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Volumn 57, Issue 20, 2009, Pages 9418-9426

Influence of chocolate matrix composition on cocoa flavan-3-ol bioaccessibility in vitro and bioavailability in humans

Author keywords

Bioavailability; Caco 2 cells; Catechin; Chocolate; Epicatechin; Food matrix; In vitro digestion; Theobroma cacao

Indexed keywords

FLAVAN 3 OL; FLAVAN-3-OL; FLAVONOID; MILK PROTEIN; PLANT EXTRACT; SUGAR;

EID: 70350279308     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf902919k     Document Type: Article
Times cited : (82)

References (57)
  • 1
    • 34247589583 scopus 로고    scopus 로고
    • Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate
    • DOI 10.1021/jf063277c
    • (1) Cooper, K. A.; Campos-Gimenez, E.; Alvarez, D. J.; Nagy, K.; Donovan, J. L.; Williamson, G. Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate. J. Agric. Food Chem. 2007, 55 (8), 2841-2847. (Pubitemid 46668287)
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , Issue.8 , pp. 2841-2847
    • Cooper, K.A.1    Campos-Gimenez, E.2    Alvarez, D.J.3    Nagy, K.4    Donovan, J.L.5    Williamson, G.6
  • 2
    • 33745504721 scopus 로고    scopus 로고
    • Prior, R. L. Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products
    • Gu, L. W.; House, S. E.; Wu, X. L.; Ou, B. X.; Prior, R. L. Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products. J. Agric. Food Chem. 2006, 54 (11), 4057-4061.
    • (2006) J. Agric. Food Chem. , vol.54 , Issue.11 , pp. 4057-4061
    • Gu, L.W.1    House, S.E.2    Wu, X.L.3    Ou, B.X.4
  • 3
    • 0344198059 scopus 로고    scopus 로고
    • Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine
    • Lee, K. W.; Kim, Y. J.; Lee, H. J.; Lee, C. Y. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J. Agric. Food Chem. 2003, 51 (25), 7292-7295.
    • (2003) J. Agric. Food Chem. , vol.51 , Issue.25 , pp. 7292-7295
    • Lee, K.W.1    Kim, Y.J.2    Lee, H.J.3    Lee, C.Y.4
  • 5
    • 0041597204 scopus 로고    scopus 로고
    • Liquid chromatographic/electrospray ionization tandem mass spectrometric study of the phenolic composition of cocoa (Theobroma cacao)
    • Sanchez-Rabaneda, F.; Jauregui, O.; Casals, I.; Andres-Lacueva, C.; Izquierdo-Pulido, M.; Lamuela-Raventos, R. M. Liquid chromatographic/ electrospray ionization tandem mass spectrometric study of the phenolic composition of cocoa (Theobroma cacao). J. Mass Spectrom. 2003, 38 (1), 35-42.
    • (2003) J. Mass Spectrom. , vol.38 , Issue.1 , pp. 35-42
    • Sanchez-Rabaneda, F.1    Jauregui, O.2    Casals, I.3    Andres-Lacueva, C.4    Izquierdo-Pulido, M.5    Lamuela-Raventos, R.M.6
  • 6
    • 33745504721 scopus 로고    scopus 로고
    • Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products
    • Gu, L. W.; House, S. E.; Wu, X. L.; Ou, B. X.; Prior, R. L. Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products. J. Agric. Food Chem. 2006, 54 (11), 4057-4061.
    • (2006) J. Agric. Food Chem. , vol.54 , Issue.11 , pp. 4057-4061
    • Gu, L.W.1    House, S.E.2    Wu, X.L.3    Ou, B.X.4    Prior, R.L.5
  • 7
    • 33745506035 scopus 로고    scopus 로고
    • Antioxidant activity and polyphenol and procyanidin contents of selected commercially available cocoa-containing and chocolate products in the United States
    • Miller, K. B.; Stuart, D. A.; Smith, N. L.; Lee, C. Y.; Mchale, N. L.; Flanagan, J. A.; Ou, B. X.; Hurst, W. J. Antioxidant activity and polyphenol and procyanidin contents of selected commercially available cocoa-containing and chocolate products in the United States. J. Agric. Food Chem. 2006, 54 (11) 4062-4068.
    • (2006) J. Agric. Food Chem. , vol.54 , Issue.11 , pp. 4062-4068
    • Miller, K.B.1    Stuart, D.A.2    Smith, N.L.3    Lee, C.Y.4    Mchale, N.L.5    Flanagan, J.A.6    Ou, B.X.7    Hurst, W.J.8
  • 8
    • 0034916111 scopus 로고    scopus 로고
    • Simultaneous determination of (+)-catechin and (-)-epicatechin in cacao and its products by high-performance liquid chromatography with electrochemical detection
    • DOI 10.1002/pca.583
    • (8) Subagio, A.; Sari, P.; Morita, N. Simultaneous determination of (+)-catechin and (-)-epicatechin in cacao and its products by high-performance liquid chromatography with electrochemical detection. Phytochem. Anal. 2001, 12 (4), 271-276. (Pubitemid 32685472)
    • (2001) Phytochemical Analysis , vol.12 , Issue.4 , pp. 271-276
    • Subagio, A.1    Sari, P.2    Morita, N.3
  • 11
    • 33847613258 scopus 로고    scopus 로고
    • Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: Protection by (-)-epicatechin
    • DOI 10.1016/j.freeradbiomed.2006.12.024, PII S0891584906008173
    • (11) Steffen, Y.; Jung, T.; Klotz, L. O.; Schewe, T.; Grune, T.; Sies, H. Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: Protection by (-)-epicatechin. Free Radical Biol. Med. 2007, 42 (7) 955-970. (Pubitemid 46356890)
    • (2007) Free Radical Biology and Medicine , vol.42 , Issue.7 , pp. 955-970
    • Steffen, Y.1    Jung, T.2    Klotz, L.-O.3    Schewe, T.4    Grune, T.5    Sies, H.6
  • 12
    • 33751234225 scopus 로고    scopus 로고
    • Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American diets
    • Vinson, J. A.; Proch, J.; Bose, P.; Muchler, S.; Taffera, P.; Shuta, D.; Samman, N.; Agbor, G. A. Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American diets. J. Agric. Food Chem. 2006, 54 (21), 8071-8076.
    • (2006) J. Agric. Food Chem. , vol.54 , Issue.21 , pp. 8071-8076
    • Vinson, J.A.1    Proch, J.2    Bose, P.3    Muchler, S.4    Taffera, P.5    Shuta, D.6    Samman, N.7    Agbor, G.A.8
  • 13
    • 47249091864 scopus 로고    scopus 로고
    • Acute dark chocolate and cocoa ingestion and endothelial function: A randomized controlled crossover trial
    • Faridi, Z.; Njike, V. Y.; Dutta, S.; Ali, A.; Katz, D. L. Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am. J. Clin. Nutr. 2008, 88 (1), 58-63.
    • (2008) Am. J. Clin. Nutr. , vol.88 , Issue.1 , pp. 58-63
    • Faridi, Z.1    Njike, V.Y.2    Dutta, S.3    Ali, A.4    Katz, D.L.5
  • 14
    • 15744388677 scopus 로고    scopus 로고
    • Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons
    • Grassi, D.; Lippi, C.; Necozione, S.; Desideri, G.; Ferri, C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am. J. Clin. Nutr. 2005, 81 (3), 611-614.
    • (2005) Am. J. Clin. Nutr. , vol.81 , Issue.3 , pp. 611-614
    • Grassi, D.1    Lippi, C.2    Necozione, S.3    Desideri, G.4    Ferri, C.5
  • 15
    • 23244468093 scopus 로고    scopus 로고
    • Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    • DOI 10.1161/01.HYP.0000174990.46027.70
    • (15) Grassi, D.; Necozione, S.; Lippi, C.; Croce, G.; Valeri, L.; Pasqualetti, P.; Desideri, G.; Blumberg, J. B.; Ferri, C. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension 2005, 46 (2), 398-405. (Pubitemid 41099176)
    • (2005) Hypertension , vol.46 , Issue.2 , pp. 398-405
    • Grassi, D.1    Necozione, S.2    Lippi, C.3    Croce, G.4    Valeri, L.5    Pasqualetti, P.6    Desideri, G.7    Blumberg, J.B.8    Ferri, C.9
  • 16
    • 51049107708 scopus 로고    scopus 로고
    • Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 1.5 days of consuming high-polyphenol dark chocolate
    • Grassi, D.; Desideri, G.; Necozione, S.; Lippi, C.; Casale, R.; Properzi, G.; Blumberg, J. B.; Ferri, C. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 1.5 days of consuming high-polyphenol dark chocolate. J. Nutr. 2008, 138 (9), 1671-1676.
    • (2008) J. Nutr. , vol.138 , Issue.9 , pp. 1671-1676
    • Grassi, D.1    Desideri, G.2    Necozione, S.3    Lippi, C.4    Casale, R.5    Properzi, G.6    Blumberg, J.B.7    Ferri, C.8
  • 17
  • 19
    • 33847775158 scopus 로고    scopus 로고
    • Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans
    • Baba, S.; Osakabe, N.; Kato, Y.; Natsume, M.; Yasuda, A.; Kido, T.; Fukuda, K.; Muto, Y.; Kondo, K. Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. Am. J. Clin. Nutr. 2007, 85 (3), 709-717.
    • (2007) Am. J. Clin. Nutr. , vol.85 , Issue.3 , pp. 709-717
    • Baba, S.1    Osakabe, N.2    Kato, Y.3    Natsume, M.4    Yasuda, A.5    Kido, T.6    Fukuda, K.7    Muto, Y.8    Kondo, K.9
  • 20
    • 5444245110 scopus 로고    scopus 로고
    • Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans
    • Mursu, J.; Voutilainen, S.; Nurmi, T.; Rissanen, T. H.; Virtanen, J. K.; Kaikkonen, J.; Nyyssoonen, K.; Salonen, J. T. Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radical Biol. Med. 2004, 37 (9), 1351-1359.
    • (2004) Free Radical Biol. Med. , vol.37 , Issue.9 , pp. 1351-1359
    • Mursu, J.1    Voutilainen, S.2    Nurmi, T.3    Rissanen, T.H.4    Virtanen, J.K.5    Kaikkonen, J.6    Nyyssoonen, K.7    Salonen, J.T.8
  • 21
    • 0034749936 scopus 로고    scopus 로고
    • Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans
    • Wan, Y.; Vinson, J. A.; Etherton, T. D.; Proch, J.; Lazarus, S. A.; Kris-Etherton, P. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am. J. Clin. Nutr. 2001, 74 (5), 596-602.
    • (2001) Am. J. Clin. Nutr. , vol.74 , Issue.5 , pp. 596-602
    • Wan, Y.1    Vinson, J.A.2    Etherton, T.D.3    Proch, J.4    Lazarus, S.A.5    Kris-Etherton, P.6
  • 23
    • 0033867144 scopus 로고    scopus 로고
    • A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage
    • Wang, J. F.; Schramm, D. D.; Holt, R. R.; Ensunsa, J. L.; Fraga, C. G.; Schmitz, H. H.; Keen, C. L. A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage. J. Nutr. 2000, 130 (8), 2115S-2119S.
    • (2000) J. Nutr. , vol.130 , Issue.8
    • Wang, J.F.1    Schramm, D.D.2    Holt, R.R.3    Ensunsa, J.L.4    Fraga, C.G.5    Schmitz, H.H.6    Keen, C.L.7
  • 24
    • 18744383019 scopus 로고    scopus 로고
    • Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans
    • (24) Mathur, S.; Devaraj, S.; Grundy, S. M.; Jialal, I. Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans. J. Nutr. 2002, 132 (12), 3663-3667. (Pubitemid 35435044)
    • (2002) Journal of Nutrition , vol.132 , Issue.12 , pp. 3663-3667
    • Mathur, S.1    Devaraj, S.2    Grundy, S.M.3    Jialal, I.4
  • 25
    • 49449085678 scopus 로고    scopus 로고
    • Bioavailability of polyphenon e flavan-3-ols in humans with an ileostomy
    • Auger, C.; Mullen, W.; Hara, Y.; Crozier, A. Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy. J. Nutr. 2008, 138 (8), 1535-1542.
    • (2008) J. Nutr. , vol.138 , Issue.8 , pp. 1535-1542
    • Auger, C.1    Mullen, W.2    Hara, Y.3    Crozier, A.4
  • 26
    • 0036165985 scopus 로고    scopus 로고
    • Urinary excretion of catechin metabolites by human subjects after red wine consumption
    • Donovan, J. L.; Kasim-Karakas, S.; German, J. B.; Waterhouse, A. L. Urinary excretion of catechin metabolites by human subjects after red wine consumption. Br. J. Nutr. 2002, 87 (1), 31-37.
    • (2002) Br. J. Nutr. , vol.87 , Issue.1 , pp. 31-37
    • Donovan, J.L.1    Kasim-Karakas, S.2    German, J.B.3    Waterhouse, A.L.4
  • 27
    • 16544394714 scopus 로고    scopus 로고
    • Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement
    • Henning, S. M.; Niu, Y. T.; Lee, N. H.; Thames, G. D.; Minutti, R. R.; Wang, H. J.; Go, V. L. W.; Heber, D. Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. Am. J. Clin. Nutr. 2004, 80 (6), 1558-1564.
    • (2004) Am. J. Clin. Nutr. , vol.80 , Issue.6 , pp. 1558-1564
    • Henning, S.M.1    Niu, Y.T.2    Lee, N.H.3    Thames, G.D.4    Minutti, R.R.5    Wang, H.J.6    Go, V.L.W.7    Heber, D.8
  • 28
    • 0042364944 scopus 로고    scopus 로고
    • Plasma antioxidants from chocolate;Dark chocolate may offer its consumers health benefits the milk variety cannot match
    • Serafini, M.; Bugianesi, R.; Maiani, G.; Valtuena, S.; De Santis, S.; Crozier, A. Plasma antioxidants from chocolate;Dark chocolate may offer its consumers health benefits the milk variety cannot match. Nature 2003, 424 (6952), 1013.
    • (2003) Nature , vol.424 , pp. 1013
    • Serafini, M.1    Bugianesi, R.2    Maiani, G.3    Valtuena, S.4    De Santis, S.5    Crozier, A.6
  • 30
    • 0347357619 scopus 로고    scopus 로고
    • Nutrition;Milk and absorption of dietary flavanols
    • Schroeter, H.; Holt, R. R.; Orozoco, T. J.; Schmitz, H. H.; Keen, C. L. Nutrition;Milk and absorption of dietary flavanols. Nature 2003, 426 (6968), 787-788.
    • (2003) Nature , vol.426 , Issue.6968 , pp. 787-788
    • Schroeter, H.1    Holt, R.R.2    Orozoco, T.J.3    Schmitz, H.H.4    Keen, C.L.5
  • 32
    • 34147126028 scopus 로고    scopus 로고
    • The effect of milk protein on the bioavailability of cocoa polyphenols
    • DOI 10.1111/j.1750-3841.2007.00314.x
    • (32) Keogh, J. B.; McInerney, J.; Clifton, P. M. The effect of milk protein on the bioavailability of cocoa polyphenols. J. Food Sci. 2007, 72 (3), S230-S233. (Pubitemid 46558141)
    • (2007) Journal of Food Science , vol.72 , Issue.3
    • Keogh, J.B.1    McInerney, J.2    Clifton, P.M.3
  • 33
    • 0032893641 scopus 로고    scopus 로고
    • Plasma kinetics in man of epicatechin from black chocolate
    • Richelle, M.; Tavazzi, I.; Enslen, M.; Offord, E. A. Plasma kinetics in man of epicatechin from black chocolate. Eur. J. Clin. Nutr. 1999, 53 (1), 22-26.
    • (1999) Eur. J. Clin. Nutr. , vol.53 , Issue.1 , pp. 22-26
    • Richelle, M.1    Tavazzi, I.2    Enslen, M.3    Offord, E.A.4
  • 34
    • 23844479261 scopus 로고    scopus 로고
    • Rapid liquid chromatography tandem mass spectrometry assay to quantify plasma (-)-epicatechin metabolites after ingestion of a standard portion of cocoa beverage in humans
    • Roura, E.; Andrés-Lacueva, C.; Jáuregui, O.; Badia, E.; Estruch, R.; Izquierdo-Pulido, M.; Lamuela-Raventós, R. M. Rapid liquid chromatography tandem mass spectrometry assay to quantify plasma (-)-epicatechin metabolites after ingestion of a standard portion of cocoa beverage in humans. J. Agric. Food Chem. 2005, 53 (16), 6190-6194.
    • (2005) J. Agric. Food Chem. , vol.53 , Issue.16 , pp. 6190-6194
    • Roura, E.1    Andrés-Lacueva, C.2    Jáuregui, O.3    Badia, E.4    Estruch, R.5    Izquierdo-Pulido, M.6    Lamuela-Raventós, R.M.7
  • 35
    • 51749117180 scopus 로고    scopus 로고
    • The effects of milk as a food matrix for polyphenols on the excretion profile of cocoa (-)-epicatechin metabolites in healthy human subjects
    • Roura, E.; Andrés-Lacueva, C.; Estruch, R.; Bilbao, M. L. M.; Izquierdo-Pulido, M.; Lamuela-Raventós, R. M. The effects of milk as a food matrix for polyphenols on the excretion profile of cocoa (-)-epicatechin metabolites in healthy human subjects. Br. J. Nutr. 2008, 100 (4), 846-851.
    • (2008) Br. J. Nutr. , vol.100 , Issue.4 , pp. 846-851
    • Roura, E.1    Andrés-Lacueva, C.2    Estruch, R.3    Bilbao, M.L.M.4    Izquierdo-Pulido, M.5    Lamuela-Raventós, R.M.6
  • 37
    • 33845271866 scopus 로고    scopus 로고
    • Chlorogenic acid is poorly absorbed, independently of the food matrix: A Caco-2 cells and rat chronic absorption study
    • Dupas, C.; Baglieri, A. M.; Ordonaud, C.; Tome, D.; Maillard, M. N. Chlorogenic acid is poorly absorbed, independently of the food matrix: A Caco-2 cells and rat chronic absorption study. Mol. Nutr. Food Res. 2006, 50 (11), 1053-1060.
    • (2006) Mol. Nutr. Food Res. , vol.50 , Issue.11 , pp. 1053-1060
    • Dupas, C.1    Baglieri, A.M.2    Ordonaud, C.3    Tome, D.4    Maillard, M.N.5
  • 38
    • 70349106346 scopus 로고    scopus 로고
    • Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: Implications for treatment in Alzheimer's disease
    • Published online
    • Ferruzzi, M. G.; Lobo, J. K.; Janle, E. M.; Whittaker, N.; Cooper, B.; Simom, J. E.; Wu, Q.; Welch, C.; Ho, L.; Weaver, C.; Pasinetti, G. M. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: Implications for treatment in Alzheimer's disease. J. Alzheimer's Dis. 2009, Published online.
    • (2009) J. Alzheimer's Dis.
    • Ferruzzi, M.G.1    Lobo, J.K.2    Janle, E.M.3    Whittaker, N.4    Cooper, B.5    Simom, J.E.6    Wu, Q.7    Welch, C.8    Ho, L.9    Weaver, C.10    Pasinetti, G.M.11
  • 39
    • 33748489370 scopus 로고    scopus 로고
    • Simple HPLC method, with fluorometric detection, for studying the oral absorption of monomeric catechins in a small animal model
    • Gossai, D.; Lau-Cam, C. A. Simple HPLC method, with fluorometric detection, for studying the oral absorption of monomeric catechins in a small animal model. J. Liq. Chromatogr. Relat. Technol. 2006, 29 (17), 2571-2586.
    • (2006) J. Liq. Chromatogr. Relat. Technol. , vol.29 , Issue.17 , pp. 2571-2586
    • Gossai, D.1    Lau-Cam, C.A.2
  • 40
    • 0032965140 scopus 로고    scopus 로고
    • Identification of (-)-epicatechin metabolites and their metabolic fate in the rat
    • Okushio, K.; Suzuki, M.; Matsumoto, N.; Nanjo, F.; Hara, Y. Identification of (-)-epicatechin metabolites and their metabolic fate in the rat. Drug Metab. Dispos. 1999, 27 (2), 309-316.
    • (1999) Drug Metab. Dispos. , vol.27 , Issue.2 , pp. 309-316
    • Okushio, K.1    Suzuki, M.2    Matsumoto, N.3    Nanjo, F.4    Hara, Y.5
  • 41
    • 0033213505 scopus 로고    scopus 로고
    • Development of an in vitro digestion method to assess carotenoid bioavailability from meals
    • Garrett, D. A.; Failla, M. L.; Sarama, R. J. Development of an in vitro digestion method to assess carotenoid bioavailability from meals. J. Agric. Food Chem. 1999, 47 (10), 4301-4309.
    • (1999) J. Agric. Food Chem. , vol.47 , Issue.10 , pp. 4301-4309
    • Garrett, D.A.1    Failla, M.L.2    Sarama, R.J.3
  • 42
    • 0035167804 scopus 로고    scopus 로고
    • In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats
    • Baba, S.; Osakabe, N.; Natsume, M.; Muto, Y.; Takizawa, T.; Terao, J. In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats. J. Nutr. 2001, 131 (11), 2885-2891.
    • (2001) J. Nutr. , vol.131 , Issue.11 , pp. 2885-2891
    • Baba, S.1    Osakabe, N.2    Natsume, M.3    Muto, Y.4    Takizawa, T.5    Terao, J.6
  • 43
    • 33749241530 scopus 로고    scopus 로고
    • (+)-Catechin is more bioavailable than (-)-catechin: Relevance to the bioavailability of catechin from cocoa
    • Donovan, J. L.; Crespy, V.; Oliveria, M.; Cooper, K. A.; Gibson, B. B.; Williamson, G. (+)-Catechin is more bioavailable than (-)-catechin: Relevance to the bioavailability of catechin from cocoa. Free Radical Res. 2006, 40 (10), 1029-1034.
    • (2006) Free Radical Res. , vol.40 , Issue.10 , pp. 1029-1034
    • Donovan, J.L.1    Crespy, V.2    Oliveria, M.3    Cooper, K.A.4    Gibson, B.B.5    Williamson, G.6
  • 45
    • 66849115650 scopus 로고    scopus 로고
    • Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans
    • Mullen, W.; Borges, G.; Donovan, J. L.; Edwards, C. A.; Serafini, M.; Lean, M. E. J.; Crozier, A. Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am. J. Clin. Nutr. 2009, 89 (6), 1784-1791.
    • (2009) Am. J. Clin. Nutr. , vol.89 , Issue.6 , pp. 1784-1791
    • Mullen, W.1    Borges, G.2    Donovan, J.L.3    Edwards, C.A.4    Serafini, M.5    Lean, M.E.J.6    Crozier, A.7
  • 46
    • 57449120731 scopus 로고    scopus 로고
    • Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. Am
    • Muniyappa, R.; Hall, G.; Kolodziej, T. L.; Karne, R. J.; Crandon, S. K.; Quon, M. J. Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. Am. J. Clin. Nutr. 2008, 88 (6), 1685-1696.
    • (2008) J. Clin. Nutr. , vol.88 , Issue.6 , pp. 1685-1696
    • Muniyappa, R.1    Hall, G.2    Kolodziej, T.L.3    Karne, R.J.4    Crandon, S.K.5    Quon, M.J.6
  • 47
    • 0033867415 scopus 로고    scopus 로고
    • Epicatechin in human plasma: In vivo determination and effect of chocolate consumption on plasma oxidation status
    • Rein, D.; Lotito, S.; Holt, R. R.; Keen, C. L.; Schmitz, H. H.; Fraga, C. G. Epicatechin in human plasma: In vivo determination and effect of chocolate consumption on plasma oxidation status. J. Nutr. 2000, 130 (8), 2109S-2114S.
    • (2000) J. Nutr. , vol.130 , Issue.8
    • Rein, D.1    Lotito, S.2    Holt, R.R.3    Keen, C.L.4    Schmitz, H.H.5    Fraga, C.G.6
  • 49
    • 34347404130 scopus 로고    scopus 로고
    • Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide;A randomized controlled trial. JAMA
    • Taubert, D.; Roesen, R.; Lehmann, C.; Jung, N.; Schomig, E. Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide;A randomized controlled trial. JAMA, J. Am. Med. Assoc. 2007, 298 (1), 49-60.
    • (2007) J. Am. Med. Assoc. , vol.298 , Issue.1 , pp. 49-60
    • Taubert, D.1    Roesen, R.2    Lehmann, C.3    Jung, N.4    Schomig, E.5
  • 51
    • 34147126028 scopus 로고    scopus 로고
    • The effect of milk protein on the bioavailability of cocoa polyphenols
    • DOI 10.1111/j.1750-3841.2007.00314.x
    • (51) Keogh, J. B.; McInerney, J.; Clifton, P. M. The effect of milk protein on the bioavailability of cocoa polyphenols. J. Food Sci. 2007, 72 (3), S230-S233. (Pubitemid 46558141)
    • (2007) Journal of Food Science , vol.72 , Issue.3
    • Keogh, J.B.1    McInerney, J.2    Clifton, P.M.3
  • 52
    • 34948860094 scopus 로고    scopus 로고
    • Common tea formulations modulate in vitro digestive recovery of green tea catechins
    • Green, R. J.; Murphy, A. S.; Schulz, B.; Watkins, B. A.; Ferruzzi, M. G. Common tea formulations modulate in vitro digestive recovery of green tea catechins. Mol. Nutr. Food Res. 2007, 51 (9), 1152-1162.
    • (2007) Mol. Nutr. Food Res. , vol.51 , Issue.9 , pp. 1152-1162
    • Green, R.J.1    Murphy, A.S.2    Schulz, B.3    Watkins, B.A.4    Ferruzzi, M.G.5
  • 53
    • 0037141470 scopus 로고    scopus 로고
    • Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)
    • DOI 10.1038/sj.bjc.6600295
    • (53) Salucci, M.; Stivala, L. A.; Maiani, G.; Bugianesi, R.; Vannini, V. Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2). Br. J. Cancer 2002, 86 (10), 1645-1651. (Pubitemid 34628121)
    • (2002) British Journal of Cancer , vol.86 , Issue.10 , pp. 1645-1651
    • Salucci, M.1    Stivala, L.A.2    Maiani, G.3    Bugianesi, R.4    Vannini, V.5
  • 54
    • 2142714474 scopus 로고    scopus 로고
    • Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles
    • Tammela, P.; Laitinen, L.; Galkin, A.; Wennberg, T.; Heczko, R.; Vuorela, H.; Slotte, J. P.; Vuorela, P. Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. Arch. Biochem. Biophys. 2004, 425 (2), 193-199.
    • (2004) Arch. Biochem. Biophys. , vol.425 , Issue.2 , pp. 193-199
    • Tammela, P.1    Laitinen, L.2    Galkin, A.3    Wennberg, T.4    Heczko, R.5    Vuorela, H.6    Slotte, J.P.7    Vuorela, P.8
  • 55
    • 0034770989 scopus 로고    scopus 로고
    • Transport and metabolism of the tea flavonoid (-)-epicatechin by the human intestinal cell line Caco-2
    • Vaidyanathan, J. B.; Walle, T. Transport and metabolism of the tea flavonoid (-)-epicatechin by the human intestinal cell line Caco-2. Pharm. Res. 2001, 18 (10), 1420-1425.
    • (2001) Pharm. Res. , vol.18 , Issue.10 , pp. 1420-1425
    • Vaidyanathan, J.B.1    Walle, T.2
  • 56
    • 0142241274 scopus 로고    scopus 로고
    • Cellular uptake and efflux of the tea flavonoid (-)-epicatechin-3-gallate in the human intestinal cell line Caco-2
    • Vaidyanathan, J. B.; Walle, T. Cellular uptake and efflux of the tea flavonoid (-)-epicatechin-3-gallate in the human intestinal cell line Caco-2. J. Pharmacol. Exp. Ther. 2003, 307 (2), 745-752.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , Issue.2 , pp. 745-752
    • Vaidyanathan, J.B.1    Walle, T.2
  • 57
    • 8444230840 scopus 로고    scopus 로고
    • Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model
    • Zhang, L.; Zheng, Y.; Chow, M. S. S.; Zuo, Z. Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. Int. J. Pharm. 2004, 287 (1-2), 1-12.
    • (2004) Int. J. Pharm. , vol.287 , Issue.1-2 , pp. 1-12
    • Zhang, L.1    Zheng, Y.2    Chow, M.S.S.3    Zuo, Z.4


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