17 AAG for HSP90 inhibition in cancer - From bench to bedside

Current Molecular Medicine

Volumn 9, Issue 5, 2009, Pages 654-664

  Usmani, Saad Z ^a   Bona, Robert ^a   Li, Zihai ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

17 AAG; Cancer; Clinical trials; Heat shock protein 90

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTIHISTAMINIC AGENT; ARSENIC TRIOXIDE; BORTEZOMIB; CELL PROTEIN; CHAPERONE; CISPLATIN; CREMOPHOR; CYTARABINE; DIMETHYL SULFOXIDE; DOXORUBICIN; ETOPOSIDE; EXCIPIENT; GEFITINIB; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; IMATINIB; JANUS KINASE INHIBITOR; MELPHALAN; MITOXANTRONE; PACLITAXEL; PANOBINOSTAT; RAPAMYCIN; STEROID; TAMOXIFEN; TANESPIMYCIN; THALIDOMIDE; TRASTUZUMAB; UNINDEXED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CELL CYCLE PROGRESSION; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CYTOPLASM; DISEASE MARKER; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFICACY; DRUG INDICATION; DRUG TARGETING; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; HUMAN; IN VIVO STUDY; LIVER TOXICITY; MALIGNANT NEOPLASTIC DISEASE; MITOCHONDRION; MULTIPLE MYELOMA; NEOPLASM; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION;

BENZOQUINONES; CELL LINE, TUMOR; CLINICAL TRIALS AS TOPIC; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; NAUSEA; NEOPLASMS; VOMITING;

EUKARYOTA;

EID: 70350548428     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652409788488757     Document Type: Review

References (103)

1. Hanahan, D. and Weinberg, RA. (2000) Cell, 100, 57-70.
2. Ritossa, F. (1962) Experentia, 18, 571-573.
3. Tissires, A., Mitchell, H.K. and Tracy U. (1974) J. Mol. Biol., 84, 389-398
4. Csermely, P., Schnaider, T., Soti, C., Prohászka, Z. an Nardai, G. (1998) Pharmacol. Ther., 79, 129-168.
5. Zhao, R., Davey, M., Hsu, Y.C., Kaplanek, P., Tong, A., Parsons, A.B., Krogan, N., Cagney, G., Mai, D., Greenblatt, J., Boone, C., Emili, A. and Houry, W.A. (2005) Cell, 120, 715-727.
6. Ellis, J. (1987) Nature, 328, 378-379
7. Bagatell, R and Whitesell, L. (2004) Mol. Cancer. Ther., 8, 1021-1030
8. Chen, B., Piel, W.H., Gui, L., Bruford, E. and Monteiro, A. (2005) Genomics, 86, 627-637
9. Rebbe, N.F., Ware, J., Bertina, R.M., Modrich, P. and Stafford, D.W. (1987) Gene, 53, 235-245.
10. Hoffmann, T. and Hovemann, B. (1988) Gene, 74, 491-501.
11. Grammatikakis, N., Vultur, A., Ramana, C.V., Siganou, A., Schweinfest, C.W., Watson, D.K. and Raptis, L. (2002) J. Biol. Chem., 277, 8312-8320.
12. Prodromou, C., Roe, S.M., Piper, P.W. and Pearl, L.H. (1997) Nat. Struct. Biol., 4, 477-482.
13. Prodromou, C., Panaretou, B., Chohan, S., Siligardi, G., O'Brien, R., Ladbury, J.E., Roe, S.M., Piper, P.W. and Pearl, L.H. (2000) EMBO J., 19, 4383-4392.
14. Pratt, W.B. and Toft, D.O. (2000) Exp. Biol. Med., 228,111-133
15. DeBoer, C., Meulman, P.A., Wnuk, R.J. and Peterson, D.H. (1970) J. Antibiot., 23, 442-447
16. Whitesell, L., Mimnaugh, E.G., De Costa, B., Myers, C.E. and Neckers, L.M. (1994) Proc. Natl. Acad. Sci. USA, 91, 8324-8328
17. Supko, J.G., Hickman, R.L., Grever, M.R. and Malspeis, L. (1995) Cancer Chemother. Pharmacol., 36, 305-315
18. Schulte, T.W. and Neckers, L.M. (1998) Cancer Chemother. Pharmacol., 42, 273-279
19. Davis, J.M., Rowley, S.D., Braine, H.G., Piantadosi, S. and Santos, G.W. (1990) Blood, 75, 781-786
20. Dye, D. and Watkins, J. (1983) Br. J. Anaesth., 55, 469-471
21. Feijoo, C., Hall-Jackson, C., Wu, R., Jenkins, D., Leitch, J., Gilbert, D.M. and Smythe, C. (2001) J. Cell Biol., 154, 913-923.
22. Arlander, S.J.H., Eapen, A.K., Vroman, B.T., McDonald, R.J., Toft, D.O. and Karnitz, L.M. (2003) J. Biol. Chem., 278, 52572-52577.
23. Mesa, R.A., Loegering, D., Powell, H.L., Flatten, K., Arlander, S.J., Dai, N.T., Heldebrant, M.P., Vroman, B.T., Smith, B.D., Karp, J.E., Eyck, C.J., Erlichman, C., Kaufmann, S.H. and Karnitz, LM. (2005) Blood, 106, 318-327
24. Fuse, E., Tanii, H., Kurata, N., Kobayashi, H., Shimada, Y., Tamura, T., Sasaki, Y., Tanigawara, Y., Lush, R.D., Headlee, D., Figg, W.D., Arbuck, S.G., Senderowicz, A.M., Sausville, E.A., Akinaga, S., Kuwabara, T. and Kobayashi, S. (1998) Cancer Res., 58,3248-3253.
25. Jia. W., Yu, C., Rahmani, M., Krystal, G., Sausville, E.A., Dent, P. and Grant, S. (2003) Blood, 102, 1824-1832
26. Gilliland, D.G. and Griffin, J.D. (2002) Blood, 100, 1532-15 42.
27. Levis, M. and Small, D. (2003) Leukemia, 17, 1738-1752.
28. Yao, Q., Nishiuchi, R., Li, Q., Kumar, A.R., Hudson, W.A. and Kersey, J.H. (2003) Clin. Cancer Res., 9, 4483-4493.
29. Minami, Y., Kiyoi, H, Yamamoto, Y., Yamamoto, K., Ueda, R., Saito, H. and Naoe T. (2002) Leukemia, 16, 1535-1540.
30. Yao, Q., Weigel, B. and Kersey, J. (2007) Clin. Cancer Res., 13, 1591-1600
31. George, P., Bali, P., Cohen, P., Tao, J., Guo, F., Sigua, C., Vishvanath, A., Fiskus, W., Scuto, A., Annavarapu, S., Moscinski, L. and Bhalla, K. (2004) Cancer Res., 64, 3645-3652
32. George, P., Bali, P., Annavarapu, S., Scuto, A., Fiskus, W., Guo, F., Sigua, C., Sondarva, G., Moscinski, L., Atadja, P. and Bhalla, K. (2005) Blood, 105, 1768-1776
33. Pelicano, H., Carew, J.S., McQueen, T.J., Andreeff, M., Plunkett, W., Keating, M.J., Huang, P. (2006) Leukemia, 20, 610-619
34. Nimmanapalli, R., O'Bryan, E. and Bhalla, K. (2001) Cancer Res., 61, 799-804.
35. Gorre, M.E., Ellwood-Yen, K., Chiosis, G., Rosen, N. and Sawyers, C.L. (2002) Blood, 100, 3041-3044
36. Nimmanapalli, R., O'Bryan, E., Huang, M., Bali, P., Burnette, P.K., Loughran, T., Tepperberg, J., Jove, R. and Bhalla, K. (2002) Cancer Res., 62, 5761-5769
37. Withey, J.M., Harvey, A.J. and Crompton, M.R. (2006) Leuk. Res., 30, 553-560
38. Barengm, J., Jilani, I. and Gorre, M. (2007) Leuk. Lymphoma, 48, 2189-2195
39. Johnson, A.J., Wagner, A.J., Cheney, C.M., Smith, L.L., Lucas, D.M., Guster, S.K., Grever, M.R., Lin, T.S. and Byrd, J.C. (2007) Br. J. Haematol., 139, 837-844
40. Rassenti, L.Z., Huynh, L., Toy, T.L., Chen, L., Keating, M.J., Gribben, J.G., Neuberg, D.S., Flinn, I.W., Rai, K.R., Byrd, J.C., Kay, N.E., Greaves, A., Weiss, A. and Kipps, T.J. (2004) N. Engl. J. Med., 351, 893-901.
41. Castro, J.E., Prada, C.E., Loria, O., Kamal, A., Chen, L., Burrows, F.J. and Kipps, T.J. (2005) Blood, 106, 2506-2512
42. Basso, A.D., Solit, D.B., Munster, P.N. and Rosen, N. (2002) Oncogene, 21, 1159-1166
43. Chiosis, G., Caldas Lopes, E. and Solit, D. (2006) Curr. Opin. Investig. Drugs,7, 534-541
44. Zsebik, B., Citri, A., Isola, J., Yarden, Y., Szöllosi, J. and Vereb, G. (2006) Immunol. Lett., 104, 146-155
45. Beliakoff, J., Bagatell, R., Paine-Murrieta, G., Taylor, C.W., Lykkesfeldt, A.E. and Whitesell, L. (2003) Clin. Cancer Res., 9, 4961-4971
46. Munster, P.N., Bass, A., Solit, D., Norton, L. and Rosen, N. (2001) Clin. Cancer Res. ,7, 2228-2236
47. Lang. S.A., Klein, D., Moser, C., Gaumann, A., Glockzin, G., Dahlke, M.H., Dietmaier, W., Bolder, U., Schlitt, H.J., Geissler, E.K. and Stoeltzing, O. (2007) Mol. Cancer Ther., 6, 1123-1132
48. Clarke, P.A., Hostein, I., Banerji, U., Stefano, F.D., Maloney, A., Walton, M., Judson, I. and Workman, P. (2000) Oncogene, 19, 4125-4133
49. Hostein, I., Robertson, D., DiStefano, F., Workman, P. and Clarke, P.A. (2001) Cancer Res., 61, 4003-4009
50. Chung, Y.L., Troy, H., Banerji, U., Jackson, L.E., Walton, M.I., Stubbs, M., Griffiths, J.R., Judson, I.R., Leach, M.O., Workman, P. and Ronen, S.M. (2003) J. Natl. Cancer Inst., 95, 1624-1633
51. Vasilevskaya, I.A., Rakitina, T.V. and O'Dwyer, P.J. (2004) Mol. Pharmacol., 65, 235-243
52. Rakitina, T.V., Vasilevskaya, I.A and O'Dwyer, P.J. (2003) Cancer Res. , 63, 8600-8605
53. Newcomb, E.W., Lukyanov, Y., Schnee, T., Esencay, M., Fischer, I, Hong, D., Shao, Y. and Zagzag, D. (2007) Anticancer Drugs, 18, 875-882
54. Premkumar, D.R., Arnold, B. and Pollack, I.F. (2006) Mol. Carcinog., 45, 288-301.
55. Machida, H., Nakajima, S., Shikano, N., Nishio, J., Okada, S., Asayama, M., Shirai, M. and Kubota, N. (2005) Cancer Sci., 96, 911-917
56. Shintani, S., Zhang, T., Aslam, A., Sebastian, K., Yoshimura, T. and Hamakawa, H. (2006) Int. J. Oncol., 29, 1111-1117
57. Sordella, R., Bell, D.W., Haber, D.A. and Settleman, J. (2004) Science, 305, 1163-1167.
58. Lynch, T.J., Bell, D.W., Sordella, R., Gurubhagavatula, S., Okimoto, R.A., Brannigan, B.W., Harris, P.L., Haserlat, S.M., Supko, J.G., Haluska, F.G., Louis, D.N., Christiani, D.C., Settleman, J. and Haber, D.A. (2004) N. Engl. J. Med., 350, 2129-2139.
59. Balsara, B.R., Pei, J., Mitsuuchi, Y., Page, R., Klein-Szanto, A., Wang, H., Unger, M. and Testa, J.R. (2004) Carcinogenesis, 25, 2053-2059.
60. Fujita, T., Kiyama, M., Tomizawa, Y., Kohno, T. and Yokota, J. (1999) Int. J. Oncol., 15, 927-934.
61. Senju, M., Sueoka, N., Sato, A., Iwanaga, K., Sakao, Y., Tomimitsu, S., Tominaga, M., Irie, K., Hayashi, S. and Sueoka, E. (2006) J. Cancer Res. Clin. Oncol., 132, 150-158
62. Wang, X., Ju, W., Renouard, J., Aden, J., Belinsky, S.A. and Lin, Y. (2006) Cancer Res., 66, 1089-1095
63. Nguyen, D.M., Desai, S., Chen, A., Weiser, T.S. and Schrump, D.S. (2000) Ann. Thorac. Surg., 70, 1853-1860
64. Nguyen, D.M., Lorang, D., Chen, G.A., Stewart, J.H. 4th, Tabibi, E. and Schrump, D.S. (2001) Ann. Thorac Surg., 72, 371-378
65. Georgakis, G.V., Li, Y., Rassidakis, G.Z., Martinez-Valdez, H., Medeiros, L.J., Younes, A. (2006) Clin. Cancer Res., 12, 584-590
66. Bonvini, P., Dalla Rosa, H., Vignes, N. and Rosolen, A. (2004) Cancer Res., 64, 3256-3264
67. Bonvini, P., Gastaldi, T., Falini, B. and Rosolen, A. (2002) Cancer Res., 62, 1559-1566
68. Georgakis, G.V., Li, Y. and Younes, A. (2006) Br. J. Haematol., 135, 68-71.
69. Jeon, Y.K., Park, C.H., Kim, K.Y., Li, Y.C., Kim, J., Kim, Y.A., Paik, J.H., Park, B.K., Kim, C.W. and Kim YN. (2007) J. Pathol., 213, 170-179
70. Grbovic, O.M., Basso, A.D., Sawai, A., Ye, Q., Friedlander, P., Solit, D. and Rosen, N. (2006) Proc. Natl. Acad. Sci. USA, 103, 57-62.
71. Burger, A.M., Fiebig, H.H., Stinson, S.F. and Sausville, E.A. (2004) Anticancer Drugs, 15, 377-387
72. Hideshima, T., Bergsagel, P.L., Kuehl, W.M. and Anderson, KC. (2004) Blood, 104, 607-618.
73. Mitsiades, C.S., Mitsiades, N.S., McMullan, C.J., Poulaki, V., Kung, A.L., Davies, F.E., Morgan, G., Akiyama, M., Shringarpure, R., Munshi, N.C., Richardson, P.G., Hideshima, T., Chauhan, D., Gu, X., Bailey, C., Joseph, M., Libermann, T.A., Rosen, N.S. and Anderson, KC. (2006) Blood, 107, 1092-1100
74. Duus, J., Bahar, H.I., Venkataraman, G., Ozpuyan, F., Izban, K.F., Al-Masri, H., Maududi, T., Toor, A. and Alkan, S. (2006) Leuk. Lymphoma, 47, 1369-1378
75. Francis, L.K., Alsayed, Y., Leleu, X., Jia, X., Singha, U.K., Anderson, J., Timm, M., Ngo, H., Lu, G., Huston, A., Ehrlich, L.A., Dimmock, E., Lentzsch, S., Hideshima, T., Roodman, G.D., Anderson, K.C. and Ghobrial, I.M. (2006) Clin. Cancer Res., 12, 6826-6835
76. Davenport, E.L., Moore, H.E., Dunlop, A.S., Sharp, S.Y., Workman, P., Morgan, G.J. and Davies, F.E. (2007) Blood, 110, 2641-2649
77. Yuan, Z.Q., Sun, M., Feldman, R.I., Wang, G., Ma, X., Jiang, C., Coppola, D., Nicosia, S.V. and Cheng, J.Q. (2000) Oncogene, 19, 2324-2330
78. Sain, N., Krishnan, B., Ormerod, M.G., De Rienzo, A., Liu, W.M., Kaye, S.B., Workman, P. and Jackman, A.L. (2006) Mol. Cancer Ther., 5, 1197-1208
79. Banerji, U., Walton, M., Raynaud, F., Grimshaw, R., Kelland, L., Valenti, M., Judson, I. and Workman, P. (2005) Clin. Cancer Res., 11, 7023-7032
80. Mabjeesh, N.J., Post, D.E., Willard, M.T., Kaur, B., Van Meir, E.G., Simons, J.W. and Zhong, H. (2002) Cancer Res., 62, 2478-2482
81. Solit, D.B., Zheng, F.F., Drobnjak, M., Münster, P.N., Higgins, B., Verbel, D., Heller, G., Tong, W., Cordon-Cardo, C., Agus, D.B., Scher, H.I. and Rosen, N. (2002) Clin. Cancer Res., 8, 986-993
82. Georget, V., Terouanne, B., Nicolas, J.C. and Sultan, C. (2002) Biochemistry, 41,11824-11831
83. Solit, D.B., Scher, H.I. and Rosen, N. (2003) Semin. Oncol., 30, 709-716
84. Vanaja, D.K., Mitchell, S.H., Toft, D.O. and Young, C.Y. (2002) Cell Stress Chaperones, 7, 55-64.
85. Gan, Y., Au, J.L., Lu and Wientjes, M.G. (1998) Pharmacol. Res., 15, 1760-1766
86. Enmon, R., Yang, W.H., Ballangrud, A.M., Solit, D.B., Heller, G., Rosen, N., Scher, H.I. and Sgouros, G. (2003) Cancer Res., 63, 8393-8399
87. Williams, C.R., Tabios, R., Linehan, W.M. and Neckers, L. (2007) J. Urol., 178, 1528-1532
88. Kelland, L.R, Sharp, S.W. and Rogers, P.M. (1991) JNCI, 91, 1940-1949.
89. Santos, N.C., Figueira-Coelho, J., Martins-Silva, J. and Saldanha, C. (2003) Biochem. Pharmacol., 65, 1035-1041.
90. Ronnen, E.A., Kondagunta, G.V., Ishill, N., Sweeney, S.M., Deluca, J.K., Schwartz, L., Bacik, J. and Motzer, R.J. (2006) Invest. New Drugs, 24, 543-546
91. Heath, E.I., Hillman, D.W., Vaishampayan, U., Sheng, S., Sarkar, F., Harper, F., Gaskins, M., Pitot, H.C., Tan, W., Ivy, S.P., Pili, R., Carducci, M.A., Erlichman, C. and Liu G. (2008) Clin. Cancer Res., 14, 7940-7946
92. Yang, Y., Liu, B., Dai, J., Srivastava, P.K., Zammit, D.J., Lefrançois, L. and Li, Z. (2007) Immunity, 26, 215-226
93. Banerji, U., O'Donnell, A., Scurr, M., Pacey, S., Stapleton, S., Asad, Y., Simmons, L., Maloney, A., Raynaud, F., Campbell, M., Walton, M., Lakhani, S., Kaye, S., Workman, P. and Judson I. (2005) J. Clin. Oncol. , 23, 4152-4161
94. Grem, J.L., Morrison, G., Guo, X.D., Agnew, E., Takimoto, C.H., Thomas, R., Szabo, E., Grochow, L., Grollman, F., Hamilton, J.M., Neckers, L. and Wilson RH. (2005) J. Clin. Oncol., 23, 1885-1893
95. Goetz, M.P., Toft, D., Reid, J., Ames, M., Stensgard, B., Safgren, S., Adjei, A.A., Sloan, J., Atherton, P., Vasile, V., Salazaar, S., Adjei, A., Croghan, G. and Erlichman, C. (2005) J. Clin. Oncol., 23, 1078-1087
96. Ramanathan, R.K., Trump, D.L., Eiseman, J.L., Belani, C.P., Agarwala, S.S., Zuhowski, E.G., Lan, J., Potter, D.M., Ivy, S.P., Ramalingam, S., Brufsky, A.M., Wong, M.K., Tutchko, S. and Egorin, M.J. (2005) Clin. Cancer Res., 11, 3385-3391
97. Nowakowski, G.S., McCollum, A.K., Ames, M.M., Mandrekar, S.J., Reid, J.M., Adjei, A.A., Toft, D.O., Safgren, S.L. and Erlichman, C. (2006) Clin. Cancer Res., 12, 6087-6093
98. Ramanathan, R.K., Egorin, M.J., Eiseman, J.L., Ramalingam, S., Friedland, D., Agarwala, S.S., Ivy, S.P., Potter, D.M., Chatta, G., Zuhowski, E.G., Stoller, R.G., Naret, C., Guo, J. and Belani, C.P. (2007) Clin. Cancer Res., 13, 1769-1774
99. Solit, D.B., Ivy, S.P., Kopil, C., Sikorski, R., Morris, M.J., Slovin, S.F., Kelly, W..K, DeLaCruz, A., Curley, T., Heller, G., Larson, S., Schwartz, L., Egorin, M.J., Rosen, N. and Scher, H.I. (2007) Clin. Cancer Res., 13, 1775-1782
100. Musquire, L.A., Ramalingam, S., Egorin, M.J., et al. (2007) J. Clin. Oncol. 25, 14028.
101. Modi, S., Stopeck, A.T., Gordon, M.S., Mendelson, D., Solit, D.B., Bagatell, R., Ma, W., Wheler, J., Rosen, N., Norton, L., Cropp, G.F., Johnson, R.G., Hannah, A.L. and Hudis, C.A. (2007) J. Clin. Oncol., 25, 5410-5417
102. Solit, D.B., Osman, I., Polsky, D., Panageas, K.S., Daud, A., Goydos, J.S., Teitcher, J., Wolchok, J.D., Germino, F.J., Krown, S.E., Coit, D., Rosen, N. and Chapman, P.B. (2008) Clin. Cancer Res., 14, 8302-8307
103. Ramalingam, S.S., Egorin, M.J., Ramanathan, R.K., Remick, S.C., Sikorski, R.P., Lagattuta, T.F., Chatta, G.S., Friedland, D.M., Stoller, R.G., Potter, D.M., Ivy, S.P., Belani, C.P. (2008) Clin. Cancer Res., 14, 3456-3461