Dopamine and spatial working memory in rats and monkeys: Pharmacological reversal of stress-induced impairment

Journal of Neuroscience

Volumn 16, Issue 23, 1996, Pages 7768-7775

  Murphy, Beth L ^a   Arnsten, Amy F T ^a   Jentsch, J David ^a   Roth, Robert H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

(+)HA 966; clonidine; cognition; D cycloserine; delayed alternation; delayed response; dopamine; FG7142; memory; NMDA; norepinephrine; prefrontal cortex; prepranolol; primate; rat

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; CLONIDINE; CYCLOSERINE; DOPAMINE; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEMALE; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MACACA; MALE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; STRESS; VENTRAL TEGMENTUM; WORKING MEMORY;

EID: 0029985114     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-23-07768.1996     Document Type: Article

References (67)

1. American Psychiatric Association (1994) DSM-IV: diagnostic and statistical manual of mental disorders, 4th Ed., pp 78-85, 424-429. Washington, DC: American Psychiatric Association.
2. Arnsten AFT, Goldman-Rakic PS (1986) Reversal of stress-induced delayed response deficits in rhesus monkeys by clonidine and naloxone. Soc Neurosci Abstr 12:1464.
3. Arnsten AFT, Goldman-Rakic PS (1990) Stress impairs prefrontal cortex cognitive function in monkeys: role of dopamine. Soc Neurosci Abstr 16:164.
4. Arnold LE, Jensen PS (1995) Attention deficit disorders. In: Comprehensive textbook of psychiatry/VI, Vol 2 (Kaplan HI, Sadock BJ, eds), pp 2295-2310. Philadelphia: Williams and Wilkins.
5. Barkley RA, Grodzinsky G, DuPaul GJ (1979) Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report. J Abnorm Child Psychol 20:163-188.
6. Bean AJ, Roth RH (1991) Stimulated release of cotransmitters from rat prefrontal cortex in vivo: effects of stimulation frequency pattern and dopamine autoreceptors on dopamine and neurotensin release. J Neurosci 11:2694-2702.
7. Bebbington P, Wilkins S, Jones P, Foerster A, Murray R, Toone B, Shon L (1993) Life events and psychosis. Initial results from the Camberwell collaborative psychosis study. Br J Psychol 162:72-79.
8. Benson DF (1991) The role of frontal dysfunction in attention deficit hyperactivity disorder. J Child Neurol 6:S9-S12.
9. Bowers Jr MB, Morton JB (1994) Regional brain catecholamines and metabolites following THC, PCP, and MK-801. Prog Neuropsychopharmacol Biol Psychiatry 18:961-964.
10. Bradberry CW, Lory JS, Roth RH (1991) The anxiogenic beta-carboline FG7142 selectively increases dopamine release in the rat prefrontal cortex as measured by microdialysis. J Neurochem 56:748-752.
11. Breier A, Wolkowitz OM, Pickar D (1991) Stress and schizophrenia. Advances in neuropsychiatry and psychopharmacology. In: Schizophrenia research, Vol 1 (Tamminga CA, Schult SC, eds). New York: Raven.
12. Bremner JD, Krystal JH, Southwick SM, Charney DS (1996) Noradrenergic mechanisms in stress and anxiety. I. Preclinical studies. Synapse 23:28-38.
13. Brozoski TJ, Brown R, Rosvold HE, Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in the prefrontal cortex of rhesus monkeys. Science 205:929-931.
14. Bubser M, Schmidt WJ (1990) 6-Hydroxydopamine lesions of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze. Behav Brain Res 37:157-168.
15. Chergui K, Charlety PJ, Akaoka H, Saunier CH, Brunet JL, Buda M, Svensson TH, Chouvet G (1993) Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur J Neurosci 5:137-144.
16. Crawley JN, Ninan PT, Pickar D, Chrousos GP, Linnoila M, Skolnick P, Paul SM (1985) Neuropharmacological antagonism of the β-carboline-induced "anxiety" response in rhesus monkeys. J Neurosci 5:477-485.
17. Deutch AY (1992) The regulation of subcortical dopamine systems by the prefrontal cortex: interaction of central dopaminergic systems and the pathogenesis of schizophrenia. J Neural Transm Suppl 36:61-89.
18. Deutch AY (1993) Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease. J Neural Transm Suppl 91:197-221.
19. Deutch AY, Roth RH (1990) The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog Brain Res 85:367-403.
20. Deutch AY, Young CD (1995) A model of the stress-induced activation of prefrontal cortical dopamine systems. In: Neurobiological and clinical consequences of stress. From normal adaptation to post-traumatic stress disorder. (Friedman MJ, Charney DS, Deutch AY, eds). New York: Lippincott-Raven.
21. Domesick VB (1988) Neuroanatomical organization of dopamine neurons in the ventral tegmental area. Ann NY Acad Sci 537:10-26.
22. Elsworth JD, Roth RH, Redmond Jr DE (1983) Relative importance of 3-methoxy-4-hydroxyphenylglycol and 3,4-dihydroxyphenylglycol as norepinephrine metabolites in rat, monkey, and humans. J Neurochem 41:786-792.
23. Elsworth JD, Deutch AY, Redmond Jr DE, Taylor JR, Sladek Jr JR, Roth RH (1989) Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates: biochemical changes in striatal regions. Neuroscience 33:323-332.
24. Fallon JH (1988) Topographic organization of ascending dopaminergic projections. Ann NY Acad Sci 537:1-9.
25. Goldman-Rakic PS (1991) Prefrontal cortical dysfunction in schizophrenia: the relevance of working memory. In: Psychopathology and the brain (Carroll BJ, Barrett JE, eds), pp 1-23. New York: Raven.
26. Goldman-Rakic PS (1994) Working memory in schizophrenia. J Neuropsychiatry Clin Neurosci 6:348-357.
27. Goldman-Rakic PS, Lidow MS, Smiley JF, Williams MS (1992) The anatomy of dopamine in monkey and human prefrontal cortex. J Neural Transm Suppl 36:163-177.
28. Goldstein M, Deutch AY (1992) Dopaminergic mechanisms in the pathogenesis of schizophrenia. FASEB J 6:2413-2421.
29. Goldstein LE, Rasmussen AM, Bunney BS, Roth RH (1994) The NMDA glycine site antagonist (+)HA966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. J Neurosci 14:4937-4950.
30. Gonon FG (1988) Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience 24:19-28.
31. Grenhoff J, Svensson TH (1989) Clonidine modulates dopamine cell firing in rat ventral tegmental area. Eur J Pharmacol 165:11-18.
32. Hauber W (1993) Clozapine improves dizocilpine-induced delayed alternation impairment in rats. J Neural Transm Gen Sect 94:223-233.
33. Herman JP, Guillonneau D, Dantzer R, Scatton B, Semerdjan-Rouquier L, LeMoal M (1982) Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat. Life Sci 30:2207-2214.
34. Herve D, Blanc G, Glowinski J, Tassin JP (1982) Reduction in dopamine utilization in the prefrontal cortex but not in the nucleus accumbens after selective destruction of the noradrenergic fibers innervating the ventral tegmental area in the rat. Brain Res 237:510-516.
35. Ida Y, Elsworth JD, Roth RH (1991) Anxiogenic beta-carboline FG7142 produces activation of noradrenergic neurons in specific brain regions of rats. Pharmacol Biochem Behav 39:791-793.
36. Jentsch JD, Andrusiak E, Tran A, Roth RH (1996) HA966 prevents increases in prefrontal cortical dopamine turnover and impairments of working memory induced by psychotomimetic drugs. FASEB J 20:A716.
37. Kalivas PW (1993) Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res Rev 18:75-113.
38. Kalivas PW, Duffy P, Barrow J (1989) Regulation of the mesocorticolimbic dopamine system by glutamic acid receptor subtypes. J Pharmacol Exp Ther 251:378-387.
39. Kalivas PW, Duffy P, Eberhardt H (1990) Modulation of A10 dopamine neurons by γ-aminobutyric acid agonists. J Pharmacol Exp Ther 253:858-866.
40. Kashiwa A, Nishikawa T, Nishijima K, Umino A, Takahashi K (1995) Dizocilpine (MK-801) elicits a tetrodotoxin-sensitive increase in extracellular release of dopamine in rat medial frontal cortex. Neurochem Int 26:269-279.
41. Lewis DA (1992) The catecholaminergic innervation of primate prefrontal cortex. J Neural Transm Suppl 36:179-200.
42. Lewis DA, Hayes TL, Lund JS, Oeth KM (1992) Dopamine and the neural circuitry of primate prefrontal cortex: implications for schizophrenia research. Neuropsychopharmacology 6:127-134.
43. Maurice T, Hiramatsu M, Itoh J, Kameyama T, Hasegawa T, Nabeshima T (1994) Behavioral evidence for a modulating role of sigma ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia. Brain Res 647:44-56.
44. McMillen BA, Williams HL, Lehmann H, Shepard PD (1992) On central muscle relaxants, strychnine-insensitive glycine receptors, and two old drugs: zoxazolamine and (+)HA966. J Neural Transm Gen Sect 89:11-25.
45. Moore H, Stuckman S, Sarter M, Bruno JP (1995) Stimulation of cortical acetylcholine efflux by FG7142 measured with repeated microdialysis sampling. Synapse 21:324-331.
46. Morrow BA, Clark WA, Roth RH (1993) Stress activation of mesocorticolimbic dopamine neurons: effects of a glycine/NMDA receptor antagonist. Eur J Pharmacol 238:255-262.
47. Morrow BA, George TP, Lee EJK, Roth RH (1996) Noradrenergic alpha-2 agonists diminish behavioral and dopaminergic responses to conditioned fear. Soc Neurosci Abstr 22:810.9.
48. Murphy BL, Roth RH, Arnsten AFT (1994) The effects of FG7142 on prefrontal cortical dopamine and spatial working memory in rat and monkey. Soc Neurosci Abstr 20:1010.
49. Murphy BL, Arnsten AFT, Goldman-Rakic PS, Roth RH (1996) Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc Natl Acad Sci USA 93:1325-1329.
50. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. New York: Academic.
51. Rao TS, Kim HS, Lehmann J, Martin LL, Wood PL (1989) Differential effects of phencyclidine (PCP) and ketamine on mesocritical and mesostriatal dopamine release in vivo. Life Sci 45:1065-1072.
52. Robbins TW (1990) The case of frontostriatal dysfunction in schizophrenia. Schizophr Bull 16:391-402.
53. Roth RH, Tam S-Y (1987) Regulatory control of midbrain dopamine neurons. In: Amino acids in health and disease: new perspectives, Vol 55 (Kaufman S, ed), pp 159-178. New York: Liss.
54. Roth RH, Tam S-Y, Ida Y, Yang J-X, Deutch AY (1988) Stress and the mesocorticolimbic dopamine systems. Ann NY Acad Sci 537:138-147.
55. Southwick SM, Yehuda R, Morgan CA III (1995) Clinical studies of neurotransmitter alterations in post-traumatic stress disorder. In: Neurobiological and clinical consequences of stress. From normal adaptation to post-traumatic stress disorder (Friedman MJ, Charney DS, Deutch AY, eds). New York: Lippincott-Raven.
56. Tam S-Y (1986) Mesoprefrontal dopamine neurons: studies on their regulatory control. Doctoral thesis, Yale University.
57. Tam S-Y, Roth RH (1985) Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG7142. Biochem Pharmacol 34:1595-1598.
58. Tam S-Y, Roth RH (1990) Modulation of mesoprefrontal dopamine neurons by central benzodiazepine receptors. I. Pharmacological characterization. J Pharmacol Exp Ther 252:989-996.
59. Thierry AM, Tassin JP, Glanc G, Glowinski J (1976) Selective activation of mesocortical DA system by stress. Nature 263:242-244.
60. Turski L, Niemann W, Stephens DN (1990) Differential effects of anti-epileptic drugs and beta-carbolines on seizures induced by excitatory amino acids. Neuroscience 39:799-807.
61. Verma A, Moghaddam B (1996) NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats - modulation by dopamine. J Neurosci 16:373-379.
62. Wang T, O'Connor, Ungerstedt U, French ED (1994) N-Methyl-D-aspartic acid biphasically regulates the biochemical and electrophysiological response of A10 dopamine neurons in the ventral tegmental area: in vivo microdialysis and in vitro electrophysiological studies. Brain Res 666:255-262.
63. Weinberger DR, Berman ZF, Zed RF (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 43:114-124.
64. Weinberger DR, Aloia MS, Goldberg TE, Berman KF (1994) The frontal lobes and schizophrenia. J Neuropsychiatry Clin Neurosci 6:419-427.
65. White F (1996) Synaptic regulation of mesocorticolimbic dopamine neurons. Annu Rev Neurosci 19:405-436.
66. Williams GV, Goldman-Rakic PS (1995) Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 376:572-575.
67. Zahrt J, Taylor JR, Arnsten AFT (1996) Supranormal stimulation of dopamine D1 receptors in the prefrontal cortex impairs spatial working memory performance in rats. Soc Neurosci Abstr 22:446.10.