Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection

American Journal of Surgery

Volumn 195, Issue 4, 2008, Pages 537-545

  Aviles, Hernan ^a   O'Donnell, Phyllis ^a   Orshal, Julia ^a   Fujii, Hajime ^b   Sun, Buxiang ^b   Sonnenfeld, Gerald ^a  

^a BINGHAMTON UNIVERSITY   (United States)

^b Amino Up Chemical Co   (Japan)

Author keywords

Clearance; Cytokines; Humoral immunity; Klebsiella pneumoniae; Mice; Peripheral leukocytes

Indexed keywords

ACTIVE HEXOSE CORRELATED COMPOUND; HEXOSE; INTERLEUKIN 12; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FOOD DEPRIVATION; IMMUNE RESPONSE; IMMUNOMODULATION; INFECTION COMPLICATION; LEUKOCYTE COUNT; MICROBIAL ACTIVITY; MONOCYTE; MOUSE; MYOSITIS; NONHUMAN; PERIPHERAL LYMPHOCYTE; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; SURGICAL MORTALITY;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, BACTERIAL; BIOLOGICAL MARKERS; CHEMOKINE CCL2; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNITY, NATURAL; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INJECTIONS, INTRAMUSCULAR; INTERLEUKIN-12; INTERLEUKIN-6; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LEUKOCYTE COUNT; MICE; POLYSACCHARIDES; SPECIFIC PATHOGEN-FREE ORGANISMS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 40949143200     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2007.05.045     Document Type: Article

References (59)

1. Altemeier W. Sepsis in surgery. Presidential address. Arch Surg 117 (1982) 107-112
2. Polk Jr. H., Cheadle W., Livingston D., et al. A randomized prospective clinical trial to determine the efficacy of interferon-γ in severely injured patients. Am J Surg 193 (1992) 191-196
3. Abraham E., Wunderink R., Silverman H., et al. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha Mab Sepsis Study Group. JAMA 273 (1995) 934-941
4. Reinhart K., Menges T., Gardlund B., et al. Randomized placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: the Ramses study. Crit Care Med 29 (2001) 765-769
5. Hershman M., Sonnenfeld G., Mays B., et al. Effects of interferon-γ treatment on surgically simulated wound infection in mice. Microb Pathog 4 (1988) 165-168
6. Heldricks D., Polk Jr. H., and Fry D. Surgical aspects of infection. In: Goldsmith H. (Ed). The Practice of Surgery (1987), Harper and Row, Hagerstown, MD 1-33
7. Goris R., and Draaisma J. Causes of death after blunt trauma. J Trauma 22 (1982) 141-146
8. Gottrup F., Melling A., and Hollander D. An overview of surgical site infections: aetiology, incidence and risk factors. World Wide Wounds. http://www.worldwidewounds.com September 2005
9. Aviles H., O'Donnell P., Sun B., et al. Active hexose correlated compound enhances resistance to infection in a mouse model of surgical wound infection. Surg Infect 7 (2006) 527-535
10. Hershman M., Polk Jr. H., Pietsch J., et al. Modulation of Klebsiella pneumoniae infection of mice by interferon-γ. Clin Exp Immunol 72 (1988) 406-409
11. Miller S., Miller C., and Trunkey D. The immune consequences of trauma. Surg Clin North Am 62 (1982) 167-181
12. Polk Jr. H., Wellhausen S., Regan M., et al. A systematic study of host defense processes in badly injured patients. Ann Surg 204 (1980) 282-299
13. Rodrick M., Wood J., O'Mahony J., et al. Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man: production of interleukin 1 and 2. J Clin Immunol 6 (1986) 310-318
14. Faist E., Mewes A., Strasser T., et al. Alteration of monocyte function following major injury. Arch Surg 123 (1988) 287-292
15. Freitag K., Saker K., Thomas E., et al. Acute starvation and subsequent refeeding affect lymphocyte subsets and proliferation in cats. J Nutr 130 (2000) 2444-2449
16. Pallinger E., and Csaba G. Influence of acute stress on the triiodothyronine (T3) and serotonin content of rat's immune cells. Acta Physiol Hung 92 (2005) 47-52
17. Duggal P., Ryan N., Van der Hoek K., et al. Effects of leptin administration and feed restriction on thecal leucocytes in the preovulatory rat ovary and the effects of leptin on meiotic maturation, granulosa cell proliferation, steroid hormone and PGE2 release in cultured rat ovarian follicles. Reproduction 123 (2002) 891-898
18. Galland R., and Polk H. Non-specific stimulation of host defenses against a bacterial challenge in malnourished hosts. Br J Surg 69 (1982) 665-668
19. Aviles H., Belay T., Fountain K., et al. Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 95 (2003) 491-496
20. Kidd P. The use of mushrooms glucans and proteoglycans in cancer treatment. Altern Med Rev 5 (2000) 4-27
21. Matsui Y., Uhara J., Satoi S., et al. Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol 37 (2002) 78-86
22. Kodama N., Murata Y., and Nanba H. Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice. J Med Food 7 (2004) 141-145
23. Kaneno R., Fontanari L., Santos S., et al. Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice. Food Chem Toxicol 42 (2004) 909-916
24. Ho J., Sze S., Shen W., et al. Mitogenic activity of edible mushroom lectins. Biochim Biophys Acta 1671 (2004) 9-17
25. Wang S., Wakame K., Igarashi Y., et al. Beneficial effects of active hexose correlated compound on immobilization stress in the rat. Dokkyo J Med Sci 28 (2001) 559-565
26. Borchers A., Stern J., Hackman R., et al. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med 221 (1999) 281-293
27. Burikhanov R., Wakame K., Igarashi Y., et al. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr Regul 34 (2000) 181-188
28. Ye S., Wakame K., Ichimura K., et al. Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38 (2004) 7-13
29. Matsushita K., Kuramitsu Y., Ohiro Y., et al. Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anticancer Drugs 9 (1998) 343-350
30. Yagita A., Maruyama S., Wakasugi S., et al. H-2 haplotype-dependent serum IL-12 production in tumor-bearing mice treated with various mycelial extracts. In Vivo 16 (2002) 49-54
31. Ghoneum M., Wimbley M., Salem F., et al. Immunomodulatory and anticancer effects of active hemicellulose compound (AHCC). Int J Immunother 21 (1995) 23-28
32. Gao Y., Zhang D., Sun B., et al. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol Immunother 16 (2005) 1-9
33. Wakame K. Protective effects of active hexose correlated compound (AHCC) on the onset of diabetes induced by storeptozotocin in rats. Biomed Res 20 (1999) 145-152
34. Mizuno T., Yeohlui P., Kinoshita T., et al. Antitumor activity and chemical modification of polysaccharides from nioshimeji mushroom. Biosci Biotechnol Biochem 60 (1996) 30-33
35. Sakagami H., and Aoki T. Induction of immunopotentiation activity by a protein-bound polysaccharide, PSK. Anticancer Res 11 (1991) 993-1000
36. Ye S., Ichimura K., Wakame K., et al. Suppressive effects of active hexose correlated compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci 74 (2003) 593-602
37. Rukavina T., Vasiljev V., and Ticac B. Proinflammatory cytokines in antilipopolysaccharide immunity against Klebsiella infections. Mediators Inflamm 2 (2005) 88-95
38. Greenberg M., Kunkel S., Strieter R., et al. IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. J Immunol 157 (1996) 3006-3012
39. Brightbill H., Libraty D., Krutzik S., et al. Host defense mechanisms triggered by microbial lipoproteins trough toll-like receptors. Science 285 (1999) 732-736
40. Broug-Holub E., Toews G., Freek Van Iwaarden J., et al. Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect Immun 65 (1997) 1139-1146
41. Karteris E., Machado R., Chen J., et al. Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex. Am J Physiol 288 (2005) E1089-E1100
42. Putwatana R., Reodecha P., Sirapo-ngam Y., et al. Nutrition screening tools and the prediction of postoperative infectious and wound complications: comparison of methods in presence of risk adjustment. Nutrition 21 (2005) 691-697
43. Schneider S., Veyres P., Pivot X., et al. Malnutrition is an independent factor associated with nosocomial infections. Br J Nutr 92 (2004) 105-111
44. Zisman D., Kunkel S., Strieter R., et al. MCP-1 protects mice in lethal endotoxemia. J Clin Invest 99 (1997) 2832-2836
45. Soares A., Souza D., Pinho V., et al. Impaired host defense to Klebsiella pneumoniae infection in mice treated with the PDE4 inhibitor rolipram. Br J Pharmacol 140 (2003) 855-862
46. Lawlor M., Handley S., and Miller V. Comparison of the host responses to wild-type and cps mutant Klebsiella pneumoniae infections. Infect Immun 74 (2006) 5402-5407
47. Moore T., Lau H., Cogen A., et al. Defective innate antibacterial host responses during murine Klebsiella pneumoniae bacteremia: tumor necrosis factor (TNF) receptor 1 deficiency versus therapy with anti-TNF-α. Clin Infect Dis 41 (2005) S213-S217
48. Oarada M., Nikawa T., and Kurita N. Effect of timing of food deprivation on host resistance to fungal infection in mice. Br J Nutr 88 (2002) 151-158
49. Aviles H., Belay T., Vance M., et al. Effects of space flight conditions on the function of the immune system and catecholamine production simulated in a rodent model of hindlimb unloading. Neuroimmunomodulation 12 (2005) 173-181
50. Ikeda T., Ishibashi H., Fujisaki R., et al. Prophylactic efficacy of a basidiomycetes preparation AHCC against lethal Candida albicans infection in experimental granulocytopenic mice. Nippon Ishinkin Gakkai Zasshi 44 (2003) 127-131
51. Aviles H., Belay T., Vance M., et al. Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 97 (2004) 1437-1444
52. Cowawintaweewat S., Manoromana S., Sriplung H., et al. Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment. Asian Pac J Allergy Immunol 24 (2006) 33-45
53. Ritz B., Nogusa S., Ackerman E., et al. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr 136 (2006) 2868-2873
54. Duclos M., Bouchet M., Vettier A., et al. Genetic differences in hypothalamic-pituitary-adrenal axis activity and food restriction-induced hyperactivity in three inbred strains of rats. J Neuroendocrinol 17 (2005) 740-752
55. Jhanwar-Uniyal M., Darwish M., Levin B., et al. Alterations in catecholamine levels and turnover in discrete brain areas after food deprivation. Pharmacol Biochem Behav 26 (1987) 271-275
56. Crespi E., and Denver R. Ancient origins of human developmental plasticity. Am J Hum Biol 17 (2005) 44-54
57. Lyte M., and Ernst S. Catecholamine induced growth of gram-negative bacteria. Life Sci 50 (1992) 203-213
58. Belay T., Aviles H., Vance M., et al. Catecholamines and in vitro growth of pathogenic bacteria: enhancement of growth varies greatly among bacterial species. Life Sci 73 (2003) 1527-1535
59. O'Donnell P., Aviles H., Lyte M., et al. Enhancement of in vitro growth of pathogenic bacteria by norepinephrine: importance of inoculum density and role of transferrin. Appl Environ Microbiol 72 (2006) 5097-5099