Catechol-O-methyltransferase val 108/158met genotype predicts working memory response to antipsychotic medications

Biological Psychiatry

Volumn 56, Issue 9, 2004, Pages 677-682

  Weickert, Thomas W ^a   Goldberg, Terry E ^a   Mishara, Aaron ^a   Apud, Jose A ^a   Kolachana, Bhaskar S ^a   Egan, Michael F ^a   Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

antipsychotics; Catechol O methyltransferase; dopamine; prefrontal cortex; schizophrenia; working memory

Indexed keywords

BENZATROPINE; CATECHOL METHYLTRANSFERASE; CLOZAPINE; HALOPERIDOL; LITHIUM; METHIONINE; NEUROLEPTIC AGENT; OLANZAPINE; PAROXETINE; PERPHENAZINE; PLACEBO; QUETIAPINE; RISPERIDONE; SERTRALINE; TRIHEXYPHENIDYL; VALINE; VALPROIC ACID; ZIPRASIDONE;

ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; COGNITION; ENZYME POLYMORPHISM; FEMALE; GENOTYPE; HOMOZYGOSITY; HUMAN; MALE; PRIORITY JOURNAL; PSYCHOLOGIC TEST; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; WORKING MEMORY;

ADULT; ANALYSIS OF VARIANCE; ANTIPSYCHOTIC AGENTS; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; DOUBLE-BLIND METHOD; FEMALE; GENOTYPE; HUMANS; MALE; MEMORY, SHORT-TERM; MENTAL STATUS SCHEDULE; METHIONINE; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; RETROSPECTIVE STUDIES; SCHIZOPHRENIA; VALINE;

EID: 7444232703     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2004.08.012     Document Type: Article

References (37)

1. J. Addington, D. Addington Premorbid functioning, cognitive functioning, symptoms and outcome in schizophrenia J Psychiatry Neurosci 18 1993 18 23
2. M. Arranz, D. Collier, M. Sodhi, D. Ball, G. Roberts, J. Price, P. Sham, R. Kerwin Association between clozapine response and allelic variation in 5-HT2A receptor gene Lancet 346 1995 281 282
3. 108/158met genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. Am J Psychiatry 161 2004 1798 1805
4. N.J. Bray, P.R. Buckland, N.M. Williams, H.J. Williams, N. Norton, M.J. Owen, M.C. O'Donovan A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain Am J Hum Genet 73 2003 152 161
5. J.H. Callicott, V.S. Mattay, A. Bertolino, K. Finn, R. Coppola, J.A Frank Physiological characteristics of capacity constraints in working memory as revealed by functional MRI Cereb Cortex 9 1999 20 26
6. J.H. Callicott, M.F. Egan, V.S. Mattay, A. Bertolino, A.D. Bone, B. Verchinksi, D.R. Weinberger Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia Am J Psychiatry 160 2003 709 719
7. M.M. DeMille, J.R. Kidd, V. Ruggeri, M.A. Palmatier, D. Goldman, A. Odunsi Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation Hum Genet 111 2002 521 537
8. A. Diamond, L. Briand, J. Fossella, L. Gehlbach Genetic and neurochemical modulation of prefrontal cognitive functions in children Am J Psychiatry 161 2004 125 132
9. M.F. Egan, T.E. Goldberg, B.S. Kolachana, J.H. Callicott, C.M. Mazzanti, R.E. Straub Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia Proc Natl Acad Sci U S A 98 2001 6917 6922
10. J. Gallinat, M. Bajbouj, T. Sander, P. Schlattmann, K. Xu, E.F. Ferro Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing Biol Psychiatry 54 2003 40 48
11. T.E. Goldberg, M.F. Egan, T. Gscheidle, R. Coppola, T. Weickert, B.S. Kolachana Executive subprocesses in working memory Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia Arch Gen Psychiatry 60 2003 889 896
12. P.S. Goldman-Rakic Regional and cellular fractionation of working memory Proc Natl Acad Sci U S A 93 1996 13473 13480
13. M.F. Green What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153 1996 321 330
14. R.K. Heaton, G.J. Chelune, J.K. Talley, G.G. Kay, G. Curtis Wisconsin Card Sorting Test Manual Revised and Expanded 1993 Psychological Assessment Resources Odessa, Florida
15. A. Himei, J. Koh, J. Sakai, Y. Inada, K. Akabame, H. Yoneda The influence on the schizophrenic symptoms by the DRD2Ser/Cys311 and -141C Ins/Del polymorphisms Psychiatry Clin Neurosci 56 2002 97 102
16. H.M. Jones, L.S. Pilowsky Dopamine and antipsychotic drug action revisited Br J Psychiatry 181 2002 271 275
17. A.S. Kaufman Assessing Adolescent and Adult Intelligence. 1990 Allyn and Bacon Needham, Massachusetts
18. S.R. Kay, A. Fiszbein, L.A. Opler The positive and negative syndrome scale (PANSS) for schizophrenia Schizophr Bull 13 1987 261 276
19. R.S. Keefe, S.G. Silva, D.O. Perkins, J.A. Lieberman The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia A review and meta-analysis Schizophr Bull 25 1999 201 222
20. A.K. Malhotra, L.J. Kestler, C. Mazzanti, J.A. Bates, T. Goldberg, D. Goldman A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition Am J Psychiatry 159 2002 652 654
21. M. Masellis, V. Basile, H.Y. Meltzer, J.A. Lieberman, S. Sevy, F.M. Macciardi Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients Neuropsychopharmacology 19 1998 123 132
22. V.S. Mattay, A. Tessitore, J.H. Callicott, A. Bertolino, T.E. Goldberg, T.N. Chase Dopaminergic modulation of cortical function in patients with Parkinson's disease Ann Neurol 51 2002 156 164
23. V.S. Mattay, T.E. Goldberg, F. Fera, A.R. Hariri, A. Tessitore, M.F. Egan Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine Proc Natl Acad Sci U S A 100 2003 6186 6191
24. F.E. McGuigan, S.H. Ralston Single nucleotide polymorphism detection Allelic discrimination using TaqMan Psychiatr Genet 12 2002 133 136
25. K. Mihara, T. Kondo, A. Suzuki, N. Yasui, U. Nagashima, S. Ono Prolactin response to nemonapride, a selective antagonist for D2 like dopamine receptors, in schizophrenic patients in relation to Taq1A polymorphism of DRD2 gene Psychopharmacology 149 2000 246 250
26. C.D. Missar, J.M. Gold, T.E. Goldberg WAIS-R short forms in chronic schizophrenia Schizophr Res 12 1994 247 250
27. G.P. Reynolds, Z. Zhang, X. Zhang Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain Am J Psychiatry 160 2003 677 679
28. P. Seeman, T. Tallerico Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors Mol Psychiatry 3 1998 123 134
29. S. Shifman, M. Bronstein, M. Sternfeld, A. Pisante-Shalom, E. Lev-Lehman, A. Weizman A highly significant association between a COMT haplotype and schizophrenia Am J Hum Genet 71 2002 1296 1302
30. O. Spreen, E. Strauss A Compendium of Neuropsychological Tests. 1991 Oxford University Press New York
31. A. Suzuki, T. Kondo, K. Mihara, H. Furukori, U. Nagashima, S. Ono, K. Otani, S. Kaneko Association between Taq1 a dopamine D2 receptor polymorphism and psychopathology of schizophrenia in Japanese patients Prog Neuropsychopharmacol Biol Psychiatry 24 2000 1105 1113
32. D. Wechsler Wechsler Adult Intelligence Scale-Revised Manual. 1981 The Psychological Corporation San Antonio, Texas
33. D. Wechsler Wechsler Memory Scale-Revised Manual. 1987 The Psychological Corporation New York
34. T.W. Weickert, T.E. Goldberg, S. Marenco, L.B. Bigelow, M.F. Egan, D.R. Weinberger Comparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia Critical examination of confounds Neuropsychopharmacology 28 8 2003 1491 1500
35. D.R. Weinberger Dopamine, the prefrontal cortex and a genetic mechanism of schizophrenia S. Kapur Y. Lecrubier Dopamine in the Pathophysiology and Treatment of Schizophrenia 2003 Martin Dunitz New York 129 154
36. G.V. Williams, P.S. Goldman-Rakic Modulation of memory fields by dopamine D1 receptors in prefrontal cortex Nature 376 1995 572 575
37. G. Winterer, D.R. Weinberger Cortical signal-to-noise ratio Insight into the pathophysiology and genetics of schizophrenia Clin Neurosci Res 3 2003 55 66