메뉴 건너뛰기




Volumn 11, Issue 9, 2006, Pages 867-877

Impact of complex genetic variation in COMT on human brain function

Author keywords

COMT; fMRI; Haplotypes; n back; Prefrontal cortex; Schizophrenia

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

EID: 33748055408     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001860     Document Type: Article
Times cited : (277)

References (50)
  • 4
    • 10044294770 scopus 로고    scopus 로고
    • Evaluating associations of haplotypes with traits
    • Schaid DJ. Evaluating associations of haplotypes with traits. Genet Epidemiol 2004; 27: 348-364.
    • (2004) Genet Epidemiol , vol.27 , pp. 348-364
    • Schaid, D.J.1
  • 6
    • 0035953175 scopus 로고    scopus 로고
    • Dopamine transporter immunoreactivity in monkey cerebral cortex: Regional, laminar, and ultrastructural localization
    • Lewis DA, Melchitzky DS, Sesack SR, Whitehead RE, Auh S, Sampson A. Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. J Comp Neurol 2001; 432: 119-136.
    • (2001) J Comp Neurol , vol.432 , pp. 119-136
    • Lewis, D.A.1    Melchitzky, D.S.2    Sesack, S.R.3    Whitehead, R.E.4    Auh, S.5    Sampson, A.6
  • 7
    • 2942614921 scopus 로고    scopus 로고
    • Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
    • Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ. Catechol-o- methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. J Neurosci 2004; 24: 5331-5335.
    • (2004) J Neurosci , vol.24 , pp. 5331-5335
    • Tunbridge, E.M.1    Bannerman, D.M.2    Sharp, T.3    Harrison, P.J.4
  • 8
    • 12344327212 scopus 로고    scopus 로고
    • Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence
    • image 45
    • Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10: 40-68; image 45.
    • (2005) Mol Psychiatry , vol.10 , pp. 40-68
    • Harrison, P.J.1    Weinberger, D.R.2
  • 9
    • 0037006412 scopus 로고    scopus 로고
    • Schizophrenia and velo-cardio-facial syndrome
    • Murphy KC. Schizophrenia and velo-cardio-facial syndrome. Lancet 2002; 359: 426-430.
    • (2002) Lancet , vol.359 , pp. 426-430
    • Murphy, K.C.1
  • 10
    • 6344265879 scopus 로고    scopus 로고
    • Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain
    • Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 2004; 75: 807-821.
    • (2004) Am J Hum Genet , vol.75 , pp. 807-821
    • Chen, J.1    Lipska, B.K.2    Halim, N.3    Ma, Q.D.4    Matsumoto, M.5    Melhem, S.6
  • 12
    • 0141791141 scopus 로고    scopus 로고
    • Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
    • Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS et al. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 2003; 60: 889-896.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 889-896
    • Goldberg, T.E.1    Egan, M.F.2    Gscheidle, T.3    Coppola, R.4    Weickert, T.5    Kolachana, B.S.6
  • 13
    • 0037947438 scopus 로고    scopus 로고
    • Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    • Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF et al. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 2003; 100: 6186-6191.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6186-6191
    • Mattay, V.S.1    Goldberg, T.E.2    Fera, F.3    Hariri, A.R.4    Tessitore, A.5    Egan, M.F.6
  • 16
    • 0037365978 scopus 로고    scopus 로고
    • Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: Meta-analysis of case-control and family-based studies
    • Glatt SJ, Faraone SV, Tsuang MT. Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. Am J Psychiatry 2003; 160: 469-476.
    • (2003) Am J Psychiatry , vol.160 , pp. 469-476
    • Glatt, S.J.1    Faraone, S.V.2    Tsuang, M.T.3
  • 17
    • 12144252916 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis
    • Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY et al. Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Biol Psychiatry 2005; 57: 139-144.
    • (2005) Biol Psychiatry , vol.57 , pp. 139-144
    • Fan, J.B.1    Zhang, C.S.2    Gu, N.F.3    Li, X.W.4    Sun, W.W.5    Wang, H.Y.6
  • 19
    • 0038389841 scopus 로고    scopus 로고
    • A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain
    • Bray NJ, Buckland PR, Williams NM, Williams HJ, Norton N, Owen MJ et al. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73: 152-161.
    • (2003) Am J Hum Genet , vol.73 , pp. 152-161
    • Bray, N.J.1    Buckland, P.R.2    Williams, N.M.3    Williams, H.J.4    Norton, N.5    Owen, M.J.6
  • 21
    • 0029130796 scopus 로고
    • Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
    • Excoffier L, Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 1995; 12: 921-927.
    • (1995) Mol Biol Evol , vol.12 , pp. 921-927
    • Excoffier, L.1    Slatkin, M.2
  • 23
    • 0242691208 scopus 로고    scopus 로고
    • A comparison of bayesian methods for haplotype reconstruction from population genotype data
    • Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73: 1162-1169.
    • (2003) Am J Hum Genet , vol.73 , pp. 1162-1169
    • Stephens, M.1    Donnelly, P.2
  • 24
    • 0038406155 scopus 로고    scopus 로고
    • A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies
    • Zhao LP, Li SS, Khalid N. A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies. Am J Hum Genet 2003; 72: 1231-1250.
    • (2003) Am J Hum Genet , vol.72 , pp. 1231-1250
    • Zhao, L.P.1    Li, S.S.2    Khalid, N.3
  • 25
    • 0141993288 scopus 로고    scopus 로고
    • Estimation of multilocus haplotype effects using weighted penalised log-likelihood: Analysis of five sequence variations at the cholesteryl ester transfer protein gene locus
    • Tanck MW, Klerkx AH, Jukema JW, De Knijff P, Kastelein JJ, Zwinderman AH. Estimation of multilocus haplotype effects using weighted penalised log-likelihood: analysis of five sequence variations at the cholesteryl ester transfer protein gene locus. Ann Hum Genet 2003; 67(Part 2): 175-184.
    • (2003) Ann Hum Genet , vol.67 , Issue.2 PART , pp. 175-184
    • Tanck, M.W.1    Klerkx, A.H.2    Jukema, J.W.3    De Knijff, P.4    Kastelein, J.J.5    Zwinderman, A.H.6
  • 26
    • 0036155283 scopus 로고    scopus 로고
    • Score tests for association between traits and haplotypes when linkage phase is ambiguous
    • Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002; 70: 425-434.
    • (2002) Am J Hum Genet , vol.70 , pp. 425-434
    • Schaid, D.J.1    Rowland, C.M.2    Tines, D.E.3    Jacobson, R.M.4    Poland, G.A.5
  • 27
    • 0036284203 scopus 로고    scopus 로고
    • Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals
    • Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 2002; 53: 79-91.
    • (2002) Hum Hered , vol.53 , pp. 79-91
    • Zaykin, D.V.1    Westfall, P.H.2    Young, S.S.3    Karnoub, M.A.4    Wagner, M.J.5    Ehm, M.G.6
  • 29
    • 0036941355 scopus 로고    scopus 로고
    • Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation
    • DeMille MM, Kidd JR, Ruggeri V, Palmatier MA, Goldman D, Odunsi A et al. Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation. Hum Genet 2002; 111: 521-537.
    • (2002) Hum Genet , vol.111 , pp. 521-537
    • Demille, M.M.1    Kidd, J.R.2    Ruggeri, V.3    Palmatier, M.A.4    Goldman, D.5    Odunsi, A.6
  • 30
    • 0029116316 scopus 로고
    • Modulation of memory fields by dopamine D1 receptors in prefrontal cortex
    • Williams GV, Goldman-Rakic PS. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 1995; 376: 572-575.
    • (1995) Nature , vol.376 , pp. 572-575
    • Williams, G.V.1    Goldman-Rakic, P.S.2
  • 31
    • 21244453517 scopus 로고    scopus 로고
    • Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia
    • Handoko HY, Nyholt DR, Hayward NK, Nertney DA, Hannah DE, Windus LC et al. Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia. Mol Psychiatry 2005; 10: 589-597.
    • (2005) Mol Psychiatry , vol.10 , pp. 589-597
    • Handoko, H.Y.1    Nyholt, D.R.2    Hayward, N.K.3    Nertney, D.A.4    Hannah, D.E.5    Windus, L.C.6
  • 32
    • 0035058585 scopus 로고    scopus 로고
    • Haplotypes vs single marker linkage disequilibrium tests: What do we gain?
    • Akey J, Jin L, Xiong M. Haplotypes vs single marker linkage disequilibrium tests: what do we gain? Eur J Hum Genet 2001; 9: 291-300.
    • (2001) Eur J Hum Genet , vol.9 , pp. 291-300
    • Akey, J.1    Jin, L.2    Xiong, M.3
  • 33
    • 0032827782 scopus 로고    scopus 로고
    • The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
    • Long AD, Langley CH. The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits. Genome Res 1999; 9: 720-731.
    • (1999) Genome Res , vol.9 , pp. 720-731
    • Long, A.D.1    Langley, C.H.2
  • 34
    • 10044279127 scopus 로고    scopus 로고
    • Use of unphased multilocus genotype data in indirect association studies
    • Clayton D, Chapman J, Cooper J. Use of unphased multilocus genotype data in indirect association studies. Genet Epidemiol 2004; 27: 415-428.
    • (2004) Genet Epidemiol , vol.27 , pp. 415-428
    • Clayton, D.1    Chapman, J.2    Cooper, J.3
  • 35
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645.
    • (2003) Am J Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 37
    • 0025890053 scopus 로고
    • D1 dopamine receptors in prefrontal cortex: Involvement in working memory
    • Sawaguchi T, Goldman-Rakic PS. D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science 1991; 251: 947-950.
    • (1991) Science , vol.251 , pp. 947-950
    • Sawaguchi, T.1    Goldman-Rakic, P.S.2
  • 38
    • 0032519004 scopus 로고    scopus 로고
    • D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat
    • Seamans JK, Floresco SB, Phillips AG. D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat. J Neurosci 1998; 18: 1613-1621.
    • (1998) J Neurosci , vol.18 , pp. 1613-1621
    • Seamans, J.K.1    Floresco, S.B.2    Phillips, A.G.3
  • 39
    • 0033119840 scopus 로고    scopus 로고
    • A neurocomputational theory of the dopaminergic modulation of working memory functions
    • Durstewitz D, Kelc M, Gunturkun O. A neurocomputational theory of the dopaminergic modulation of working memory functions. J Neurosci 1999; 19: 2807-2822.
    • (1999) J Neurosci , vol.19 , pp. 2807-2822
    • Durstewitz, D.1    Kelc, M.2    Gunturkun, O.3
  • 40
    • 0742304657 scopus 로고    scopus 로고
    • The principal features and mechanisms of dopamine modulation in the prefrontal cortex
    • Seamans JK, Yang CR. The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 2004; 74: 1-58.
    • (2004) Prog Neurobiol , vol.74 , pp. 1-58
    • Seamans, J.K.1    Yang, C.R.2
  • 41
    • 19944433662 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
    • Smolka MN, Schumann G, Wrase J, Grusser SM, Flor H, Mann K et al. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci 2005; 25: 836-842.
    • (2005) J Neurosci , vol.25 , pp. 836-842
    • Smolka, M.N.1    Schumann, G.2    Wrase, J.3    Grusser, S.M.4    Flor, H.5    Mann, K.6
  • 42
    • 0035143710 scopus 로고    scopus 로고
    • Event-related fMRI study of response inhibition
    • Liddle PF, Kiehl KA, Smith AM. Event-related fMRI study of response inhibition. Hum Brain Mapp 2001; 12: 100-109.
    • (2001) Hum Brain Mapp , vol.12 , pp. 100-109
    • Liddle, P.F.1    Kiehl, K.A.2    Smith, A.M.3
  • 43
    • 0442292147 scopus 로고    scopus 로고
    • A rapid presentation event-related functional magnetic resonance imaging study of response inhibition in macaque monkeys
    • Morita M, Nakahara K, Hayashi T. A rapid presentation event-related functional magnetic resonance imaging study of response inhibition in macaque monkeys. Neurosci Lett 2004; 356: 203-206.
    • (2004) Neurosci Lett , vol.356 , pp. 203-206
    • Morita, M.1    Nakahara, K.2    Hayashi, T.3
  • 44
    • 15244343865 scopus 로고    scopus 로고
    • Dissociation of neural systems mediating shifts in behavioral response and cognitive set
    • Shafritz KM, Kartheiser P, Belger A. Dissociation of neural systems mediating shifts in behavioral response and cognitive set. Neuroimage 2005; 25: 600-606.
    • (2005) Neuroimage , vol.25 , pp. 600-606
    • Shafritz, K.M.1    Kartheiser, P.2    Belger, A.3
  • 45
    • 0033529198 scopus 로고    scopus 로고
    • Right hemispheric dominance of inhibitory control: An event-related functional MRI study
    • Garavan H, Ross TJ, Stein EA. Right hemispheric dominance of inhibitory control: an event-related functional MRI study. Proc Natl Acad Sci USA 1999; 96: 8301-8306.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8301-8306
    • Garavan, H.1    Ross, T.J.2    Stein, E.A.3
  • 47
    • 0742287966 scopus 로고    scopus 로고
    • Acquiring and inhibiting prepotent responses in schizophrenia: Event-related brain potentials and functional magnetic resonance imaging
    • Ford JM, Gray M, Whitfield SL, Turken AU, Glover G, Faustman WO et al. Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging. Arch Gen Psychiatry 2004; 61: 119-129.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 119-129
    • Ford, J.M.1    Gray, M.2    Whitfield, S.L.3    Turken, A.U.4    Glover, G.5    Faustman, W.O.6
  • 48
    • 33846363929 scopus 로고    scopus 로고
    • Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3 and DISC1: Influence on risk of schizophrenia
    • Submitted
    • Nikodemus KK, Kolachana BS, Vakkalanta R, Straub RE, Giegling I, Egan MF et al. Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3 and DISC1: influence on risk of schizophrenia. Hum Genet, Submitted.
    • Hum Genet
    • Nikodemus, K.K.1    Kolachana, B.S.2    Vakkalanta, R.3    Straub, R.E.4    Giegling, I.5    Egan, M.F.6
  • 49
    • 0034017850 scopus 로고    scopus 로고
    • GOLD - Graphical overview of linkage disequilibrium
    • Abecasis GR, Cookson WO. GOLD - graphical overview of linkage disequilibrium. Bioinformatics 2000; 16: 182-183.
    • (2000) Bioinformatics , vol.16 , pp. 182-183
    • Abecasis, G.R.1    Cookson, W.O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.