-
1
-
-
33750310241
-
Genetic disorders of adipose tissue development, differentiation, and death
-
Agarwal, A.K. and Garg, A. (2006). Genetic disorders of adipose tissue development, differentiation, and death. Annu. Rev. Genomics Hum. Genet. 7, 175-199
-
(2006)
Annu. Rev. Genomics Hum. Genet
, vol.7
, pp. 175-199
-
-
Agarwal, A.K.1
Garg, A.2
-
2
-
-
0041919374
-
Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia
-
Agarwal, A.K., Fryns, J.P., Auchus, R.J., and Garg, A. (2003). Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. Hum. Mol. Genet. 12, 1995-2001
-
(2003)
Hum. Mol. Genet
, vol.12
, pp. 1995-2001
-
-
Agarwal, A.K.1
Fryns, J.P.2
Auchus, R.J.3
Garg, A.4
-
3
-
-
59449102799
-
Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment
-
Barrowman, J., Hamblet, C., George, C.M., and Michaelis, S. (2008). Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment. Mol. Biol. Cell 19, 5398-5408
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5398-5408
-
-
Barrowman, J.1
Hamblet, C.2
George, C.M.3
Michaelis, S.4
-
4
-
-
30844467746
-
Lipid posttranslational modifications. Farnesyl transferase inhibitors
-
Basso, A.D., Kirschmeier, P., and Bishop, W.R. (2006). Lipid posttranslational modifications. Farnesyl transferase inhibitors. J. Lipid Res. 47, 15-31
-
(2006)
J. Lipid Res
, vol.47
, pp. 15-31
-
-
Basso, A.D.1
Kirschmeier, P.2
Bishop, W.R.3
-
5
-
-
0036791026
-
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
-
Bergo, M.O., Gavino, B., Ross, J., Schmidt, W.K., Hong, C., Kendall, L.V., Mohr, A., Meta, M., Genant, H., Jiang, Y., et al. (2002). Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc. Natl. Acad. Sci. USA 99, 13049-13054
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13049-13054
-
-
Bergo, M.O.1
Gavino, B.2
Ross, J.3
Schmidt, W.K.4
Hong, C.5
Kendall, L.V.6
Mohr, A.7
Meta, M.8
Genant, H.9
Jiang, Y.10
-
6
-
-
0031664339
-
Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae afactor
-
Boyartchuk, V.L. and Rine, J. (1998). Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae afactor. Genetics 150, 95-101
-
(1998)
Genetics
, vol.150
, pp. 95-101
-
-
Boyartchuk, V.L.1
Rine, J.2
-
7
-
-
0030909336
-
Modulation of Ras and a-factor function by carboxyl-terminal proteolysis
-
Boyartchuk, V.L., Ashby, M.N., and Rine, J. (1997). Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science 275, 1796-1800
-
(1997)
Science
, vol.275
, pp. 1796-1800
-
-
Boyartchuk, V.L.1
Ashby, M.N.2
Rine, J.3
-
8
-
-
34047155594
-
The prelamin A pre-peptide induces cardiac and skeletal myoblast differentiation
-
Brodsky, G.L., Bowersox, J.A., Fitzgerald-Miller, L., Miller, L.A., and Maclean, K.N. (2007). The prelamin A pre-peptide induces cardiac and skeletal myoblast differentiation. Biochem. Biophys. Res. Commun. 356, 872-879
-
(2007)
Biochem. Biophys. Res. Commun
, vol.356
, pp. 872-879
-
-
Brodsky, G.L.1
Bowersox, J.A.2
Fitzgerald-Miller, L.3
Miller, L.A.4
MacLean, K.N.5
-
9
-
-
33745915850
-
Nuclear Lamins: Laminopathies and Their Role in Premature Ageing
-
Broers, J.L., Ramaekers, F.C., Bonne, G., Yaou, R.B., and Hutchison, C.J. (2006). Nuclear lamins: laminopathies and their role in premature ageing. Physiol. Rev. 86, 967-1008
-
(2006)
Physiol. Rev
, vol.86
, pp. 967-1008
-
-
Broers, J.L.1
Ramaekers, F.C.2
Bonne, G.3
Yaou, R.B.4
Hutchison, C.J.5
-
10
-
-
0037444824
-
Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans
-
Cadinanos, J., Schmidt, W.K., Fueyo, A., Varela, I., Lopez-Otin, C., and Freije, J.M. (2003). Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Biochem. J. 370, 1047-1054
-
(2003)
Biochem. J
, vol.370
, pp. 1047-1054
-
-
Cadinanos, J.1
Schmidt, W.K.2
Fueyo, A.3
Varela, I.4
Lopez-Otin, C.5
Freije, J.M.6
-
11
-
-
33845286555
-
Human laminopathies: Nuclei gone genetically awry
-
Capell, B.C. and Collins, F.S. (2006). Human laminopathies: nuclei gone genetically awry. Nat. Rev. Genet. 7, 940-952
-
(2006)
Nat. Rev. Genet
, vol.7
, pp. 940-952
-
-
Capell, B.C.1
Collins, F.S.2
-
12
-
-
24644520772
-
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson- Gilford progeria syndrome
-
Capell, B.C., Erdos, M.R., Madigan, J.P., Fiordalisi, J.J., Varga, R., Conneely, K.N., Gordon, L.B., Der, C.J., Cox, A.D., and Collins, F.S. (2005). Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson- Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA 102, 12879-12884
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 12879-12884
-
-
Capell, B.C.1
Erdos, M.R.2
Madigan, J.P.3
Fiordalisi, J.J.4
Varga, R.5
Conneely, K.N.6
Gordon, L.B.7
Der, C.J.8
Cox, A.D.9
Collins, F.S.10
-
13
-
-
34447620100
-
Mechanisms of cardiovascular disease in accelerated aging syndromes
-
Capell, B.C., Collins, F.S., and Nabel, E.G. (2007). Mechanisms of cardiovascular disease in accelerated aging syndromes. Circ. Res. 101, 13-26
-
(2007)
Circ. Res
, vol.101
, pp. 13-26
-
-
Capell, B.C.1
Collins, F.S.2
Nabel, E.G.3
-
14
-
-
57349159315
-
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
-
Capell, B.C., Olive, M., Erdos, M.R., Cao, K., Faddah, D.A., Tavarez, U.L., Conneely, K.N., Qu, X., San, H., Ganesh, S.K., et al. (2008). A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proc. Natl. Acad. Sci. USA 105, 15902-15907
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15902-15907
-
-
Capell, B.C.1
Olive, M.2
Erdos, M.R.3
Cao, K.4
Faddah, D.A.5
Tavarez, U.L.6
Conneely, K.N.7
Qu, X.8
San, H.9
Ganesh, S.K.10
-
15
-
-
1042263432
-
Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation
-
Caron, M., Auclair, M., Sterlingot, H., Kornprobst, M., and Capeau, J. (2003). Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation. AIDS 17, 2437-2444
-
(2003)
AIDS
, vol.17
, pp. 2437-2444
-
-
Caron, M.1
Auclair, M.2
Sterlingot, H.3
Kornprobst, M.4
Capeau, J.5
-
16
-
-
34548713556
-
Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
-
Caron, M., Auclair, M., Donadille, B., Bereziat, V., Guerci, B., Laville, M., Narbonne, H., Bodemer, C., Lascols, O., Capeau, J., et al. (2007). Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. Cell Death Differ. 14, 1759-1767
-
(2007)
Cell Death Differ
, vol.14
, pp. 1759-1767
-
-
Caron, M.1
Auclair, M.2
Donadille, B.3
Bereziat, V.4
Guerci, B.5
Laville, M.6
Narbonne, H.7
Bodemer, C.8
Lascols, O.9
Capeau, J.10
-
17
-
-
0031055072
-
Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor
-
Chen, P., Sapperstein, S.K., Choi, J.D., and Michaelis, S. (1997). Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor. J. Cell Biol. 136, 251-269
-
(1997)
J. Cell Biol
, vol.136
, pp. 251-269
-
-
Chen, P.1
Sapperstein, S.K.2
Choi, J.D.3
Michaelis, S.4
-
18
-
-
35348814977
-
HIV protease inhibitors and nuclear lamin processing: Getting the right bells and whistles
-
Clarke, S.G. (2007). HIV protease inhibitors and nuclear lamin processing: getting the right bells and whistles. Proc. Natl. Acad. Sci. USA 104, 13857-13858
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 13857-13858
-
-
Clarke, S.G.1
-
19
-
-
34548063171
-
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells
-
Coffinier, C., Hudon, S.E., Farber, E.A., Chang, S.Y., Hrycyna, C.A., Young, S.G., and Fong, L.G. (2007). HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc. Natl. Acad. Sci. USA 104, 13432-13437
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 13432-13437
-
-
Coffinier, C.1
Hudon, S.E.2
Farber, E.A.3
Chang, S.Y.4
Hrycyna, C.A.5
Young, S.G.6
Fong, L.G.7
-
20
-
-
44349132197
-
A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells
-
Coffinier, C., Hudon, S.E., Lee, R., Farber, E.A., Nobumori, C., Miner, J.H., Andres, D.A., Spielmann, H.P., Hrycyna, C.A., Fong, L.G., et al. (2008). A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J. Biol. Chem. 283, 9797-9804
-
(2008)
J. Biol. Chem
, vol.283
, pp. 9797-9804
-
-
Coffinier, C.1
Hudon, S.E.2
Lee, R.3
Farber, E.A.4
Nobumori, C.5
Miner, J.H.6
Andres, D.A.7
Spielmann, H.P.8
Hrycyna, C.A.9
Fong, L.G.10
-
21
-
-
0032511057
-
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum
-
Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. (1998). Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J. Biol. Chem. 273, 15030-15034
-
(1998)
J. Biol. Chem
, vol.273
, pp. 15030-15034
-
-
Dai, Q.1
Choy, E.2
Chiu, V.3
Romano, J.4
Slivka, S.R.5
Steitz, S.A.6
Michaelis, S.7
Philips, M.R.8
-
22
-
-
34247383902
-
Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging
-
Dechat, T., Shimi, T., Adam, S.A., Rusinol, A.E., Andres, D.A., Spielmann, H.P., Sinensky, M.S., and Goldman, R.D. (2007). Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. Proc. Natl. Acad. Sci. USA 104, 4955-4960
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4955-4960
-
-
Dechat, T.1
Shimi, T.2
Adam, S.A.3
Rusinol, A.E.4
Andres, D.A.5
Spielmann, H.P.6
Sinensky, M.S.7
Goldman, R.D.8
-
23
-
-
33744985605
-
A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes hutchinson- gilford progeria syndrome (HGPS): Insights into the pathophysiology of HGPS
-
Denecke, J., Brune, T., Feldhaus, T., Robenek, H., Kranz, C., Auchus, R.J., Agarwal, A.K., and Marquardt, T. (2006). A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson- Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hum. Mutat. 27, 524-531
-
(2006)
Hum. Mutat
, vol.27
, pp. 524-531
-
-
Denecke, J.1
Brune, T.2
Feldhaus, T.3
Robenek, H.4
Kranz, C.5
Auchus, R.J.6
Agarwal, A.K.7
Marquardt, T.8
-
24
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
Eriksson, M., Brown, W.T., Gordon, L.B., Glynn, M.W., Singer, J., Scott, L., Erdos, M.R., Robbins, C.M., Moses, T.Y., Berglund, P., et al. (2003). Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423, 293-298
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
Brown, W.T.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
Scott, L.6
Erdos, M.R.7
Robbins, C.M.8
Moses, T.Y.9
Berglund, P.10
-
25
-
-
42049117585
-
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
-
Espada, J., Varela, I., Flores, I., Ugalde, A.P., Cadinanos, J., Pendas, A.M., Stewart, C.L., Tryggvason, K., Blasco, M.A., Freije, J.M., et al. (2008). Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J. Cell Biol. 181, 27-35
-
(2008)
J. Cell Biol
, vol.181
, pp. 27-35
-
-
Espada, J.1
Varela, I.2
Flores, I.3
Ugalde, A.P.4
Cadinanos, J.5
Pendas, A.M.6
Stewart, C.L.7
Tryggvason, K.8
Blasco, M.A.9
Freije, J.M.10
-
26
-
-
19944428509
-
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice
-
Fong, L.G., Ng, J.K., Meta, M., Cote, N., Yang, S.H., Stewart, C.L., Sullivan, T., Burghardt, A., Majumdar, S., Reue, K., et al. (2004). Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. USA 101, 18111-18116
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 18111-18116
-
-
Fong, L.G.1
Ng, J.K.2
Meta, M.3
Cote, N.4
Yang, S.H.5
Stewart, C.L.6
Sullivan, T.7
Burghardt, A.8
Majumdar, S.9
Reue, K.10
-
27
-
-
33645060977
-
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
-
Fong, L.G., Frost, D., Meta, M., Qiao, X., Yang, S.H., Coffinier, C., and Young, S.G. (2006). A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science 311, 1621-1623
-
(2006)
Science
, vol.311
, pp. 1621-1623
-
-
Fong, L.G.1
Frost, D.2
Meta, M.3
Qiao, X.4
Yang, S.H.5
Coffinier, C.6
Young, S.G.7
-
28
-
-
0033564670
-
Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins
-
Freije, J.M., Blay, P., Pendas, A.M., Cadinanos, J., Crespo, P., and Lopez-Otin, C. (1999). Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. Genomics 58, 270-280
-
(1999)
Genomics
, vol.58
, pp. 270-280
-
-
Freije, J.M.1
Blay, P.2
Pendas, A.M.3
Cadinanos, J.4
Crespo, P.5
Lopez-Otin, C.6
-
29
-
-
0031048991
-
A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor
-
Fujimura-Kamada, K., Nouvet, F.J., and Michaelis, S. (1997). A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor. J. Cell Biol. 136, 271-285
-
(1997)
J. Cell Biol
, vol.136
, pp. 271-285
-
-
Fujimura-Kamada, K.1
Nouvet, F.J.2
Michaelis, S.3
-
30
-
-
33748767111
-
Therapeutic intervention based on protein prenylation and associated modifications
-
Gelb, M.H., Brunsveld, L., Hrycyna, C.A., Michaelis, S., Tamanoi, F., Van Voorhis, W.C., and Waldmann, H. (2006). Therapeutic intervention based on protein prenylation and associated modifications. Nat. Chem. Biol. 2, 518-528
-
(2006)
Nat. Chem. Biol
, vol.2
, pp. 518-528
-
-
Gelb, M.H.1
Brunsveld, L.2
Hrycyna, C.A.3
Michaelis, S.4
Tamanoi, F.5
Van Voorhis, W.C.6
Waldmann, H.7
-
31
-
-
27544498316
-
Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition
-
Glynn, M.W. and Glover, T.W. (2005). Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition. Hum. Mol. Genet. 14, 2959-2969
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 2959-2969
-
-
Glynn, M.W.1
Glover, T.W.2
-
32
-
-
11244320353
-
The nuclear lamina comes of age
-
Gruenbaum, Y., Margalit, A., Goldman, R.D., Shumaker, D.K., and Wilson, K.L. (2005). The nuclear lamina comes of age. Nat. Rev. Mol. Cell. Biol. 6, 21-31
-
(2005)
Nat. Rev. Mol. Cell. Biol
, vol.6
, pp. 21-31
-
-
Gruenbaum, Y.1
Margalit, A.2
Goldman, R.D.3
Shumaker, D.K.4
Wilson, K.L.5
-
33
-
-
34548148047
-
Thematic review series: Adipocyte biology. Lipodystrophies: Windows on adipose biology and metabolism
-
Hegele, R.A., Joy, T.R., Al-Attar, S.A., and Rutt, B.K. (2007). Thematic review series: Adipocyte biology. Lipodystrophies: windows on adipose biology and metabolism. J. Lipid Res. 48, 1433-1444
-
(2007)
J. Lipid Res
, vol.48
, pp. 1433-1444
-
-
Hegele, R.A.1
Joy, T.R.2
Al-Attar, S.A.3
Rutt, B.K.4
-
34
-
-
48349108128
-
HIV-protease inhibitors block the enzymatic activity of purified Ste24p
-
Hudon, S.E., Coffinier, C., Michaelis, S., Fong, L.G., Young, S.G., and Hrycyna, C.A. (2008). HIV-protease inhibitors block the enzymatic activity of purified Ste24p. Biochem. Biophys. Res. Commun. 374, 365-368
-
(2008)
Biochem. Biophys. Res. Commun
, vol.374
, pp. 365-368
-
-
Hudon, S.E.1
Coffinier, C.2
Michaelis, S.3
Fong, L.G.4
Young, S.G.5
Hrycyna, C.A.6
-
35
-
-
33748848484
-
Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export
-
Huyer, G., Kistler, A., Nouvet, F.J., George, C.M., Boyle, M.L., and Michaelis, S. (2006). Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export. Eukaryot. Cell 5, 1560-1570
-
(2006)
Eukaryot. Cell
, vol.5
, pp. 1560-1570
-
-
Huyer, G.1
Kistler, A.2
Nouvet, F.J.3
George, C.M.4
Boyle, M.L.5
Michaelis, S.6
-
36
-
-
0025184422
-
Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum
-
Jackson, M.R., Nilsson, T., and Peterson, P.A. (1990). Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO J. 9, 3153-3162
-
(1990)
EMBO J
, vol.9
, pp. 3153-3162
-
-
Jackson, M.R.1
Nilsson, T.2
Peterson, P.A.3
-
37
-
-
35148898709
-
New approaches to progeria
-
Kieran, M.W., Gordon, L., and Kleinman, M. (2007). New approaches to progeria. Pediatrics 120, 834-841
-
(2007)
Pediatrics
, vol.120
, pp. 834-841
-
-
Kieran, M.W.1
Gordon, L.2
Kleinman, M.3
-
38
-
-
0033034937
-
Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p
-
Kumagai, H., Kawamura, Y., Yanagisawa, K., and Komano, H. (1999). Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p. Biochim. Biophys. Acta 1426, 468-474
-
(1999)
Biochim. Biophys. Acta
, vol.1426
, pp. 468-474
-
-
Kumagai, H.1
Kawamura, Y.2
Yanagisawa, K.3
Komano, H.4
-
39
-
-
0035800833
-
Biochemical studies of Zmpste24-deficient mice
-
Leung, G.K., Schmidt, W.K., Bergo, M.O., Gavino, B., Wong, D.H., Tam, A., Ashby, M.N., Michaelis, S., and Young, S.G. (2001). Biochemical studies of Zmpste24-deficient mice. J. Biol. Chem. 276, 29051-29058
-
(2001)
J. Biol. Chem
, vol.276
, pp. 29051-29058
-
-
Leung, G.K.1
Schmidt, W.K.2
Bergo, M.O.3
Gavino, B.4
Wong, D.H.5
Tam, A.6
Ashby, M.N.7
Michaelis, S.8
Young, S.G.9
-
40
-
-
22544466685
-
Genomic instability in laminopathy-based premature aging
-
Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J.D., Li, K.M., Chau, P.Y., Chen, D.J., et al. (2005). Genomic instability in laminopathy-based premature aging. Nat. Med. 11, 780-785
-
(2005)
Nat. Med
, vol.11
, pp. 780-785
-
-
Liu, B.1
Wang, J.2
Chan, K.M.3
Tjia, W.M.4
Deng, W.5
Guan, X.6
Huang, J.D.7
Li, K.M.8
Chau, P.Y.9
Chen, D.J.10
-
41
-
-
33845699084
-
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
-
Liu, Y., Rusinol, A., Sinensky, M., Wang, Y., and Zou, Y. (2006). DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J. Cell Sci. 119, 4644-4649
-
(2006)
J. Cell Sci
, vol.119
, pp. 4644-4649
-
-
Liu, Y.1
Rusinol, A.2
Sinensky, M.3
Wang, Y.4
Zou, Y.5
-
42
-
-
0026559677
-
Nucleoplasmic localization of prelamin A: Implications for prenylation-dependent lamin A assembly into the nuclear lamina
-
Lutz, R.J., Trujillo, M.A., Denham, K.S., Wenger, L., and Sinensky, M. (1992). Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina. Proc. Natl. Acad. Sci. USA 89, 3000-3004
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 3000-3004
-
-
Lutz, R.J.1
Trujillo, M.A.2
Denham, K.S.3
Wenger, L.4
Sinensky, M.5
-
43
-
-
26444463068
-
Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutch inson-Gilford progeria syndrome
-
Mallampalli, M.P., Huyer, G., Bendale, P., Gelb, M.H., and Michaelis, S. (2005). Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutch inson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA 102, 14416-14421
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14416-14421
-
-
Mallampalli, M.P.1
Huyer, G.2
Bendale, P.3
Gelb, M.H.4
Michaelis, S.5
-
44
-
-
35148833800
-
Small-molecule inhibitors of the rce1p caax protease
-
Manandhar, S.P., Hildebrandt, E.R., and Schmidt, W.K. (2007). Small-molecule inhibitors of the Rce1p CaaX protease. J. Biomol. Screen. 12, 983-993
-
(2007)
J. Biomol. Screen
, vol.12
, pp. 983-993
-
-
Manandhar, S.P.1
Hildebrandt, E.R.2
Schmidt, W.K.3
-
45
-
-
46249086799
-
Premature aging in mice activates a systemic metabolic response involving autophagy induction
-
Marino, G., Ugalde, A.P., Salvador-Montoliu, N., Varela, I., Quiros, P.M., Cadinanos, J., van der Pluijm, I., Freije, J.M., and Lopez-Otin, C. (2008). Premature aging in mice activates a systemic metabolic response involving autophagy induction. Hum. Mol. Genet. 17, 2196-2211
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. 2196-2211
-
-
Marino, G.1
Ugalde, A.P.2
Salvador-Montoliu, N.3
Varela, I.4
Quiros, P.M.5
Cadinanos, J.6
Van Der Pluijm, I.7
Freije, J.M.8
Lopez-Otin, C.9
-
46
-
-
33646536969
-
Nuclear lamins, diseases and aging
-
Mattout, A., Dechat, T., Adam, S.A., Goldman, R.D., and Gruenbaum, Y. (2006). Nuclear lamins, diseases and aging. Curr. Opin. Cell Biol. 18, 335-341
-
(2006)
Curr. Opin. Cell Biol
, vol.18
, pp. 335-341
-
-
Mattout, A.1
Dechat, T.2
Adam, S.A.3
Goldman, R.D.4
Gruenbaum, Y.5
-
47
-
-
41649101975
-
The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin
-
McClintock, D., Ratner, D., Lokuge, M., Owens, D.M., Gordon, L.B., Collins, F.S., and Djabali, K. (2007). The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS ONE 2, e1269
-
(2007)
PLoS ONE
, vol.2
-
-
McClintock, D.1
Ratner, D.2
Lokuge, M.3
Owens, D.M.4
Gordon, L.B.5
Collins, F.S.6
Djabali, K.7
-
48
-
-
33749130220
-
Protein farnesyltransferase inhibitors and progeria
-
Meta, M., Yang, S.H., Bergo, M.O., Fong, L.G., and Young, S.G. (2006). Protein farnesyltransferase inhibitors and progeria. Trends Mol. Med. 12, 480-487
-
(2006)
Trends Mol. Med
, vol.12
, pp. 480-487
-
-
Meta, M.1
Yang, S.H.2
Bergo, M.O.3
Fong, L.G.4
Young, S.G.5
-
49
-
-
43449130399
-
Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two japanese siblings
-
Miyoshi, Y., Akagi, M., Agarwal, A.K., Namba, N., Kato-Nishimura, K., Mohri, I., Yamagata, M., Nakajima, S., Mushiake, S., Shima, M., et al. (2008). Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings. Clin. Genet. 73, 535-544
-
(2008)
Clin. Genet
, vol.73
, pp. 535-544
-
-
Miyoshi, Y.1
Akagi, M.2
Agarwal, A.K.3
Namba, N.4
Kato-Nishimura, K.5
Mohri, I.6
Yamagata, M.7
Nakajima, S.8
Mushiake, S.9
Shima, M.10
-
50
-
-
67449131556
-
Restrictive dermopathy-a lethal congenital laminopathy. Case report and review of the literature
-
Morais, P., Magina, S., do Ribeiro, M., Rodrigues, M., Lopes, J.M., Thanh, H.L., Wehnert, M., and Guimarã es, H. (2009). Restrictive dermopathy-a lethal congenital laminopathy. Case report and review of the literature. Eur. J. Pediatr. 168, 1007-1012
-
(2009)
Eur. J. Pediatr
, Issue.168
, pp. 1007-1012
-
-
Morais, P.1
Magina, S.2
Do Ribeiro, M.3
Rodrigues, M.4
Lopes, J.M.5
Thanh, H.L.6
Wehnert, M.7
Guimarã Es, H.8
-
51
-
-
30844451421
-
Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy
-
Moulson, C.L., Go, G., Gardner, J.M., van der Wal, A.C., Smitt, J.H., van Hagen, J.M., and Miner, J.H. (2005). Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. J. Invest. Dermatol. 125, 913-919
-
(2005)
J. Invest. Dermatol
, vol.125
, pp. 913-919
-
-
Moulson, C.L.1
Go, G.2
Gardner, J.M.3
Van Der Wal, A.C.4
Smitt, J.H.5
Van Hagen, J.M.6
Miner, J.H.7
-
52
-
-
34848882814
-
Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes
-
Moulson, C.L., Fong, L.G., Gardner, J.M., Farber, E.A., Go, G., Passariello, A., Grange, D.K., Young, S.G., and Miner, J.H. (2007). Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. Hum. Mutat. 28, 882-889
-
(2007)
Hum. Mutat
, vol.28
, pp. 882-889
-
-
Moulson, C.L.1
Fong, L.G.2
Gardner, J.M.3
Farber, E.A.4
Go, G.5
Passariello, A.6
Grange, D.K.7
Young, S.G.8
Miner, J.H.9
-
53
-
-
19544374472
-
Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy
-
Navarro, C.L., De Sandre-Giovannoli, A., Bernard, R., Boccaccio, I., Boyer, A., Genevieve, D., Hadj-Rabia, S., Gaudy-Marqueste, C., Smitt, H.S., Vabres, P., et al. (2004). Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. Hum. Mol. Genet. 13, 2493-2503
-
(2004)
Hum. Mol. Genet
, vol.13
, pp. 2493-2503
-
-
Navarro, C.L.1
De Sandre-Giovannoli, A.2
Bernard, R.3
Boccaccio, I.4
Boyer, A.5
Genevieve, D.6
Hadj-Rabia, S.7
Gaudy-Marqueste, C.8
Smitt, H.S.9
Vabres, P.10
-
54
-
-
20444506041
-
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors
-
Navarro, C.L., Cadinanos, J., De Sandre-Giovannoli, A., Bernard, R., Courrier, S., Boccaccio, I., Boyer, A., Kleijer,W.J.,Wagner, A., Giuliano, F., et al. (2005). Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. Hum. Mol. Genet. 14, 1503-1513
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 1503-1513
-
-
Navarro, C.L.1
Cadinanos, J.2
De Sandre-Giovannoli, A.3
Bernard, R.4
Courrier, S.5
Boccaccio, I.6
Boyer, A.7
Kleijerw, A.8
Giuliano, F.9
-
55
-
-
58349098943
-
Accelerated ageing: From mechanism to therapy through animal models
-
Osorio, F.G., Obaya, A.J., Lopez-Otin, C., and Freije, J.M. (2009). Accelerated ageing: from mechanism to therapy through animal models. Transgenic Res. 18, 7-15
-
(2009)
Transgenic Res
, vol.18
, pp. 7-15
-
-
Osorio, F.G.1
Obaya, A.J.2
Lopez-Otin, C.3
Freije, J.M.4
-
56
-
-
0036578920
-
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase- deficient mice
-
Pendas, A.M., Zhou, Z., Cadinanos, J., Freije, J.M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodriguez, F., Tryggvason, K., et al. (2002). Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase- deficient mice. Nat. Genet. 31, 94-99
-
(2002)
Nat. Genet
, vol.31
, pp. 94-99
-
-
Pendas, A.M.1
Zhou, Z.2
Cadinanos, J.3
Freije, J.M.4
Wang, J.5
Hultenby, K.6
Astudillo, A.7
Wernerson, A.8
Rodriguez, F.9
Tryggvason, K.10
-
57
-
-
34249690834
-
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones
-
Porter, S.B., Hildebrandt, E.R., Breevoort, S.R., Mokry, D.Z., Dore, T.M., and Schmidt, W.K. (2007). Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones. Biochim. Biophys. Acta 1773, 853-862
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 853-862
-
-
Porter, S.B.1
Hildebrandt, E.R.2
Breevoort, S.R.3
Mokry, D.Z.4
Dore, T.M.5
Schmidt, W.K.6
-
58
-
-
33846484332
-
Human progeroid syndromes, aging and cancer: New genetic and epigenetic insights into old questions
-
Ramirez, C.L., Cadinanos, J., Varela, I., Freije, J.M., and Lopez- Otin, C. (2007). Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell. Mol. Life Sci. 64, 155-170
-
(2007)
Cell. Mol. Life Sci
, Issue.64
, pp. 155-170
-
-
Ramirez, C.L.1
Cadinanos, J.2
Varela, I.3
Freije, J.M.4
Lopez- Otin, C.5
-
59
-
-
33748296316
-
The laminopathies: A clinical review
-
Rankin, J. and Ellard, S. (2006). The laminopathies: a clinical review. Clin. Genet. 70, 261-274
-
(2006)
Clin. Genet
, vol.70
, pp. 261-274
-
-
Rankin, J.1
Ellard, S.2
-
60
-
-
60149098422
-
An ABC transporter controls export of a Drosophila germ cell attractant
-
Ricardo, S. and Lehmann, R. (2009). An ABC transporter controls export of a Drosophila germ cell attractant. Science 323, 943-946
-
(2009)
Science
, vol.323
, pp. 943-946
-
-
Ricardo, S.1
Lehmann, R.2
-
61
-
-
67649188781
-
Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging
-
Epublication ahead of print;doi DOI: 10.1038/ejhg.2008.270.
-
Rodriguez, S., Coppede, F., Sagelius, H., and Eriksson, M. (2009). Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging. Eur. J. Hum. Genet., epublication ahead of print; DOI: 10.1038/ejhg.2008.270.
-
(2009)
Eur. J. Hum. Genet
-
-
Rodriguez, S.1
Coppede, F.2
Sagelius, H.3
Eriksson, M.4
-
62
-
-
0035157562
-
Topological and mutational analysis of Saccharomyces cerevisiae Ste14p, founding member of the isoprenylcysteine carboxyl methyltransferase family
-
Romano, J.D. and Michaelis, S. (2001). Topological and mutational analysis of Saccharomyces cerevisiae Ste14p, founding member of the isoprenylcysteine carboxyl methyltransferase family. Mol. Biol. Cell 12, 1957-1971
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1957-1971
-
-
Romano, J.D.1
Michaelis, S.2
-
63
-
-
33748760066
-
Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors
-
Rusinol, A.E. and Sinensky, M.S. (2006). Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors. J. Cell Sci. 119, 3265-3272
-
(2006)
J. Cell Sci
, vol.119
, pp. 3265-3272
-
-
Rusinol, A.E.1
Sinensky, M.S.2
-
64
-
-
51849099004
-
A newly identified splice site mutation in ZMPSTE24 causes restrictive dermopathy in the Middle East
-
Sander, C.S., Salman, N., van Geel, M., Broers, J.L., Al-Rahmani, A., Chedid, F., Hausser, I., Oji, V., Al Nuaimi, K., Berger, T.G., and Verstraeten, V.L., (2008). A newly identified splice site mutation in ZMPSTE24 causes restrictive dermopathy in the Middle East. Br. J. Dermatol. 159, 961-967
-
(2008)
Br. J. Dermatol
, vol.159
, pp. 961-967
-
-
Sander, C.S.1
Salman, N.2
Van Geel, M.3
Broers, J.L.4
Al-Rahmani, A.5
Chedid, F.6
Hausser, I.7
Oji, V.8
Al Nuaimi, K.9
Berger, T.G.10
Verstraeten, V.L.11
-
65
-
-
0028831126
-
Lamin A precursor is localized to intranuclear foci
-
Sasseville, A.M. and Raymond, Y. (1995). Lamin A precursor is localized to intranuclear foci. J. Cell Sci. 108, 273-285
-
(1995)
J. Cell Sci
, vol.108
, pp. 273-285
-
-
Sasseville, A.M.1
Raymond, Y.2
-
66
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging
-
Scaffidi, P. and Misteli, T. (2006). Lamin A-dependent nuclear defects in human aging. Science 312, 1059-1063
-
(2006)
Science
, vol.312
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
67
-
-
43149124203
-
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
-
Scaffidi, P. and Misteli, T. (2008). Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat. Cell Biol. 10, 452-459
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 452-459
-
-
Scaffidi, P.1
Misteli, T.2
-
68
-
-
27844561561
-
The cell nucleus and aging: Tantalizing clues and hopeful promises
-
Scaffidi, P., Gordon, L., and Misteli, T. (2005). The cell nucleus and aging: tantalizing clues and hopeful promises. PLoS Biol. 3, e395
-
(2005)
PLoS Biol
, vol.3
-
-
Scaffidi, P.1
Gordon, L.2
Misteli, T.3
-
69
-
-
30844465108
-
The Ste24p protease
-
A.J. Barrett, N. Rawlings and J.F. Woessner, eds. (London, UK: Academic Press)
-
Schmidt, W.K. and Michaelis, S. (2004). The Ste24p protease. In: Handbook of Proteolytic Enzymes, 2nd edn., A.J. Barrett, N. Rawlings and J.F. Woessner, eds. (London, UK: Academic Press), pp. 460-465
-
(2004)
Handbook of Proteolytic Enzymes, 2nd Edn
, pp. 460-465
-
-
Schmidt, W.K.1
Michaelis, S.2
-
70
-
-
0032530150
-
Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxylterminal CAAX protein processing and amino-terminal afactor cleavage
-
Schmidt, W.K., Tam, A., Fujimura-Kamada, K., and Michaelis, S. (1998). Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxylterminal CAAX protein processing and amino-terminal afactor cleavage. Proc. Natl. Acad. Sci. USA 95, 11175-11180
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11175-11180
-
-
Schmidt, W.K.1
Tam, A.2
Fujimura-Kamada, K.3
Michaelis, S.4
-
71
-
-
0034052099
-
Reconstitution of the Ste24p-dependent N-terminal proteolytic step in yeast a-factor biogenesis
-
Schmidt, W.K., Tam, A., and Michaelis, S. (2000). Reconstitution of the Ste24p-dependent N-terminal proteolytic step in yeast a-factor biogenesis. J. Biol. Chem. 275, 6227-6233
-
(2000)
J. Biol. Chem
, vol.275
, pp. 6227-6233
-
-
Schmidt, W.K.1
Tam, A.2
Michaelis, S.3
-
72
-
-
26844489762
-
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
-
Schuldiner, M., Collins, S.R., Thompson, N.J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J.F., et al. (2005). Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123, 507-519
-
(2005)
Cell
, vol.123
, pp. 507-519
-
-
Schuldiner, M.1
Collins, S.R.2
Thompson, N.J.3
Denic, V.4
Bhamidipati, A.5
Punna, T.6
Ihmels, J.7
Andrews, B.8
Boone, C.9
Greenblatt, J.F.10
-
73
-
-
30844469352
-
Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype
-
Shackleton, S., Smallwood, D.T., Clayton, P., Wilson, L.C., Agarwal, A.K., Garg, A., and Trembath, R.C. (2005). Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype. J. Med. Genet. 42, e36
-
(2005)
J. Med. Genet
, vol.42
-
-
Shackleton, S.1
Smallwood, D.T.2
Clayton, P.3
Wilson, L.C.4
Agarwal, A.K.5
Garg, A.6
Trembath, R.C.7
-
74
-
-
33745016642
-
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
-
Shumaker, D.K., Dechat, T., Kohlmaier, A., Adam, S.A., Bozovsky, M.R., Erdos, M.R., Eriksson, M., Goldman, A.E., Khuon, S., Collins, F.S., et al. (2006). Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc. Natl. Acad. Sci. USA 103, 8703-8708
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 8703-8708
-
-
Shumaker, D.K.1
Dechat, T.2
Kohlmaier, A.3
Adam, S.A.4
Bozovsky, M.R.5
Erdos, M.R.6
Eriksson, M.7
Goldman, A.E.8
Khuon, S.9
Collins, F.S.10
-
75
-
-
0028118904
-
The processing pathway of prelamin A
-
Sinensky, M., Fantle, K., Trujillo, M., McLain, T., Kupfer, A., and Dalton, M. (1994). The processing pathway of prelamin A. J. Cell Sci. 107, 61-67
-
(1994)
J. Cell Sci
, vol.107
, pp. 61-67
-
-
Sinensky, M.1
Fantle, K.2
Trujillo, M.3
McLain, T.4
Kupfer, A.5
Dalton, M.6
-
76
-
-
0033615969
-
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
-
Sullivan, T., Escalante-Alcalde, D., Bhatt, H., Anver, M., Bhat, N., Nagashima, K., Stewart, C.L., and Burke, B. (1999). Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J. Cell Biol. 147, 913-920
-
(1999)
J. Cell Biol
, vol.147
, pp. 913-920
-
-
Sullivan, T.1
Escalante-Alcalde, D.2
Bhatt, H.3
Anver, M.4
Bhat, N.5
Nagashima, K.6
Stewart, C.L.7
Burke, B.8
-
77
-
-
0031874938
-
Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOHterminal CAAX processing
-
Tam, A., Nouvet, F.J., Fujimura-Kamada, K., Slunt, H., Sisodia, S.S., and Michaelis, S. (1998). Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOHterminal CAAX processing. J. Cell Biol. 142, 635-649
-
(1998)
J. Cell Biol
, vol.142
, pp. 635-649
-
-
Tam, A.1
Nouvet, F.J.2
Fujimura-Kamada, K.3
Slunt, H.4
Sisodia, S.S.5
Michaelis, S.6
-
78
-
-
0035861547
-
The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor
-
Tam, A., Schmidt, W.K., and Michaelis, S. (2001). The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. J. Biol. Chem. 276, 46798-46806
-
(2001)
J. Biol. Chem
, vol.276
, pp. 46798-46806
-
-
Tam, A.1
Schmidt, W.K.2
Michaelis, S.3
-
79
-
-
0036223875
-
Yeast genes controlling responses to topogenic signals in a model transmembrane protein
-
Tipper, D.J. and Harley, C.A. (2002). Yeast genes controlling responses to topogenic signals in a model transmembrane protein. Mol. Biol. Cell 13, 1158-1174
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 1158-1174
-
-
Tipper, D.J.1
Harley, C.A.2
-
80
-
-
24644459728
-
Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
-
Toth, J.I., Yang, S.H., Qiao, X., Beigneux, A.P., Gelb, M.H., Moulson, C.L., Miner, J.H., Young, S.G., and Fong, L.G. (2005). Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc. Natl. Acad. Sci. USA 102, 12873-12878
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 12873-12878
-
-
Toth, J.I.1
Yang, S.H.2
Qiao, X.3
Beigneux, A.P.4
Gelb, M.H.5
Moulson, C.L.6
Miner, J.H.7
Young, S.G.8
Fong, L.G.9
-
81
-
-
0034724520
-
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
-
Travers, K.J., Patil, C.K., Wodicka, L., Lockhart, D.J., Weissman, J.S., and Walter, P. (2000). Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101, 249-258
-
(2000)
Cell
, vol.101
, pp. 249-258
-
-
Travers, K.J.1
Patil, C.K.2
Wodicka, L.3
Lockhart, D.J.4
Weissman, J.S.5
Walter, P.6
-
82
-
-
0034119314
-
The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities
-
Trueblood, C.E., Boyartchuk, V.L., Picologlou, E.A., Rozema, D., Poulter, C.D., and Rine, J. (2000). The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities. Mol. Cell. Biol. 20, 4381-4392
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 4381-4392
-
-
Trueblood, C.E.1
Boyartchuk, V.L.2
Picologlou, E.A.3
Rozema, D.4
Poulter, C.D.5
Rine, J.6
-
83
-
-
25644440744
-
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
-
Varela, I., Cadinanos, J., Pendas, A.M., Gutierrez-Fernandez, A., Folgueras, A.R., Sanchez, L.M., Zhou, Z., Rodriguez, F.J., Stewart, C.L., Vega, J.A., et al. (2005). Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437, 564-568
-
(2005)
Nature
, vol.437
, pp. 564-568
-
-
Varela, I.1
Cadinanos, J.2
Pendas, A.M.3
Gutierrez-Fernandez, A.4
Folgueras, A.R.5
Sanchez, L.M.6
Zhou, Z.7
Rodriguez, F.J.8
Stewart, C.L.9
Vega, J.A.10
-
84
-
-
46849106102
-
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
-
Varela, I., Pereira, S., Ugalde, A.P., Navarro, C.L., Suarez, M.F., Cau, P., Cadinanos, J., Osorio, F.G., Foray, N., Cobo, J., et al. (2008). Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat. Med. 14, 767-772
-
(2008)
Nat. Med
, vol.14
, pp. 767-772
-
-
Varela, I.1
Pereira, S.2
Ugalde, A.P.3
Navarro, C.L.4
Suarez, M.F.5
Cau, P.6
Cadinanos, J.7
Osorio, F.G.8
Foray, N.9
Cobo, J.10
-
85
-
-
18344394166
-
Post-prenylation-processing enzymes as new targets in oncogenesis
-
Winter-Vann, A.M. and Casey, P.J. (2005). Post-prenylation-processing enzymes as new targets in oncogenesis. Nat. Rev. Cancer 5, 405-412
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 405-412
-
-
Winter-Vann, A.M.1
Casey, P.J.2
-
86
-
-
34249788998
-
Laminopathies': A wide spectrum of human diseases
-
Worman, H.J. and Bonne, G. (2007). 'Laminopathies': a wide spectrum of human diseases. Exp. Cell Res. 313, 2121-2133
-
(2007)
Exp. Cell Res
, vol.313
, pp. 2121-2133
-
-
Worman, H.J.1
Bonne, G.2
-
87
-
-
33646777423
-
Thematic review series: Lipid posttranslational modifications. CAAX modification and membrane targeting of Ras
-
Wright, L.P. and Philips, M.R. (2006). Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. J. Lipid Res. 47, 883-891
-
(2006)
J. Lipid Res
, vol.47
, pp. 883-891
-
-
Wright, L.P.1
Philips, M.R.2
-
88
-
-
22544440839
-
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson- Gilford progeria syndrome mutation
-
Yang, S.H., Bergo, M.O., Toth, J.I., Qiao, X., Hu, Y., Sandoval, S., Meta, M., Bendale, P., Gelb, M.H., Young, S.G., et al. (2005). Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson- Gilford progeria syndrome mutation. Proc. Natl. Acad. Sci. USA 102, 10291-10296
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10291-10296
-
-
Yang, S.H.1
Bergo, M.O.2
Toth, J.I.3
Qiao, X.4
Hu, Y.5
Sandoval, S.6
Meta, M.7
Bendale, P.8
Gelb, M.H.9
Young, S.G.10
-
89
-
-
33746715642
-
A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
-
Yang, S.H., Meta, M., Qiao, X., Frost, D., Bauch, J., Coffinier, C., Majumdar, S., Bergo, M.O., Young, S.G., and Fong, L.G. (2006). A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J. Clin. Invest. 116, 2115-2121
-
(2006)
J. Clin. Invest
, vol.116
, pp. 2115-2121
-
-
Yang, S.H.1
Meta, M.2
Qiao, X.3
Frost, D.4
Bauch, J.5
Coffinier, C.6
Majumdar, S.7
Bergo, M.O.8
Young, S.G.9
Fong, L.G.10
-
90
-
-
39049111972
-
Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation
-
Yang, S.H., Qiao, X., Fong, L.G., and Young, S.G. (2008). Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. Biochim. Biophys. Acta 1781, 36-39
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 36-39
-
-
Yang, S.H.1
Qiao, X.2
Fong, L.G.3
Young, S.G.4
-
91
-
-
30844434561
-
Prelamin A, Zmpste24, misshapen cell nuclei, and progeria-new evidence suggesting that protein farnesylation could be important for disease pathogenesis
-
Young, S.G., Fong, L.G., and Michaelis, S. (2005). Prelamin A, Zmpste24, misshapen cell nuclei, and progeria-new evidence suggesting that protein farnesylation could be important for disease pathogenesis. J. Lipid Res. 46, 2531-2558
-
(2005)
J. Lipid Res
, vol.46
, pp. 2531-2558
-
-
Young, S.G.1
Fong, L.G.2
Michaelis, S.3
-
92
-
-
33845998966
-
Prelamin A farnesylation and progeroid syndromes
-
Young, S.G., Meta, M., Yang, S.H., and Fong, L.G. (2006). Prelamin A farnesylation and progeroid syndromes. J. Biol. Chem. 281, 39741-39745
-
(2006)
J. Biol. Chem
, vol.281
, pp. 39741-39745
-
-
Young, S.G.1
Meta, M.2
Yang, S.H.3
Fong, L.G.4
-
93
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang, F.L. and Casey, P.J. (1996). Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65, 241-269
-
(1996)
Annu. Rev. Biochem
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
|