메뉴 건너뛰기




Volumn 86, Issue 5, 2009, Pages 1027-1038

Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?

Author keywords

Deep space mission; Immune depression; Microgravity; Stress

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

EID: 70350741504     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0309167     Document Type: Review
Times cited : (234)

References (155)
  • 1
    • 33846682390 scopus 로고    scopus 로고
    • Space exploration: Where 24 men have gone before
    • DOI 10.1038/445474a, PII 445474A
    • Brumfiel, G. (2007) Space exploration: where 24 men have gone before. Nature 445, 474-478. (Pubitemid 46197611)
    • (2007) Nature , vol.445 , Issue.7127 , pp. 474-478
    • Brumfiel, G.1
  • 2
    • 45749109778 scopus 로고    scopus 로고
    • Spaceward ho! The future of humans in space
    • Heppener, M. (2008) Spaceward ho! The future of humans in space. EMBO Rep. 9 (Suppl. 1), S4-S12.
    • (2008) EMBO Rep. , vol.9 , Issue.SUPPL. 1
    • Heppener, M.1
  • 3
    • 0032162029 scopus 로고    scopus 로고
    • Weightlessness and the human body
    • White, R. J. (1998) Weightlessness and the human body. Sci. Am. 279, 58-63.
    • (1998) Sci. Am. , vol.279 , pp. 58-63
    • White, R.J.1
  • 5
    • 0029012716 scopus 로고
    • Person-to-person transfer of Candida albicans in the spacecraft environment
    • Pierson, D. L., Mehta, S. K., Magee, B. B., Mishra, S. K. (1995) Person-to-person transfer of Candida albicans in the spacecraft environment. J. Med. Vet. Mycol. 33, 145-150.
    • (1995) J. Med. Vet. Mycol. , vol.33 , pp. 145-150
    • Pierson, D.L.1    Mehta, S.K.2    Magee, B.B.3    Mishra, S.K.4
  • 6
    • 0003037528 scopus 로고
    • Hematology and immunology studies
    • R. S. Johnson, L. F. Dietlein, eds., Washington, DC, USA, NASA
    • Kimzey, S. L. (1977) Hematology and immunology studies. In Biomedical Results from Skylab (R. S. Johnson, L. F. Dietlein, eds.), Washington, DC, USA, NASA, 248-282.
    • (1977) Biomedical Results from Skylab , pp. 248-282
    • Kimzey, S.L.1
  • 8
    • 0017093358 scopus 로고
    • Autoflora in the upper respiratory tract of Apollo astronauts
    • Decelle, J. G., Taylor, G. R. (1976) Autoflora in the upper respiratory tract of Apollo astronauts. Appl. Environ. Microbiol. 32, 659-665.
    • (1976) Appl. Environ. Microbiol. , vol.32 , pp. 659-665
    • Decelle, J.G.1    Taylor, G.R.2
  • 9
    • 0035382565 scopus 로고    scopus 로고
    • Microbial contamination of spacecraft
    • Pierson, D. L. (2001) Microbial contamination of spacecraft. Gravit. Space Biol. Bull. 14, 1-6.
    • (2001) Gravit. Space Biol. Bull. , vol.14 , pp. 1-6
    • Pierson, D.L.1
  • 10
    • 16344391798 scopus 로고    scopus 로고
    • Microbiological status of cosmonauts during orbital spaceflights on Salyut and Mir orbital stations
    • Ilyin, V. K. (2005) Microbiological status of cosmonauts during orbital spaceflights on Salyut and Mir orbital stations. Acta Astronaut. 56, 839-850.
    • (2005) Acta Astronaut. , vol.56 , pp. 839-850
    • Ilyin, V.K.1
  • 11
    • 0014792189 scopus 로고
    • Summary of medical experience in the Apollo 7 through 11 manned spaceflights
    • Berry, C. A. (1970) Summary of medical experience in the Apollo 7 through 11 manned spaceflights. Aerosp. Med. 41, 500-519.
    • (1970) Aerosp. Med. , vol.41 , pp. 500-519
    • Berry, C.A.1
  • 13
    • 2342482278 scopus 로고    scopus 로고
    • Review of the knowledge of microbial contamination of the Russian manned spacecraft
    • Novikova, N. D. (2004) Review of the knowledge of microbial contamination of the Russian manned spacecraft. Microb. Ecol. 47, 127-132.
    • (2004) Microb. Ecol. , vol.47 , pp. 127-132
    • Novikova, N.D.1
  • 14
    • 34247603159 scopus 로고    scopus 로고
    • Isolation and characterization of bacteria capable of tolerating the extreme conditions of clean room environments
    • DOI 10.1128/AEM.03007-06
    • La Duc, M. T., Dekas, A., Osman, S., Moissl, C., Newcombe, D., Venkateswaran, K. (2007) Isolation and characterization of bacteria capable of tolerating the extreme conditions of clean room environments. Appl. Environ. Microbiol. 73, 2600-2611. (Pubitemid 46668753)
    • (2007) Applied and Environmental Microbiology , vol.73 , Issue.8 , pp. 2600-2611
    • La Duc, M.T.1    Dekas, A.2    Osman, S.3    Moissl, C.4    Newcombe, D.5    Venkateswaran, K.6
  • 15
  • 17
    • 0037063353 scopus 로고    scopus 로고
    • YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae
    • DOI 10.1016/S0014-5793(02)03220-9, PII S0014579302032209
    • Collister, M., Didmon, M. P., MacIsaac, F., Stark, M. J., MacDonald, N. Q., Keyse, S. M. (2002) YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae. FEBS Lett. 527, 186-192. (Pubitemid 35253863)
    • (2002) FEBS Letters , vol.527 , Issue.1-3 , pp. 186-192
    • Collister, M.1    Didmon, M.P.2    MacIsaac, F.3    Stark, M.J.4    MacDonald, N.Q.5    Keyse, S.M.6
  • 18
    • 0034634251 scopus 로고    scopus 로고
    • Norepinephrine as a growth stimulating factor in bacteria - Mechanistic studies
    • Kinney, K. S., Austin, C. E., Morton, D. S., Sonnenfeld, G. (2000) Norepinephrine as a growth stimulating factor in bacteria - mechanistic studies. Life Sci. 67, 3075-3085.
    • (2000) Life Sci. , vol.67 , pp. 3075-3085
    • Kinney, K.S.1    Austin, C.E.2    Morton, D.S.3    Sonnenfeld, G.4
  • 19
    • 0038303298 scopus 로고    scopus 로고
    • Catecholamines and in vitro growth of pathogenic bacteria: Enhancement of growth varies greatly among bacterial species
    • DOI 10.1016/S0024-3205(03)00472-7
    • Belay, T., Aviles, H., Vance, M., Fountain, K., Sonnenfeld, G. (2003) Catecholamines and in vitro growth of pathogenic bacteria: enhancement of growth varies greatly among bacterial species. Life Sci. 73, 1527-1535. (Pubitemid 36831136)
    • (2003) Life Sciences , vol.73 , Issue.12 , pp. 1527-1535
    • Belay, T.1    Aviles, H.2    Vance, M.3    Fountain, K.4    Sonnenfeld, G.5
  • 20
    • 0037077036 scopus 로고    scopus 로고
    • Differential effects of catecholamines on in vitro growth of pathogenic bacteria
    • DOI 10.1016/S0024-3205(02)01683-1, PII S0024320502016831
    • Belay, T., Sonnenfeld, G. (2002) Differential effects of catecholamines on in vitro growth of pathogenic bacteria. Life Sci. 71, 447-456. (Pubitemid 34607307)
    • (2002) Life Sciences , vol.71 , Issue.4 , pp. 447-456
    • Belay, T.1    Sonnenfeld, G.2
  • 21
    • 0033302165 scopus 로고    scopus 로고
    • Space flight, microgravity, stress, and immune responses
    • Sonnenfeld, G. (1999) Space flight, microgravity, stress, and immune responses. Adv. Space Res. 23, 1945-1953.
    • (1999) Adv. Space Res. , vol.23 , pp. 1945-1953
    • Sonnenfeld, G.1
  • 23
    • 0033237305 scopus 로고    scopus 로고
    • Long-term exposure to spaceflight conditions affects bacterial response to antibiotics
    • Juergensmeyer, M. A., Juergensmeyer, E. A., Guikema, J. A. (1999) Long-term exposure to spaceflight conditions affects bacterial response to antibiotics. Microgravity Sci. Technol. 12, 41-47.
    • (1999) Microgravity Sci. Technol. , vol.12 , pp. 41-47
    • Juergensmeyer, M.A.1    Juergensmeyer, E.A.2    Guikema, J.A.3
  • 25
  • 26
    • 0034739681 scopus 로고    scopus 로고
    • Analysis of deletion mutations of the rpsL gene in the yeast Saccharomyces cerevisiae detected after long-term flight on the Russian space station Mir
    • DOI 10.1016/S1383-5742(00)00054-5, PII S1383574200000545
    • Fukuda, T., Fukuda, K., Takahashi, A., Ohnishi, T., Nakano, T., Sato, M., Gunge, N. (2000) Analysis of deletion mutations of the rpsL gene in the yeast Saccharomyces cerevisiae detected after long-term flight on the Russian space station Mir. Mutat. Res. 470, 125-132. (Pubitemid 30750865)
    • (2000) Mutation Research - Genetic Toxicology and Environmental Mutagenesis , vol.470 , Issue.2 , pp. 125-132
    • Fukuda, T.1    Fukuda, K.2    Takahashi, A.3    Ohnishi, T.4    Nakano, T.5    Sato, M.6    Gunge, N.7
  • 27
    • 33746748794 scopus 로고    scopus 로고
    • Alterations in the virulence potential of enteric pathogens and bacterial-host cell interactions under simulated microgravity conditions
    • DOI 10.1080/15287390500361792, PII L54531815L136084
    • Chopra, V., Fadl, A. A., Sha, J., Chopra, S., Galindo, C. L., Chopra, A. K. (2006) Alterations in the virulence potential of enteric pathogens and bacterial-host cell interactions under simulated microgravity conditions. J. Toxicol. Environ. Health A 69, 1345-1370. (Pubitemid 44469361)
    • (2006) Journal of Toxicology and Environmental Health - Part A: Current Issues , vol.69 , Issue.14 , pp. 1345-1370
    • Chopra, V.1    Fadl, A.A.2    Sha, J.3    Chopra, S.4    Galindo, C.L.5    Chopra, A.K.6
  • 28
    • 45349103718 scopus 로고    scopus 로고
    • Increased Filamentous Growth of Candida albicans in Simulated Microgravity
    • DOI 10.1016/S1672-0229(08)60019-4, PII S1672022908600194
    • Altenburg, S. D., Nielsen-Preiss, S. M., Hyman, L. E. (2008) Increased filamentous growth of Candida albicans in simulated microgravity. Genomics Proteomics Bioinformatics 6, 42-50. (Pubitemid 351847760)
    • (2008) Genomics, Proteomics and Bioinformatics , vol.6 , Issue.1 , pp. 42-50
    • Altenburg, S.D.1    Nielsen-Preiss, S.M.2    Hyman, L.E.3
  • 29
    • 0016220373 scopus 로고
    • Effect of bioisolation and the intestinal flora of mice upon evaluation of an Apollo diet
    • Luckey, T. D., Bengson, M. H., Kaplan, H. (1974) Effect of bioisolation and the intestinal flora of mice upon evaluation of an Apollo diet. Aerosp. Med. 45, 509-518.
    • (1974) Aerosp. Med. , vol.45 , pp. 509-518
    • Luckey, T.D.1    Bengson, M.H.2    Kaplan, H.3
  • 30
    • 0343618709 scopus 로고    scopus 로고
    • Microgravity as a novel environmental signal affecting Salmonella enterica serovar Typhimurium virulence
    • DOI 10.1128/IAI.68.6.3147-3152.2000
    • Nickerson, C. A., Ott, C. M., Mister, S. J., Morrow, B. J., Burns-Keliher, L., Pierson, D. L. (2000) Microgravity as a novel environmental signal affecting Salmonella enterica serovar Typhimurium virulence. Infect. Immun. 68, 3147-3152. (Pubitemid 30340402)
    • (2000) Infection and Immunity , vol.68 , Issue.6 , pp. 3147-3152
    • Nickerson, C.A.1    Mark Ott, C.2    Mister, S.J.3    Morrow, B.J.4    Burns-Keliher, L.5    Pierson, D.L.6
  • 37
    • 0022613139 scopus 로고
    • Thymic involution in the suspended rat: Adrenal hypertrophy and glucocorticoid receptor content
    • Steffen, J. M., Musacchia, X. J. (1986) Thymic involution in the suspended rat: adrenal hypertrophy and glucocorticoid receptor content. Aviat. Space Environ. Med. 57, 162-167.
    • (1986) Aviat. Space Environ. Med. , vol.57 , pp. 162-167
    • Steffen, J.M.1    Musacchia, X.J.2
  • 38
    • 0033637894 scopus 로고    scopus 로고
    • Spaceflight induces changes in splenocyte subpopulations: Effectiveness of ground-based models
    • Pecaut, M. J., Simske, S. J., Fleshner, M. (2000) Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279, R2072-R2078.
    • (2000) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.279
    • Pecaut, M.J.1    Simske, S.J.2    Fleshner, M.3
  • 42
    • 0023430340 scopus 로고
    • Inhibited interferon-γ but normal interleukin-3 production from rats flown on the space shuttle
    • Gould, C. L., Lyte, M., Williams, J., Mandel, A. D., Sonnenfeld, G. (1987) Inhibited interferon-γ but normal interleukin-3 production from rats flown on the space shuttle. Aviat. Space Environ. Med. 58, 983-986.
    • (1987) Aviat. Space Environ. Med. , vol.58 , pp. 983-986
    • Gould, C.L.1    Lyte, M.2    Williams, J.3    Mandel, A.D.4    Sonnenfeld, G.5
  • 43
    • 0029086636 scopus 로고
    • The effect of a 10-day space flight on the function, phenotype, and adhesion molecule expression of splenocytes and lymph node lymphocytes
    • Grove, D. S., Pishak, S. A., Mastro, A. M. (1995) The effect of a 10-day space flight on the function, phenotype, and adhesion molecule expression of splenocytes and lymph node lymphocytes. Exp. Cell Res. 219, 102-109.
    • (1995) Exp. Cell Res. , vol.219 , pp. 102-109
    • Grove, D.S.1    Pishak, S.A.2    Mastro, A.M.3
  • 45
    • 0030472554 scopus 로고    scopus 로고
    • Human physiology in space
    • Vernikos, J. (1996) Human physiology in space. Bioessays 18, 1029-1037.
    • (1996) Bioessays , vol.18 , pp. 1029-1037
    • Vernikos, J.1
  • 46
  • 50
    • 0033937197 scopus 로고    scopus 로고
    • Altered cytokine production by specific human peripheral blood cell subsets immediately following space flight
    • Crucian, B. E., Cubbage, M. L., Sams, C. F. (2000) Altered cytokine production by specific human peripheral blood cell subsets immediately following space flight. J. Interferon Cytokine Res. 20, 547-556.
    • (2000) J. Interferon Cytokine Res. , vol.20 , pp. 547-556
    • Crucian, B.E.1    Cubbage, M.L.2    Sams, C.F.3
  • 51
    • 0035186168 scopus 로고    scopus 로고
    • Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration
    • Mills, P. J., Meck, J. V., Waters, W. W., D'Aunno, D., Ziegler, M. G. (2001) Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Psychosom. Med. 63, 886-890. (Pubitemid 33101373)
    • (2001) Psychosomatic Medicine , vol.63 , Issue.6 , pp. 886-890
    • Mills, P.J.1    Meck, J.V.2    Waters, W.W.3    D'Aunno, D.4    Ziegler, M.G.5
  • 53
    • 0346753744 scopus 로고    scopus 로고
    • Effects of mission duration on neuroimmune responses in astronauts
    • Stowe, R. P., Sams, C. F., Pierson, D. L. (2003) Effects of mission duration on neuroimmune responses in astronauts. Aviat. Space Environ. Med. 74, 1281-1284.
    • (2003) Aviat. Space Environ. Med. , vol.74 , pp. 1281-1284
    • Stowe, R.P.1    Sams, C.F.2    Pierson, D.L.3
  • 54
    • 48549089914 scopus 로고    scopus 로고
    • Humoral and cellular immunity in cosmonauts after the ISS missions
    • Rykova, M. P., Antropova, E. N., Larina, I. M., Morukov, B. V. (2008) Humoral and cellular immunity in cosmonauts after the ISS missions. Acta Astraunautica 63, 697-705.
    • (2008) Acta Astraunautica , vol.63 , pp. 697-705
    • Rykova, M.P.1    Antropova, E.N.2    Larina, I.M.3    Morukov, B.V.4
  • 55
    • 51149084801 scopus 로고    scopus 로고
    • Immune system dysregulation following short- Vs. long-duration spaceflight
    • Crucian, B. E., Stowe, R. P., Pierson, D. L., Sams, C. F. (2008) Immune system dysregulation following short- vs. long-duration spaceflight. Aviat. Space Environ. Med. 79, 835-843.
    • (2008) Aviat. Space Environ. Med. , vol.79 , pp. 835-843
    • Crucian, B.E.1    Stowe, R.P.2    Pierson, D.L.3    Sams, C.F.4
  • 59
    • 55449106962 scopus 로고    scopus 로고
    • Effect of spaceflight on ability of monocytes to respond to endotoxins of gram-negative bacteria
    • Kaur, I., Simons, E. R., Kapadia, A. S., Ott, C. M., Pierson, D. L. (2008) Effect of spaceflight on ability of monocytes to respond to endotoxins of gram-negative bacteria. Clin. Vaccine Immunol. 15, 1523-1528.
    • (2008) Clin. Vaccine Immunol. , vol.15 , pp. 1523-1528
    • Kaur, I.1    Simons, E.R.2    Kapadia, A.S.3    Ott, C.M.4    Pierson, D.L.5
  • 60
    • 16644372986 scopus 로고    scopus 로고
    • Endotoxin recognition and signal transduction by the TLR4/MD2-complex
    • Fitzgerald, K. A., Rowe, D. C., Golenbock, D. T. (2004) Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 6, 1361-1367.
    • (2004) Microbes Infect. , vol.6 , pp. 1361-1367
    • Fitzgerald, K.A.1    Rowe, D.C.2    Golenbock, D.T.3
  • 61
    • 1642384019 scopus 로고    scopus 로고
    • Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2
    • DOI 10.1016/j.tim.2004.02.009, PII S0966842X04000502
    • Miyake, K. (2004) Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Trends Microbiol. 12, 186-192. (Pubitemid 38393739)
    • (2004) Trends in Microbiology , vol.12 , Issue.4 , pp. 186-192
    • Miyake, K.1
  • 63
    • 0026696043 scopus 로고
    • In vivo testing confirms a blunting of the human cell-mediated immune mechanism during space flight
    • Taylor, G. R., Janney, R. P. (1992) In vivo testing confirms a blunting of the human cell-mediated immune mechanism during space flight. J. Leukoc. Biol. 51, 129-132.
    • (1992) J. Leukoc. Biol. , vol.51 , pp. 129-132
    • Taylor, G.R.1    Janney, R.P.2
  • 66
    • 0029380336 scopus 로고
    • The natural cytotoxicity in cosmonauts on board space stations
    • Meshkov, D., Rykova, M. (1995) The natural cytotoxicity in cosmonauts on board space stations. Acta Astronaut. 36, 719-726.
    • (1995) Acta Astronaut. , vol.36 , pp. 719-726
    • Meshkov, D.1    Rykova, M.2
  • 68
    • 0028930343 scopus 로고
    • The effects of rM-CSF and rIL-6 therapy on immunosuppressed antiorthostatically suspended mice
    • Armstrong, J. W., Kirby-Dobbels, K., Chapes, S. K. (1995) The effects of rM-CSF and rIL-6 therapy on immunosuppressed antiorthostatically suspended mice. J. Appl. Physiol. 78, 968-975.
    • (1995) J. Appl. Physiol. , vol.78 , pp. 968-975
    • Armstrong, J.W.1    Kirby-Dobbels, K.2    Chapes, S.K.3
  • 69
    • 0022416449 scopus 로고
    • Regulation of hematopoiesis in rats exposed to antiorthostatic, hypokinetic/hypodynamia: I. Model description
    • Dunn, C. D., Johnson, P. C., Lange, R. D., Perez, L., Nessel, R. (1985) Regulation of hematopoiesis in rats exposed to antiorthostatic, hypokinetic/hypodynamia: I. Model description. Aviat. Space Environ. Med. 56, 419-426.
    • (1985) Aviat. Space Environ. Med. , vol.56 , pp. 419-426
    • Dunn, C.D.1    Johnson, P.C.2    Lange, R.D.3    Perez, L.4    Nessel, R.5
  • 71
    • 0028474544 scopus 로고
    • Effect of space flight on cytokine production
    • Sonnenfeld, G. (1994) Effect of space flight on cytokine production. Acta Astronaut. 33, 143-147.
    • (1994) Acta Astronaut. , vol.33 , pp. 143-147
    • Sonnenfeld, G.1
  • 74
    • 0025726221 scopus 로고
    • Effects of corticosterone and microgravity on inflammatory cell production of superoxide
    • Fleming, S. D., Edelman, L. S., Chapes, S. K. (1991) Effects of corticosterone and microgravity on inflammatory cell production of superoxide. J. Leukoc. Biol. 50, 69-76.
    • (1991) J. Leukoc. Biol. , vol.50 , pp. 69-76
    • Fleming, S.D.1    Edelman, L.S.2    Chapes, S.K.3
  • 75
    • 0033710839 scopus 로고    scopus 로고
    • Reactivation and shedding of cytomegalovirus in astronauts during spaceflight
    • Mehta, S. K., Stowe, R. P., Feiveson, A. H., Tyring, S. K., Pierson, D. L. (2000) Reactivation and shedding of cytomegalovirus in astronauts during spaceflight. J. Infect. Dis. 182, 1761-1764.
    • (2000) J. Infect. Dis. , vol.182 , pp. 1761-1764
    • Mehta, S.K.1    Stowe, R.P.2    Feiveson, A.H.3    Tyring, S.K.4    Pierson, D.L.5
  • 77
    • 0035191538 scopus 로고    scopus 로고
    • Elevated stress hormone levels relate to Epstein-Barr virus reactivation in astronauts
    • Stowe, R. P., Pierson, D. L., Barrett, A. D. (2001) Elevated stress hormone levels relate to Epstein-Barr virus reactivation in astronauts. Psychosom. Med. 63, 891-895.
    • (2001) Psychosom. Med. , vol.63 , pp. 891-895
    • Stowe, R.P.1    Pierson, D.L.2    Barrett, A.D.3
  • 79
    • 43249130506 scopus 로고    scopus 로고
    • Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts
    • Cohrs, R. J., Mehta, S. K., Schmid, D. S., Gilden, D. H., Pierson, D. L. (2008) Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts. J. Med. Virol. 80, 1116-1122.
    • (2008) J. Med. Virol. , vol.80 , pp. 1116-1122
    • Cohrs, R.J.1    Mehta, S.K.2    Schmid, D.S.3    Gilden, D.H.4    Pierson, D.L.5
  • 80
    • 0023085087 scopus 로고
    • Enhancement of viral pathogenesis in mice maintained in an antiorthostatic suspension model: Coordination with effects on interferon production
    • Gould, C. L., Sonnenfeld, G. (1987) Enhancement of viral pathogenesis in mice maintained in an antiorthostatic suspension model: coordination with effects on interferon production. J. Biol. Regul. Homeost. Agents 1, 33-36.
    • (1987) J. Biol. Regul. Homeost. Agents , vol.1 , pp. 33-36
    • Gould, C.L.1    Sonnenfeld, G.2
  • 81
    • 0038309473 scopus 로고    scopus 로고
    • Increased susceptibility to Pseudomonas aeruginosa infection under hindlimb-unloading conditions
    • Aviles, H., Belay, T., Fountain, K., Vance, M., Sonnenfeld, G. (2003) Increased susceptibility to Pseudomonas aeruginosa infection under hindlimb-unloading conditions. J. Appl. Physiol. 95, 73-80. (Pubitemid 36753786)
    • (2003) Journal of Applied Physiology , vol.95 , Issue.1 , pp. 73-80
    • Aviles, H.1    Belay, T.2    Fountain, K.3    Vance, M.4    Sonnenfeld, G.5
  • 82
    • 20944449956 scopus 로고    scopus 로고
    • Effects of space flight conditions on the function of the immune system and catecholamine production simulated in a rodent model of hindlimb unloading
    • DOI 10.1159/000084850
    • Aviles, H., Belay, T., Vance, M., Sonnenfeld, G. (2005) Effects of space flight conditions on the function of the immune system and catecholamine production simulated in a rodent model of hindlimb unloading. Neuroimmunomodulation 12, 173-181. (Pubitemid 40868678)
    • (2005) NeuroImmunoModulation , vol.12 , Issue.3 , pp. 173-181
    • Aviles, H.1    Belay, T.2    Vance, M.3    Sonnenfeld, G.4
  • 83
    • 58149138936 scopus 로고    scopus 로고
    • Effects of exposure of mice to hindlimb unloading on leukocyte subsets and sympathetic nervous system activity
    • O'Donnell, P. M., Orshal, J. M., Sen, D., Sonnenfeld, G., Aviles, H. O. (2009) Effects of exposure of mice to hindlimb unloading on leukocyte subsets and sympathetic nervous system activity. Stress 12, 82-88.
    • (2009) Stress , vol.12 , pp. 82-88
    • O'Donnell, P.M.1    Orshal, J.M.2    Sen, D.3    Sonnenfeld, G.4    Aviles, H.O.5
  • 85
    • 0027378979 scopus 로고
    • The role of psychoneuroendocrine factors on spaceflight-induced immunological alterations
    • Meehan, R., Whitson, P., Sams, C. (1993) The role of psychoneuroendocrine factors on spaceflight-induced immunological alterations. J. Leukoc. Biol. 54, 236-244. (Pubitemid 23300689)
    • (1993) Journal of Leukocyte Biology , vol.54 , Issue.3 , pp. 236-244
    • Meehan, R.1    Whitson, P.2    Sams, C.3
  • 86
    • 0022413517 scopus 로고
    • Characterization of the β-adrenergic receptor of the rat peritoneal macrophage
    • Abrass, C. K., O'Connor, S. W., Scarpace, P. J., Abrass, I. B. (1985) Characterization of the β-adrenergic receptor of the rat peritoneal macrophage. J. Immunol. 135, 1338-1341. (Pubitemid 16237457)
    • (1985) Journal of Immunology , vol.135 , Issue.2 , pp. 1338-1341
    • Abrass, C.K.1    O'Connor, S.W.2    Scarpace, P.J.3    Abrass, I.B.4
  • 87
    • 0024586552 scopus 로고
    • Identification and characterization of a homogeneous population of β 2-adrenergic receptors on human alveolar macrophages
    • Liggett, S. B. (1989) Identification and characterization of a homogeneous population of β 2-adrenergic receptors on human alveolar macrophages. Am. Rev. Respir. Dis. 139, 552-555.
    • (1989) Am. Rev. Respir. Dis. , vol.139 , pp. 552-555
    • Liggett, S.B.1
  • 88
    • 0035179038 scopus 로고    scopus 로고
    • Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection
    • DOI 10.1128/IAI.69.12.7234-7241.2001
    • Miura, T., Kudo, T., Matsuki, A., Sekikawa, K., Tagawa, Y., Iwakura, Y., Nakane, A. (2001) Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection. Infect. Immun. 69, 7234-7241. (Pubitemid 33086543)
    • (2001) Infection and Immunity , vol.69 , Issue.12 , pp. 7234-7241
    • Miura, T.1    Kudo, T.2    Matsuki, A.3    Sekikawa, K.4    Tagawa, Y.-I.5    Iwakura, Y.6    Nakane, A.7
  • 89
    • 0032589995 scopus 로고    scopus 로고
    • β2-Adrenergic receptor stimulation inhibits nitric oxide generation by Mycobacterium avium infected macrophages
    • Boomershine, C. S., Lafuse, W. P., Zwilling, B. S. (1999) β2-Adrenergic receptor stimulation inhibits nitric oxide generation by Mycobacterium avium infected macrophages. J. Neuroimmunol. 101, 68-75.
    • (1999) J. Neuroimmunol. , vol.101 , pp. 68-75
    • Boomershine, C.S.1    Lafuse, W.P.2    Zwilling, B.S.3
  • 90
    • 0015817944 scopus 로고
    • Study of the reactivity of blood lymphoid cells in crew members of the Soyuz-6, 7 and 8 spaceships before and after flight
    • Konstantinova, I. V., Antropova, Y. N., Legenkov, V. I., Zazhirey, V. D. (1973) Study of the reactivity of blood lymphoid cells in crew members of the Soyuz-6, 7 and 8 spaceships before and after flight. Kosm. Biol. Med., 35-40.
    • (1973) Kosm. Biol. Med. , pp. 35-40
    • Konstantinova, I.V.1    Antropova, Y.N.2    Legenkov, V.I.3    Zazhirey, V.D.4
  • 91
    • 0026662022 scopus 로고
    • Variable lymphocyte responses in rats after space flight
    • Nash, P. V., Mastro, A. M. (1992) Variable lymphocyte responses in rats after space flight. Exp. Cell Res. 202, 125-131.
    • (1992) Exp. Cell Res. , vol.202 , pp. 125-131
    • Nash, P.V.1    Mastro, A.M.2
  • 92
    • 27744597196 scopus 로고    scopus 로고
    • Lessons from Immune 1-3: What did we learn and what do we need to do in the future?
    • Chapes, S. K. (2004) Lessons from Immune 1-3: what did we learn and what do we need to do in the future? J. Gravit. Physiol. 11, P45-P48.
    • (2004) J. Gravit. Physiol. , vol.11
    • Chapes, S.K.1
  • 99
    • 0002376427 scopus 로고    scopus 로고
    • Influence of microgravity on mitogen binding, motility and cytoskeleton patterns of T lymphocytes and jurkat cells-experiments on sounding rockets
    • Cogoli-Greuter, M., Spano, A., Sciola, L., Pippia, P., Cogoli, A. (1998) Influence of microgravity on mitogen binding, motility and cytoskeleton patterns of T lymphocytes and Jurkat cells-experiments on sounding rockets. Japanese Journal of Aerospace and Environmental Medicine 35, 27-39. (Pubitemid 128705673)
    • (1998) Japanese Journal of Aerospace and Environmental Medicine , vol.35 , Issue.2 , pp. 27-39
    • Cogoli-Greuter, M.1
  • 101
    • 0027405991 scopus 로고
    • The IL-2 receptor complex: Its structure, function, and target genes
    • Minami, Y., Kono, T., Miyazaki, T., Taniguchi, T. (1993) The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11, 245-268. (Pubitemid 23115008)
    • (1993) Annual Review of Immunology , vol.11 , pp. 245-267
    • Minami, Y.1    Kono, T.2    Miyazaki, T.3    Taniguchi, T.4
  • 102
    • 0032722326 scopus 로고    scopus 로고
    • T cell activation responses are differentially regulated during clinorotation and in spaceflight
    • Hashemi, B. B., Penkala, J. E., Vens, C., Huls, H., Cubbage, M., Sams, C. F. (1999) T cell activation responses are differentially regulated during clinorotation and in spaceflight. FASEB J. 13, 2071-2082. (Pubitemid 29517637)
    • (1999) FASEB Journal , vol.13 , Issue.14 , pp. 2071-2082
    • Hashemi, B.B.1    Penkala, J.E.2    Vens, C.3    Huls, H.4    Cubbage, M.5    Sams, C.F.6
  • 103
    • 0032566605 scopus 로고    scopus 로고
    • Simulated microgravity inhibits the genetic expression of interleukin-2 and its receptor in mitogen-activated T lymphocytes
    • DOI 10.1016/S0014-5793(98)01107-7, PII S0014579398011077
    • Walther, I., Pippia, P., Meloni, M. A., Turrini, F., Mannu, F., Cogoli, A. (1998) Simulated microgravity inhibits the genetic expression of interleukin-2 and its receptor in mitogen-activated T lymphocytes. FEBS Lett. 436, 115-118. (Pubitemid 28454617)
    • (1998) FEBS Letters , vol.436 , Issue.1 , pp. 115-118
    • Walther, I.1    Pippia, P.2    Meloni, M.A.3    Turrini, F.4    Mannu, F.5    Cogoli, A.6
  • 106
    • 0027493083 scopus 로고
    • The effect of hypogravity and hypergravity on cells of the immune system
    • Cogoli, A. (1993) The effect of hypogravity and hypergravity on cells of the immune system. J. Leukoc. Biol. 54, 259-268. (Pubitemid 23300692)
    • (1993) Journal of Leukocyte Biology , vol.54 , Issue.3 , pp. 259-268
    • Cogoli, A.1
  • 107
    • 0031923535 scopus 로고    scopus 로고
    • Suppressed PHA activation of T lymphocytes in simulated microgravity is restored by direct activation of protein kinase C
    • Cooper, D., Pellis, N. R. (1998) Suppressed PHA activation of T lymphocytes in simulated microgravity is restored by direct activation of protein kinase C. J. Leukoc. Biol. 63, 550-562. (Pubitemid 28193767)
    • (1998) Journal of Leukocyte Biology , vol.63 , Issue.5 , pp. 550-562
    • Cooper, D.1    Pellis, N.R.2
  • 109
    • 33845754939 scopus 로고    scopus 로고
    • Cytoskeleton changes and impaired motility of monocytes at modelled low gravity
    • DOI 10.1007/s00709-006-0210-2, Gravitational Biology
    • Meloni, M. A., Galleri, G., Pippia, P., Cogoli-Greuter, M. (2006) Cytoskeleton changes and impaired motility of monocytes at modeled low gravity. Protoplasma 229, 243-249. (Pubitemid 44974261)
    • (2006) Protoplasma , vol.229 , Issue.2-4 , pp. 243-249
    • Meloni, M.A.1    Galleri, G.2    Pippia, P.3    Cogoli-Greuter, M.4
  • 110
    • 0031850240 scopus 로고    scopus 로고
    • The cytoskeleton and cell signaling: Component localization and mechanical coupling
    • Janmey, P. A. (1998) The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiol. Rev. 78, 763-781.
    • (1998) Physiol. Rev. , vol.78 , pp. 763-781
    • Janmey, P.A.1
  • 112
    • 0032952039 scopus 로고    scopus 로고
    • How cells (might) sense microgravity
    • Ingber, D. (1999) How cells (might) sense microgravity. FASEB J. 13 (Suppl.), S3-S15. (Pubitemid 29220669)
    • (1999) FASEB Journal , vol.13 , Issue.8 SUPPL.
    • Ingber, D.1
  • 113
    • 0028215576 scopus 로고
    • Dynamic properties of ankyrin in T lymphocytes: Colocalization with spectrin and protein kinase C β
    • Gregorio, C. C., Repasky, E. A., Fowler, V. M., Black, J. D. (1994) Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C β. J. Cell Biol. 125, 345-358.
    • (1994) J. Cell Biol. , vol.125 , pp. 345-358
    • Gregorio, C.C.1    Repasky, E.A.2    Fowler, V.M.3    Black, J.D.4
  • 114
    • 0031854839 scopus 로고    scopus 로고
    • Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat)
    • Lewis, M. L., Reynolds, J. L., Cubano, L. A., Hatton, J. P., Lawless, B. D., Piepmeier, E. H. (1998) Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat). FASEB J. 12, 1007-1018.
    • (1998) FASEB J. , vol.12 , pp. 1007-1018
    • Lewis, M.L.1    Reynolds, J.L.2    Cubano, L.A.3    Hatton, J.P.4    Lawless, B.D.5    Piepmeier, E.H.6
  • 115
    • 0035432020 scopus 로고    scopus 로고
    • CDNA microarray reveals altered cytoskeletal gene expression in space-flown leukemic T lymphocytes (Jurkat)
    • Lewis, M. L., Cubano, L. A., Zhao, B., Dinh, H. K., Pabalan, J. G., Piepmeier, E. H., Bowman, P. D. (2001) cDNA microarray reveals altered cytoskeletal gene expression in space-flown leukemic T lymphocytes (Jurkat). FASEB J. 15, 1783-1785.
    • (2001) FASEB J. , vol.15 , pp. 1783-1785
    • Lewis, M.L.1    Cubano, L.A.2    Zhao, B.3    Dinh, H.K.4    Pabalan, J.G.5    Piepmeier, E.H.6    Bowman, P.D.7
  • 116
    • 0346910529 scopus 로고    scopus 로고
    • Function of the cytoskeleton in gravisensing during spaceflight
    • Hughes-Fulford, M. (2003) Function of the cytoskeleton in gravisensing during spaceflight. Adv. Space Res. 32, 1585-1593.
    • (2003) Adv. Space Res. , vol.32 , pp. 1585-1593
    • Hughes-Fulford, M.1
  • 118
    • 0032948508 scopus 로고    scopus 로고
    • The kinetics of translocation and cellular quantity of protein kinase C in human leukocytes are modified during spaceflight
    • Hatton, J. P., Gaubert, F., Lewis, M. L., Darsel, Y., Ohlmann, P., Cazenave, J. P., Schmitt, D. (1999) The kinetics of translocation and cellular quantity of protein kinase C in human leukocytes are modified during spaceflight. FASEB J. 13 (Suppl.), S23-S33. (Pubitemid 29220671)
    • (1999) FASEB Journal , vol.13 , Issue.8 SUPPL.
    • Hatton, J.P.1    Gaubert, F.2    Lewis, M.L.3    Darsel, Y.4    Ohlmann, P.5    Cazenave J-, P.6    Schmitt, D.7
  • 119
    • 0036351097 scopus 로고    scopus 로고
    • Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells
    • DOI 10.1002/jcb.10273
    • Hatton, J. P., Gaubert, F., Cazenave, J. P., Schmitt, D. (2002) Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells. J. Cell. Biochem. 87, 39-50. (Pubitemid 34969146)
    • (2002) Journal of Cellular Biochemistry , vol.87 , Issue.1 , pp. 39-50
    • Hatton, J.P.1    Gaubert, F.2    Cazenave, J.-P.3    Schmitt, D.4
  • 122
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • DOI 10.1189/jlb.0603252
    • Schroder, K., Hertzog, P. J., Ravasi, T., Hume, D. A. (2004) Interferon-γ: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75, 163-189. (Pubitemid 38174573)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 123
    • 38449105556 scopus 로고    scopus 로고
    • IFN-γ: Recent advances in understanding regulation of expression, biological functions, and clinical applications
    • Young, H. A., Bream, J. H. (2007) IFN-γ: recent advances in understanding regulation of expression, biological functions, and clinical applications. Curr. Top. Microbiol. Immunol. 316, 97-117.
    • (2007) Curr. Top. Microbiol. Immunol. , vol.316 , pp. 97-117
    • Young, H.A.1    Bream, J.H.2
  • 124
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: Fates, functions, and faults
    • Zhu, J., Paul, W. E. (2008) CD4 T cells: fates, functions, and faults. Blood 112, 1557-1569.
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 125
    • 0036313167 scopus 로고    scopus 로고
    • Myeloid, B and T lymphoid and mixed lineage thymic lymphomas in the irradiated mouse
    • Boulton, E., Cleary, H., Plumb, M. (2002) Myeloid, B and T lymphoid and mixed lineage thymic lymphomas in the irradiated mouse. Carcinogenesis 23, 1079-1085. (Pubitemid 34752966)
    • (2002) Carcinogenesis , vol.23 , Issue.6 , pp. 1079-1085
    • Boulton, E.1    Cleary, H.2    Plumb, M.3
  • 126
    • 0021142617 scopus 로고
    • Prolonged weightlessness and humoral immunity
    • Voss Jr., E. W. (1984) Prolonged weightlessness and humoral immunity. Science 225, 214-215.
    • (1984) Science , vol.225 , pp. 214-215
    • Voss Jr., E.W.1
  • 128
    • 14144255413 scopus 로고    scopus 로고
    • Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl
    • DOI 10.1152/japplphysiol.00957.2004
    • Boxio, R., Dournon, C., Frippiat, J. P. (2005) Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl. J. Appl. Physiol. 98, 905-910. (Pubitemid 40283671)
    • (2005) Journal of Applied Physiology , vol.98 , Issue.3 , pp. 905-910
    • Boxio, R.1    Dournon, C.2    Frippiat, J.-P.3
  • 129
    • 70349309418 scopus 로고    scopus 로고
    • Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl
    • Bascove, M., Huin-Schohn, C., Gueguinou, N., Tschirhart, E., Frippiat, J. P. (2009) Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl. FASEB J. 23, 1607-1615.
    • (2009) FASEB J. , vol.23 , pp. 1607-1615
    • Bascove, M.1    Huin-Schohn, C.2    Gueguinou, N.3    Tschirhart, E.4    Frippiat, J.P.5
  • 130
    • 34848854484 scopus 로고    scopus 로고
    • A new isotype of immunoglobulin heavy chain in the urodele amphibian Pleurodeles waltl predominantly expressed in larvae
    • DOI 10.1016/j.molimm.2007.06.356, PII S0161589007006128, Theories and Modelling of T Cell Behaviour
    • Schaerlinger, B., Bascove, M., Frippiat, J. P. (2008) A new isotype of immunoglobulin heavy chain in the urodele amphibian Pleurodeles waltl predominantly expressed in larvae. Mol. Immunol. 45, 776-786. (Pubitemid 47498578)
    • (2008) Molecular Immunology , vol.45 , Issue.3 , pp. 776-786
    • Schaerlinger, B.1    Bascove, M.2    Frippiat, J.-P.3
  • 131
    • 18444413976 scopus 로고    scopus 로고
    • Antibody binding in altered gravity: Implications for immunosorbent assay during space flight
    • Maule, J., Fogel, M., Steele, A., Wainwright, N., Pierson, D. L., McKay, D. S. (2003) Antibody binding in altered gravity: implications for immunosorbent assay during space flight. J. Gravit. Physiol. 10, 47-55.
    • (2003) J. Gravit. Physiol. , vol.10 , pp. 47-55
    • Maule, J.1    Fogel, M.2    Steele, A.3    Wainwright, N.4    Pierson, D.L.5    McKay, D.S.6
  • 135
  • 136
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A. K., Murphy, K. M., Sher, A. (1996) Functional diversity of helper T lymphocytes. Nature 383, 787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 138
    • 15544377117 scopus 로고    scopus 로고
    • Detection of oxidative stress induced by low- And high-linear energy transfer radiation in cultured human epithelial cells
    • DOI 10.1667/0033-7587(2005)163[0364:DOOSIB]2.0.CO;2
    • Wan, X. S., Bloch, P., Ware, J. H., Zhou, Z., Donahue, J. J., Guan, J., Stewart, J., Kennedy, A. R. (2005) Detection of oxidative stress induced by low- and high-linear energy transfer radiation in cultured human epithelial cells. Radiat. Res. 163, 364-368. (Pubitemid 40404643)
    • (2005) Radiation Research , vol.163 , Issue.4 , pp. 364-368
    • Wan, X.S.1    Bloch, P.2    Ware, J.H.3    Zhou, Z.4    Donahue, J.J.5    Guan, J.6    Stewart, J.7    Kennedy, A.R.8
  • 139
    • 46649103614 scopus 로고    scopus 로고
    • Nutrition issues for space exploration
    • Smith, S. M., Zwart, S. R. (2008) Nutrition issues for space exploration. Acta Astronaut. 63, 609-613.
    • (2008) Acta Astronaut. , vol.63 , pp. 609-613
    • Smith, S.M.1    Zwart, S.R.2
  • 140
    • 33645375380 scopus 로고    scopus 로고
    • Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents
    • Wan, X. S., Ware, J. H., Zhou, Z., Donahue, J. J., Guan, J., Kennedy, A. R. (2006) Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents. Int. J. Radiat. Oncol. Biol. Phys. 64, 1475-1481.
    • (2006) Int. J. Radiat. Oncol. Biol. Phys. , vol.64 , pp. 1475-1481
    • Wan, X.S.1    Ware, J.H.2    Zhou, Z.3    Donahue, J.J.4    Guan, J.5    Kennedy, A.R.6
  • 141
    • 34248227316 scopus 로고    scopus 로고
    • Countermeasures against space radiation induced oxidative stress in mice
    • DOI 10.1007/s00411-007-0105-4, Proceedings of the 4th IWSRR
    • Kennedy, A. R., Guan, J., Ware, J. H. (2007) Countermeasures against space radiation induced oxidative stress in mice. Radiat. Environ. Biophys. 46, 201-203. (Pubitemid 46726009)
    • (2007) Radiation and Environmental Biophysics , vol.46 , Issue.2 , pp. 201-203
    • Kennedy, A.R.1    Guan, J.2    Ware, J.H.3
  • 143
    • 0032213543 scopus 로고    scopus 로고
    • Nutrition, endocrinology, and body composition during space flight
    • DOI 10.1016/S0271-5317(98)00162-6, PII S0271531798001626
    • Lane, H. W., Gretebeck, R. J., Smith, S. M. (1998) Nutrition, endocrinology, and body composition during space flight. Nutr. Res. 18, 1923-1934. (Pubitemid 28484068)
    • (1998) Nutrition Research , vol.18 , Issue.11 , pp. 1923-1934
    • Lane, H.W.1    Gretebeck, R.J.2    Smith, S.M.3
  • 145
    • 0036141210 scopus 로고    scopus 로고
    • Nutrients and their role in host resistance to infection
    • Field, C. J., Johnson, I. R., Schley, P. D. (2002) Nutrients and their role in host resistance to infection. J. Leukoc. Biol. 71, 16-32.
    • (2002) J. Leukoc. Biol. , vol.71 , pp. 16-32
    • Field, C.J.1    Johnson, I.R.2    Schley, P.D.3
  • 146
    • 0036545626 scopus 로고    scopus 로고
    • A countermeasure to ameliorate immune dysfunction in in vitro simulated microgravity environment: Role of cellular nucleotide nutrition
    • DOI 10.1290/1071-2690(2002)038<0213:ACTAID>2.0.CO;2
    • Hales, N. W., Yamauchi, K., Alicea, A., Sundaresan, A., Pellis, N. R., Kulkarni, A. D. (2002) A countermeasure to ameliorate immune dysfunction in in vitro simulated microgravity environment: role of cellularnucleotide nutrition. In Vitro Cell. Dev. Biol. Anim. 38, 213-217. (Pubitemid 34975845)
    • (2002) In Vitro Cellular and Developmental Biology - Animal , vol.38 , Issue.4 , pp. 213-217
    • Hales, N.W.1    Yamauchi, K.2    Alicea, A.3    Sundaresan, A.4    Pellis, N.R.5    Kulkarni, A.D.6
  • 149
    • 0035991449 scopus 로고    scopus 로고
    • Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: A prospective cohort study
    • DOI 10.1016/S0168-8278(02)00091-0, PII S0168827802000910
    • Matsui, Y., Uhara, J., Satoi, S., Kaibori, M., Yamada, H., Kitade, H., Imamura, A., Takai, S., Kawaguchi, Y., Kwon, A. H., Kamiyama, Y. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J. Hepatol. 37, 78-86. (Pubitemid 34713058)
    • (2002) Journal of Hepatology , vol.37 , Issue.1 , pp. 78-86
    • Matsui, Y.1    Uhara, J.2    Satoi, S.3    Kaibori, M.4    Yamada, H.5    Kitade, H.6    Imamura, A.7    Takai, S.8    Kawaguchi, Y.9    Kwon, A.-H.10    Kamiyama, Y.11
  • 150
    • 0032843046 scopus 로고    scopus 로고
    • Protective effects of active hexose correlated compound (AHCC) on the onset of diabetes induced by streptozotocin in the rat
    • Wakame, K. (1999) Protective effects of active hexose correlated compound (AHCC) on the onset of diabetes induced by streptozotocin in the rat. Biomed. Res. 20, 145-152.
    • (1999) Biomed. Res. , vol.20 , pp. 145-152
    • Wakame, K.1
  • 151
    • 0041627936 scopus 로고    scopus 로고
    • Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditions
    • Aviles, H., Belay, T., Fountain, K., Vance, M., Sun, B., Sonnenfeld, G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditions. J. Appl. Physiol. 95, 491-496. (Pubitemid 36944268)
    • (2003) Journal of Applied Physiology , vol.95 , Issue.2 , pp. 491-496
    • Aviles, H.1    Belay, T.2    Fountain, K.3    Vance, M.4    Sun, B.5    Sonnenfeld, G.6
  • 152
    • 4644288955 scopus 로고    scopus 로고
    • Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions
    • DOI 10.1152/japplphysiol.00259.2004
    • Aviles, H., Belay, T., Vance, M., Sun, B., Sonnenfeld, G. (2004) Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions. J. Appl. Physiol. 97, 1437-1444. (Pubitemid 39299363)
    • (2004) Journal of Applied Physiology , vol.97 , Issue.4 , pp. 1437-1444
    • Aviles, H.1    Belay, T.2    Vance, M.3    Sun, B.4    Sonnenfeld, G.5
  • 153
    • 33847408946 scopus 로고    scopus 로고
    • Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection
    • DOI 10.1089/sur.2006.7.527
    • Aviles, H., O'Donnell, P., Sun, B., Sonnenfeld, G. (2006) Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection. Surg. Infect. (Larchmt) 7, 527-535. (Pubitemid 46348303)
    • (2006) Surgical Infections , vol.7 , Issue.6 , pp. 527-535
    • Aviles, H.1    O'Donnell, P.2    Sun, B.3    Sonnenfeld, G.4
  • 154
    • 40949143200 scopus 로고    scopus 로고
    • Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection
    • Aviles, H., O'Donnell, P., Orshal, J., Fujii, H., Sun, B., Sonnenfeld, G. (2008) Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am. J. Surg. 195, 537-545.
    • (2008) Am. J. Surg. , vol.195 , pp. 537-545
    • Aviles, H.1    O'Donnell, P.2    Orshal, J.3    Fujii, H.4    Sun, B.5    Sonnenfeld, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.