Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele

Molecular Psychiatry

Volumn 7, Issue 7, 2002, Pages 706-711

  Avramopoulos, D ^a   Stefanis, N C ^a   Hantoumi, I ^a   Smyrnis, N ^a   Evdokimidis, I ^a   Stefanis, C N ^a  

^a UNIVERSITY MENTAL HEALTH RESEARCH INSTITUTE   (Greece)

Author keywords

Aggression; Catechol O methyltransferase; Chromosomes; Genes; Human; Pair 22; Questionnaires; Schizophrenia; Schizotypy

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

ADULT; AGGRESSION; ALLELE; ARTICLE; CHROMOSOME 22Q; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; GENE DELETION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PATHOGENESIS; PERSONALITY DISORDER; PRIORITY JOURNAL; QUESTIONNAIRE; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; VELOCARDIOFACIAL SYNDROME;

ADOLESCENT; ADULT; AGGRESSION; ALLELES; CATECHOL O-METHYLTRANSFERASE; CHROMOSOMES, HUMAN, PAIR 22; GENOTYPE; HUMANS; MALE; QUESTIONNAIRES; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER;

EID: 0036360702     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001070     Document Type: Article

References (59)

1. Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12-q13.1: Part 1
2. Genomic scan for genes predisposing to schizophrenia
3. Follow-up report of potential linkage for schizophrenia on chromosome 22q: Part 3
4. A combined analysis of D22S278 marker alleles in affected sibpairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12
5. Searching for susceptibility genes in schizophrenia by genetic linkage analysis
6. A genome-wide search for schizophrenia susceptibility genes
7. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives
8. High rates of schizophrenia in adults with velo-cardio-facial syndrome
9. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11
10. Methylation reactions in the formation and metabolism of catecholamines and other biogenic amines
11. S-adenosylmethionine and catechol-O-methyl-transferase in schizophrenia
12. Soluble and membrane catechol-o-methyl transferases in red blood cells of schizophrenic patients
13. Catechol O-methyltransferase in red blood cells of schizophrenic, depressed, and normal human subjects
14. Electrophoretic pattern of red blood cell catechol-o-methyltransferase in schizophrenia and manic-depressive illness
15. Activities of types A and B MAO and catechol-o-methyl-transferase in blood cells and skin fibroblasts of normal and chronic schizophrenic subjects
16. Erythrocyte catechol O-methyltransferase activity in schizophrenia: Analysis of family data
17. Inheritance of low erythrocyte catechol-o-methyltransferase activity in man
18. Genetics of red cell COMT activity: Analysis of thermal stability and family data
19. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme
20. Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders
21. Preferential transmission of the high activity allele of COMT in schizophrenia
22. Catechol-O-methyltransferase polymorphisms and schizophrenia: A transmission disequilibrium study in multiply affected families
23. Family-based linkage disequilibrium mapping using SNP marker haplotypes: Application to a potential locus for schizophrenia at chromosome 22q11
24. Lack of evidence for association between the COMT locus and schizophrenia
25. Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility
26. Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia
27. Genetic linkage and complex diseases, with special reference to psychiatric disorders
28. The latent structure of schizotypy: I. Premorbid indicators of a taxon of individuals at risk for schizophrenia-spectrum disorders
29. Schizotypal and paranoid personality disorder in the relatives of patients with schizophrenia and affective disorders: A review
30. Personality disorders among the relatives of schizophrenia patients
31. Sex differences in self-reported schizotypal traits in relatives of schizophrenic probands
32. Elevated levels of cognitive-perceptual deficits in individuals with a family history of schizophrenia spectrum disorders
33. Correlates of psychosis proneness in relatives of schizophrenic patients
34. A twin study of personality disorders
35. Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives
36. The SPQ: A scale for the assessment of schizotypal personality based on DSM-III-R criteria
37. Scales for physical and social anhedonia
38. Thought disorder, perceptual aberrations, and schizotypy
39. Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives
40. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: Evidence for association with aggressive and anti-social behavior
41. Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder
42. The aggression questionnaire
43. A psychobiological model of temperament and character
44. Validation of the determination of deltaF508 mutations of the cystic fibrosis gene in over 11 000 mouthwashes
45. Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder
46. Elementary phenotypes in the neurobiological and genetic study of schizophrenia
47. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease
48. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
49. Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families
50. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis
51. Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families
52. 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: Reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model
53. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
54. Interaction of COMT gene deletion and environment on cognition
55. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence
56. Functional hypofrontality and working memory dysfunction in schizophrenia
57. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited
58. Spatial working memory deficits in the relatives of schizophrenic patients
59. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia