Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice

European Journal of Pharmacology

Volumn 624, Issue 1-3, 2009, Pages 77-83

  Ito, Masahiko ^a   Ishihara, Akane ^a   Gomori, Akira ^a   Egashira, Shinichiro ^a   Matsushita, Hiroko ^a   Mashiko, Satoshi ^a   Ito, Junko ^a   Ito, Makoto ^a   Nakase, Kazuho ^a   Haga, Yuji ^a   Iwaasa, Hisashi ^a   Suzuki, Takao ^a   Ohtake, Norikazu ^a   Moriya, Minoru ^a   Sato, Nagaaki ^a   MacNeil, Douglas J ^b   Takenaga, Norihiro ^a   Tokita, Shigeru ^a   Kanatani, Akio ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Melanin concentrating hormone 1 receptor Antagonist; Obesity; Receptor occupancy

Indexed keywords

2 (3,4 DIFLUOROPHENYL) N ETHYL N [3 [6 FLUORO 1'H,3H SPIRO(2 BENZOFURAN 1,4' PIPERIDIN) 1' YL]PROPYL] 2 [4 (METHYLSULFONYL) 2 OXO 1 PIPERAZINYL]ETHANAMIDE; 4 (BENZYLOXY) 1 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL]PYRIDIN 2(1H) ONE; 4 [(4 FLUOROBENZYL)OXY] 1 [4 (2 PYRROLIDINE 1 YLETHOXY)PHENYL]PYRIDIN 2(1H) ONE; 4 [(5 CHLOROPYRIDIN 2 YL)METHOXY] 1 [4 [2 (DIETHYLAMINO)ETHOXY]PHENYL]PYRIDIN 2(1H) ONE; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; N [2 [ 3 [ISOBUTYRYL(METHYL)AMINO]PYRROLIDIN 1 YL]QUINOLIN 6 YL] 5 PHENYLPYRIMIDINE 2 CARBOXAMIDE; NEUROPEPTIDE; RADIOLIGAND; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING ASSAY; BRAIN SLICE; CONTROLLED STUDY; DIET; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG STRUCTURE; ENERGY BALANCE; EX VIVO STUDY; FEEDING BEHAVIOR; HYPOTHALAMUS; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RECEPTOR BINDING; RECEPTOR OCCUPANCY; RODENT; WEIGHT GAIN;

ANIMAL FEED; ANIMALS; ANTI-OBESITY AGENTS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PITUITARY HORMONE; WEIGHT GAIN;

EID: 70350745400     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.10.004     Document Type: Article

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