Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium

Pharmaceutical Research

Volumn 19, Issue 2, 2002, Pages 132-139

  Horisawa, E ^a   Kubota, K ^a   Tuboi, I ^a   Sato, K ^a   Yamamoto, H ^b   Takeuchi, H ^b   Kawashima, Y ^b  

^a Maruho Co   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

DL lactide glycolide copolymer microspheres; DL lactide glycolide copolymer nanospheres; Emulsion solvent diffusion method; Intra articular injection; Macrophage, biocompatibility; Phagocytosis

Indexed keywords

COPOLYMER; FLUORESCEIN DERIVATIVE; FLUORESCEINAMINE; MICROSPHERE; POLYGLACTIN; SOLVENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CELL PROLIFERATION; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; EMULSION; FLUORESCENCE MICROSCOPY; GIANT CELL; GRANULATION TISSUE; HISTOPATHOLOGY; INFLAMMATION; JOINT CAVITY; MACROPHAGE; NONHUMAN; PARTICULATE MATTER; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SYNOVIUM;

ANIMALS; BIOCOMPATIBLE MATERIALS; CHEMISTRY, PHYSICAL; DRUG COMPOUNDING; EXCIPIENTS; INJECTIONS, INTRA-ARTICULAR; LACTIC ACID; MALE; MATERIALS TESTING; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; PHAGOCYTOSIS; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; SYNOVIAL FLUID;

EID: 0036182057     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014260513728     Document Type: Article

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