A slow release formulation of insulin as a treatment for osteoarthritis

Osteoarthritis and Cartilage

Volumn 10, Issue 9, 2002, Pages 692-706

  Cai, L ^a   Okumu, F W ^a   Cleland, J L ^a   Beresini, M ^a   Hogue, D ^a   Lin, Z ^a   Filvaroff, E H ^a  

^a GENENTECH INC   (United States)

Author keywords

Cartilage; Growth factors; Insulin; Matrix breakdown; Osteoarthritis

Indexed keywords

AGGRECANASE; INTERLEUKIN 1; NITRIC OXIDE; POLYGLACTIN; PROTEOGLYCAN; RECOMBINANT HUMAN INSULIN; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

AGE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CELL PROLIFERATION; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG SPECIFICITY; DRUG STABILITY; ENZYME INHIBITION; EXPLANT; FEMALE; FIBROBLAST; GUINEA PIG; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; KNEE OSTEOARTHRITIS; MALE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; SLOW RELEASE FORMULATION;

EID: 0036714542     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.2002.0813     Document Type: Article

References (49)

1. Degradation and repair of articular cartilage
2. The use of growth factors in cartilage repair
3. IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis
4. Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants
5. Local disruption of the insulin-like growth factor system in the arthritic joint
6. Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4
7. Age-related decline in chondrocyte response to insulin-like growth factor-I: The role of growth factor binding proteins
8. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: Studies in a non-human primate model of naturally occurring disease
9. The action of insulin on the metabolism of cell cultures
10. Insulin dependence of cells in primary culture: Influence on ribosome integrity
11. Importance of amino acids in the action of insulin and serum sulfation factor to stimulate sulfate uptake by cartilage cells from hypophysectomized rats
12. 3H)thymidine into DNA of costal cartilage from hypophysectomized rats
13. The metabolism of mucopolysaccharides in animals. IV. The influence of insulin
14. Effect of insulin on bone in tissue culture
15. Stimulation of growth and mucopolysaccharide synthesis by insulin treatment of chick embryo chondrocytes in cell culture
16. Characterization of proteoglycans synthesized by rat chondrosarcoma chondrocytes treated with multiplication-stimulating activity and insulin
17. Kinase receptor activation (KIRA): A rapid and accurate alternative to end-point bioassays
18. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction
19. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
20. Assay of proteoglycan degradation
21. The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism
22. A fluorometric assay for the measurement of nitrite in biological samples
23. Nitric oxide and cartilage metabolism
24. 3H-acetate
25. Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors
26. A month-long effect from a single injection of microencapsulated human growth hormone
27. Recombinant human insulin. III. High-performance liquid chromatography and high-performance capillary electrophoresis control in the analysis of step-by-step production of recombinant human insulin
28. Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo
29. Production of binding proteins and role of the insulin-like growth factor I binding protein 3 in human articular cartilage explants
30. Effects of basic fibroblast growth factor transforming growth factor-beta 1, insulin-like growth factor-1, and insulin on human osteoarthritic articular cartilage explants
31. Spontaneous cartilage degeneration in guinea pigs
32. Osteoarthrosis in guinea pigs: Histopathologic and scanning electron microscopic features
33. Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: Histologic, radiologic, and biochemical changes
34. Correlation of morphologic and biochemical changes in the natural history of spontaneous osteoarthrosis in guinea pigs
35. Mechanical load and primary guinea pig osteoarthrosis
36. The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin
37. An insulin-like growth factor-I-resistant state in cartilage of diabetic rats is ameliorated by hypophysectomy. Possible role of metabolism
38. Dest(1-3)IGF-I: A truncated form of insulin-like growth factor-I
39. Interleukin-1 receptor antagonist: Role in biology
40. The role of nitric oxide in articular cartilage breakdown in osteoarthritis
41. Insulin Formulation and Delivery in Protein Delivery
42. Endocrinology
43. Effects of diabetes mellitus on the biomechanical properties of human ankle cartilage
44. Changes in proteoglycans of intervertebral disc in diabetic patients. A possible cause of increased back pain
45. Response of rat connective tissues to streptozotocin diabetes. Tissue specific effects to streptozotocin diabetes. Tissue specific effects on collagen metabolism
46. Sulfate35 uptake and incorporation into aortic mucopolsaccharides in experimental diabetes
47. 35S-sulfate uptake into aortic mucopolysaccharides in normal and diabetic rats
48. Correlation between decreased colagen production in diabetic animals and in cells exposed to diabetic serum: Response to Insulin