메뉴 건너뛰기




Volumn 50, Issue 11, 2009, Pages 2193-2202

Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis

Author keywords

Diabetes; Inflammation; Insulin resistance; Obesity; Palmitate; Signal transduction

Indexed keywords

4 PHENYLBUTYRIC ACID; ADIPONECTIN RECEPTOR; CCAAT ENHANCER BINDING PROTEIN BETA; CHAPERONE; FENOFIBRATE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 2; PALMITIC ACID; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; TRIACYLGLYCEROL; TUNICAMYCIN;

EID: 70350399324     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800633-JLR200     Document Type: Article
Times cited : (42)

References (69)
  • 1
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell, E. E., W. G. Cooksley, R. Hanson, J. Searle, J. W. Halliday, and L. W. Powell. 1990. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 11: 74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 3
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell, G. C., and C. Z. Larter. 2006. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 43: S99-112.
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 5
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specifi c HCV genotype and visceral obesity
    • Adinolfi, L. E., M. Gambardella, A. Andreana, M. F. Tripodi, R. Utili, and G. Ruggiero. 2001. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specifi c HCV genotype and visceral obesity. Hepatology. 33: 1358-1364.
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 6
    • 0037203345 scopus 로고    scopus 로고
    • Lipoapoptosis: Its mechanism and its diseases
    • Unger, R. H., and L. Orci. 2002. Lipoapoptosis: its mechanism and its diseases. Biochim. Biophys. Acta. 1585: 202-212.
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 202-212
    • Unger, R.H.1    Orci, L.2
  • 7
    • 18244370762 scopus 로고    scopus 로고
    • Infl ammation, stress, and diabetes
    • Wellen, K. E., and G. S. Hotamisligil. 2005. Infl ammation, stress, and diabetes. J. Clin. Invest. 115: 1111-1119.
    • (2005) J. Clin. Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 9
    • 34547586298 scopus 로고    scopus 로고
    • Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice
    • Lin, H. V., J. Y. Kim, A. Pocai, L. Rossetti, L. Shapiro, P. E. Scherer, and D. Accili. 2007. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes. 56: 1969-1976.
    • (2007) Diabetes , vol.56 , pp. 1969-1976
    • Lin, H.V.1    Kim, J.Y.2    Pocai, A.3    Rossetti, L.4    Shapiro, L.5    Scherer, P.E.6    Accili, D.7
  • 12
    • 84984586017 scopus 로고    scopus 로고
    • Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C
    • Liu, C. J., P. J. Chen, Y. M. Jeng, W. L. Huang, W. S. Yang, M. Y. Lai, J. H. Kao, and D. S. Chen. 2005. Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C. J. Hepatol. 43: 235-242.
    • (2005) J. Hepatol , vol.43 , pp. 235-242
    • Liu, C.J.1    Chen, P.J.2    Jeng, Y.M.3    Huang, W.L.4    Yang, W.S.5    Lai, M.Y.6    Kao, J.H.7    Chen, D.S.8
  • 13
    • 58849119649 scopus 로고    scopus 로고
    • Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease
    • Ma, H., V. Gomez, L. Lu, X. Yang, X. Wu, and S. Y. Xiao. 2009. Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol. 24: 233-237.
    • (2009) J. Gastroenterol. Hepatol , vol.24 , pp. 233-237
    • Ma, H.1    Gomez, V.2    Lu, L.3    Yang, X.4    Wu, X.5    Xiao, S.Y.6
  • 14
    • 14144249423 scopus 로고    scopus 로고
    • Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study
    • Vuppalanchi, R., S. Marri, D. Kolwankar, R. V. Considine, and N. Chalasani. 2005. Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study. J. Clin. Gastroenterol. 39: 237-242.
    • (2005) J. Clin. Gastroenterol , vol.39 , pp. 237-242
    • Vuppalanchi, R.1    Marri, S.2    Kolwankar, D.3    Considine, R.V.4    Chalasani, N.5
  • 18
    • 37349007791 scopus 로고    scopus 로고
    • Adiponectin: Is it a novel treatment modality to alleviate liver injury in non-alcoholic fatty liver disease (NAFLD)?
    • Aygun, C., O. Kocaman, and O. Senturk. 2008. Adiponectin: Is it a novel treatment modality to alleviate liver injury in non-alcoholic fatty liver disease (NAFLD)? Med. Hypotheses. 70: 457-458.
    • (2008) Med. Hypotheses , vol.70 , pp. 457-458
    • Aygun, C.1    Kocaman, O.2    Senturk, O.3
  • 19
    • 46249111657 scopus 로고    scopus 로고
    • Hepatitis C virus infection: Molecular pathways to metabolic syndrome
    • Sheikh, M. Y., J. Choi, I. Qadri, J. E. Friedman, and A. J. Sanyal. 2008. Hepatitis C virus infection: molecular pathways to metabolic syndrome. Hepatology. 47: 2127-2133.
    • (2008) Hepatology , vol.47 , pp. 2127-2133
    • Sheikh, M.Y.1    Choi, J.2    Qadri, I.3    Friedman, J.E.4    Sanyal, A.J.5
  • 20
    • 34848827915 scopus 로고    scopus 로고
    • The story of adiponectin and its receptors AdipoR1 and R2: To follow
    • Capeau, J. 2007. The story of adiponectin and its receptors AdipoR1 and R2: to follow. J. Hepatol. 47: 736-738.
    • (2007) J. Hepatol , vol.47 , pp. 736-738
    • Capeau, J.1
  • 21
    • 33645156429 scopus 로고    scopus 로고
    • From acute ER stress to physiological roles of the unfolded protein response
    • Wu, J., and R. J. Kaufman. 2006. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ. 13: 374-384.
    • (2006) Cell Death Differ , vol.13 , pp. 374-384
    • Wu, J.1    Kaufman, R.J.2
  • 24
    • 24144472287 scopus 로고    scopus 로고
    • Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding
    • Ji, C., R. Mehrian-Shai, C. Chan, Y. H. Hsu, and N. Kaplowitz. 2005. Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol. Clin. Exp. Res. 29: 1496-1503.
    • (2005) Alcohol. Clin. Exp. Res , vol.29 , pp. 1496-1503
    • Ji, C.1    Mehrian-Shai, R.2    Chan, C.3    Hsu, Y.H.4    Kaplowitz, N.5
  • 25
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day, C. P., and O. F. James. 1998. Steatohepatitis: a tale of two "hits"? Gastroenterology. 114: 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 26
    • 0032491401 scopus 로고    scopus 로고
    • The role of C/EBP isoforms in the control of infl ammatory and native immunity functions
    • Poli, V. 1998. The role of C/EBP isoforms in the control of infl ammatory and native immunity functions. J. Biol. Chem. 273: 29279-29282.
    • (1998) J. Biol. Chem , vol.273 , pp. 29279-29282
    • Poli, V.1
  • 27
    • 0036683653 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding proteins: Structure, function and regulation
    • Ramji, D. P., and P. Foka. 2002. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 365: 561-575.
    • (2002) Biochem. J , vol.365 , pp. 561-575
    • Ramji, D.P.1    Foka, P.2
  • 28
    • 34248681601 scopus 로고    scopus 로고
    • CCAAT/enhancing binding protein beta deletion in mice attenuates infl ammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    • Rahman, S. M., J. M. Schroeder-Gloeckler, R. C. Janssen, H. Jiang, I. Qadri, K. N. Maclean, and J. E. Friedman. 2007. CCAAT/enhancing binding protein beta deletion in mice attenuates infl ammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. Hepatology. 45: 1108-1117.
    • (2007) Hepatology , vol.45 , pp. 1108-1117
    • Rahman, S.M.1    Schroeder-Gloeckler, J.M.2    Janssen, R.C.3    Jiang, H.4    Qadri, I.5    Maclean, K.N.6    Friedman, J.E.7
  • 29
    • 0034623816 scopus 로고    scopus 로고
    • Effi cient initiation of HCV RNA replication in cell culture
    • Blight, K. J., A. A. Kolykhalov, and C. M. Rice. 2000. Effi cient initiation of HCV RNA replication in cell culture. Science. 290: 1972-1974.
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 30
    • 33746217409 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression
    • Qadri, I., M. Iwahashi, G. A. Kullak-Ublick, and F. R. Simon. 2006. Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression. Mol. Pharmacol. 70: 627-636.
    • (2006) Mol. Pharmacol , vol.70 , pp. 627-636
    • Qadri, I.1    Iwahashi, M.2    Kullak-Ublick, G.A.3    Simon, F.R.4
  • 31
    • 1642464020 scopus 로고    scopus 로고
    • Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: Role of JNK, p38 MAPK and AP-1
    • Qadri, I., M. Iwahashi, J. M. Capasso, M. W. Hopken, S. Flores, J. Schaack, and F. R. Simon. 2004. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem. J. 378: 919-928.
    • (2004) Biochem. J , vol.378 , pp. 919-928
    • Qadri, I.1    Iwahashi, M.2    Capasso, J.M.3    Hopken, M.W.4    Flores, S.5    Schaack, J.6    Simon, F.R.7
  • 32
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • Schoonjans, K., B. Staels, and J. Auwerx. 1996. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37: 907-925.
    • (1996) J. Lipid Res , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 34
    • 0033617520 scopus 로고    scopus 로고
    • Orphan nuclear receptors: Shifting endocrinology into reverse
    • Kliewer, S. A., J. M. Lehmann, and T. M. Willson. 1999. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 284: 757-760.
    • (1999) Science , vol.284 , pp. 757-760
    • Kliewer, S.A.1    Lehmann, J.M.2    Willson, T.M.3
  • 36
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purifi cation
    • Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purifi cation. Can. J. Biochem. Physiol. 37: 911-917.
    • (1959) Can. J. Biochem. Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 37
    • 40749083206 scopus 로고    scopus 로고
    • Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury
    • Ji, C. 2008. Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J. Gastroenterol. Hepatol. 23: S16-24.
    • (2008) J. Gastroenterol. Hepatol , vol.23
    • Ji, C.1
  • 38
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding, H. P., Y. Zhang, and D. Ron. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 397: 271-274.
    • (1999) Nature , vol.397 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 39
    • 3142545837 scopus 로고    scopus 로고
    • Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence
    • Chen, C., E. E. Dudenhausen, Y. X. Pan, C. Zhong, and M. S. Kilberg. 2004. Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence. J. Biol. Chem. 279: 27948-27956.
    • (2004) J. Biol. Chem , vol.279 , pp. 27948-27956
    • Chen, C.1    Dudenhausen, E.E.2    Pan, Y.X.3    Zhong, C.4    Kilberg, M.S.5
  • 41
    • 33750823407 scopus 로고    scopus 로고
    • Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
    • Solinas, G., W. Naugler, F. Galimi, M. S. Lee, and M. Karin. 2006. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc. Natl. Acad. Sci. USA. 103: 16454-16459.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 16454-16459
    • Solinas, G.1    Naugler, W.2    Galimi, F.3    Lee, M.S.4    Karin, M.5
  • 42
    • 24344495336 scopus 로고    scopus 로고
    • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis
    • Vilatoba, M., C. Eckstein, G. Bilbao, C. A. Smyth, S. Jenkins, J. A. Thompson, D. E. Eckhoff, and J. L. Contreras. 2005. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Surgery. 138: 342-351.
    • (2005) Surgery , vol.138 , pp. 342-351
    • Vilatoba, M.1    Eckstein, C.2    Bilbao, G.3    Smyth, C.A.4    Jenkins, S.5    Thompson, J.A.6    Eckhoff, D.E.7    Contreras, J.L.8
  • 43
    • 34548183744 scopus 로고    scopus 로고
    • Studying hepatitis C virus: Making the best of a bad virus
    • Tellinghuisen, T. L., M. J. Evans, T. von Hahn, S. You, and C. M. Rice. 2007. Studying hepatitis C virus: making the best of a bad virus. J. Virol. 81: 8853-8867.
    • (2007) J. Virol , vol.81 , pp. 8853-8867
    • Tellinghuisen, T.L.1    Evans, M.J.2    von Hahn, T.3    You, S.4    Rice, C.M.5
  • 44
    • 34347205995 scopus 로고    scopus 로고
    • Hepatitis C and steatosis
    • Bjornsson, E., and P. Angulo. 2007. Hepatitis C and steatosis. Arch. Med. Res. 38: 621-627.
    • (2007) Arch. Med. Res , vol.38 , pp. 621-627
    • Bjornsson, E.1    Angulo, P.2
  • 45
    • 16244405250 scopus 로고    scopus 로고
    • Hepatitis C virus, ER stress, and oxidative stress
    • Tardif, K. D., G. Waris, and A. Siddiqui. 2005. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol. 13: 159-163.
    • (2005) Trends Microbiol , vol.13 , pp. 159-163
    • Tardif, K.D.1    Waris, G.2    Siddiqui, A.3
  • 46
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
    • Ozcan, U., L. Ozcan, E. Yilmaz, K. Duvel, M. Sahin, B. D. Manning, and G. S. Hotamisligil. 2008. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell. 29: 541-551.
    • (2008) Mol. Cell , vol.29 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Duvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 47
    • 31644451456 scopus 로고    scopus 로고
    • Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A
    • Cheng, Y., S. Dharancy, M. Malapel, and P. Desreumaux. 2005. Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A. World J. Gastroenterol. 11: 7591-7596.
    • (2005) World J. Gastroenterol , vol.11 , pp. 7591-7596
    • Cheng, Y.1    Dharancy, S.2    Malapel, M.3    Desreumaux, P.4
  • 48
    • 33847633412 scopus 로고    scopus 로고
    • HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma
    • Kim, K. H., S. P. Hong, K. Kim, M. J. Park, K. J. Kim, and J. Cheong. 2007. HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma. Biochem. Biophys. Res. Commun. 355: 883-888.
    • (2007) Biochem. Biophys. Res. Commun , vol.355 , pp. 883-888
    • Kim, K.H.1    Hong, S.P.2    Kim, K.3    Park, M.J.4    Kim, K.J.5    Cheong, J.6
  • 49
    • 28844447277 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion
    • Domitrovich, A. M., D. J. Felmlee, and A. Siddiqui. 2005. Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion. J. Biol. Chem. 280: 39802-39808.
    • (2005) J. Biol. Chem , vol.280 , pp. 39802-39808
    • Domitrovich, A.M.1    Felmlee, D.J.2    Siddiqui, A.3
  • 50
    • 33750902737 scopus 로고    scopus 로고
    • The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control
    • Gorlach, A., P. Klappa, and T. Kietzmann. 2006. The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid. Redox Signal. 8: 1391-1418.
    • (2006) Antioxid. Redox Signal , vol.8 , pp. 1391-1418
    • Gorlach, A.1    Klappa, P.2    Kietzmann, T.3
  • 51
    • 34547617328 scopus 로고    scopus 로고
    • Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes
    • Guo, W., S. Wong, W. Xie, T. Lei, and Z. Luo. 2007. Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. Am. J. Physiol. Endocrinol. Metab. 293: E576-586.
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.293
    • Guo, W.1    Wong, S.2    Xie, W.3    Lei, T.4    Luo, Z.5
  • 52
    • 0034716887 scopus 로고    scopus 로고
    • Tripartite management of unfolded proteins in the endoplasmic reticulum
    • Mori, K. 2000. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 101: 451-454.
    • (2000) Cell , vol.101 , pp. 451-454
    • Mori, K.1
  • 53
    • 0036437307 scopus 로고    scopus 로고
    • Transcriptional and translational control in the Mammalian unfolded protein response
    • Harding, H. P., M. Calfon, F. Urano, I. Novoa, and D. Ron. 2002. Transcriptional and translational control in the Mammalian unfolded protein response. Annu. Rev. Cell Dev. Biol. 18: 575-599.
    • (2002) Annu. Rev. Cell Dev. Biol , vol.18 , pp. 575-599
    • Harding, H.P.1    Calfon, M.2    Urano, F.3    Novoa, I.4    Ron, D.5
  • 54
    • 33845575826 scopus 로고    scopus 로고
    • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    • Borradaile, N. M., X. Han, J. D. Harp, S. E. Gale, D. S. Ory, and J. E. Schaffer. 2006. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J. Lipid Res. 47: 2726-2737
    • (2006) J. Lipid Res , vol.47 , pp. 2726-2737
    • Borradaile, N.M.1    Han, X.2    Harp, J.D.3    Gale, S.E.4    Ory, D.S.5    Schaffer, J.E.6
  • 55
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • Wang, D., Y. Wei, and M. J. Pagliassotti. 2006. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology. 147: 943-951.
    • (2006) Endocrinology , vol.147 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 56
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • Bandyopadhyay, G. K., J. G. Yu, J. Ofrecio, and J. M. Olefsky. 2006. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes. 55: 2277-2285.
    • (2006) Diabetes , vol.55 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 57
    • 33645092172 scopus 로고    scopus 로고
    • Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats
    • Kraegen, E. W., A. K. Saha, E. Preston, D. Wilks, A. J. Hoy, G. J. Cooney, and N. B. Ruderman. 2006. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. Am. J. Physiol. Endocrinol. Metab. 290: E471-479.
    • (2006) Am. J. Physiol. Endocrinol. Metab , vol.290
    • Kraegen, E.W.1    Saha, A.K.2    Preston, E.3    Wilks, D.4    Hoy, A.J.5    Cooney, G.J.6    Ruderman, N.B.7
  • 58
    • 33845941190 scopus 로고    scopus 로고
    • Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
    • Cao, J., J. L. Li, D. Li, J. F. Tobin, and R. E. Gimeno. 2006. Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA. 103: 19695-19700.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 19695-19700
    • Cao, J.1    Li, J.L.2    Li, D.3    Tobin, J.F.4    Gimeno, R.E.5
  • 59
    • 33845571750 scopus 로고    scopus 로고
    • Role of malonyl-CoA in heart disease and the hypothalamic control of obesity
    • Folmes, C. D., and G. D. Lopaschuk. 2007. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc. Res. 73: 278-287.
    • (2007) Cardiovasc. Res , vol.73 , pp. 278-287
    • Folmes, C.D.1    Lopaschuk, G.D.2
  • 60
    • 0033695790 scopus 로고    scopus 로고
    • Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-gammaresponsive adipose tissue-specific genes in the liver of obese diabetic mice
    • Memon, R. A., L. H. Tecott, K. Nonogaki, A. Beigneux, A. H. Moser, C. Grunfeld, and K. R. Feingold. 2000. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gammaresponsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology. 141: 4021-4031.
    • (2000) Endocrinology , vol.141 , pp. 4021-4031
    • Memon, R.A.1    Tecott, L.H.2    Nonogaki, K.3    Beigneux, A.4    Moser, A.H.5    Grunfeld, C.6    Feingold, K.R.7
  • 64
    • 34547444610 scopus 로고    scopus 로고
    • Insulin resistance and liver injury in hepatitis C is not associated with virus-specifi c changes in adipocytokines
    • Cua, I. H., J. M. Hui, P. Bandara, J. G. Kench, G. C. Farrell, G. W. McCaughan, and J. George. 2007. Insulin resistance and liver injury in hepatitis C is not associated with virus-specifi c changes in adipocytokines. Hepatology. 46: 66-73.
    • (2007) Hepatology , vol.46 , pp. 66-73
    • Cua, I.H.1    Hui, J.M.2    Bandara, P.3    Kench, J.G.4    Farrell, G.C.5    McCaughan, G.W.6    George, J.7
  • 65
    • 33646812161 scopus 로고    scopus 로고
    • Fenofi brate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver
    • Harano, Y., K. Yasui, T. Toyama, T. Nakajima, H. Mitsuyoshi, M. Mimani, T. Hirasawa, Y. Itoh, and T. Okanoue. 2006. Fenofi brate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver. Liver Int. 26: 613-620.
    • (2006) Liver Int , vol.26 , pp. 613-620
    • Harano, Y.1    Yasui, K.2    Toyama, T.3    Nakajima, T.4    Mitsuyoshi, H.5    Mimani, M.6    Hirasawa, T.7    Itoh, Y.8    Okanoue, T.9
  • 66
    • 0037438377 scopus 로고    scopus 로고
    • Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation
    • Kleemann, R., P. P. Gervois, L. Verschuren, B. Staels, H. M. Princen, and T. Kooistra. 2003. Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood. 101: 545-551.
    • (2003) Blood , vol.101 , pp. 545-551
    • Kleemann, R.1    Gervois, P.P.2    Verschuren, L.3    Staels, B.4    Princen, H.M.5    Kooistra, T.6
  • 67
    • 1942533537 scopus 로고    scopus 로고
    • Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofi brate
    • Gervois, P., R. Kleemann, A. Pilon, F. Percevault, W. Koenig, B. Staels, and T. Kooistra. 2004. Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofi brate. J. Biol. Chem. 279: 16154-16160.
    • (2004) J. Biol. Chem , vol.279 , pp. 16154-16160
    • Gervois, P.1    Kleemann, R.2    Pilon, A.3    Percevault, F.4    Koenig, W.5    Staels, B.6    Kooistra, T.7
  • 68
    • 34047197114 scopus 로고    scopus 로고
    • Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice
    • Bullen, J. W., Jr., S. Bluher, T. Kelesidis, and C. S. Mantzoros. 2007. Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. Am. J. Physiol. Endocrinol. Metab. 292: E1079-1086.
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.292
    • Bullen Jr., J.W.1    Bluher, S.2    Kelesidis, T.3    Mantzoros, C.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.