메뉴 건너뛰기




Volumn 73, Issue 2, 2009, Pages 205-218

Intra-articular drug delivery systems for the treatment of rheumatic diseases: A review of the factors influencing their performance

Author keywords

Depot formulation; Drug delivery; Intra articular; Liposomes; Microparticles; Nanoparticles; Osteoarthritis; Review; Rheumatoid arthritis

Indexed keywords

ADALIMUMAB; BETAMETHASONE SODIUM PHOSPHATE; CALCIUM ALGINATE; CELECOXIB; CHITOSAN; CORTICOSTEROID; DEXAMETHASONE; DICLOFENAC; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; FLURBIPROFEN; GELATIN; INFLIXIMAB; KETOPROFEN; LIPOSOME; METHOTREXATE; MICROSPHERE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NANOPARTICLE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHOSPHOLIPID; POLYGLACTIN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TACROLIMUS; TRIAMCINOLONE ACETONIDE; UNINDEXED DRUG; VERTEPORFIN;

EID: 70349335682     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.06.009     Document Type: Review
Times cited : (141)

References (166)
  • 1
    • 85182489357 scopus 로고    scopus 로고
    • Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition
    • Studer R.K., Bergman R., Stubbs T., and Decker K. Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther. 6 (2004) R56-R64
    • (2004) Arthritis Res. Ther. , vol.6
    • Studer, R.K.1    Bergman, R.2    Stubbs, T.3    Decker, K.4
  • 2
    • 16244421738 scopus 로고    scopus 로고
    • Inactivation of p38 kinase delays the onset of senescence in rabbit articuilar chondrocytes
    • Kang S., Jung M., Kim C.W., and Shin D.Y. Inactivation of p38 kinase delays the onset of senescence in rabbit articuilar chondrocytes. Mech. Ageing Dev. 126 (2005) 591-597
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 591-597
    • Kang, S.1    Jung, M.2    Kim, C.W.3    Shin, D.Y.4
  • 3
    • 0034887261 scopus 로고    scopus 로고
    • VX-745, Vertex pharmaceuticals
    • Haddad J.J. VX-745, Vertex pharmaceuticals. Curr. Opin. Invest. Drugs 2 (2001) 1070-1076
    • (2001) Curr. Opin. Invest. Drugs , vol.2 , pp. 1070-1076
    • Haddad, J.J.1
  • 4
    • 0035040946 scopus 로고    scopus 로고
    • IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase
    • Kumar S., Votta B.J., Rieman D.J., Badger A.M., Gowen M., and Lee J.C. IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase. J. Cell. Physiol. 187 (2001) 294-303
    • (2001) J. Cell. Physiol. , vol.187 , pp. 294-303
    • Kumar, S.1    Votta, B.J.2    Rieman, D.J.3    Badger, A.M.4    Gowen, M.5    Lee, J.C.6
  • 5
    • 0038179379 scopus 로고    scopus 로고
    • Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis
    • Pargellis C., and Regan J. Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis. Curr. Opin. Invest. Drugs 4 (2003) 566-571
    • (2003) Curr. Opin. Invest. Drugs , vol.4 , pp. 566-571
    • Pargellis, C.1    Regan, J.2
  • 6
    • 14244269637 scopus 로고    scopus 로고
    • p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-β
    • Studer R.K., and Chu C.R. p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-β. J. Orthop. Res. 23 (2005) 454-461
    • (2005) J. Orthop. Res. , vol.23 , pp. 454-461
    • Studer, R.K.1    Chu, C.R.2
  • 7
    • 33645215052 scopus 로고    scopus 로고
    • Septic knee arthritis after intra-articular hyaluronate injection: two case reports
    • Albert C., Brocq O., Gerard D., Roux C., and Euller-Ziegler L. Septic knee arthritis after intra-articular hyaluronate injection: two case reports. Joint Bone Spine 73 (2006) 205-207
    • (2006) Joint Bone Spine , vol.73 , pp. 205-207
    • Albert, C.1    Brocq, O.2    Gerard, D.3    Roux, C.4    Euller-Ziegler, L.5
  • 10
    • 0028928330 scopus 로고
    • Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response
    • Gaffney K., Ledingham J., and Perry J.D. Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response. Ann. Rheum. Dis. 54 (1995) 379-381
    • (1995) Ann. Rheum. Dis. , vol.54 , pp. 379-381
    • Gaffney, K.1    Ledingham, J.2    Perry, J.D.3
  • 11
    • 0018387798 scopus 로고
    • Electron microscopic study of depot corticosteroid crystals with clinical studies after intra-articular injection
    • Gordon G.V., and Schumacher H.R. Electron microscopic study of depot corticosteroid crystals with clinical studies after intra-articular injection. J. Rheumatol. 61 (1978) 7-14
    • (1978) J. Rheumatol. , vol.61 , pp. 7-14
    • Gordon, G.V.1    Schumacher, H.R.2
  • 12
    • 33646704714 scopus 로고    scopus 로고
    • Crystal-induced arthropathies: recent investigative advances
    • Ellman M.H., and Becker M.A. Crystal-induced arthropathies: recent investigative advances. Curr. Opin. Rheumatol. 18 (2006) 249-255
    • (2006) Curr. Opin. Rheumatol. , vol.18 , pp. 249-255
    • Ellman, M.H.1    Becker, M.A.2
  • 13
    • 0006260294 scopus 로고
    • Steroid induced arthropathy
    • Tosu T. Steroid induced arthropathy. J. Joint Surg. 11 (1992) 87-95
    • (1992) J. Joint Surg. , vol.11 , pp. 87-95
    • Tosu, T.1
  • 14
    • 0004513581 scopus 로고    scopus 로고
    • Arthrocentesis technique and intraarticular therapy
    • Koopman W.J., and Moreland L.W. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Moore G.F. Arthrocentesis technique and intraarticular therapy. In: Koopman W.J., and Moreland L.W. (Eds). Arthritis and Allied Conditions - A Textbook of Rheumatology (2005), Lippincott Williams & Wilkins, Philadelphia 775-785
    • (2005) Arthritis and Allied Conditions - A Textbook of Rheumatology , pp. 775-785
    • Moore, G.F.1
  • 15
    • 55749091798 scopus 로고    scopus 로고
    • Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders
    • Larsen C., Øsergaard J., Larsen S.W., Jensen H., Jacobsen S., Lindegaard C., and Andersen A.H. Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders. J. Pharm. Sci. 97 (2008) 4622-4654
    • (2008) J. Pharm. Sci. , vol.97 , pp. 4622-4654
    • Larsen, C.1    Øsergaard, J.2    Larsen, S.W.3    Jensen, H.4    Jacobsen, S.5    Lindegaard, C.6    Andersen, A.H.7
  • 16
    • 54049149432 scopus 로고    scopus 로고
    • Drug delivery systems for the treatment of rheumatoid arthritis
    • Tarner I.H., and Muller-Ladner U. Drug delivery systems for the treatment of rheumatoid arthritis. Exp. Opin. Drug Deliv. 5 (2008) 1027-1037
    • (2008) Exp. Opin. Drug Deliv. , vol.5 , pp. 1027-1037
    • Tarner, I.H.1    Muller-Ladner, U.2
  • 18
    • 54149083949 scopus 로고    scopus 로고
    • Stem cell transplantation for rheumatic autoimmune diseases
    • Hugle T., and van Laar J.M. Stem cell transplantation for rheumatic autoimmune diseases. Arthritis Res. Ther. 10 (2008)
    • (2008) Arthritis Res. Ther. , vol.10
    • Hugle, T.1    van Laar, J.M.2
  • 19
    • 33845882484 scopus 로고    scopus 로고
    • Biologic therapies in rheumatology: lessons, learned future directions
    • Strand V., Kimberly R., and Isaacs J.D. Biologic therapies in rheumatology: lessons, learned future directions. Nat. Rev. Drug Discov. 6 (2007) 75-92
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 75-92
    • Strand, V.1    Kimberly, R.2    Isaacs, J.D.3
  • 20
    • 0023881194 scopus 로고
    • The synovial membrane in osteoarthritis: a histological study including the characterization of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies
    • Revell P.A., Mayston V., and Lalor P. The synovial membrane in osteoarthritis: a histological study including the characterization of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann. Rheum. Dis. 47 (1988) 300-307
    • (1988) Ann. Rheum. Dis. , vol.47 , pp. 300-307
    • Revell, P.A.1    Mayston, V.2    Lalor, P.3
  • 21
    • 0002943987 scopus 로고
    • Anatomy, biology, and biomechanics of tendon ligament and meniscus
    • Simon S.R. (Ed), American Academy of Orthopaedic Surgeons, Chicago
    • Woo S.L.Y., An K.N., and Arnoczky S.P. Anatomy, biology, and biomechanics of tendon ligament and meniscus. In: Simon S.R. (Ed). Orthopaedic Basic Science (1994), American Academy of Orthopaedic Surgeons, Chicago 45-88
    • (1994) Orthopaedic Basic Science , pp. 45-88
    • Woo, S.L.Y.1    An, K.N.2    Arnoczky, S.P.3
  • 22
    • 0000239182 scopus 로고
    • Fine structure of joints
    • Sokoloff L. (Ed), Academic, San Diego
    • Ghadially F.N. Fine structure of joints. In: Sokoloff L. (Ed). The Joints and Synovial Fluid (1978), Academic, San Diego 105-168
    • (1978) The Joints and Synovial Fluid , pp. 105-168
    • Ghadially, F.N.1
  • 23
    • 0002118906 scopus 로고
    • Form and function of articular cartilage
    • Simon S.R. (Ed), American Academy of Orthopaedic Surgeons, Chicago
    • Mankin H.J., and Mow V.C. Form and function of articular cartilage. In: Simon S.R. (Ed). Orthopaedic Basic Science (1994), American Academy of Orthopaedic Surgeons, Chicago 2-44
    • (1994) Orthopaedic Basic Science , pp. 2-44
    • Mankin, H.J.1    Mow, V.C.2
  • 25
    • 0030198629 scopus 로고    scopus 로고
    • Surface and subsurface morphology of bovine humeral articular cartilage by atomic force transmission electron microscopy
    • Jurvelin J.S., Müller D.J., Wong M., and Suder D. Surface and subsurface morphology of bovine humeral articular cartilage by atomic force transmission electron microscopy. J. Struct. Biol. 117 (1996) 45-54
    • (1996) J. Struct. Biol. , vol.117 , pp. 45-54
    • Jurvelin, J.S.1    Müller, D.J.2    Wong, M.3    Suder, D.4
  • 26
    • 68749089598 scopus 로고    scopus 로고
    • Surface topography of viable articular cartilage measured with scanning white light interferometry
    • in press
    • V.K. Shekhawat, M.P. Laurent, C. Muehlman, M.A. Wimmer, Surface topography of viable articular cartilage measured with scanning white light interferometry, Osteoarthr. Cartil., 2009, in press.
    • (2009) Osteoarthr. Cartil
    • Shekhawat, V.K.1    Laurent, M.P.2    Muehlman, C.3    Wimmer, M.A.4
  • 27
    • 0029781306 scopus 로고    scopus 로고
    • Glycosaminoglycan concentration in synovium and other tissues of rabbit knee in relation to synovial hydraulic resistance
    • Price F.M., Levick J.R., and Mason R.M. Glycosaminoglycan concentration in synovium and other tissues of rabbit knee in relation to synovial hydraulic resistance. J. Physiol. 495 (1996) 803-820
    • (1996) J. Physiol. , vol.495 , pp. 803-820
    • Price, F.M.1    Levick, J.R.2    Mason, R.M.3
  • 28
    • 70349323813 scopus 로고    scopus 로고
    • Observations on the volume, viscosity and nitrogen content of synovial fluid with a note on the histological appearance of synovial membrane
    • Davies D.V. Observations on the volume, viscosity and nitrogen content of synovial fluid with a note on the histological appearance of synovial membrane. J. Anat. 78 (2003) 68-78
    • (2003) J. Anat. , vol.78 , pp. 68-78
    • Davies, D.V.1
  • 29
    • 0001884202 scopus 로고    scopus 로고
    • Etiopathogenesis of osteoarthritis
    • Moskowitz R.W., Howell D.S., Altman R.D., Buckwalter J.A., and Goldberg V.M. (Eds), Diagnosis and Medical/Surgical Management, W.B. Saunders Company, Philadelphia
    • Poole A.R., and Howell D.S. Etiopathogenesis of osteoarthritis. In: Moskowitz R.W., Howell D.S., Altman R.D., Buckwalter J.A., and Goldberg V.M. (Eds). Osteoarthritis (2001), Diagnosis and Medical/Surgical Management, W.B. Saunders Company, Philadelphia 29-47
    • (2001) Osteoarthritis , pp. 29-47
    • Poole, A.R.1    Howell, D.S.2
  • 30
    • 0347480219 scopus 로고    scopus 로고
    • Rheumatoid arthritis: regulation of synovial inflammation
    • Sweeney S.E., and Firestein G.S. Rheumatoid arthritis: regulation of synovial inflammation. Int. J. Biochem. Cell Biol. 36 (2004) 372-378
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 372-378
    • Sweeney, S.E.1    Firestein, G.S.2
  • 31
    • 0002924042 scopus 로고
    • Molecular and cellular biology of inflammation and neoplasia
    • Simon S.R. (Ed), American academy of orthopaedic surgeons, Rosemont
    • Springfield D.S., Bolander M.E., Friedlaender G.E., and Lane N. Molecular and cellular biology of inflammation and neoplasia. In: Simon S.R. (Ed). Orthopaedic Basic Science (1994), American academy of orthopaedic surgeons, Rosemont 219-276
    • (1994) Orthopaedic Basic Science , pp. 219-276
    • Springfield, D.S.1    Bolander, M.E.2    Friedlaender, G.E.3    Lane, N.4
  • 34
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy E.H., and Panayi G.S. Cytokine pathways and joint inflammation in rheumatoid arthritis. New Engl. J. Med. 344 (2001) 907-916
    • (2001) New Engl. J. Med. , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 35
    • 0033926254 scopus 로고    scopus 로고
    • Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis
    • Chabaud M., Garnero P., Dayer J.M., Guerne P.A., Fossiez F., and Miossec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine 12 (2000) 1092-1099
    • (2000) Cytokine , vol.12 , pp. 1092-1099
    • Chabaud, M.1    Garnero, P.2    Dayer, J.M.3    Guerne, P.A.4    Fossiez, F.5    Miossec, P.6
  • 37
    • 33646698188 scopus 로고    scopus 로고
    • Epidemiology of osteoarthritis: an update
    • Sharma L., Kapoor D., and Issa S. Epidemiology of osteoarthritis: an update. Curr. Opin. Rheumatol. 18 (2006) 147-156
    • (2006) Curr. Opin. Rheumatol. , vol.18 , pp. 147-156
    • Sharma, L.1    Kapoor, D.2    Issa, S.3
  • 39
    • 0028806589 scopus 로고
    • Guidelines for the medical management of osteoarthritis
    • Hochberg M.C., Altman R.D., and Brandt K.D. Guidelines for the medical management of osteoarthritis. Arthritis Rheum. 38 (1995) 1535-1540
    • (1995) Arthritis Rheum. , vol.38 , pp. 1535-1540
    • Hochberg, M.C.1    Altman, R.D.2    Brandt, K.D.3
  • 40
    • 0034757564 scopus 로고    scopus 로고
    • A critique of the 2000 update of the American College of Rheumatology recommendations for management of hip and knee osteoarthritis
    • Brandt K.D. A critique of the 2000 update of the American College of Rheumatology recommendations for management of hip and knee osteoarthritis. Arthritis Rheum. 44 (2001) 2451-2455
    • (2001) Arthritis Rheum. , vol.44 , pp. 2451-2455
    • Brandt, K.D.1
  • 43
    • 33344467770 scopus 로고    scopus 로고
    • Osteoarthritis of the knee
    • Felson D.T. Osteoarthritis of the knee. New Engl. J. Med. 354 (2006) 841-848
    • (2006) New Engl. J. Med. , vol.354 , pp. 841-848
    • Felson, D.T.1
  • 44
    • 33645650115 scopus 로고    scopus 로고
    • Nonsurgical management of osteoarthritis of the knee
    • Michael L.T., and Kelley T. Nonsurgical management of osteoarthritis of the knee. JAAPA 19 (2006) 26-32
    • (2006) JAAPA , vol.19 , pp. 26-32
    • Michael, L.T.1    Kelley, T.2
  • 47
    • 0002369199 scopus 로고    scopus 로고
    • Management of osteoarthritis
    • Koopman W.J., and Moreland L.W. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Lozada C.J., and Altman R.D. Management of osteoarthritis. In: Koopman W.J., and Moreland L.W. (Eds). Arthritis and Allied Conditions - A Textbook of Rheumatology (2005), Lippincott Williams & Wilkins, Philadelphia 2257-2276
    • (2005) Arthritis and Allied Conditions - A Textbook of Rheumatology , pp. 2257-2276
    • Lozada, C.J.1    Altman, R.D.2
  • 48
    • 0242375646 scopus 로고    scopus 로고
    • The pharmacological treatment of osteoarthritis
    • Moskowitz R.W., Howell D.S., Altman R.D., Buckwalter J.A., and Goldberg V.M. (Eds), W.B. Saunders Company, Philadelphia
    • Simon L.S., and Stand V. The pharmacological treatment of osteoarthritis. In: Moskowitz R.W., Howell D.S., Altman R.D., Buckwalter J.A., and Goldberg V.M. (Eds). Osteoarthritis (2001), W.B. Saunders Company, Philadelphia 371-391
    • (2001) Osteoarthritis , pp. 371-391
    • Simon, L.S.1    Stand, V.2
  • 49
    • 3242685960 scopus 로고    scopus 로고
    • Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? - a meta-analysis of randomised controlled trials
    • Zhang W., Jones A., and Doherty M. Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? - a meta-analysis of randomised controlled trials. Ann. Rheum. Dis. 63 (2004) 901-907
    • (2004) Ann. Rheum. Dis. , vol.63 , pp. 901-907
    • Zhang, W.1    Jones, A.2    Doherty, M.3
  • 50
    • 4344661128 scopus 로고    scopus 로고
    • Comparison of luminacoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomized controlled trial
    • Schnitzer T., Burmester G.R., Mysler E., Hochberg M.C., Doherty M., Ehrsam E., Gitton X., Krammer G., Mellein B., Matchaba P., GImona A., and Hawley C. Comparison of luminacoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomized controlled trial. Lancet 363 (2004) 665-674
    • (2004) Lancet , vol.363 , pp. 665-674
    • Schnitzer, T.1    Burmester, G.R.2    Mysler, E.3    Hochberg, M.C.4    Doherty, M.5    Ehrsam, E.6    Gitton, X.7    Krammer, G.8    Mellein, B.9    Matchaba, P.10    GImona, A.11    Hawley, C.12
  • 51
    • 0038124335 scopus 로고    scopus 로고
    • Corticosteroid compared with hyaluronic acid injections for the treatment of osteoarthritis of the knee. A prospective, randomized trial
    • Leopold S.S., Redd B.B., Warme W.J., Wehrle P.A., Pettis P.D., and Shott S. Corticosteroid compared with hyaluronic acid injections for the treatment of osteoarthritis of the knee. A prospective, randomized trial. J. Bone Joint Surg. Am. 85-A (2003) 1197-1203
    • (2003) J. Bone Joint Surg. Am. , vol.85 -A , pp. 1197-1203
    • Leopold, S.S.1    Redd, B.B.2    Warme, W.J.3    Wehrle, P.A.4    Pettis, P.D.5    Shott, S.6
  • 52
    • 34547427477 scopus 로고    scopus 로고
    • Glucosamine for pain in osteoarthritis: why do trial results differ?
    • Vlad S.C., LaValley M.P., McAlindon T.E., and Felson D.T. Glucosamine for pain in osteoarthritis: why do trial results differ?. Arthritis Rheum. 56 (2007) 2267-2277
    • (2007) Arthritis Rheum. , vol.56 , pp. 2267-2277
    • Vlad, S.C.1    LaValley, M.P.2    McAlindon, T.E.3    Felson, D.T.4
  • 53
    • 27344443286 scopus 로고    scopus 로고
    • Nutritional factors and osteoarthritis: recent developments
    • McAlindon T.E., and Biggee B.A. Nutritional factors and osteoarthritis: recent developments. Curr. Opin. Rheumatol. 17 (2005) 647-652
    • (2005) Curr. Opin. Rheumatol. , vol.17 , pp. 647-652
    • McAlindon, T.E.1    Biggee, B.A.2
  • 54
    • 0035109130 scopus 로고    scopus 로고
    • Pharmacotherapy of rheumatoid arthritis: an overview
    • El Desoky E.S. Pharmacotherapy of rheumatoid arthritis: an overview. Curr. Ther. Res. 62 (2001) 92-112
    • (2001) Curr. Ther. Res. , vol.62 , pp. 92-112
    • El Desoky, E.S.1
  • 55
    • 2342627946 scopus 로고    scopus 로고
    • Leflunomide in the treatment of rheumatoid arthritis
    • Li E.K., Tam L.-S., and Tomlinson B. Leflunomide in the treatment of rheumatoid arthritis. Clin. Ther. 26 (2004) 447-459
    • (2004) Clin. Ther. , vol.26 , pp. 447-459
    • Li, E.K.1    Tam, L.-S.2    Tomlinson, B.3
  • 56
    • 34247161833 scopus 로고    scopus 로고
    • Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis
    • Kitahara K., and Kawai S. Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis. Curr. Opin. Rheumatol. 19 (2007) 238-245
    • (2007) Curr. Opin. Rheumatol. , vol.19 , pp. 238-245
    • Kitahara, K.1    Kawai, S.2
  • 57
    • 33645276306 scopus 로고    scopus 로고
    • Safety of tacrolimus, an immunosuppressive agent, in the treatment of rheumatoid arthritis in elderly patients
    • Kawai S., and Yamamoto K. Safety of tacrolimus, an immunosuppressive agent, in the treatment of rheumatoid arthritis in elderly patients. Rheumatology (Oxford) 45 (2006) 441-444
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 441-444
    • Kawai, S.1    Yamamoto, K.2
  • 59
    • 33747338728 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibitors for rheumatoid arthritis
    • Scott D.L., and Kingsley G.H. Tumor necrosis factor inhibitors for rheumatoid arthritis. Reply, New Engl. J. Med. 355 (2006) 2048
    • (2006) Reply, New Engl. J. Med. , vol.355 , pp. 2048
    • Scott, D.L.1    Kingsley, G.H.2
  • 60
    • 53149127993 scopus 로고    scopus 로고
    • Rituximab: a new therapeutic alternative in rheumatoid arthritis
    • Sibilia J., Gottenberg J.E., and Mariette X. Rituximab: a new therapeutic alternative in rheumatoid arthritis. Joint Bone Spine 75 (2008) 526-532
    • (2008) Joint Bone Spine , vol.75 , pp. 526-532
    • Sibilia, J.1    Gottenberg, J.E.2    Mariette, X.3
  • 62
    • 85047104233 scopus 로고    scopus 로고
    • Accuracy of needle placement into the intra-articular space of the knee
    • Dabke V H. Accuracy of needle placement into the intra-articular space of the knee. J. Bone Joint Surg. Am. 86-A (2004) 433-434
    • (2004) J. Bone Joint Surg. Am. , vol.86 -A , pp. 433-434
    • Dabke V, H.1
  • 63
    • 85047103235 scopus 로고    scopus 로고
    • Accuracy of needle placement into the intra-articular space of the knee
    • Post III J.H. Accuracy of needle placement into the intra-articular space of the knee. J. Bone Joint Surg. Am. 85-A (2003) 2481
    • (2003) J. Bone Joint Surg. Am. , vol.85 -A , pp. 2481
    • Post III, J.H.1
  • 64
    • 0036713362 scopus 로고    scopus 로고
    • Accuracy of needle placement into the intra-articular space of the knee
    • Jackson D.W., Evans N.A., and Thomas B.M. Accuracy of needle placement into the intra-articular space of the knee. J. Bone Joint Surg. Am. 84-A (2002) 1522-1527
    • (2002) J. Bone Joint Surg. Am. , vol.84 -A , pp. 1522-1527
    • Jackson, D.W.1    Evans, N.A.2    Thomas, B.M.3
  • 65
    • 77953370804 scopus 로고    scopus 로고
    • Intra-articular therapy
    • Moskowitz R.W., Howell D.S., Altman R.D., Buckwalter J.A., and Goldberg V.M. (Eds), W.B. Saunders Company, Philadelphia
    • Neustadt D.H. Intra-articular therapy. In: Moskowitz R.W., Howell D.S., Altman R.D., Buckwalter J.A., and Goldberg V.M. (Eds). Osteoarthritis (2001), W.B. Saunders Company, Philadelphia 393-411
    • (2001) Osteoarthritis , pp. 393-411
    • Neustadt, D.H.1
  • 66
    • 0034749190 scopus 로고    scopus 로고
    • Injections in the treatment of osteoarthritis
    • Ayral X. Injections in the treatment of osteoarthritis. Best Pract. Res. Clin. Rheumatol. 15 (2001) 609-626
    • (2001) Best Pract. Res. Clin. Rheumatol. , vol.15 , pp. 609-626
    • Ayral, X.1
  • 67
    • 29244445850 scopus 로고    scopus 로고
    • The structure and function of joints
    • Koopman W.J., and Moreland L.W. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Wooley P.H., Grimm M.J., and Radin E.L. The structure and function of joints. In: Koopman W.J., and Moreland L.W. (Eds). Arthritis and Allied Conditions - A Textbook of Rheumatology (2005), Lippincott Williams & Wilkins, Philadelphia 149-175
    • (2005) Arthritis and Allied Conditions - A Textbook of Rheumatology , pp. 149-175
    • Wooley, P.H.1    Grimm, M.J.2    Radin, E.L.3
  • 68
    • 0020024368 scopus 로고
    • Ultrastructural evidence for two distinct types of synoviocytes in rat synovial membrane
    • Graabæk P.M. Ultrastructural evidence for two distinct types of synoviocytes in rat synovial membrane. J. Ultrastruct. Res. 78 (1982) 321-339
    • (1982) J. Ultrastruct. Res. , vol.78 , pp. 321-339
    • Graabæk, P.M.1
  • 69
    • 28244432880 scopus 로고    scopus 로고
    • Hyaluronan secretion by synoviocytes is mechanosensitive
    • Momberger T.S., Levick J.R., and Mason R.M. Hyaluronan secretion by synoviocytes is mechanosensitive. Matrix Biol. 24 (2005) 510-519
    • (2005) Matrix Biol. , vol.24 , pp. 510-519
    • Momberger, T.S.1    Levick, J.R.2    Mason, R.M.3
  • 70
    • 33745228622 scopus 로고    scopus 로고
    • Structure and functions of synoviocytes
    • Koopman W.J., and Moreland L.W. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Müller-Ladner U., Gay R.E., and Gay S. Structure and functions of synoviocytes. In: Koopman W.J., and Moreland L.W. (Eds). Arthritis and Allied Conditions - A Textbook of Rheumatology (2005), Lippincott Williams & Wilkins, Philadelphia 271-287
    • (2005) Arthritis and Allied Conditions - A Textbook of Rheumatology , pp. 271-287
    • Müller-Ladner, U.1    Gay, R.E.2    Gay, S.3
  • 71
    • 0026785741 scopus 로고
    • Light microscopic characterization of the fibroblast-like synovial intimal cell (synoviocyte)
    • Wilkinson L.S., Pitsillides A.A., Worrall J.G., and Edwards J.C.W. Light microscopic characterization of the fibroblast-like synovial intimal cell (synoviocyte). Arthritis Rheum. 35 (1992) 1179-1184
    • (1992) Arthritis Rheum. , vol.35 , pp. 1179-1184
    • Wilkinson, L.S.1    Pitsillides, A.A.2    Worrall, J.G.3    Edwards, J.C.W.4
  • 72
    • 33747262692 scopus 로고    scopus 로고
    • Ultrastructural study of cells at the synovium-cartilage junction: response of synovial cells of the rat knee joint to intra-articularly injected latex particles
    • Senda H., Sakuma E., Wada I., Wang H.J., Maruyama H., and Matsui N. Ultrastructural study of cells at the synovium-cartilage junction: response of synovial cells of the rat knee joint to intra-articularly injected latex particles. Acta Anat. Nippon. 74 (1999) 525-535
    • (1999) Acta Anat. Nippon. , vol.74 , pp. 525-535
    • Senda, H.1    Sakuma, E.2    Wada, I.3    Wang, H.J.4    Maruyama, H.5    Matsui, N.6
  • 73
    • 0019834651 scopus 로고
    • Permeability of the rheumatoid and normal synovium to specific plasma proteins
    • Levick J.R. Permeability of the rheumatoid and normal synovium to specific plasma proteins. Arthritis Rheum. 24 (1981) 1550-1560
    • (1981) Arthritis Rheum. , vol.24 , pp. 1550-1560
    • Levick, J.R.1
  • 74
    • 70349315736 scopus 로고    scopus 로고
    • Synovial physiology
    • Koopman W.J., and Moreland L.W. (Eds), Lippincott, Williams & Wilkins, Philadelphia
    • Simkin P.A. Synovial physiology. In: Koopman W.J., and Moreland L.W. (Eds). Arthritis and Allied Conditions - A Textbook of Rheumatology (2005), Lippincott, Williams & Wilkins, Philadelphia
    • (2005) Arthritis and Allied Conditions - A Textbook of Rheumatology
    • Simkin, P.A.1
  • 75
    • 0022256060 scopus 로고
    • Antibiotic absorption from infected and normal joints using a rabbit knee joint model
    • Schurman D.J., and Kajiyama G. Antibiotic absorption from infected and normal joints using a rabbit knee joint model. J. Orthop. Res. 3 (1985) 185-188
    • (1985) J. Orthop. Res. , vol.3 , pp. 185-188
    • Schurman, D.J.1    Kajiyama, G.2
  • 76
    • 0030680907 scopus 로고    scopus 로고
    • Hyaluronan secretion into the synovial cavity of rabbit knees and comparison with albumin turnover
    • Coleman P.J., Scott D., Ray J., Mason R.M., and Levick J.R. Hyaluronan secretion into the synovial cavity of rabbit knees and comparison with albumin turnover. J. Physiol. 503 (1997) 645-656
    • (1997) J. Physiol. , vol.503 , pp. 645-656
    • Coleman, P.J.1    Scott, D.2    Ray, J.3    Mason, R.M.4    Levick, J.R.5
  • 78
    • 0035093660 scopus 로고    scopus 로고
    • A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis
    • Song J., Suh C.H., Park Y.B., Lee S.H., Yoo N.C., Lee J.D., Kim K.H., and Lee S.K. A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis. Eur. J. Nucl. Med. 28 (2001) 489-497
    • (2001) Eur. J. Nucl. Med. , vol.28 , pp. 489-497
    • Song, J.1    Suh, C.H.2    Park, Y.B.3    Lee, S.H.4    Yoo, N.C.5    Lee, J.D.6    Kim, K.H.7    Lee, S.K.8
  • 79
    • 0017198768 scopus 로고
    • Liposomal retention of a modified anti-inflammatory steroid
    • Shaw I.H., Knight C.G., and Dingle J.T. Liposomal retention of a modified anti-inflammatory steroid. Biochem. J. 158 (1976) 473-476
    • (1976) Biochem. J. , vol.158 , pp. 473-476
    • Shaw, I.H.1    Knight, C.G.2    Dingle, J.T.3
  • 80
    • 0023567361 scopus 로고
    • Studies of pharmacokinetics and therapeutic effects of glucocorticoids entrapped in liposomes after intraarticular application in healthy rabbits and in rabbits with antigen-induced arthritis
    • Bonanomi M.H., Velvart M., Stimpel M., Roos K.M., Fehr K., and Weder H.G. Studies of pharmacokinetics and therapeutic effects of glucocorticoids entrapped in liposomes after intraarticular application in healthy rabbits and in rabbits with antigen-induced arthritis. Rheumatol. Int. 7 (1987) 203-212
    • (1987) Rheumatol. Int. , vol.7 , pp. 203-212
    • Bonanomi, M.H.1    Velvart, M.2    Stimpel, M.3    Roos, K.M.4    Fehr, K.5    Weder, H.G.6
  • 81
    • 0029739322 scopus 로고    scopus 로고
    • A single intra-articular injection of liposomally conjugated methotrexate suppresses joint inflammation in rat antigen-induced arthritis
    • Williams A.S., Camilleri J.P., Goodfellow R.M., and Williams B.D. A single intra-articular injection of liposomally conjugated methotrexate suppresses joint inflammation in rat antigen-induced arthritis. Br. J. Rheumatol. 35 (1996) 719-724
    • (1996) Br. J. Rheumatol. , vol.35 , pp. 719-724
    • Williams, A.S.1    Camilleri, J.P.2    Goodfellow, R.M.3    Williams, B.D.4
  • 82
    • 0030933795 scopus 로고    scopus 로고
    • Comparison of systemic absorption of aqueous and liposomal lidocaine following intra-articular injection in rabbits
    • Hou S.-M., and Yu H.-Y. Comparison of systemic absorption of aqueous and liposomal lidocaine following intra-articular injection in rabbits. J. Formos. Med. Assoc. 96 (1997) 141-142
    • (1997) J. Formos. Med. Assoc. , vol.96 , pp. 141-142
    • Hou, S.-M.1    Yu, H.-Y.2
  • 84
    • 36248986201 scopus 로고    scopus 로고
    • Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic marker
    • Edwards S.H.R., Cake M.A., Spoelstra G., and Read R.A. Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic marker. J. Liposome Res. 17 (2007) 249-261
    • (2007) J. Liposome Res. , vol.17 , pp. 249-261
    • Edwards, S.H.R.1    Cake, M.A.2    Spoelstra, G.3    Read, R.A.4
  • 85
    • 34547516520 scopus 로고    scopus 로고
    • Preparation and evaluation of biodegradable flurbiprofen gelatin micro-spheres for intra-articular administration
    • Lu Y., Zhang G., Sun D., and Zhong Y. Preparation and evaluation of biodegradable flurbiprofen gelatin micro-spheres for intra-articular administration. J. Microencapsul. 24 (2007) 515-524
    • (2007) J. Microencapsul. , vol.24 , pp. 515-524
    • Lu, Y.1    Zhang, G.2    Sun, D.3    Zhong, Y.4
  • 86
    • 4444325013 scopus 로고    scopus 로고
    • Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints
    • Thakkar H., Sharma R.K., Mishra A.K., Chuttani K., and Murthy R.S.R. Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints. J. Pharm. Pharmacol. 56 (2004) 1091-1099
    • (2004) J. Pharm. Pharmacol. , vol.56 , pp. 1091-1099
    • Thakkar, H.1    Sharma, R.K.2    Mishra, A.K.3    Chuttani, K.4    Murthy, R.S.R.5
  • 87
    • 1842429963 scopus 로고    scopus 로고
    • Methotrexate loaded poly(l-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint
    • Liang L., Jackson J., Min W., Risovic V., Wasan K.M., and Burt H.M. Methotrexate loaded poly(l-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint. J. Pharm. Sci. 93 (2003) 943-956
    • (2003) J. Pharm. Sci. , vol.93 , pp. 943-956
    • Liang, L.1    Jackson, J.2    Min, W.3    Risovic, V.4    Wasan, K.M.5    Burt, H.M.6
  • 88
    • 21344449508 scopus 로고    scopus 로고
    • Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbits
    • Liang L.S., Wong W., and Burt H.M. Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbits. J. Pharm. Sci. 94 (2005) 1204-1215
    • (2005) J. Pharm. Sci. , vol.94 , pp. 1204-1215
    • Liang, L.S.1    Wong, W.2    Burt, H.M.3
  • 89
    • 39749198122 scopus 로고    scopus 로고
    • Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage
    • Rothenfluh D.A., Bermudez H., O'Neil C.P., and Hubbell J.A. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat. Mater. 7 (2008) 248-254
    • (2008) Nat. Mater. , vol.7 , pp. 248-254
    • Rothenfluh, D.A.1    Bermudez, H.2    O'Neil, C.P.3    Hubbell, J.A.4
  • 90
    • 33646381864 scopus 로고    scopus 로고
    • Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis
    • Koning G.A., Schiffelers R.M., Wauben M.H., Kok R.J., Mastrobattista E., Molema G., ten Hagen T.L.M., and Storm G. Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arthritis Rheum. 54 (2006) 1198-1208
    • (2006) Arthritis Rheum. , vol.54 , pp. 1198-1208
    • Koning, G.A.1    Schiffelers, R.M.2    Wauben, M.H.3    Kok, R.J.4    Mastrobattista, E.5    Molema, G.6    ten Hagen, T.L.M.7    Storm, G.8
  • 91
    • 33646378394 scopus 로고    scopus 로고
    • Targeting the inflamed synovium: the quest for selectivity
    • Garrood T., and Pitzalis C. Targeting the inflamed synovium: the quest for selectivity. Arthritis Rheum. 54 (2006) 1055-1060
    • (2006) Arthritis Rheum. , vol.54 , pp. 1055-1060
    • Garrood, T.1    Pitzalis, C.2
  • 92
    • 70349338089 scopus 로고    scopus 로고
    • Lipidated glycoprotein particles and methods of use,
    • Patent No. WO/2006/017195, 2006
    • R. Margalit, D. Peer, Lipidated glycoprotein particles and methods of use, Patent No. WO/2006/017195, 2006.
    • Margalit, R.1    Peer, D.2
  • 93
    • 18644366540 scopus 로고    scopus 로고
    • Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilage defects in a rabbit model
    • Tanaka H., Sugita T., Yasunaga Y., Shimose S., Deie M., Kubo T., Murakami T., and Ochi M. Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilage defects in a rabbit model. J. Biomed. Mater. Res. A 73A (2005) 255-263
    • (2005) J. Biomed. Mater. Res. A , vol.73 A , pp. 255-263
    • Tanaka, H.1    Sugita, T.2    Yasunaga, Y.3    Shimose, S.4    Deie, M.5    Kubo, T.6    Murakami, T.7    Ochi, M.8
  • 94
    • 67449119169 scopus 로고    scopus 로고
    • Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, and in vitro and in vivo drug release
    • Butoescu N., Jordan O., Burdet P., Hebert C., Stadelmann P., Petri-Fink A., Hofmann H., and Doelker E. Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, and in vitro and in vivo drug release. Eur. J. Pharm. Biopharm. 72 (2009) 529-538
    • (2009) Eur. J. Pharm. Biopharm. , vol.72 , pp. 529-538
    • Butoescu, N.1    Jordan, O.2    Burdet, P.3    Hebert, C.4    Stadelmann, P.5    Petri-Fink, A.6    Hofmann, H.7    Doelker, E.8
  • 95
    • 47749137867 scopus 로고    scopus 로고
    • Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery
    • Butoescu N., Jordan O., Petri-Fink A., Hofmann H., and Doelker E. Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery. J. Micoencapsul. 25 (2008) 339-350
    • (2008) J. Micoencapsul. , vol.25 , pp. 339-350
    • Butoescu, N.1    Jordan, O.2    Petri-Fink, A.3    Hofmann, H.4    Doelker, E.5
  • 96
    • 67649424761 scopus 로고    scopus 로고
    • Magnetically retainable microparticles for drug delivery to the joint: efficacy studies on an antigen-induced arthritis model in mice
    • Butoescu N., Seemayer C.A., Palmer G., Guerne P.-A., Gabay C., Doelker E., and Jordan O. Magnetically retainable microparticles for drug delivery to the joint: efficacy studies on an antigen-induced arthritis model in mice. Arthritis Res. Ther. 11 (2009) R72
    • (2009) Arthritis Res. Ther. , vol.11
    • Butoescu, N.1    Seemayer, C.A.2    Palmer, G.3    Guerne, P.-A.4    Gabay, C.5    Doelker, E.6    Jordan, O.7
  • 99
    • 7344255442 scopus 로고
    • Liposomes as steroid carriers in the intra-articular therapy of rheumatoid arthritis
    • Gregoriadis G., and Allison A.C. (Eds), John Wiley & Sons, Ltd., London pp. 299-324
    • Shaw I.H., and Dingle J.T. Liposomes as steroid carriers in the intra-articular therapy of rheumatoid arthritis. In: Gregoriadis G., and Allison A.C. (Eds). Liposomes in Biological Systems (1980), John Wiley & Sons, Ltd., London pp. 299-324
    • (1980) Liposomes in Biological Systems
    • Shaw, I.H.1    Dingle, J.T.2
  • 100
    • 0023636450 scopus 로고
    • Fate of different kinds of liposomes containing dexamethasone palmitate after intra-articular injection into rabbit joints
    • Bonanomi M.H., Velvart M., and Weder H.G. Fate of different kinds of liposomes containing dexamethasone palmitate after intra-articular injection into rabbit joints. J. Microencapsul. 4 (1987) 189-200
    • (1987) J. Microencapsul. , vol.4 , pp. 189-200
    • Bonanomi, M.H.1    Velvart, M.2    Weder, H.G.3
  • 104
    • 0027234537 scopus 로고
    • The synovial response to intraarticular injection in rats of polyethylene wear particles
    • Howie D.W., Manthey B., Hay S., and Vernon-Roberts B. The synovial response to intraarticular injection in rats of polyethylene wear particles. Clin. Orthop. Relat. Res. 292 (1993) 352-357
    • (1993) Clin. Orthop. Relat. Res. , vol.292 , pp. 352-357
    • Howie, D.W.1    Manthey, B.2    Hay, S.3    Vernon-Roberts, B.4
  • 105
    • 0036182057 scopus 로고    scopus 로고
    • Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium
    • Horisawa E., Kubota K., Tuboi I., Sato K., Yamamoto H., Takeuchi H., and Kawashima Y. Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium. Pharm. Res. 19 (2002) 132-139
    • (2002) Pharm. Res. , vol.19 , pp. 132-139
    • Horisawa, E.1    Kubota, K.2    Tuboi, I.3    Sato, K.4    Yamamoto, H.5    Takeuchi, H.6    Kawashima, Y.7
  • 106
    • 0032859167 scopus 로고    scopus 로고
    • Fate of biodegradable d,l-lactic acid oligomer microspheres in the articulus
    • Nishide M., Kamei S., Takakura Y., and Tamai S. Fate of biodegradable d,l-lactic acid oligomer microspheres in the articulus. J. Bioact. Compat. Polym. 14 (1999) 385-398
    • (1999) J. Bioact. Compat. Polym. , vol.14 , pp. 385-398
    • Nishide, M.1    Kamei, S.2    Takakura, Y.3    Tamai, S.4
  • 107
    • 0021234749 scopus 로고
    • Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs
    • Ratcliffe J.H., Hunneyball I.M., Smith A., Wilson C.G., and Davis S.S. Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs. J. Pharm. Pharmacol. 36 (1984) 431-436
    • (1984) J. Pharm. Pharmacol. , vol.36 , pp. 431-436
    • Ratcliffe, J.H.1    Hunneyball, I.M.2    Smith, A.3    Wilson, C.G.4    Davis, S.S.5
  • 108
    • 0023127212 scopus 로고
    • Albumin microspheres for intra-articular drug-delivery: investigation of their retention in normal and arthritic knee joints of rabbits
    • Ratcliffe J.H., Hunneyball I.M., Wilson C.G., Smith A., and Davis S.S. Albumin microspheres for intra-articular drug-delivery: investigation of their retention in normal and arthritic knee joints of rabbits. J. Pharm. Pharmacol. 39 (1986) 290-295
    • (1986) J. Pharm. Pharmacol. , vol.39 , pp. 290-295
    • Ratcliffe, J.H.1    Hunneyball, I.M.2    Wilson, C.G.3    Smith, A.4    Davis, S.S.5
  • 109
    • 0344097408 scopus 로고    scopus 로고
    • Bioabsorbable microspheres for local drug release in the articulus
    • Ramesh D.V., Tabata Y., and Ikada Y. Bioabsorbable microspheres for local drug release in the articulus. J. Bioact. Compat. Polym. 14 (1999) 137-149
    • (1999) J. Bioact. Compat. Polym. , vol.14 , pp. 137-149
    • Ramesh, D.V.1    Tabata, Y.2    Ikada, Y.3
  • 110
    • 4344579795 scopus 로고    scopus 로고
    • Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits
    • Liggins R.T., Cruz T., Min W., Liang L., Hunter W.L., and Burt H.M. Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits. Inflamm. Res. 53 (2004) 363-372
    • (2004) Inflamm. Res. , vol.53 , pp. 363-372
    • Liggins, R.T.1    Cruz, T.2    Min, W.3    Liang, L.4    Hunter, W.L.5    Burt, H.M.6
  • 111
    • 0034925520 scopus 로고    scopus 로고
    • Phospholipid composition of articular cartilage boundary lubricant
    • Sarma A.V., Powell G.L., and LaBerge M. Phospholipid composition of articular cartilage boundary lubricant. J. Orthop. Res. 19 (2001) 671-676
    • (2001) J. Orthop. Res. , vol.19 , pp. 671-676
    • Sarma, A.V.1    Powell, G.L.2    LaBerge, M.3
  • 112
    • 0019324697 scopus 로고
    • Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro
    • Kirby C., Clarke J., and Gregoriadis G. Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro. Biochem. J. 186 (1980) 591-598
    • (1980) Biochem. J. , vol.186 , pp. 591-598
    • Kirby, C.1    Clarke, J.2    Gregoriadis, G.3
  • 113
    • 0021275457 scopus 로고
    • The effects of charge and size on the interaction of unilamellar liposomes with macrophages
    • Schwendener R.A., Lagocki P.A., and Rahman Y.E. The effects of charge and size on the interaction of unilamellar liposomes with macrophages. Biochim. Biophys. Acta, Biomembr. 772 (1984) 93-101
    • (1984) Biochim. Biophys. Acta, Biomembr. , vol.772 , pp. 93-101
    • Schwendener, R.A.1    Lagocki, P.A.2    Rahman, Y.E.3
  • 114
    • 0018691960 scopus 로고
    • Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis
    • Phillips N.C., Page Thomas D.P., Knight C.G., and Dingle J.T. Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis. Ann. Rheum. Dis. 38 (1979) 553-557
    • (1979) Ann. Rheum. Dis. , vol.38 , pp. 553-557
    • Phillips, N.C.1    Page Thomas, D.P.2    Knight, C.G.3    Dingle, J.T.4
  • 115
    • 40749148535 scopus 로고    scopus 로고
    • Polymer therapeutics: reservoir drugs
    • Setton L. Polymer therapeutics: reservoir drugs. Nat. Mater. 7 (2008) 172-174
    • (2008) Nat. Mater. , vol.7 , pp. 172-174
    • Setton, L.1
  • 116
    • 0034977175 scopus 로고    scopus 로고
    • In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium
    • Bozdag S., Calis S., Kas H.S., Ercan M.T., Peksoy I., and Hincal A.A. In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium. J. Microencapsul. 18 (2000) 443-456
    • (2000) J. Microencapsul. , vol.18 , pp. 443-456
    • Bozdag, S.1    Calis, S.2    Kas, H.S.3    Ercan, M.T.4    Peksoy, I.5    Hincal, A.A.6
  • 118
    • 0342546477 scopus 로고    scopus 로고
    • Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and in vitro/in vivo evaluation
    • Tuncay M., Calis S., Kas H.S., Ercan M.T., Peksoy I., and Hincal A.A. Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and in vitro/in vivo evaluation. Int. J. Pharm. 195 (2000) 179-188
    • (2000) Int. J. Pharm. , vol.195 , pp. 179-188
    • Tuncay, M.1    Calis, S.2    Kas, H.S.3    Ercan, M.T.4    Peksoy, I.5    Hincal, A.A.6
  • 119
    • 0036822140 scopus 로고    scopus 로고
    • Transforming growth factor-β in calcium alginate beads for the treatment of articular cartilage defects in the rabbit
    • Mierisch C.M., Cohen S.B., Jordan L.C., Robertson P.G., Balian G., Diduch D.R., and Robertson P.G. Transforming growth factor-β in calcium alginate beads for the treatment of articular cartilage defects in the rabbit. Arthroscopy 18 (2002) 892-900
    • (2002) Arthroscopy , vol.18 , pp. 892-900
    • Mierisch, C.M.1    Cohen, S.B.2    Jordan, L.C.3    Robertson, P.G.4    Balian, G.5    Diduch, D.R.6    Robertson, P.G.7
  • 121
    • 0036108432 scopus 로고    scopus 로고
    • Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for intra-articular delivery system in antigen-induced arthritic rabbit
    • Horisawa E., Hirota T., Kawazoe S., Yamada J., Yamamoto H., Takeuchi H., and Kawashima Y. Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for intra-articular delivery system in antigen-induced arthritic rabbit. Pharm. Res. 19 (2002) 403-410
    • (2002) Pharm. Res. , vol.19 , pp. 403-410
    • Horisawa, E.1    Hirota, T.2    Kawazoe, S.3    Yamada, J.4    Yamamoto, H.5    Takeuchi, H.6    Kawashima, Y.7
  • 122
    • 1842429963 scopus 로고    scopus 로고
    • Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint
    • Liang L.S., Jackson J., Min W., Risovic V., Wasan K.M., and Burt H.M. Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint. J. Pharm. Sci. 93 (2004) 943-956
    • (2004) J. Pharm. Sci. , vol.93 , pp. 943-956
    • Liang, L.S.1    Jackson, J.2    Min, W.3    Risovic, V.4    Wasan, K.M.5    Burt, H.M.6
  • 123
    • 0022642114 scopus 로고
    • The formation and characterization of hydrocortisone-loaded poly((±)-lactide) microspheres
    • Cavalier M., Benoit J.P., and Thies C. The formation and characterization of hydrocortisone-loaded poly((±)-lactide) microspheres. J. Pharm. Pharmacol. 38 (1986) 249-253
    • (1986) J. Pharm. Pharmacol. , vol.38 , pp. 249-253
    • Cavalier, M.1    Benoit, J.P.2    Thies, C.3
  • 124
    • 0034977175 scopus 로고    scopus 로고
    • In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium
    • Bozdag S., Calis S., Kas H.S., Ercan M.T., Peksoy I., and Hincal A.A. In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium. J. Micoencapsul. 18 (2001) 443-456
    • (2001) J. Micoencapsul. , vol.18 , pp. 443-456
    • Bozdag, S.1    Calis, S.2    Kas, H.S.3    Ercan, M.T.4    Peksoy, I.5    Hincal, A.A.6
  • 125
    • 4444325013 scopus 로고    scopus 로고
    • Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints
    • Thakkar H., Sharma R.K., Mishra A.K., Chuttani K., and Murthy R.S.R. Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints. JPP 56 (2004) 1091-1099
    • (2004) JPP , vol.56 , pp. 1091-1099
    • Thakkar, H.1    Sharma, R.K.2    Mishra, A.K.3    Chuttani, K.4    Murthy, R.S.R.5
  • 126
    • 0015337045 scopus 로고
    • Synovectomy of the knee in rheumatoid arthritis. II. Results of surgery
    • Taylor A.R., Harbison J.S., and Pepler C. Synovectomy of the knee in rheumatoid arthritis. II. Results of surgery. Ann. Rheum. Dis. 31 (1972) 159-161
    • (1972) Ann. Rheum. Dis. , vol.31 , pp. 159-161
    • Taylor, A.R.1    Harbison, J.S.2    Pepler, C.3
  • 127
    • 0018752291 scopus 로고
    • Intra-articular liposomal therapy
    • Dingle J.T., Jacques P.J., and Shaw I.H. (Eds), North-Holland, Publishing Company, Amsterdam
    • Page Thomas D.P., and Phillips N.C. Intra-articular liposomal therapy. In: Dingle J.T., Jacques P.J., and Shaw I.H. (Eds). Lysosomes in Applied Biology and Therapeutics (1979), North-Holland, Publishing Company, Amsterdam 601-623
    • (1979) Lysosomes in Applied Biology and Therapeutics , pp. 601-623
    • Page Thomas, D.P.1    Phillips, N.C.2
  • 128
    • 0020640872 scopus 로고
    • Leakage of radioactive particle systems from a synovial joint studied with a gamma camera. Its application to radioactive synovectomy
    • Noble J., Jones A.G., Davies M.A., Sledge C.B., Kramer R.I., and Livni E. Leakage of radioactive particle systems from a synovial joint studied with a gamma camera. Its application to radioactive synovectomy. J. Bone Joint Surg. 65-A (1983) 381-389
    • (1983) J. Bone Joint Surg. , vol.65 -A , pp. 381-389
    • Noble, J.1    Jones, A.G.2    Davies, M.A.3    Sledge, C.B.4    Kramer, R.I.5    Livni, E.6
  • 129
    • 0026509484 scopus 로고
    • Polymeric microspheres for radionuclide synovectomy containing neutron-activated holmium-166
    • Mumper R.J., Mills B.J., Ryo U.Y., and Jay M. Polymeric microspheres for radionuclide synovectomy containing neutron-activated holmium-166. J. Nucl. Med. 33 (1992) 398-402
    • (1992) J. Nucl. Med. , vol.33 , pp. 398-402
    • Mumper, R.J.1    Mills, B.J.2    Ryo, U.Y.3    Jay, M.4
  • 130
    • 0344076115 scopus 로고    scopus 로고
    • A trial of clodronate liposomes as anti-macrophage treatment in a sheep model of arthritis
    • Highton J., Guevremont D., Thomson J., Carlisle B., and Tucker I. A trial of clodronate liposomes as anti-macrophage treatment in a sheep model of arthritis. Clin. Exp. Rheumatol. 17 (1999) 43-48
    • (1999) Clin. Exp. Rheumatol. , vol.17 , pp. 43-48
    • Highton, J.1    Guevremont, D.2    Thomson, J.3    Carlisle, B.4    Tucker, I.5
  • 131
    • 0031818876 scopus 로고    scopus 로고
    • Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis
    • van Lent P.L.E.M., Holthuysen A.E.M., Van Rooijen N., Van De Putte L.B.A., and van den Berg W. Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis. Ann. Rheum. Dis. 57 (1998) 408-413
    • (1998) Ann. Rheum. Dis. , vol.57 , pp. 408-413
    • van Lent, P.L.E.M.1    Holthuysen, A.E.M.2    Van Rooijen, N.3    Van De Putte, L.B.A.4    van den Berg, W.5
  • 132
    • 0018739230 scopus 로고
    • Liposomes as carriers of anti-inflammatory steroids
    • Dingle J.T., Jacques P.J., and Shaw I.H. (Eds), North-Holland Publishing Company, Amsterdam
    • Knight C.G., and Shaw I.H. Liposomes as carriers of anti-inflammatory steroids. In: Dingle J.T., Jacques P.J., and Shaw I.H. (Eds). Lysosomes in Applied Biology and Therapeutics (1979), North-Holland Publishing Company, Amsterdam 575-601
    • (1979) Lysosomes in Applied Biology and Therapeutics , pp. 575-601
    • Knight, C.G.1    Shaw, I.H.2
  • 134
    • 0020960274 scopus 로고
    • The retention and distribution in the rabbit knee of a radionuclide complexed with a lipophilic chelator in liposomes
    • Bard D.R., Knight C.G., and Page Thomas D.P. The retention and distribution in the rabbit knee of a radionuclide complexed with a lipophilic chelator in liposomes. Clin. Exp. Rheumatol. 1 (1983) 113-117
    • (1983) Clin. Exp. Rheumatol. , vol.1 , pp. 113-117
    • Bard, D.R.1    Knight, C.G.2    Page Thomas, D.P.3
  • 136
    • 0023735250 scopus 로고
    • 3H]methotrexate injected into normal or arthritic rabbit joints
    • 3H]methotrexate injected into normal or arthritic rabbit joints. J. Pharm. Pharmacol. 40 (1987) 464-468
    • (1987) J. Pharm. Pharmacol. , vol.40 , pp. 464-468
    • Foong, W.C.1    Green, K.L.2
  • 137
    • 0027401487 scopus 로고
    • Treatment of antigen-induced arthritis in rabbits with liposome-entrapped methotrexate injected intra-articularly
    • Foong W.C., and Green K.L. Treatment of antigen-induced arthritis in rabbits with liposome-entrapped methotrexate injected intra-articularly. J. Pharm. Pharmacol. 45 (1993) 204-209
    • (1993) J. Pharm. Pharmacol. , vol.45 , pp. 204-209
    • Foong, W.C.1    Green, K.L.2
  • 139
    • 0035125609 scopus 로고    scopus 로고
    • Growth-factor-induced healing of partial-thickness defects in adult articular cartilage
    • Hunziker E.B. Growth-factor-induced healing of partial-thickness defects in adult articular cartilage. Osteoarthr. Cartil. 9 (2001) 22-32
    • (2001) Osteoarthr. Cartil. , vol.9 , pp. 22-32
    • Hunziker, E.B.1
  • 143
    • 31044432008 scopus 로고    scopus 로고
    • The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee
    • Inoue A., Takahashi K.A., Arai Y., Tonomura H., and Sakao K. The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee. Arthritis Rheum. 54 (2006) 264-270
    • (2006) Arthritis Rheum. , vol.54 , pp. 264-270
    • Inoue, A.1    Takahashi, K.A.2    Arai, Y.3    Tonomura, H.4    Sakao, K.5
  • 144
    • 38349147330 scopus 로고    scopus 로고
    • In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis
    • Haerdi-Landerer M.C., Suter M.M., Steiner A., Wittenbrink M.M., Pickl A., and Gander B.A. In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis. J. Antimicrob. Chemother. 61 (2008) 332-340
    • (2008) J. Antimicrob. Chemother. , vol.61 , pp. 332-340
    • Haerdi-Landerer, M.C.1    Suter, M.M.2    Steiner, A.3    Wittenbrink, M.M.4    Pickl, A.5    Gander, B.A.6
  • 145
    • 0034916865 scopus 로고    scopus 로고
    • Use of an isolated joint model to detect early changes induced by intra-articular injection of paclitaxel-impregnated polymeric microspheres
    • Bragdon B., Bertone A.L., Hardy J., Simmons E.J., and Weisbrode S.E. Use of an isolated joint model to detect early changes induced by intra-articular injection of paclitaxel-impregnated polymeric microspheres. J. Invest. Surg. 14 (2001) 169-182
    • (2001) J. Invest. Surg. , vol.14 , pp. 169-182
    • Bragdon, B.1    Bertone, A.L.2    Hardy, J.3    Simmons, E.J.4    Weisbrode, S.E.5
  • 146
    • 0023727294 scopus 로고
    • Potential use of albumin microspheres as a drug delivery system: II. In vivo deposition and release of steroids
    • Burgess D.J., and Davis S.S. Potential use of albumin microspheres as a drug delivery system: II. In vivo deposition and release of steroids. Int. J. Pharm. 46 (1988) 69-76
    • (1988) Int. J. Pharm. , vol.46 , pp. 69-76
    • Burgess, D.J.1    Davis, S.S.2
  • 147
    • 44949269296 scopus 로고
    • In-vivo stability of ferric hydroxide macroaggregates (FHMA). Is it a suitable carrier for radionuclides used in synovectomy?
    • Chinol M., Vallabhajosula S., Zuckerman J.D., and Goldsmith S.J. In-vivo stability of ferric hydroxide macroaggregates (FHMA). Is it a suitable carrier for radionuclides used in synovectomy?. Nucl. Med. Biol. 17 (1990) 479-486
    • (1990) Nucl. Med. Biol. , vol.17 , pp. 479-486
    • Chinol, M.1    Vallabhajosula, S.2    Zuckerman, J.D.3    Goldsmith, S.J.4
  • 150
    • 0024383971 scopus 로고
    • Radiopharmaceuticals for radiation synovectomy
    • Davies M.A., and Chinol M. Radiopharmaceuticals for radiation synovectomy. J. Nucl. Med. 30 (1989) 1047-1055
    • (1989) J. Nucl. Med. , vol.30 , pp. 1047-1055
    • Davies, M.A.1    Chinol, M.2
  • 151
    • 1542788001 scopus 로고    scopus 로고
    • MR evaluation of radiation synovectomy of the knee by means of intra-articular injection of holmium-166-chitosan complex in patients with rheumatoid arthritis: results at 4-month follow-up
    • Lee S.H., Suh J.S., Kim H.S., Lee J.D., Song J., and Lee S.K. MR evaluation of radiation synovectomy of the knee by means of intra-articular injection of holmium-166-chitosan complex in patients with rheumatoid arthritis: results at 4-month follow-up. Korean J. Radiol. 4 (2003) 170-178
    • (2003) Korean J. Radiol. , vol.4 , pp. 170-178
    • Lee, S.H.1    Suh, J.S.2    Kim, H.S.3    Lee, J.D.4    Song, J.5    Lee, S.K.6
  • 152
    • 0037136041 scopus 로고    scopus 로고
    • Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurements
    • Cevc G., Schatzlein A., and Richardsen H. Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurements. Biochim. Biophys. Acta, Biomembr. 1564 (2002) 21-30
    • (2002) Biochim. Biophys. Acta, Biomembr. , vol.1564 , pp. 21-30
    • Cevc, G.1    Schatzlein, A.2    Richardsen, H.3
  • 153
    • 34548169017 scopus 로고    scopus 로고
    • Efficacy and safety of epicutaneous ketoprofen in Transferosome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomized controlled trial
    • Rother M., Lavins B.J., Kneer W., Lehnhardt K., Seidel E.J., and Mazgareanu S. Efficacy and safety of epicutaneous ketoprofen in Transferosome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomized controlled trial. Ann. Rheum. Dis. 66 (2007) 1178-1183
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 1178-1183
    • Rother, M.1    Lavins, B.J.2    Kneer, W.3    Lehnhardt, K.4    Seidel, E.J.5    Mazgareanu, S.6
  • 154
    • 70349326930 scopus 로고    scopus 로고
    • Cytokines and cytokine receptors
    • Koopman W.J., and Moreland L.W. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Gabay C. Cytokines and cytokine receptors. In: Koopman W.J., and Moreland L.W. (Eds). Arthritis and Allied Conditions - A Textbook of Rheumatology (2005), Lippincott Williams & Wilkins, Philadelphia 423-476
    • (2005) Arthritis and Allied Conditions - A Textbook of Rheumatology , pp. 423-476
    • Gabay, C.1
  • 155
    • 34548800403 scopus 로고    scopus 로고
    • p38 pathway kinases as anti-inflammatory drug targets
    • Schindler J.F., Monahan J.B., and Smith W.G. p38 pathway kinases as anti-inflammatory drug targets. J. Dent. Res. 86 (2007) 800-811
    • (2007) J. Dent. Res. , vol.86 , pp. 800-811
    • Schindler, J.F.1    Monahan, J.B.2    Smith, W.G.3
  • 156
    • 33646473843 scopus 로고    scopus 로고
    • p38 MAP kinase inhibitors: a future therapy for inflammatory diseases
    • Mayer R.J., and Callahan J.F. p38 MAP kinase inhibitors: a future therapy for inflammatory diseases. Drug Discov. Today 3 (2006) 49-54
    • (2006) Drug Discov. Today , vol.3 , pp. 49-54
    • Mayer, R.J.1    Callahan, J.F.2
  • 157
    • 0031803059 scopus 로고    scopus 로고
    • SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes
    • Badger A.M., Cook M.N., Lark M.W., Newman-Tarr T.M., Swift B.A., Nelson A.H., Barone F.C., and Kumar S. SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes. J. Immunol. 161 (1998) 467-473
    • (1998) J. Immunol. , vol.161 , pp. 467-473
    • Badger, A.M.1    Cook, M.N.2    Lark, M.W.3    Newman-Tarr, T.M.4    Swift, B.A.5    Nelson, A.H.6    Barone, F.C.7    Kumar, S.8
  • 159
    • 0030426902 scopus 로고    scopus 로고
    • Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
    • Badger A.M., Bradbeer J.N., Votta B., Lee J.C., Adams J.L., and Griswold D.E. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279 (1996) 1453-1461
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 1453-1461
    • Badger, A.M.1    Bradbeer, J.N.2    Votta, B.3    Lee, J.C.4    Adams, J.L.5    Griswold, D.E.6
  • 161
  • 162
    • 33751036696 scopus 로고    scopus 로고
    • Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome
    • Ding C. Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Curr. Opin. Invest. Drugs 7 (2006) 1020-1025
    • (2006) Curr. Opin. Invest. Drugs , vol.7 , pp. 1020-1025
    • Ding, C.1
  • 164
    • 2642559875 scopus 로고    scopus 로고
    • Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention
    • Braddock M., and Quinn A. Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention. Nat. Rev. Drug Discov. 3 (2004) 1-10
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 1-10
    • Braddock, M.1    Quinn, A.2
  • 165
    • 0141727395 scopus 로고    scopus 로고
    • Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis
    • Rudolphi K., Gerwin N., Verzijl N., van der Kraan P., and van den Berg W. Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthr. Cartil. 11 (2003) 738-746
    • (2003) Osteoarthr. Cartil. , vol.11 , pp. 738-746
    • Rudolphi, K.1    Gerwin, N.2    Verzijl, N.3    van der Kraan, P.4    van den Berg, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.