, S., Brown, E.J. and Baltimore, D. (2002) Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295: 868-872.
16. Lu, W., Yamamoto, V., Ortega, B. and Baltimore, D. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119: 97-108.
17. Mäkinen, P.I., Koponen, J.K., Kärkkäinen, A-M., Malm, T.M., Pulkkinen, K.H., Koistinaho, J., Turunen, M.P. and Ylä-Herttuala, S. (2006) Stable RNA interference:comparison of U6 and H1 promoters in endothelial cells and in mouse brain. J Gene Med 8: 433-441.
18. Miyoshi, H., Blomer, U., Takahashi, M., Gage, F.H. and Verma, I.M. (1998) Development of a self-inactivating lentivirus vector. J Virol 72: 8150-8157.
19. Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M. and Torbett, B.E. (1999) Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science 283: 682-686.
20. Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F.H., Verma, I.M. and Trono, D. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263-267.
21. Oberdoerffer, P., Kanellopoulou, C., Heissmeyer, V., Paeper, C., Borowski, C., Aifantis, I., Rao, A. and Rajewsky, K. (2005) Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol 25: 3896-3905.
22. Pawliuk, R., Westerman, K.A., Fabry, M.E., et al. (2001) Correction of sickle cell disease in transgenic mouse models by gene therapy. Science 294: 2368-2371.
23. Pfeifer, A., Ikawa, M., Dayn, Y. and Verma, I.M. (2002) Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc Natl Acad Sci USA 99: 2140-2145.
24. Rao, M.K., Pham, J., Imam, J.S., MacLean, J.A., Murali, D., Furuta, Y., Sinha-Hikim, A.P. and Wilkinson, M.F. (2006) Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev 20: 147-152.
25. Raoul, C., Abbas-Terki, T., Bensadoun, J.C., Guillot, S., Haase, G., Szulc, J., Henderson, C.E. and Aebischer, P. (2005) Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med 11: 423-428.
26. Rubinson, D.A., Dillon, C.P., Kwiatkowski, A.V., et al. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 233: 401-406.
27. Silva, J.M., Li, M.Z., Chang, K., et al. (2005) Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet 37: 1281-1288.
28. Singer, O., Tiscornia, G., Ikawa, M. and Verma, I.M. (2006) Rapid generation of knockdown transgenic mice by silencing lentiviral vectors. Nat Protocols 1: 286-292.
29. Stegmeier, F., Hu, G., Rickles, R.J., Hannon, G.J. and Elledge, S.J. (2005) A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci USA 102: 13212-13217.
30. Szulc, J., Wiznerowicz, M., Sauvain, M.O., Trono, D. and Aebischer, P. (2006) A versatile tool for conditional gene expression and knockdown. Nat Methods 3:109-116.
31. Tang, F.C., Meng, G.L., Yang, H.B., Li, C.J., Shi, Y., Ding, M.X., Shang, K.G., Zhang, B. and Xue, Y.F. (2004) Stable suppression of gene expression in murine embryonic stem cells by RNAi directed from DNA vector-based short hairpin RNA. Stem Cells 22: 93-99.
32. Tiscornia, G., Singer, O., Ikawa, M. and Verma, I.M. (2003) A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci USA 100: 1844-1848.
33. Tiscornia, G., Singer, O. and Verma, I.M. (2006) Production and purification of lentiviral vectors. Nat Protocols 1: 241-245.
34. Ventura, A., Meissner, A., Dillon, C.P., McManus, M., Sharp, P.A., Van Parijs, L., Jaenisch, R. and Jacks, T. (2004) Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci USA 101: 10380-10385.
35. Wiznerowicz, M. and Trono, D. (2003) Conditional suppression of cellular genes:lentivirus vector-mediated drug-inducible RNA interference. J Virol 77:8957-8961.
36. Xia, X.G., Zhou, H., Samper, E., Melov, S. and Xu, Z. (2006) Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet 2: e10.
37. Yi, R., Doehle, B.P., Qin, Y., Macara, I.G. and Cullen, B.R. (2005) Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA 11: 220-226.
38. Zeng, Y., Cai, X. and Cullen, B.R. (2005) Use of RNA polymerase II to transcribe artificial microRNAs. Methods Enzymol 392: 371-380.
39. Zufferey, R., Dull, T., Mandel, R.J., Bukovsky, A., Quiroz, D., Naldini, L. and Trono, D. (1998) Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 72: 9873-9880.
40. Zufferey, R., Donello, J.E., Trono, D. and Hope, T.J. (1999) Woodchuck hepatitis virus post-transcriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 73: 2886-2892.