Physiological, pharmacokinetic, and pharmacodynamic changes in space

Journal of Clinical Pharmacology

Volumn 44, Issue 8, 2004, Pages 837-853

  Graebe, Annemarie ^a   Schuck, Edgar L ^b   Lensing, Petra ^c   Putcha, Lakshmi ^d   Derendorf, Hartmut ^b  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c Dom Apotheke   (Germany)

^d NASA JOHNSON SPACE CENTER   (United States)

Author keywords

Drug dosing; Microgravity environment; Pharmacodynamics; Pharmacokinetics; Space flight; Space medicine

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ACETYLCHOLINE; ACETYLSALICYLIC ACID; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTIHYPERTENSIVE AGENT; BETA LACTAM ANTIBIOTIC; CAPTOPRIL; CORTICOSTEROID; CYTOCHROME P450; DEXAMPHETAMINE; DIURETIC AGENT; FLURAZEPAM; IBUPROFEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INDOMETACIN; MICROCIN B17; NORDAZEPAM; PARACETAMOL; PHENYLEPHRINE; PROMETHAZINE; RAPAMYCIN; SCOPOLAMINE; SEDATIVE AGENT; TEMAZEPAM; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; TRIAZOLAM; ZOLPIDEM;

ACUTE DISEASE; BACKACHE; BLOOD FLOW; BONE DEMINERALIZATION; CARDIOVASCULAR PERFORMANCE; DISEASE SEVERITY; DRUG METABOLISM; ELECTROLYTE BALANCE; ENZYME ACTIVITY; EOSINOPHIL; HEADACHE; HEMATOCRIT; HORMONE BLOOD LEVEL; HUMAN; HYPEREMIA; IMMUNOGLOBULIN BLOOD LEVEL; INSOMNIA; LYMPHOCYTE; MICROGRAVITY; MOTION SICKNESS; MUSCLE ATROPHY; NAUSEA; PLASMA VOLUME; REVIEW; SIDE EFFECT; SPACE FLIGHT; VOMITING;

NASA CENTER JSC; NASA DISCIPLINE REGULATORY PHYSIOLOGY;

FLIGHT EXPERIMENT; LONG DURATION; MANNED; MIR PROJECT; SHORT DURATION; STS SHUTTLE PROJECT;

AEROSPACE MEDICINE; BODY WATER; BONE DEMINERALIZATION, PATHOLOGIC; CARDIOVASCULAR PHYSIOLOGY; ENZYMES; ERYTHROCYTE COUNT; FEMALE; HEMODYNAMIC PROCESSES; HORMONES; HUMANS; IMMUNITY; KIDNEY; MALE; MUSCULAR ATROPHY; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SEX FACTORS; SODIUM; SPACE FLIGHT; TIME FACTORS; WEIGHTLESSNESS;

EID: 3242748854     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270004267193     Document Type: Review

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