Effect of spaceflight on ability of monocytes to respond to endotoxins of gram-negative bacteria

Clinical and Vaccine Immunology

Volumn 15, Issue 10, 2008, Pages 1523-1528

  Kaur, Indreshpal ^a,e   Simons, Elizabeth R ^b   Kapadia, Asha S ^c   Ott, C Mark ^d   Pierson, Duane L ^d  

^a Enterprise Advisory Services Inc   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^d NASA JOHNSON SPACE CENTER   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CD14 ANTIGEN; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE BINDING PROTEIN; TOLL LIKE RECEPTOR 4; ACUTE PHASE PROTEIN; CARRIER PROTEIN; ENDOTOXIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; COSMONAUT; FEMALE; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SPACE FLIGHT; STRESS; BIOSYNTHESIS; BLOOD; IMMUNOLOGY; MIDDLE AGED;

ACUTE-PHASE PROTEINS; ADULT; ANTIGENS, CD14; ASTRONAUTS; CARRIER PROTEINS; CYTOKINES; ENDOTOXINS; FEMALE; GRAM-NEGATIVE BACTERIA; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MONOCYTES; SPACE FLIGHT; TOLL-LIKE RECEPTOR 4;

EID: 55449106962     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00065-08     Document Type: Article

References (45)

1. Anderson, K. V. 2000. Toll signaling pathways in the innate immune response. Curr. Opin. Immunol. 12:13-19.
2. Arend, W. P. 2002. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 13:323-340.
3. Bihl, F., L. Salez, M. Beaubier, D. Torres, L. Lariviere, L. Laroche, A. Benedetto, D. Martel, J. M. Lapointe, B. Ryffel, and D. Malo. 2003. Overexpression of Toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice. J. Immunol. 170:6141-6150.
4. Bruunsgaard, H., A. N. Pedersen, M. Schroll, P. Skinhoj, and B. K. Pedersen. 1999. Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans. Clin. Exp. Immunol. 118:235-241.
5. Chapes, S. K., S. J. Simske, G. Sonnenfeld, E. S. Miller, and R. J. Zimmerman. 1999. Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses. J. Appl. Physiol. 86:2065-2076.
6. Chow, J. C., D. W. Young, D. T. Golenbock, W. J. Christ, and F. Gusovsky. 1999. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 274:10689-10692.
7. Cohen, J. 1973. Eta-squared and partial eta-squared in fixed factor ANOVA designs. Educ. Psychol. Measurements 33:107-112.
8. Crucian, B. E., M. L. Cubbage, and C. F. Sams. 2000. Altered cytokine production by specific human peripheral blood cell subsets immediately following space flight. J. Interferon Cytokine Res. 20:547-556.
9. Dziarski, R., and D. Gupta. 2000. Role of MD-2 in TLR2- and TLR4-mediated recognition of gram-negative and gram-positive bacteria and activation of chemokine genes. J. Endotoxin Res. 6:401-405.
10. Fitzgerald, K. A., D. C. Rowe, and D. T. Golenbock. 2004. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 6:1361-1367.
11. Heumann, D., and T. Roger. 2002. Initial responses to endotoxins and gram-negative bacteria. Clin. Chim. Acta 323:59-72.
12. Huntoon, C. L., P. C. Johnson, and N. M. Cintron. 1993. Hematology, immunology, endocrinology and biochemistry, p. 222-239. In A. E. Nicogossian, C. L. Huntoon, and S. L. Pool (ed.), Space physiology and medicine, 2nd edition. National Aeronautics & Space Administration, Washington, DC.
13. Kass, E. H. 1971. Resistance to infections in extended space flight. Life Sci. Space Res. 9:35-41.
14. Kaur, I., E. R. Simons, V. A. Castro, C. M. Ott, and D. L. Pierson. 2004. Changes in neutrophil functions in astronauts. Brain Behav. Immun. 18:443-450.
15. Kaur, I., E. R. Simons, V. A. Castro, C. M. Ott, and D. L. Pierson. 2005. Changes in monocyte functions of astronauts. Brain Behav. Immun. 19:547-554.
16. Kitchens, R. L., P. A. Thompson, S. Viriyakosol, G. E. O'Keefe, and R. S. Munford. 2001. Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins. J. Clin. Investig. 108:485-493.
17. Konstantinova, I. V., M. P. Rykova, A. T. Lesnyak, and E. A. Antropova. 1993. Immune changes during long-duration missions. J. Leukoc. Biol. 54:189-201.
18. Lamping, N., R. Dettmer, N. W. Schroder, D. Pfeil, W. Hallatschek, R. Burger, and R. R. Schumann. 1998. LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria. J. Clin. Investig. 101:2065-2071.
19. Lynch, S. V., E. L. Brodie, and A. Matin. 2004. Role and regulation of sigma S in general resistance conferred by low-shear simulated microgravity in Escherichia coli. J. Bacteriol. 186:8207-8212.
20. Meehan, R. T., L. S. Neale, E. T. Kraus, C. A. Stuart, M. L. Smith, N. M. Cintron, and C. F. Sams. 1992. Alteration in human mononuclear leucocytes following space flight. Immunology 76:491-497.
21. +) killer cell cytotoxicity after spaceflight. J. Appl. Physiol. 91:1814-1818.
22. Mills, P. J., J. V. Meck, W. W. Waters, D. D'Aunno, and M. G. Ziegler. 2001. Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Psychosom. Med. 63:886-890.
23. Miyake, K. 2004. Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Trends Microbiol. 12:186-192.
24. Nickerson, C. A., C. M. Ott, J. W. Wilson, R. Ramamurthy, C. L. LeBlanc, K. Honer zu Bentrup, T. Hammond, and D. L. Pierson. 2003. Low-shear modeled microgravity: a global environmental regulatory signal affecting bacterial gene expression, physiology, and pathogenesis. J. Microbiol. Methods 54:1-11.
25. Pearson, K. 1911. On a correction needful in the case of the correlation ratio. Biometrika 8:254-256.
26. Pierson, D. L., M. Chidambaram, J. D. Heath, L. Mallary, S. K. Mishra, B. Sharma, and G. M. Weinstock. 1996. Epidemiology of Staphylococcus aureus during space flight. FEMS Immunol. Med. Microbiol. 16:273-281.
27. Pierson, D. L., S. K. Mehta, B. B. Magee, and S. K. Mishra. 1995. Person-to-person transfer of Candida albicans in the spacecraft environment. J. Med. Vet. Mycol. 33:145-150.
28. Rhind, S. G., J. W. Castellani, I. K. Brenner, R. J. Shephard, J. Zamecnik, S. J. Montain, A. J. Young, and P. N. Shek. 2001. Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R66-R75.
29. Rietschel, E. T., T. Kirikae, F. U. Schade, U. Mamat, G. Schmidt, H. Loppnow, A. J. Ulmer, U. Zahringer, U. Seydel, F. Di Padova, M. Schreier, and H. Brade. 1994. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8:217-225.
30. Smith, C. W. 1993. Leukocyte-endothelial cell interactions. Semin. Hematol. 30:45-55.
31. Sonnenfeld, G. 2001. Extreme environments and the immune system: effects of spaceflight on immune responses. J. Allergy Clin. Immunol. 107:19-20.
32. Sonnenfeld, G., A. D. Mandel, I. V. Konstantinova, G. R. Taylor, W. D. Berry, S. R. Wellhausen, A. T. Lesnyak, and B. B. Fuchs. 1990. Effects of spaceflight on levels and activity of immune cells. Aviat. Space Environ. Med. 61:648-653.
33. Starkie, R. L., D. J. Angus, J. Rolland, M. Hargreaves, and M. A. Febbraio. 2000. Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans. J. Physiol. 528:647-655.
34. Stent, G., and S. M. Crowe. 1997. Effects of monocyte purification and culture on integrin expression. APMIS 105:663-670.
35. Stowe, R. P., D. L. Pierson, and A. D. Barrett. 2001. Elevated stress hormone levels relate to Epstein-Barr virus reactivation in astronauts. Psychosom. Med. 63:891-895.
36. Stowe, R. P., C. F. Sams, S. K. Mehta, I. Kaur, M. L. Jones, D. L. Feeback, and D. L. Pierson. 1999. Leukocyte subsets and neutrophil function after short-term spaceflight. J. Leukoc. Biol. 65:179-186.
37. Stowe, R. P., C. F. Sams, and D. L. Pierson. 2003. Effects of mission duration on neuroimmune responses in astronauts. Aviat. Space Environ. Med. 74:1281-1284.
38. Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443-451.
39. Tapping, R. I., S. Akashi, K. Miyake, P. J. Godowski, and P. S. Tobias. 2000. Toll-like receptor 4, but not Toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J. Immunol. 165:5780-5787.
40. Tapping, R. I., and P. S. Tobias. 2000. Soluble CD14-mediated cellular responses to lipopolysaccharide. Chem. Immunol. 74:108-121.
41. Taylor, G. R. 1993. Overview of spaceflight immunology studies. J. Leukoc. Biol. 54:179-188.
42. Taylor, G. R., L. S. Neale, and J. R. Dardano. 1986. Immunological analyses of U.S. Space Shuttle crewmembers. Aviat. Space Environ. Med. 57:213-217.
43. Wang, T., G. Yang, P. Hu, and X. Wen. 1997. Effect of simulated weightlessness on TNF-alpha production and the response of bone marrow cells to GM-CSF in rats. Space Med. Med. Eng. (Beijing) 10:168-171.
44. Wurfel, M. M., S. T. Kunitake, H. Lichenstein, J. P. Kane, and S. D. Wright. 1994. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J. Exp. Med. 180:1025-1035.
45. Ziegler-Heitbrock, H. W., and R. J. Ulevitch. 1993. CD14: cell surface receptor and differentiation marker. Immunol. Today 14:121-125.