Introduction: Genes, cognition and neuropsychiatry

Cognitive Neuropsychiatry

Volumn 14, Issue 4-5, 2009, Pages 261-276

  Elvevåg, Brita ^a   Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

COMT; Dopamine; Phenotypes; Prefrontal function

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; DOPAMINE TRANSPORTER; NEUROLEPTIC AGENT; TOLCAPONE;

ANXIETY DISORDER; ATTENTION DEFICIT DISORDER; COGNITIVE DEFECT; DEPRESSION; DRUG MECHANISM; EXTRAPYRAMIDAL SYMPTOM; GENE; GENOTYPE; HUMAN; NEUROPSYCHIATRY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; WORKING MEMORY; ANIMAL; COGNITION; EDITORIAL; GENETICS; INDIVIDUALITY; MENTAL DISEASE; NEUROLOGY; PHYSIOLOGY; PSYCHIATRY; PSYCHOLOGICAL ASPECT;

ANIMALS; COGNITION; DOPAMINE; HUMANS; INDIVIDUALITY; MENTAL DISORDERS; NEUROLOGY; PSYCHIATRY;

EID: 70349762098     PISSN: 13546805     EISSN: 14640619     Source Type: Journal    
DOI: 10.1080/13546800903126016     Document Type: Review

References (81)

1. Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., Gorman, J. M., & Laruelle, M. (2000). Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proceedings of the National Academy of Science of the United States of America, 97, 8104-8109.
2. Aguilera, M., Barrantes-Vidal, N., Arias, B., Moya, J., Villa, H., Ibanez, M. I., Ruiperez, M. A., Ortet, G., & Fananas, L. (2008). Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 147B, 898-902.
3. Apud, J. A., & Weinberger, D. R. (2006). Pharmacogenetic tools for the development of targetoriented cognitive-enhancing drugs. NeuroRx, 3, 106-116.
4. Apud, J. A., & Weinberger, D. R. (2007). Treatment of cognitive deficits associated with schizophrenia: Potential role of catechol-O- methyltransferase inhibitors. CNS Drugs, 21, 535-557.
5. Apud, J. A., Mattay, V., Chen, J., Kolachana, B. S., Callicott, J. H., Rasetti, R., Alce, G., Iudicello, J. E., Akbar, N., Egan, M. F., Goldberg, T. E., & Weinberger, D. R. (2007). Tolcapone improves cognition and cortical information processing in normal human subjects. Neuropsychopharmacology, 32, 1011-1020.
6. Arnsten, A. F. T., & Goldman-Rakic, P. S. (1986). Reversal of stress-induced delayed response deficits in rhesus monkeys by clonidine and naloxone. Society of Neuroscience Abstracts, 12, 1464.
7. Arnsten, A. F., & Goldman-Rakic, P. S. (1998). Noise stress impairs prefrontal cortical cognitive function in monkeys: Evidence for a hyperdopaminergic mechanism. Archives of General Psychiatry, 55, 362-368
8. Arnsten, A. F., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994). Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. Psychopharmacology (Berl), 116, 143-151
9. Avramopoulos, D., Stefanis, N. C., Hantoumi, I., Smyrnis, N., Evdokimidis, I., & Stefanis, C. N. (2002). Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Molecular Psychiatry, 7, 706-711
10. Bäckman, L., Nyberg, L., Lindenberger, U., Li, S. C., & Farde, L. (2006). The correlative triad among aging, dopamine, and cognition: Current status and future prospects. Neuroscience and Biobehavioral Reviews, 30, 791-807.
11. Bellgrove, M. A., Domschke, K., Hawi, Z., Kirley, A., Mullins, C., Robertson, I. H., & Gill, M. (2005). The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. Experimental Brain Research, 163, 352-360.
12. Bertolino, A., Caforio, G., Blasi, G., De Candia, M., Latorre, V., Petruzzella, V., Altamura, M., Nappi, G., Papa, S., Callicott, J. H., Mattay, V. S., Bellomo, A., Scarabino, T., Weinberger, D. R., & Nardini, M. (2004). Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. American Journal of Psychiatry, 161, 1798-1805
13. Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004). The catechol-Omethyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology, 29, 1943-1961.
14. Bishop, S. J., Cohen, J. D., Fossella, J., Casey, B. J., & Farah, M. J. (2006). COMT genotype influences prefrontal response to emotional distraction. Cognitive, Affective & Behavioral Neuroscience, 6, 62-70
15. Blasi, G., & Bertolino, A. (2006). Imaging genomics and response to treatment with antipsychotics in schizophrenia. NeuroRx, 3, 117-130.
16. Blasi, G., Mattay, V. S., Bertolino, A., Elvevaring;g, B., Callicott, J. H., Das, S., Kolachana, B. S., Egan, M. F., Goldberg, T. E., & Weinberger, D. R. (2005). Effect of catechol-O-methyltransferase val158met genotype on attentional control. Journal of Neuroscience, 25, 5038-5045.
17. Bruder, G. E., Keilp, J. G., Xu, H., Shikhman, M., Schori, E., Gorman, J. M., & Gilliam, T. C. (2005). Catechol-O-methyltransferase (COMT) genotypes and working memory: Associations with differing cognitive operations. Biological Psychiatry, 58, 901-907.
18. Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., Egan, M. F., Kleinman, J. E., & Weinberger, D. R. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics, 75, 807-821
19. Diaz-Asper, C. M., Goldberg, T. E., Kolachana, B. S., Straub, R. E., Egan, M. F., & Weinberger, D. R. (2008). Genetic variation in catechol-O-methyltransferase: Effects on working memory in schizophrenic patients, their siblings, and healthy controls. Biological Psychiatry, 63, 72-79.
20. Dickinson, D., & Elvevaring;g, B. (2009). Genes, cognition and brain through a COMT lens. Journal of Neuroscience, in press.
21. Dickinson, D., Ragland, J. D., Gold, J. M., & Gur, R. C. (2008). General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biological Psychiatry, 64, 823-827
22. Drabant, E. M., Hariri, A. R., Meyer-Lindenberg, A., Munoz, K. E., Mattay, V. S., Kolachana, B. S., Egan, M. F., & Weinberger, D. R. (2006). Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. Archives of General Psychiatry, 63, 1396-1406
23. Durstewitz, D., & Seamans, J. K. (2002). The computational role of dopamine D1 receptors in working memory. Neural Networks, 15, 561-572.
24. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D., & Weinberger, D. R. (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Science of the United States of America, 98, 6917-6922.
25. Flint, J., & Munafo, M. R. (2007). The endophenotype concept in psychiatric genetics. Psychological Medicine, 37, 163-180.
26. Forbes, E. E., Brown, S. M., Kimak, M., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2009). Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. Molecular Psychiatry, 14, 60-70.
27. Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R., Elliott, K. S., Lango, H., Rayner, N. W., Shields, B., Harries, L. W., Barrett, J. C., Ellard, S., Groves, C. J., Knight, B., Patch, A. M., Ness, A. R., Ebrahim, S., Lawlor, D. A., Ring, S. M., Ben-Shlomo, Y., Jarvelin, M. R., Sovio, U., Bennett, A. J.,Melzer, D., Ferrucci, L., Loos, R. J., Barroso, I., Wareham, N. J., Karpe, F., Owen, K. R., Cardon, L. R., Walker, M., Hitman, G. A., Palmer, C. N., Doney, A. S., Morris, A. D., Smith, G. D., Hattersley, A. T., & McCarthy, M. I. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316, 889-894.
28. Giakoumaki, S. G., Roussos, P., & Bitsios, P. (2008). Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism. Neuropsychopharmacology, 33, 3058-3068.
29. Goldberg, T. E., & Weinberger, D. R. (2004). Genes and the parsing of cognitive processes. Trends in Cognitive Science, 8, 325-335
30. Green, A. E., Munafò, M. R., Deyoung, C. G., Fossella, J. A., Fan, J., & Gray, J. R. (2008). Using genetic data in cognitive neuroscience: From growing pains to genuine insights. Nature Reviews Neuroscience, 9, 710-720
31. Halleland, H., Lundervold, A. J., Halmøy, A., Haavik, J., & Johansson, S. (2009). Association between Catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults. American Journal Medical Genetics part B Neuropsychiatric Genetics, 150B, 403-410
32. Hallikainen, T., Lachman, H., Saito, T., Volavka, J., Kauhanen, J., Salonen, J. T., Ryynänen, O. P., Koulu, M., Karvonen, M. K., Pohjalainen, T., Syvälahti, E., Hietala, J., & Tiihonen, J. (2000). Lack of association between the functional variant of the catechol-O-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior. American Jorunal of Medical Genetics, 96, 348-352
33. Harrison, P. J., & Tunbridge, E. M. (2008). Catechol-O- methyltransferase (COMT): A gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology, 33, 3037-3045
34. Krabbendam, L., Isusi, P., Galdos, P., Echevarria, E., Bilbao, J. R., Martin-Pagola, A., Papiol, S., Castano, L., & Van Os, J. (2006). Associations between COMTVal158Met polymorphism and cognition: Direct or indirect effects? European Psychiatry, 21, 338-342.
35. Levy, R., & Goldman-Rakic, P. S. (2000). Segregation of working memory functions within the dorsolateral prefrontal cortex. Experimental Brain Research, 133, 23-32
36. Li, S.-C., Lindenberger, U., Chicherio, C., von Oertzen, T., Nagel, I., Sander, T., Villringer, A., Heekeren, H. R., & Bäckman, L. (2008). Genetic predisposition for dopamine modulation of processing fluctuation and evidence accumulation. Presentation at the Days of Molecular Medicine meeting, Stockholm, April 17-19, 2008.
37. Lövdén, M., Li, S. C., Shing, Y. L., & Lindenberger, U. (2007). Within-person trial-to-trial variability precedes and predicts cognitive decline in old and very old age: Longitudinal data from the Berlin Aging Study. Neuropsychologia, 45, 2827-2838.
38. MacDonald, S. W., Nyberg, L., & Bäckman, L. (2006). Intra-individual variability in behavior: Links to brain structure, neurotransmission and neuronal activity. Trends in Neuroscience, 29, 474-480.
39. Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., &Weinberger, D. R. (2003). Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proceedings of the National Academy Science of the United States of America, 100, 6186-6191.
40. Meyer-Lindenberg, A., & Weinberger, D. R. (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience, 7, 818-827.
41. Meyer-Lindenberg, A., Nichols, T., Callicott, J. H., Ding, J., Kolachana, B., Buckholtz, J., Mattay, V. S., Egan, M., & Weinberger, D. R. (2006). Impact of complex genetic variation in COMTon human brain function. Molecular Psychiatry, 11, 867-877, 797.
42. Montag, C., Buckholtz, J. W., Hartmann, P., Merz, M., Burk, C., Hennig, J., & Reuter, M. (2008). COMT genetic variation affects fear processing: Psychophysiological evidence. Behavioral Neuroscience, 122, 901-909.
43. Murphy, B. L., Roth, R. H., & Arnsten, A. F. T. (1994). The effects of FG7142 on prefrontal cortical dopamine and spatial working memory in rat and monkey. Society of Neuroscience Abstracts, 20, 1018.
44. Murphy, B. L., Arnsten, A. F., Goldman-Rakic, P. S., & Roth, R. H. (1996). Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proceedings of the National Academy of Science of the United States of America, 93, 1325-1329.
45. Murphy, B. L., Arnsten, A. F., Jentsch, J. D., & Roth, R. H. (1996). Dopamine and spatial working memory in rats and monkeys: Pharmacological reversal of stress-induced impairment. Journal Neuroscience, 16, 7768-7775.
46. Murphy, B. L., Roth, R. H., & Arnsten, A. F. (1997). Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys. Neuropsychopharmacology, 16, 433-437.
47. Nagel, I. E., Chicherio, C., Li, S., von Oertzen, T., Sander, T., Villringer, A., Heekeren, H. R., Bäckman, L., & Lindenberger, U. (2008). Human aging magnifies genetic effects on executive functioning and working memory. Frontiers Human Neuroscience, 2, 1.
48. Newton-Cheh, C., Larson, M. G., Vasan, R. S., Levy, D., Bloch, K. D., Surti, A., Guiducci, C., Kathiresan, S., Benjamin, E. J., Struck, J.,Morgenthaler, N. G., Bergmann, A., Blankenberg, S., Kee, F., Nilsson, P., Yin, X., Peltonen, L., Vartiainen, E., Salomaa, V., Hirschhorn, J. N., Melander, O., & Wang, T. J. (2009). Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nature Genetics, 41, 348-353.
49. Nolan, K. A., Bilder, R. M., Lachman, H. M., & Volavka, J. (2004). Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: Differential effects of Val and Met alleles on cognitive stability and flexibility. American Journal Psychiatry, 161, 359-361.
50. O'Reilly, R. C. (2006). Biologically based computational models of high-level cognition. Science, 314, 91-94.
51. Papaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J., Weinberger, D. R., & Chen, J. (2008). Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice. Journal of Neuroscience, 28, 8709-8723.
52. Prathikanti, S., & Weinberger, D. R. (2005). Psychiatric genetics - the new era: Genetic research and some clinical implications. British Medical Bulletin, 73-74, 107-122.
53. Reuter, M., & Hennig, J. (2005). Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion. NeuroReport, 16, 1135- 1138
54. Robbins, T. W. (1990). The case of frontostriatal dysfunction in schizophrenia. Schizophrenia Bulletin, 16, 391-402.
55. Robbins, T. W. (2000). Chemical neuromodulation of frontal-executive functions in humans and other animals. Experimental Brain Research, 133, 130-138.
56. Rolls, E. T., Loh, M., Deco, G., & Winterer, G. (2008). Computational models of schizophrenia and dopamine modulation in the prefrontal cortex. Nature Reviews Neuroscience, 9, 696-709.
57. Schmack, K., Schlagenhauf, F., Sterzer, P., Wrase, J., Beck, A., Dembler, T., Kalus, P., Puls, I., Sander, T., Heinz, A., & Gallinat, J. (2008). Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation. Neuroimage, 42, 1631-1638.
58. Seamans, J. K., & Yang, C. R. (2004). The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Progress Neurobiology, 74, 1-58.
59. Seamans, J. K., Gorelova, N., Durstewitz, D., & Yang, C. R. (2001). Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. Journal Neuroscience, 21, 3628-3638.
60. Servan-Schreiber, D., Printz, H., & Cohen, J. D. (1990). A network model of catecholamine effects: Gain, signal-to-noise ratio, and behavior. Science, 249, 892-895.
61. Slifstein, M., Kolachana, B., Simpson, E. H., Tabares, P., Cheng, B., Duvall, M., Frankle, W. G., Weinberger, D. R., Laruelle, M., & Abi-Dargham, A. (2008). COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET. Molecular Psychiatry, 13, 821-827
62. Smith, P. L., & Ratcliff, R. (2004). Psychology and neurobiology of simple decisions. Trends in Neuroscience, 27, 161-168.
63. Snitz, B. E., MacDonald, A. W., & Carter, C. S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes. Schizophrenia Bulletin, 32, 179-194.
64. Stefanis, N. C., Henquet, C., Avramopoulos, D., Smyrnis, N., Evdokimidis, I., Myin-Germeys, I., Stefanis, C. N., & Van Os, J. (2007). COMT Val158Met moderation of stress-induced psychosis. Psychological Medicine, 37, 1651-1656.
65. Tan, H. Y., Chen, Q., Sust, S., Buckholtz, J. W., Meyers, J. D., Egan, M. F., Mattay, V. S., Meyer-Lindenberg, A., Weinberger, D. R., & Callicott, J. H. (2007). Epistasis between catechol-Omethyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. Proceedings of the National Academy of Science of the United States of America, 104, 12536-12541.
66. Tan, H. Y., Callicott, J. H., & Weinberger, D. R. (2008). Intermediate phenotypes in schizophrenia genetics redux: Is it a no brainer? Molecular Psychiatry, 13, 233-238.
67. Tan, H. Y., Callicott, J. H., & Weinberger, D. R. (2009). Prefrontal cognitive systems in schizophrenia: Towards human genetic brain mechanisms. Cognitive Neuropsychiatry, 14(4/5), 277-298.
68. Tsai, S. J., Hong, C. J., Yu, Y. W., & Chen, T. J. (2004). Association study of catechol-Omethyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young chinese females. Neuropsychobiology, 50, 153-156
69. Tunbridge, E. M., Bannerman, D. M., Sharp, T., & Harrison, P. J. (2004). Catechol-Omethyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. Journal of Neuroscience, 24, 5331-5335
70. Verma, A., & Moghaddam, B. (1996). NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: Modulation by dopamine. Journal of Neuroscience, 16, 373-379
71. Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. (2007). Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience, 10, 376-384.
72. Ward, L. M. (2002). Dynamical cognitive science. Cambridge, MA: MIT Press.
73. Weickert, T. W., Goldberg, T. E., Mishara, A., Apud, J. A., Kolachana, B. S., Egan, M. F., & Weinberger, D. R. (2004). Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications. Biological Psychiatry, 56, 677-682
74. Weinshilboum, R., & Wang, L. (2004). Pharmacogenomics: Bench to bedside. Nature Reviews Drug Discovery, 3, 739-748.
75. Weinshilboum, R. M., & Wang, L. (2006). Pharmacogenetics and pharmacogenomics: Development, science, and translation. Annual Review Genomics Human Genetics, 7, 223-245.
76. Weinshilboum, R. M., Otterness, D. M., & Szumlanski, C. L. (1999). Methylation pharmacogenetics: Catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annual Review Pharmacology Toxicology, 39, 19-52.
77. Williams, G. V., & Goldman-Rakic, P. S. (1995). Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature, 376, 572-575.
78. Williams, B. R., Hultsch, D. F., Strauss, E. H., Hunter,M. A., & Tannock, R. (2005). Inconsistency in reaction time across the life span. Neuropsychology, 19, 88-96.
79. Winterer, G., Coppola, R., Goldberg, T. E., Egan, M. F., Jones, D. W., Sanchez, C. E., & Weinberger, D. R. (2004). Prefrontal broadband noise, working memory, and genetic risk for schizophrenia. American Journal of Psychiatry, 161, 490-500.
80. Winterer, G., Musso, F., Vucurevic, G., Stoeter, P., Konrad, A., Seker, B., Gallinat, J., Dahmen, N., & Weinberger, D. R. (2006). COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits. Neuroimage, 32, 1722-1732.
81. Woodward, N. D., Jayathilake, K., & Meltzer, H. Y. (2007). COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophrenia Research, 90, 86-96.