A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 18, 2006, Pages 7154-7158

  Ishihara, Akane ^a   Kanatani, Akio ^a   Mashiko, Satoshi ^a   Tanaka, Takeshi ^a   Hidaka, Masayasu ^a   Gomori, Akira ^a   Iwaasa, Hisashi ^a   Murai, Naomi ^a   Egashira, Shin Ichiro ^a   Murai, Takashi ^a   Mitobe, Yuko ^a   Matsushita, Hiroko ^a   Okamoto, Osamu ^a   Sato, Nagaaki ^a   Jitsuoka, Makoto ^a   Fukuroda, Takahiro ^a   Ohe, Tomoyuki ^a   Guan, Xiaoming ^b   MacNeil, Douglas J ^b   Van Der Ploeg, Lex M T ^b   Nishikibe, Masaru ^b   Ishii, Yasuyuki ^a   Ihara, Masaki ^a   Fukami, Takehiro ^a   more..

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antiobesity effect; Receptor occupancy; Y5R deficient mice

Indexed keywords

2 [3,3 DIMETHYL 1 OXO 4(1H) XANTHEN 9 YL] 5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE; LEPTIN RECEPTOR; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y5 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DIETARY INTAKE; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENERGY TRANSFER; HOMEOSTASIS; HYPERINSULINEMIA; LEAN BODY WEIGHT; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; TREATMENT OUTCOME; WEIGHT GAIN;

ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; BODY WEIGHT; CYCLOHEXANES; DIET; INSULIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPEPTIDE Y; OBESITY; ORGAN SIZE; RATS; RATS, ZUCKER; RECEPTORS, NEUROPEPTIDE Y; WEIGHT GAIN; XANTHENES;

RODENTIA;

EID: 33646482230     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510320103     Document Type: Article

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