Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation

Archives of General Psychiatry

Volumn 63, Issue 12, 2006, Pages 1396-1406

  Drabant, Emily M ^a   Hariri, Ahmad R ^a,b   Meyer Lindenberg, Andreas ^a   Munoz, Karen E ^a   Mattay, Venkata S ^a   Kolachana, Bhaskar S ^a   Egan, Michael F ^a   Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; VALINE;

ADULT; ALLELE; AMYGDALOID NUCLEUS; ANXIETY; AROUSAL; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; DOPAMINERGIC TRANSMISSION; EMOTIONAL DISORDER; FACIAL EXPRESSION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HIPPOCAMPUS; HOMOZYGOTE; HUMAN; LIMBIC CORTEX; MAJOR CLINICAL STUDY; MALE; REGULATORY MECHANISM; TEMPERAMENT; WORKING MEMORY;

ADULT; AFFECT; AFFECTIVE SYMPTOMS; AMYGDALA; AROUSAL; BRAIN MAPPING; CATECHOL O-METHYLTRANSFERASE; EXPLORATORY BEHAVIOR; FACIAL EXPRESSION; FEMALE; GENOTYPE; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; MALE; METHIONINE; NEURAL PATHWAYS; OXYGEN; POLYMORPHISM, GENETIC; PREFRONTAL CORTEX; SYNAPTIC TRANSMISSION; TEMPERAMENT; VALINE; VISUAL PERCEPTION;

EID: 33845330255     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.63.12.1396     Document Type: Article

References (91)

1. Grace AA, Rosenkranz JA. Regulation of conditioned responses of basolateral amygdala neurons. Physiol Behav. 2002;77:489-493.
2. Karreman M, Moghaddam B. The prefrontal cortex regulates the basal release of dopamine in the limbic striatum: an effect mediated by ventral tegmental area. J Neurochem. 1996;66:589-598.
3. LeDoux J. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol. 2003;23:727-738.
4. Phillips ML. Understanding the neurobiology of emotion perception: implications for psychiatry. Br J Psychiatry. 2003;182:190-192.
5. Otmakhova NA, Lisman JE. Dopamine selectively inhibits the direct cortical pathway to the CA1 hippocampal region. J Neurosci. 1999;19:1437-1445.
6. Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, Bast T, Zhang WN, Pothuizen HH, Feldon J. Regional dissociations within the hippocampus - memory and anxiety. Neurosci Biobehav Rev. 2004;28:273-283.
7. McNaughton N. Cognitive dysfunction resulting from hippocampal hyperactivity - a possible cause of anxiety disorder? Pharmacol Biochem Behav. 1997;56:603-611.
8. Gorman JM. Discerning disorders and diseases. CNS Spectr. 2004;9:632.
9. Gordon JA, Hen R. Genetic approaches to the study of anxiety. Annu Rev Neurosci. 2004;27:193-222.
10. Seamans JK, Durstewitz D, Christie BR, Stevens CF, Sejnowski TJ. Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons. Proc Natl Acad Sci U S A. 2001;98:301-306.
11. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 1996;6:243-250.
12. Mannisto PT, Kaakkola S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev. 1999;51:593-628.
13. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet. 2004;75:807-821.
14. Meyer-Lindenberg A, Kohn PD, Kolachana B, Kippenhan S, McInerney-Leo A, Nussbaum R, Weinberger DR, Berman KF. Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat Neurosci. 2005;8:594-596.
15. Diamond A, Briand L, Fossella J, Gehlbach L. Genetic and neurochemical modulation of prefrontal cognitive functions in children. Am J Psychiatry. 2004;161:125-132.
16. Bearden CE, Jawad AF, Lynch DR, Sokol S, Kanes SJ, McDonald-McGinn DM, Saitta SC, Harris SE, Moss E, Wang PP, Zackai E, Emanuel BS, Simon TJ. Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome. Am J Psychiatry. 2004;161:1700-1702.
17. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A. 2001;98:6917-6922.
18. Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, Kolachana B, Callicott JH, Weinberger DR. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A. 2003;100:6186-6191.
19. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, Berman KF, Goldberg TE. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry. 2001;50:825-844.
20. Enoch MA, Xu K, Ferro E, Harris CR, Goldman D. Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism. Psychiatr Genet. 2003;13:33-41.
21. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci U S A. 1997;94:4572-4575.
22. Woo JM, Yoon KS, Choi YH, Oh KS, Lee YS, Yu BH. The association between panic disorder and the L/L genotype of catechol-O-methyltransferase. J Psychiatr Res. 2004;38:365-370.
23. Tiihonen J, Hallikainen T, Lachman H, Saito T, Volavka J, Kauhanen J, Salonen JT, Ryynanen OP, Koulu M, Karvonen MK, Pohjalainen T, Syvalahti E, Hietala J. Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Mol Psychiatry. 1999;4:286-289.
24. Rujescu D, Giegling I, Gietl A, Hartmann AM, Moller HJ. A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry. 2003;54:34-39.
25. Volavka J, Kennedy JL, Ni X, Czobor P, Nolan K, Sheitman B, Lindenmayer JP, Citrome L, McEvoy J, Lieberman JA. COMT158 polymorphism and hostility. Am J Med Genet B Neuropsychiatr Genet. 2004;127:28-29.
26. Reuter M, Hennig J. Association of the functional catechol-O- methyltransferase VAL158MET polymorphism with the personality trait of extraversion. Neuroreport. 2005;16:1135-1138.
27. Tsai SJ, Hong CJ, Yu YW, Chen TJ. Association study of catechol-Omethyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females. Neuropsychobiology. 2004;50:153-156.
28. Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS, Goldman D. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science. 2003;299:1240-1243.
29. Mynett-Johnson LA, Murphy VE, Claffey E, Shields DC, McKeon P. Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene. Psychiatr Genet. 1998;8:221-225.
30. Ohara K, Nagai M, Suzuki Y. Low activity allele of catechol-o- methyltransferase gene and Japanese unipolar depression. Neuroreport. 1998;9:1305-1308.
31. Domschke K, Freitag CM, Kuhlenbumer G, Schirmacher A, Sand P, Nyhuis P, Jacob C, Fritze J, Franke P, Rietschel M, Garritsen HS, Fimmers R, Nthen MM, Lesch KP, Stgbauer F, Deckert J. Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women. Int J Neuropsychopharmacol. 2004;7:183-188.
32. Ohara K, Nagai M, Suzuki Y, Ochiai M. No association between anxiety disorders and catechol-O-methyltransferase polymorphism. Psychiatry Res. 1998;80:145-148.
33. Smolka MN, Schumann G, Wrase J, Grusser SM, Flor H, Mann K, Braus DF, Goldman D, Buchel C, Heinz A. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci. 2005;25:836-842.
34. Hariri AR, Weinberger DR. Imaging genomics. Br Med Bull. 2003;65:259-270.
35. Heiman N, Stallings MC, Hofer SM, Hewitt JK. Investigating age differences in the genetic and environmental structure of the tridimensional personality questionnaire in later adulthood. Behav Genet. 2003;33:171-180.
36. Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry. 1993;50:975-990.
37. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet. 1996;12:78-80.
38. Keltikangas-Jarvinen L, Elovainio M, Kivimaki M, Lichtermann D, Ekelund J, Peltonen L. Association between the type 4 dopamine receptor gene polymorphism and novelty seeking. Psychosom Med. 2003;65:471-476.
39. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005;8:828-834.
40. Williams JB, Gibbon M, First MB, Spitzer RL, Davies M, Borus J, Howes MJ, Kane J, Pope HG Jr, Rounsaville B, Wittchen H. The Structured Clinical Interview for DSM-III-R (SCID), II: multisite test-retest reliability. Arch Gen Psychiatry. 1992;49:630-636.
41. Spitzer RL, Williams JB, Gibbon M, First MB. The Structured Clinical Interview for DSM-III-R (SCID), I: history, rationale, and description. Arch Gen Psychiatry. 1992;49:624-629.
42. Hariri AR, Mattay VS, Tessitore A, Fera F, Smith WG, Weinberger DR. Dextroamphetamine modulates the response of thehumanamygdala. Neuropsychopharmacology. 2002;27:1036-1040.
43. Hariri AR, Bookheimer SY, Mazziotta JC. Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport. 2000;11:43-48.
44. Tessitore A, Hariri AR, Fera F, Smith WG, Chase TN, Hyde TM, Weinberger DR, Mattay VS. Dopamine modulates the response of the human amygdala: a study in Parkinson's disease. J Neurosci. 2002;22:9099-9103.
45. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry. 2005;62:146-152.
46. Ekman P, Friesen W. Pictures of Facial Affect. Palo Alto, Calif: Consulting Psychologists Press; 1976.
47. Whalen PJ, Kagan J, Cook RG, Davis FC, Kim H, Polis S, McLaren DG, Somerville LH, McLean AA, Maxwell JS, Johnstone T. Human amygdala responsivity to masked fearful eye whites. Science. 2004;306:2061.
48. Vuilleumier P, Armony JL, Driver J, Dolan RJ. Distinct spatial frequency sensitivities for processing faces and emotional expressions. Nat Neurosci. 2003;6:624-631.
49. Zald DH. The human amygdala and the emotional evaluation of sensory stimuli. Brain Res Brain Res Rev. 2003;41:88-123.
50. Cloninger CR. A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev. 1986;4:167-226.
51. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR. 5-HTTLPR polymorphism impacts human cingulate-amygdala regulatory interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005;8:828-834.
52. Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR. Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience. 2003;116:127-137.
53. Ramnani N, Behrens TE, Penny W, Matthews PM. New approaches for exploring anatomical and functional connectivity in the human brain. Biol Psychiatry. 2004;56:613-619.
54. Meyer-Lindenberg A, Kohn P, Mervis CB, Kippenhan JS, Olsen RK, Morris CA, Berman KF. Neural basis of genetically determined visuospatial construction deficit in Williams syndrome. Neuron. 2004;43:623-631.
55. Livak KJ. Allelic discrimination using fluorogenic probes and the 5' nuclease assay. Genet Anal. 1999;14:143-149.
56. Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grusser SM, Flor H, Schumann G, Mann K, Buchel C. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci. 2005;8:20-21.
57. Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR. The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage. 2002;17:317-323.
58. Furmark T, Tillfors M, Garpenstrand H, Marteinsdottir I, Langstrom B, Oreland L, Fredrikson M. Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neurosci Lett. 2004;362:189-192.
59. Blair RJ. The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cogn. 2004;55:198-208.
60. Zald DH, Kim SW. Anatomy and function of the orbital frontal cortex, II: function and relevance to obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci. 1996;8:249-261.
61. Svrakic DM, Przybeck TR, Cloninger CR. Mood states and personality traits. J Affect Disord. 1992;24:217-226.
62. Kuo PH, Chih YC, Soong WT, Yang HJ, Chen WJ. Assessing personality features and their relations with behavioral problems in adolescents: Tridimensional Personality Questionnaire and Junior Eysenck Personality Questionnaire. Compr Psychiatry. 2004;45:20-28.
63. Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol. 1999;39:19-52.
64. Pritchard JK, Donnelly P. Case-control studies of association in structured or admixed populations. Theor Popul Biol. 2001;60:227-237.
65. Masuda M, Tsunoda M, Imai K. High-performance liquid chromatographyfluorescent assay of catechol-O-methyltransferase activity in rat brain. Anal Bioanal Chem. 2003;376:1069-1073.
66. Hong J, Shu-Leong H, Tao X, Lap-Ping Y. Distribution of catechol-O-methyltransferase expression in human central nervous system. Neuroreport. 1998;9:2861-2864.
67. Revay R, Vaughan R, Grant S, Kuhar MJ. Dopamine transporter immunohistochemistry in median eminence, amygdala, and other areas of the rat brain. Synapse. 1996;22:93-99.
68. Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A. 1998;95:9991-9996.
69. Tunbridge EM, Bannerman DM, Sharp T, Harrison PJ. Catechol-o- methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. J Neurosci. 2004;24:5331-5335.
70. Rusch BD, Abercrombie HC, Oakes TR, Schaefer SM, Davidson RJ. Hippocampal morphometry in depressed patients and control subjects: relations to anxiety symptoms. Biol Psychiatry. 2001;50:960-964.
71. Ploghaus A, Narain C, Beckmann CF, Clare S, Bantick S, Wise R, Matthews PM, Rawlins JN, Tracey I. Exacerbation of pain by anxiety is associated with activity in a hippocampal network. J Neurosci. 2001;21:9896-9903.
72. Deacon RM, Bannerman DM, Rawlins JN. Anxiolytic effects of cytotoxic hippocampal lesions in rats. Behav Neurosci. 2002;116:494-497.
73. McNaughton N, Gray JA. Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety. J Affect Disord. 2000;61:161-176.
74. Wittmann BC, Schott BH, Guderian S, Frey JU, Heinze HJ, Duzel E. Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron. 2005;45:459-467.
75. Fernandes C, Paya-Cano JL, Sluyter F, D'Souza U, Plomin R, Schalkwyk LC. Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour. Eur J Neurosci. 2004;19:2576-2582.
76. Kim H, Somerville LH, Johnstone T, Polis S, Alexander AL, Shin LM, Whalen PJ. Contextual modulation of amygdala responsivity to surprised faces. J Cogn Neurosci. 2004;16:1730-1745.
77. Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD. Rethinking feelings: an FMRI study of the cognitive regulation of emotion. J Cogn Neurosci. 2002;14:1215-1229.
78. Keightley ML, Winocur G, Graham SJ, Mayberg HS, Hevenor SJ, Grady CL. An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuli. Neuropsychologia. 2003;41:585-596.
79. Lange K, Williams LM, Young AW, Bullmore ET, Brammer MJ, Williams SC, Gray JA, Phillips ML. Task instructions modulate neural responses to fearful facial expressions. Biol Psychiatry. 2003;53:226-232.
80. Beauregard M, Leroux JM, Bergman S, Arzoumanian Y, Beaudoin G, Bourgouin P, Stip E. The functional neuroanatomy of major depression: an fMRI study using an emotional activation paradigm. Neuroreport. 1998;9:3253-3258.
81. Hariri AR, Mattay VS, Tessitore A, Fera F, Weinberger DR. Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry. 2003;53:494-501.
82. Ochsner KN, Ray RD, Cooper JC, Robertson ER, Chopra S, Gabrieli JD, Gross JJ. For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage. 2004;23:483-499.
83. Bilder RM, Volavka J, Lachman HM, Grace AA. The catechol-O- methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology. 2004;29:1943-1961.
84. Nolan KA, Bilder RM, Lachman HM, Volavka J. Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility. Am J Psychiatry. 2004;161:359-361.
85. Gallinat J, Bajbouj M, Sander T, Schlattmann P, Xu K, Ferro EF, Goldman D, Winterer G. Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing. Biol Psychiatry. 2003;54:40-48.
86. Rolls ET. The orbitofrontal cortex and reward. Cereb Cortex. 2000;10:284-294.
87. Dias R, Robbins TW, Roberts AC. Dissociation in prefrontal cortex of affective and attentional shifts. Nature. 1996;380:69-72.
88. Rolls ET, Hornak J, Wade D, McGrath J. Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J Neurol Neurosurg Psychiatry. 1994;57:1518-1524.
89. Cavada C, Co T, Tejedor J, Cruz-Rizzolo RJ, Reinoso-Suarez F. The anatomical connections of the macaque monkey orbitofrontal cortex: a review. Cereb Cortex. 2000;10:220-242.
90. Schoenbaum G, Chiba AA, Gallagher M. Changes in functional connectivity in orbitofrontal cortex and basolateral amygdala during learning and reversal training. J Neurosci. 2000;20:5179-5189.
91. Wall PM, Messier C. The hippocampal formation-orbitomedial prefrontal cortex circuit in the attentional control of active memory. Behav Brain Res. 2001;127:99-117.