In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis

Journal of Antimicrobial Chemotherapy

Volumn 61, Issue 2, 2008, Pages 332-340

  Haerdi landerer, M Christina ^a   Suter, Maja M ^b   Steiner, Adrian ^b   Wittenbrink, Max M ^b   Pickl, Andrea ^c   Gander, Bruno A ^c  

^a AO RESEARCH INSTITUTE   (Switzerland)

^b VETSUISSE FACULTY UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

Antimicrobial activity; In vitro toxicity; Microspheres; Septic arthritis

Indexed keywords

BETA ACTIN; DOXYCYCLINE HYCLATE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROGOL; MESSENGER RNA; MICROSPHERE; NITRIC OXIDE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BACTERIAL ARTHRITIS; BIOCOMPATIBILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG RELEASE; DRUG STABILITY; ELUTION; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; IN VITRO STUDY; MICROENCAPSULATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PARTICLE SIZE; SLOW DRUG RELEASE; SYNOVIOCYTE;

ANIMALS; ANTI-BACTERIAL AGENTS; ARTHRITIS, INFECTIOUS; CATTLE; CELLS, CULTURED; DOXYCYCLINE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; MICROSPHERES; PARTICLE SIZE;

EID: 38349147330     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkm491     Document Type: Article

References (53)

1. Lapointe JM, Laverty S, Lavoie JP. Septic arthritis in 15 standardbred racehorses after intra-articular injection. Equine Vet J 1992; 24: 430-4.
2. Steel CM, Hunt AR, Adams PL et al. Factors associated with prognosis for survival and athletic use in foals with septic arthritis: 93 cases (1987-1994). J Am Vat Mad Assoc 1999; 215: 973-7.
3. Steiner A, Hirsbrunner G, Miserez R et al. Arthroscopic lavage and implantation of gentamicin-impregnated collagen sponges for treatment of chronic septic arthritis in cattle. Vet Comp Orthop Traumatol 1999; 12: 64-9.
4. McIlwraith CW. Treatment of infectious arthritis. Vet Clin North Am Large Anim Pract 1983; 5: 363-79.
5. Hirsbrunner G, Steiner A. Treatment of infectious arthritis of the radiocarpal joint of cattle with gentamicin-impregnated collagen sponges. Vet Rec 1998; 142: 399-402.
6. Lloyd KC, Stover SM, Pascoe JR et al. Synovial fluid pH, cytologic characteristics, and gentamicin concentration after intra-articular administration of the drug in an experimental model of infectious arthritis in horses. Am J Vet Res 1990; 51: 1363-9.
7. Stover SM, Pool RR. Effect of intra-articular gentamicin sulfate on normal equine synovial membrane. Am J Vet Res 1985; 46: 2485-91.
8. Sun Y, Scruggs DW, Pang Y et al. Issues and challenges in developing long-acting veterinary antibiotic formulations. Adv Drug Deliv Rev 2004; 56: 1481-96.
9. Butson RJ, Schramme MC, Garlick MH et al. Treatment of intrasynovial infection with gentamicin-impregnated polymethylmethacrylate beads. Vet Rec 1996; 138: 460-4.
10. Kanellakopoulou K, Giamarellos-Bourboulis EJ. Carrier systems for the local delivery of antibiotics in bone infections. Drugs 2000; 59: 1223-32.
11. Ostermann PA, Seligson D, Henry SL. Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases. J Bone Joint Surg Br 1995; 77: 93-7.
12. Stemberger A, Grimm H, Bader F et al. Local treatment of bone and soft tissue infections with the collagen-gentamicin sponge. Eur J Surg Suppl 1997; 17-26.
13. Summerhays GE. Treatment of traumatically induced synovial sepsis in horses with gentamicin-impregnated collagen sponges. Vet Rec 2000; 147: 184-8.
14. Ivester KM, Adams SB, Moore GE et al. Gentamicin concentrations in synovial fluid obtained from the tarsocrural joints of horses after implantation of gentamicin-impregnated collagen sponges. Am J Vet Res 2006; 67: 1519-26.
15. Wachol-Drewek Z, Pfeiffer M, Scholl E. Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and a sponge containing gentamicin. Biomaterials 1996; 17: 1733-8.
16. Ethell MT, Bennett RA, Brown MP et al. In vitro elution of gentamicin, amikacin, and ceftiofur from polymethylmethacrylate and hydroxyapatite cement. Vet Surg 2000; 29: 375-82.
17. Hoff SF, Fitzgerald RH Jr, Kelly PJ. The depot administration of penicillin G and gentamicin in acrylic bone cement. J Bone Joint Surg Am 1981; 63: 798-804.
18. Garvin KL, Myjano JA, Robinson D et al. Polylactide/polyglycolide antibiotic implants in the treatment of osteomyelitis. A canine model. J Bone Joint Surg Am 1994; 76: 1500-6.
19. Alonge TO, Fashina AN. Ceftriaxone-PMMA beads - a slow release preparation? Int J Clin Pract 2000; 54: 353-5.
20. Verschooten F, Vermeiren D, Devriese L. Bone infection in the bovine appendicular skeleton: A clinical, radiographic, and experimental study. Vet Radiol Ultrasound 2000; 41: 250-60.
21. Van Pelt RW. Infectious arthritis in cattle caused by Corynebacterium pyogenes. J Am Vet Med Assoc 1970; 156: 457-65.
22. Bailey JV. Bovine arthritides. Classification, diagnosis, prognosis, and treatment. Vet Clin North Am Food Anim Pract 1985; 1: 39-51.
23. Joshi N, Miller DQ. Doxycycline revisited. Arch Intrnm Med 1997; 157: 1421-8.
24. Ensink JM, van Klingeren B, Houwers DJ et al. In-vitro susceptibility to antimicrobial drugs of bacterial isolates from horses in The Netherlands. Equine Vet J 1993; 25: 309-13.
25. Klein NC, Cunha BA. Tetracyclines. Med Clin North Am 1995; 79 789-801.
26. Ellison MJ. Vancomycin, metronidazole, and tetracyclines. Clin Podiatr Med Surg 1992; 9: 425-42.
27. Pereira MS, Siqueira-Junior JP. Antimicrobial drug resistance in Staphylocoocus aureus isolated from cattle in Brazil. Leff Appl Microbiol 1995; 20: 391-5.
28. Amin AR, Attur MG, Thakker GD et al. A novel mechanism of action of tetracyclines: Effect on nitric oxide syntheses. Proc Natl Acad Sci USA 1996; 93: 14014-9.
29. Greenwald RA, Moak SA, Ramamurthy NS et al. Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage. J Rheumatol 1992; 19: 927-38.
30. Shlopov BV, Stuart JM, Gumanovskaya ML et al. Regulation of cartilage collagenase by doxycycline. J Rheumatol 2001; 28: 835-42.
31. Sreekanth VR, Handa R, Wali JP et al. Doxycycline in the treatment of rheumatoid arthritis - a pilot study. J Assoc Physicians India 2000; 48: 804-7.
32. Stone M, Fortin PR, Pacheco-Tena C et al. Should tetracycline, treatment be used more extensively for rheumatoid arthritis? Metaanalysis demonstrates clinical benefit with reduction in disease activity. J Rheumatol 2003; 30: 2112-22.
33. Haerdi-Landerer MC, Suter MM, Steiner A. Intra-articular administration of doxycycline in calves. Am J Vet Res 2007; 68: 1324-31.
34. Honnorat-Banabbou VC, Lebugle AA, Sallek B et al. Stability study of tetracyclines with respect to their use in slow release systems. J Mater Sci Mater Med 2001; 12: 107-10.
35. Paquette DW. Minocycline microspheres: A complementary medical-mechanical model for the treatment of chronic periodontitis. Compend Conlin Educ Dent 2002; 23: 15-21.
36. Skulason S, Ingolfson E, Kristmundsdottir T. Development of a simple HPLC method for separation of doxycycline and its degradation products. J Pharm Biomed Anal 2003; 33: 667-72.
37. Greene WT. Behaviour of articular chondrocytes. Clin Orthop 1971; 75: 248-60.
38. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Fifteenth Informational Supplement M100-S15. CLSI, Wayne, PA, USA, 2005.
39. Bodmeier R, Chen H, Davidson RG et al. Microencapsulation of antimicrobial ceftiofur drugs. Pharm Dev Technol 1997; 2: 323-34.
40. Prior S, Gamazo C, Irache JM et al. Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections. Int J Pharm 2000; 196: 115-25.
41. Shameem M, Lee H, Burton K et al. Effect of gamma-irradiation on peptide-containing hydrophilic Poly (D,L-lactide-co-glycolide) microspheres. PDA J Pharm Sci Technol 1999; 53: 309-13.
42. Bittner B, Mader K, Kroll C et al. Tatracycline-HCl-loaded poly(DL-lactide-co-glycolide) microspheres prepared by a spray drying technique: Influence of gamma-irradiation on radical formation and polymer degradation. J Control Release 1999; 59: 23-32.
43. Armstrong S, Lees P. Effects of carprofen (R and S enantiomers and racemate) on the production of IL-1, IL-6 and TNF-alpha by equine chondrocytes and synoviocytes. J Vet Pharmacol Ther 2002; 25 145-53.
44. Borderie D, Hernvann A, Hilliquin P et al. Tetracyclines inhibit nitrosothiol production by cytokine-stimulated osteoarthritic synovial cells. Inflamm Res 2001; 50: 409-14.
45. Bertone AL, Palmer JL, Jones J. Synovial fluid cytokines and eicosanoids as markers of joint disease in horses. Vet Surg 2001; 30: 528-38.
46. Smeets TJ, Barg EC, Kraan MC et al. Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: Comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis. Ann Rheum Dis 2003; 62: 635-8.
47. Von Rechenberg B, McIlwraith CW, Akens MK et al. Spontaneous production of nitric oxide (NO), prostaglandin (PGE2) and neutral metalloproteinases (NMPs) in media of explant cultures of equine synovial membrane and articular cartilage from normal and osteoarthritic joints. Equine Vet J 2000; 32: 140-50.
48. Farrell AJ, Blake DR, Palmer RM et al. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992; 51 1219-22.
49. Stafanovic-Racic M, Stadler J, Georgescu HI et al. Nitric oxide synthesis and its regulation by rabbit synoviocytes. J Rheumatol 1994; 21: 1892-8.
50. Adler H, Frech B, Thony M et al. Inducible nitric oxide synthase in cattle. Differential cytokine regulation of nitric oxide synthase in bovine and murine macrophages. J Immunol 1995; 154: 4710-8.
51. Jauemig S, Schweighauser A, Reist M et al. The effects oi doxycycline on nitric oxide and stromelysin production in dogs with cranial cruciate ligament rupture. Vet Surg 2001; 30: 132-9.
52. Stadler J, Stefanovic-Racic M, Billiar TR et al. Articular chondrocytes synthesize nitric oxide in response to cytolkines and lipopolysaccharide. J Immunol 1991; 147: 3915-20.
53. Attur MG, Patel RN, Patel PD et al. Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide. J Immunol 1999; 162: 3160-7.