Methotrexate Loaded Poly(L-Lactic Acid) Microspheres for Intra-Articular Delivery of Methotrexate to the Joint

Journal of Pharmaceutical Sciences

Volumn 93, Issue 4, 2004, Pages 943-956

  Liang, Linda S ^a   Jackson, John ^a   Min, Weixian ^b   Risovic, Verica ^a   Wasan, Kishor M ^a   Burt, Helen M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Biocompatibility; Controlled release delivery; Intra articular delivery microspheres; Methotrexate; Pharmacokinetics; Poly(lactic acid)

Indexed keywords

BUFFER; METHOTREXATE; MICROSPHERE; POLYLACTIC ACID; SODIUM CHLORIDE; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG TOLERABILITY; DRUG URINE LEVEL; EDEMA; EVAPORATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; IN VIVO STUDY; INJECTION; JOINT; MOLECULAR WEIGHT; NONHUMAN; RABBIT; RHEUMATOID ARTHRITIS; THERMAL ANALYSIS; THERMOSTABILITY; URINALYSIS;

EID: 1842429963     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20031     Document Type: Article

References (38)

1. Grassi W, De Angelis R, Lamanna G, Cervini C. 1998. The clinical features of rheumatoid arthritis. Eur J Radiol 27(Suppl 1):S18-S24.
2. Ryan L, Brooks P. 1999. Disease-modifying antirheumatic drugs. Curr Opin Rheumatol 11:161-166.
3. Theodore P, O'Dell JR, Kremer JM. 1999. Combination therapy with multiple disease-modifying antirheumatic drugs in rheumatoid arthritis: A preventive strategy. Ann Int Med 131:768-774.
4. Cronstein BN. 1997. The mechanism of action of methotrexate. Rheum Dis Clin North Am 23:739-755.
5. van Ede AE, Laan RF, Blom HJ, De Abreu RA, van de Putte LB. 1998. Methotrexate in rheumatoid arthritis: An update with focus on mechanisms involved in toxicity. Semin Arthritis Rheum 27:277-292.
6. O'Dell JR. 1997. Methotrexate use in rheumatoid arthritis. Rheum Dis Clin North Am 23:779-796.
7. Hall GH, Jones BJM, Head AC, Jones VE. 1978. Intra-articular methotrexate. Ann Rheum Dis 37:351-356.
8. Wigginton S, Chu B, Weisman M, Howell S. 1980. Methotrexate pharmacokinetics after intraarticular injection in patients with rheumatoid arthritis. Arthritis Rheum 23:119-122.
9. Bozdag S, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA. 2001. In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium. J Microencapsul 18:443-456.
10. Bragdon B, Bertone AL, Hardy J, Simmons EJ, Weisbrode SE. 2001. Use of an isolated joint model to detect early changes induced by intra-articular injection of paclitaxel-impregnated polymeric microspheres. J Invest Surg 14:169-182.
11. Horisawa E, Hirota T, Kawazoe S, Yamada J, Yamamoto H, Takeuchi H, Kawashima Y. 2002. Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing beta-methasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit. Pharm Res 19:403-410.
12. Tuncay M, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA. 2000. Diclofenac sodium incorporated PLGA (50:50) microspheres: Formulation considerations and in vitro/in vivo evaluation. Int J Pharm 195:179-188.
13. Nishide M, Kamei S, Takakura Y, Tamai S, Tabata Y, Ikada Y. 1999. Fate of biodegradable DL-lactic acid oligomer microspheres in the articulus. J Bioact Compact Poly 14:385-398.
14. Ramesh DV, Tabata Y, Ikada Y. 1999. Biodegradable microspheres for local drug release in the articulus. J Bioact Compact Poly 14:137-149.
15. 3H]methotrexate injected into normal or arthritic rabbit joints. J Pharm Pharmacol 40:464-468.
16. Foong WC, Green KL. 1993. Treatment of antigen-induced arthritis in rabbits with liposome-entrapped methotrexate injected intra-articularly. J Pharm Pharmacol 45:204-209.
17. Williams AS, Camilleri JP, Goodfellow RM, Williams BD. 1996. A single intra-articular injection of liposomally conjugated methotrexate suppresses joint inflammation in rat antigen-induced arthritis. Br J Rheumatol 35:719-724.
18. Horisawa E, Kubota K, Tuboi I, Sato K, Yamamoto H, Takeuchi H, Kawashima Y. 2002. Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium. Pharm Res 19:132-139.
19. Ratcliffe JH, Hunneyball IM, Smith A, Wilson CG, Davis SS. 1984. Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs. J Pharm Pharmacol 36:431-436.
20. Ratcliffe JH, Hunneyball IM, Wilson CG, Smith A, Davis SS. 1987. Albumin microspheres for intra-articular drug delivery: Investigation of their retention in normal and arthritic knee joints of rabbits. J Pharm Pharmacol 39:290-295.
21. Greis PE, Georgescu HI, Fu FH, Evans CH. 1994. Particle-induced synthesis of collagenase by synovial fibroblasts: An immunocytochemical study. J Orthop Res 12:286-293.
22. Liggins R, Cruz T, Min W, Liang LS, Hunter WL, Burt HM. 2003. Intra-articular treatment of arthritis with microsphere formulation of paclitaxel: Biocompatibility and efficacy determinations in rabbits. Manuscript submitted to Inflamm Res.
23. Watts PJ, Davies MC, Melia CD. 1990. Microencapsulation using emulsification/solvent evaporation: An overview of techniques and applications. Cri Rev Ther Drug Carrier Syst 7:235-259.
24. Celli A, Scandola M. 1992. Thermal properties and physical aging of poly(L-lactic acid). Polymer 33:2699-2704.
25. Cociglio M, Hillaire-Buys D, Alric C. 1995. Determination of methotrexate and 7-hydroxymethotrexate by liquid chromatography for routine monitoring of plasma levels. J Chromatogr B Biomed Appl 674:101-110.
26. Albertioni F, Pettersson B, Beck O, Rask C, Seideman P, Peterson C. 1995. Simultaneous quantitation of methotrexate and its two main metabolites in biological fluids by a novel solid-phase extraction procedure using high-performance liquid chromatography. J Chromatogr B Biomed Appl 665:163-170.
27. Liggins R. 1998. Paclitaxel loaded poly(L-lactic acid) microspheres: Characterization and intraperitoneal administration, Ph.D. thesis, University of British Columbia, Canada.
28. Migliaresi C, Fambri L, Cohn D. 1994. A study on the in vitro degradation of poly(lactic acid). J Biomater Sci Polym Ed 5:591-606.
29. Hakkarainen M, Albertsson AC, Karlsson S. 1996. Weight losses and molecular weight changes correlated with the evolution of hydroxyacids in simulated in vivo degradation of homo and copolymers of PLA and PGA. Polym Degradation Stability 52:283-291.
30. Liggins R, Burt HM. 2001. Paclitaxel loaded poly(L-lactic acid) microspheres: Properties of microspheres made with low molecular weight polymers. Int J Pharm 222:19-33.
31. Grandfils C, Flandroy P, Jerome R. 1996. Control of the biodegradation rate of poly(DL-lactide) microparticles intended as chemoembolization materials. J Control Release 38:109-122.
32. Hakkarainen M, Karlsson S, Albertsson AC. 2000. Influence of low molecular weight lactic acid derivatives on degradability of polylactide. J Appl Polym Sci 76:228-239.
33. Windholz M, editor. 1983. The Merck index: An encyclopedia of chemicals, drugs, and biologicals. Rahway: Merck and Co.
34. Chen M, Chiou WL. 1983. Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits after intravenous administration. J Pharmacokinet Biopharm 11:499-513.
35. Hillson JL, Furst DE. 1997. Pharmacology and pharmacokinetics of methotrexate in rheumatic disease. Practical issues in treatment and design. Rheum Dis Clin North Am 23:757-778.
36. Herman RA, Veng-Pedersen P, Hoffman J. 1989. Pharmacokinetics of low-dose methotrexate in rheumatoid arthritis patients. J Pharm Sci 78:165.
37. Lewis DH. 1990. Controlled release of bioactive agents from lactide/glycolide polymers. In: Chasin M, Langer R, editors. Biodegradable polymers as drug delivery systems. New York: Marcel Dekker. pp 1-41.
38. Brown KE, Leong K, Huang CH, Dalal R, Green GD, Haimes HB, Jimenez PA, Bathon J. 1998. Gelatin/chondroitin 6-sulfate microspheres for the delivery of therapeutic proteins to the joint. Arthritis Rheum 41:2185-2195.