Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R)

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2835-2839

  Ito, Masahiko ^a   Sakamoto, Toshihiro ^a   Suzuki, Takao ^a   Egashira, Shinichiro ^a   Moriya, Minoru ^a   Ishihara, Akane ^a   Iwaasa, Hisashi ^a   Matsushita, Hiroko ^a   Nakase, Kazuho ^a   Wallace, Michael A ^b   Dean, Dennis ^b   Sato, Nagaaki ^a   Tokita, Shigeru ^a   Kanatani, Akio ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonist; Melanin concentrating hormone 1 receptor; Radioligand; Receptor occupancy

Indexed keywords

AMG 076; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; RADIOLIGAND; SNAP 7941; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EX VIVO STUDY; HUMAN; MOUSE; NONHUMAN; PHARMACODYNAMICS;

AMINO ACID SEQUENCE; ANIMALS; BENZOFURANS; BRAIN; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; KINETICS; MICE; MICE, KNOCKOUT; RECEPTORS, SOMATOSTATIN; SPIRO COMPOUNDS; SULFONAMIDES;

MUS;

EID: 65349155309     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.102     Document Type: Article

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30. Compounds 4 and 5 were resolved by Chiralpak AD. Compound 4 was eluted with hexanes:i-PrOH:TFA = 70:30:0.1 to afford 4a as a second-eluted enantiomer. Compound 5 was eluted with hexanes:i-PrOH:TFA = 80:20:0.1 to afford 5a as a second-eluted enantiomer.