메뉴 건너뛰기




Volumn 46, Issue 4, 2009, Pages 387-393

Iron Sequestration and Anemia of Inflammation

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYTOKINE; ERYTHROPOIETIN; FERRITIN; FERROPORTIN; HEMOGLOBIN; HEMOJUVELIN; HEPCIDIN; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; IRON; PROTEIN INHIBITOR; TRANSFERRIN;

EID: 70349325941     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2009.06.001     Document Type: Article
Times cited : (273)

References (79)
  • 1
    • 0003014286 scopus 로고
    • The anemia of infection. I. Hypoferremia, hypercupremia, and alterations in porphyrin metabolism in patients
    • Cartwright G.E., Lauritsen M.A., Jones P.J., Merrill I.M., and Wintrobe M.M. The anemia of infection. I. Hypoferremia, hypercupremia, and alterations in porphyrin metabolism in patients. J Clin Invest 25 (1946) 65-80
    • (1946) J Clin Invest , vol.25 , pp. 65-80
    • Cartwright, G.E.1    Lauritsen, M.A.2    Jones, P.J.3    Merrill, I.M.4    Wintrobe, M.M.5
  • 3
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    • Kemna E., Pickkers P., Nemeth E., van der H.H., and Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106 (2005) 1864-1866
    • (2005) Blood , vol.106 , pp. 1864-1866
    • Kemna, E.1    Pickkers, P.2    Nemeth, E.3    van der, H.H.4    Swinkels, D.5
  • 4
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B.K., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113 (2004) 1271-1276
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6
  • 5
    • 0018926512 scopus 로고
    • Iron-controlled infection with Neisseria meningitidis in mice
    • Holbein B.E. Iron-controlled infection with Neisseria meningitidis in mice. Infect Immun 29 (1980) 886-891
    • (1980) Infect Immun , vol.29 , pp. 886-891
    • Holbein, B.E.1
  • 6
    • 0021686564 scopus 로고
    • Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice
    • Beaumier D.L., Caldwell M.A., and Holbein B.E. Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice. Infect Immun 46 (1984) 489-494
    • (1984) Infect Immun , vol.46 , pp. 489-494
    • Beaumier, D.L.1    Caldwell, M.A.2    Holbein, B.E.3
  • 7
    • 0024463848 scopus 로고
    • Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum iron
    • Bertini R., Bianchi M., Erroi A., Villa P., and Ghezzi P. Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum iron. J Leukoc Biol 46 (1989) 254-262
    • (1989) J Leukoc Biol , vol.46 , pp. 254-262
    • Bertini, R.1    Bianchi, M.2    Erroi, A.3    Villa, P.4    Ghezzi, P.5
  • 8
    • 0037011071 scopus 로고    scopus 로고
    • Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis
    • Schaible U.E., Collins H.L., Priem F., and Kaufmann S.H. Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. J Exp Med 196 (2002) 1507-1513
    • (2002) J Exp Med , vol.196 , pp. 1507-1513
    • Schaible, U.E.1    Collins, H.L.2    Priem, F.3    Kaufmann, S.H.4
  • 9
    • 0019360750 scopus 로고
    • Enhancement of Neisseria meningitidis infection in mice by addition of iron bound to transferrin
    • Holbein B.E. Enhancement of Neisseria meningitidis infection in mice by addition of iron bound to transferrin. Infect Immun 34 (1981) 120-125
    • (1981) Infect Immun , vol.34 , pp. 120-125
    • Holbein, B.E.1
  • 10
    • 0012296376 scopus 로고
    • The role of the reticulo-endothelial cell in iron metabolism
    • NOYES W.D., Bothwell T.H., and Finch C.A. The role of the reticulo-endothelial cell in iron metabolism. Br J Haematol 6 (1960) 43-55
    • (1960) Br J Haematol , vol.6 , pp. 43-55
    • NOYES, W.D.1    Bothwell, T.H.2    Finch, C.A.3
  • 11
    • 0016221446 scopus 로고
    • Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport
    • Fillet G., Cook J.D., and Finch C.A. Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport. J Clin Invest 53 (1974) 1527-1533
    • (1974) J Clin Invest , vol.53 , pp. 1527-1533
    • Fillet, G.1    Cook, J.D.2    Finch, C.A.3
  • 12
    • 0013954846 scopus 로고
    • The anemia of chronic disorders
    • Cartwright G.E. The anemia of chronic disorders. Semin Hematol 3 (1966) 351-375
    • (1966) Semin Hematol , vol.3 , pp. 351-375
    • Cartwright, G.E.1
  • 13
    • 0033847343 scopus 로고    scopus 로고
    • Anemia of the critically ill: "acute" anemia of chronic disease
    • Corwin H.L., and Krantz S.B. Anemia of the critically ill: "acute" anemia of chronic disease. Crit Care Med 28 (2000) 3098-3099
    • (2000) Crit Care Med , vol.28 , pp. 3098-3099
    • Corwin, H.L.1    Krantz, S.B.2
  • 14
    • 22044438662 scopus 로고    scopus 로고
    • Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia
    • Maccio A., Madeddu C., Massa D., Mudu M.C., Lusso M.R., Gramignano G., et al. Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia. Blood 106 (2005) 362-367
    • (2005) Blood , vol.106 , pp. 362-367
    • Maccio, A.1    Madeddu, C.2    Massa, D.3    Mudu, M.C.4    Lusso, M.R.5    Gramignano, G.6
  • 17
    • 0029898504 scopus 로고    scopus 로고
    • Regular low-dose intravenous iron therapy improves response to erythropoietin in haemodialysis patients
    • Taylor J.E., Peat N., Porter C., and Morgan A.G. Regular low-dose intravenous iron therapy improves response to erythropoietin in haemodialysis patients. Nephrol Dial Transplant 11 (1996) 1079-1083
    • (1996) Nephrol Dial Transplant , vol.11 , pp. 1079-1083
    • Taylor, J.E.1    Peat, N.2    Porter, C.3    Morgan, A.G.4
  • 18
    • 0034254356 scopus 로고    scopus 로고
    • Erythropoietin, iron, and erythropoiesis
    • Goodnough L.T., Skikne B., and Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood 96 (2000) 823
    • (2000) Blood , vol.96 , pp. 823
    • Goodnough, L.T.1    Skikne, B.2    Brugnara, C.3
  • 19
    • 2142825053 scopus 로고    scopus 로고
    • Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter, open-label, randomized trial
    • Auerbach M., Ballard H., Trout J.R., McIlwain M., Ackerman A., Bahrain H., et al. Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter, open-label, randomized trial. J Clin Oncol 22 (2004) 1301-1307
    • (2004) J Clin Oncol , vol.22 , pp. 1301-1307
    • Auerbach, M.1    Ballard, H.2    Trout, J.R.3    McIlwain, M.4    Ackerman, A.5    Bahrain, H.6
  • 20
    • 39049101651 scopus 로고    scopus 로고
    • Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin
    • Kapoian T., O'Mara N.B., Singh A.K., Moran J., Rizkala A.R., Geronemus R., et al. Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. J Am Soc Nephrol 19 (2008) 372-379
    • (2008) J Am Soc Nephrol , vol.19 , pp. 372-379
    • Kapoian, T.1    O'Mara, N.B.2    Singh, A.K.3    Moran, J.4    Rizkala, A.R.5    Geronemus, R.6
  • 21
    • 33947212276 scopus 로고    scopus 로고
    • Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) study
    • Coyne D.W., Kapoian T., Suki W., Singh A.K., Moran J.E., Dahl N.V., et al. Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) study. J Am Soc Nephrol 18 (2007) 975-984
    • (2007) J Am Soc Nephrol , vol.18 , pp. 975-984
    • Coyne, D.W.1    Kapoian, T.2    Suki, W.3    Singh, A.K.4    Moran, J.E.5    Dahl, N.V.6
  • 22
    • 41649110613 scopus 로고    scopus 로고
    • Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression
    • Delaby C., Pilard N., Puy H., and Canonne-Hergaux F. Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression. Biochem J 411 (2008) 123-131
    • (2008) Biochem J , vol.411 , pp. 123-131
    • Delaby, C.1    Pilard, N.2    Puy, H.3    Canonne-Hergaux, F.4
  • 23
    • 64949191416 scopus 로고    scopus 로고
    • Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease
    • Ashby D.R., Gale D.P., Busbridge M., Murphy K.G., Duncan N.D., Cairns T.D., et al. Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Kidney Int 75 (2009) 976-981
    • (2009) Kidney Int , vol.75 , pp. 976-981
    • Ashby, D.R.1    Gale, D.P.2    Busbridge, M.3    Murphy, K.G.4    Duncan, N.D.5    Cairns, T.D.6
  • 24
    • 33645292462 scopus 로고
    • Anaemia of rheumatoid arthritis and iron therapy
    • Hume R., Currie W.J., and Tennant M. Anaemia of rheumatoid arthritis and iron therapy. Ann Rheum Dis 24 (1965) 451-457
    • (1965) Ann Rheum Dis , vol.24 , pp. 451-457
    • Hume, R.1    Currie, W.J.2    Tennant, M.3
  • 25
    • 0015184115 scopus 로고
    • The measurement of reticuloendothelial iron release using iron-dextran
    • Beamish M.R., Davies A.G., Eakins J.D., Jacobs A., and Trevett D. The measurement of reticuloendothelial iron release using iron-dextran. Br J Haematol 21 (1971) 617-622
    • (1971) Br J Haematol , vol.21 , pp. 617-622
    • Beamish, M.R.1    Davies, A.G.2    Eakins, J.D.3    Jacobs, A.4    Trevett, D.5
  • 26
    • 34247615981 scopus 로고    scopus 로고
    • Clinical update: intravenous iron for anaemia
    • Auerbach M., Ballard H., and Glaspy J. Clinical update: intravenous iron for anaemia. Lancet 369 (2007) 1502-1504
    • (2007) Lancet , vol.369 , pp. 1502-1504
    • Auerbach, M.1    Ballard, H.2    Glaspy, J.3
  • 27
    • 34748888895 scopus 로고    scopus 로고
    • Acute injury with intravenous iron and concerns regarding long-term safety
    • Bishu K., and Agarwal R. Acute injury with intravenous iron and concerns regarding long-term safety. Clin J Am Soc Nephrol 1 (2006) S19-S23
    • (2006) Clin J Am Soc Nephrol , vol.1
    • Bishu, K.1    Agarwal, R.2
  • 28
    • 11844298978 scopus 로고    scopus 로고
    • Potential risk for infection and atherosclerosis due to iron therapy
    • Sengoelge G., Sunder-Plassmann G., and Horl W.H. Potential risk for infection and atherosclerosis due to iron therapy. J Ren Nutr 15 (2005) 105-110
    • (2005) J Ren Nutr , vol.15 , pp. 105-110
    • Sengoelge, G.1    Sunder-Plassmann, G.2    Horl, W.H.3
  • 29
    • 34548429748 scopus 로고    scopus 로고
    • Macrophage iron, hepcidin, and atherosclerotic plaque stability
    • Sullivan J.L. Macrophage iron, hepcidin, and atherosclerotic plaque stability. Exp Biol Med (Maywood) 232 (2007) 1014-1020
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 1014-1020
    • Sullivan, J.L.1
  • 30
  • 31
    • 0042885457 scopus 로고    scopus 로고
    • Iron and liver cancer
    • Deugnier Y. Iron and liver cancer. Alcohol 30 (2003) 145-150
    • (2003) Alcohol , vol.30 , pp. 145-150
    • Deugnier, Y.1
  • 32
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park C.H., Valore E.V., Waring A.J., and Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276 (2001) 7806-7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 33
    • 24744458603 scopus 로고    scopus 로고
    • Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
    • Rivera S., Nemeth E., Gabayan V., Lopez M.A., Farshidi D., and Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 106 (2005) 2196-2199
    • (2005) Blood , vol.106 , pp. 2196-2199
    • Rivera, S.1    Nemeth, E.2    Gabayan, V.3    Lopez, M.A.4    Farshidi, D.5    Ganz, T.6
  • 34
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 98 (2001) 8780-8785
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6
  • 35
    • 20244388240 scopus 로고    scopus 로고
    • Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    • Roetto A., Papanikolaou G., Politou M., Alberti F., Girelli D., Christakis J., et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 33 (2003) 21-22
    • (2003) Nat Genet , vol.33 , pp. 21-22
    • Roetto, A.1    Papanikolaou, G.2    Politou, M.3    Alberti, F.4    Girelli, D.5    Christakis, J.6
  • 37
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
    • Weinstein D.A., Roy C.N., Fleming M.D., Loda M.F., Wolfsdorf J.I., and Andrews N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100 (2002) 3776-3781
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 38
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 39
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S., and Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275 (2000) 19906-19912
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 40
    • 0034677467 scopus 로고    scopus 로고
    • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    • Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403 (2000) 776-781
    • (2000) Nature , vol.403 , pp. 776-781
    • Donovan, A.1    Brownlie, A.2    Zhou, Y.3    Shepard, J.4    Pratt, S.J.5    Moynihan, J.6
  • 41
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5 (2000) 299-309
    • (2000) Mol Cell , vol.5 , pp. 299-309
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3    Brennan, K.4    Wehr, K.5    Barrow, D.6
  • 42
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan A., Lima C.A., Pinkus J.L., Pinkus G.S., Zon L.I., Robine S., et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1 (2005) 191-200
    • (2005) Cell Metab , vol.1 , pp. 191-200
    • Donovan, A.1    Lima, C.A.2    Pinkus, J.L.3    Pinkus, G.S.4    Zon, L.I.5    Robine, S.6
  • 43
    • 0742272103 scopus 로고    scopus 로고
    • The ferroportin disease
    • Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis 32 (2004) 131-138
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 131-138
    • Pietrangelo, A.1
  • 44
    • 54349094273 scopus 로고    scopus 로고
    • A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
    • Melis M.A., Cau M., Congiu R., Sole G., Barella S., Cao A., et al. A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica 93 (2008) 1473-1479
    • (2008) Haematologica , vol.93 , pp. 1473-1479
    • Melis, M.A.1    Cau, M.2    Congiu, R.3    Sole, G.4    Barella, S.5    Cao, A.6
  • 45
    • 13544252463 scopus 로고    scopus 로고
    • Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
    • Rivera S., Liu L., Nemeth E., Gabayan V., Sorensen O.E., and Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood 105 (2005) 1797-1802
    • (2005) Blood , vol.105 , pp. 1797-1802
    • Rivera, S.1    Liu, L.2    Nemeth, E.3    Gabayan, V.4    Sorensen, O.E.5    Ganz, T.6
  • 46
    • 34247366783 scopus 로고    scopus 로고
    • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
    • Roy C.N., Mak H.H., Akpan I., Losyev G., Zurakowski D., and Andrews N.C. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood 109 (2007) 4038-4044
    • (2007) Blood , vol.109 , pp. 4038-4044
    • Roy, C.N.1    Mak, H.H.2    Akpan, I.3    Losyev, G.4    Zurakowski, D.5    Andrews, N.C.6
  • 47
    • 60149089000 scopus 로고    scopus 로고
    • Hyporesponsiveness to erythropoietin: causes and management
    • Elliott J., Mishler D., and Agarwal R. Hyporesponsiveness to erythropoietin: causes and management. Adv Chronic Kidney Dis 16 (2009) 94-100
    • (2009) Adv Chronic Kidney Dis , vol.16 , pp. 94-100
    • Elliott, J.1    Mishler, D.2    Agarwal, R.3
  • 48
    • 70349368186 scopus 로고    scopus 로고
    • Hepcidin, hepcidin antagonists and methods of use. Amgen Inc. Patent 12/022,515.
    • USA. 1-30-2008
    • Sasu B, Hainu M, Boone TC, Bi XJ, Lee KJ, Arvedson T, et al. Hepcidin, hepcidin antagonists and methods of use. Amgen Inc. Patent 12/022,515. 2009. USA. 1-30-2008.
    • (2009)
    • Sasu, B.1    Hainu, M.2    Boone, T.C.3    Bi, X.J.4    Lee, K.J.5    Arvedson, T.6
  • 49
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110 (2002) 1037-1044
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5    Devaux, I.6
  • 50
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., and Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (2003) 2461-2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 51
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting D.M., and Andrews N.C. Interleukin-6 induces hepcidin expression through STAT3. Blood 108 (2006) 3204-3209
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 54
    • 44649116517 scopus 로고    scopus 로고
    • Isolated microcytic anemia disclosing a unicentric Castleman disease: the interleukin-6/hepcidin pathway?
    • Vinzio S., Ciarloni L., Schlienger J.L., Rohr S., Mechine A., and Goichot B. Isolated microcytic anemia disclosing a unicentric Castleman disease: the interleukin-6/hepcidin pathway?. Eur J Intern Med 19 (2008) 367-369
    • (2008) Eur J Intern Med , vol.19 , pp. 367-369
    • Vinzio, S.1    Ciarloni, L.2    Schlienger, J.L.3    Rohr, S.4    Mechine, A.5    Goichot, B.6
  • 55
    • 36048991069 scopus 로고    scopus 로고
    • Recent advances in immunopathophysiology of interleukin-6: an innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases
    • Ohsugi Y. Recent advances in immunopathophysiology of interleukin-6: an innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases. Biol Pharmaceut Bull 30 (2007) 2001-2006
    • (2007) Biol Pharmaceut Bull , vol.30 , pp. 2001-2006
    • Ohsugi, Y.1
  • 56
    • 0025183151 scopus 로고
    • Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice
    • Brandt S.J., Bodine D.M., Dunbar C.E., and Nienhuis A.W. Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest 86 (1990) 592-599
    • (1990) J Clin Invest , vol.86 , pp. 592-599
    • Brandt, S.J.1    Bodine, D.M.2    Dunbar, C.E.3    Nienhuis, A.W.4
  • 57
    • 0036915034 scopus 로고    scopus 로고
    • Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice
    • Katsume A., Saito H., Yamada Y., Yorozu K., Ueda O., Akamatsu K., et al. Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice. Cytokine 20 (2002) 304-311
    • (2002) Cytokine , vol.20 , pp. 304-311
    • Katsume, A.1    Saito, H.2    Yamada, Y.3    Yorozu, K.4    Ueda, O.5    Akamatsu, K.6
  • 58
    • 27144488346 scopus 로고    scopus 로고
    • Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
    • Nishimoto N., Kanakura Y., Aozasa K., Johkoh T., Nakamura M., Nakano S., et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 106 (2005) 2627-2632
    • (2005) Blood , vol.106 , pp. 2627-2632
    • Nishimoto, N.1    Kanakura, Y.2    Aozasa, K.3    Johkoh, T.4    Nakamura, M.5    Nakano, S.6
  • 59
    • 34347219438 scopus 로고    scopus 로고
    • Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease
    • Kawabata H., Tomosugi N., Kanda J., Tanaka Y., Yoshizaki K., and Uchiyama T. Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease. Haematologica 92 (2007) 857-858
    • (2007) Haematologica , vol.92 , pp. 857-858
    • Kawabata, H.1    Tomosugi, N.2    Kanda, J.3    Tanaka, Y.4    Yoshizaki, K.5    Uchiyama, T.6
  • 61
    • 0030015099 scopus 로고    scopus 로고
    • Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis
    • Cazzola M., Ponchio L., de Benedetti F., Ravelli A., Rosti V., Beguin Y., et al. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. Blood 87 (1996) 4824-4830
    • (1996) Blood , vol.87 , pp. 4824-4830
    • Cazzola, M.1    Ponchio, L.2    de Benedetti, F.3    Ravelli, A.4    Rosti, V.5    Beguin, Y.6
  • 62
    • 33746933151 scopus 로고    scopus 로고
    • Hemojuvelin acts as a bone morphogenetic protein co-receptor to regulate hepcidin expression [abstract]
    • Huang F.W., Babitt J.L., Wrighting D.M., Samad T.A., Xia Y., Sidis Y., et al. Hemojuvelin acts as a bone morphogenetic protein co-receptor to regulate hepcidin expression [abstract]. ASH Annual Meeting Abstracts 106 (2005) 511
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 511
    • Huang, F.W.1    Babitt, J.L.2    Wrighting, D.M.3    Samad, T.A.4    Xia, Y.5    Sidis, Y.6
  • 63
    • 46749158788 scopus 로고    scopus 로고
    • Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    • Xia Y., Babitt J.L., Sidis Y., Chung R.T., and Lin H.Y. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 (2008) 5195-5204
    • (2008) Blood , vol.111 , pp. 5195-5204
    • Xia, Y.1    Babitt, J.L.2    Sidis, Y.3    Chung, R.T.4    Lin, H.Y.5
  • 64
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
    • Truksa J., Peng H., Lee P., and Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci 103 (2006) 10289-10293
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 65
    • 34548825938 scopus 로고    scopus 로고
    • Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    • Lin L., Valore E.V., Nemeth E., Goodnough J.B., Gabayan V., and Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 110 (2007) 2182-2189
    • (2007) Blood , vol.110 , pp. 2182-2189
    • Lin, L.1    Valore, E.V.2    Nemeth, E.3    Goodnough, J.B.4    Gabayan, V.5    Ganz, T.6
  • 66
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • Babitt J.L., Huang F.W., Xia Y., Sidis Y., Andrews N.C., and Lin H.Y. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest 117 (2007) 1933-1939
    • (2007) J Clin Invest , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 67
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang R.H., Li C., Xu X., Zheng Y., Xiao C., Zerfas P., et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2 (2005) 399-409
    • (2005) Cell Metab , vol.2 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3    Zheng, Y.4    Xiao, C.5    Zerfas, P.6
  • 72
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • Niederkofler V., Salie R., and Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115 (2005) 2180-2186
    • (2005) J Clin Invest , vol.115 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 73
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt J.L., Huang F.W., Wrighting D.M., Xia Y., Sidis Y., Samad T.A., et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38 (2006) 531-539
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5    Samad, T.A.6
  • 74
    • 10244225221 scopus 로고    scopus 로고
    • Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin
    • Krijt J., Vokurka M., Chang K.T., and Necas E. Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood 104 (2004) 4308-4310
    • (2004) Blood , vol.104 , pp. 4308-4310
    • Krijt, J.1    Vokurka, M.2    Chang, K.T.3    Necas, E.4
  • 75
    • 33947531436 scopus 로고    scopus 로고
    • Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha
    • Constante M., Wang D., Raymond V.A., Bilodeau M., and Santos M.M. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170 (2007) 497-504
    • (2007) Am J Pathol , vol.170 , pp. 497-504
    • Constante, M.1    Wang, D.2    Raymond, V.A.3    Bilodeau, M.4    Santos, M.M.5
  • 76
    • 0037131264 scopus 로고    scopus 로고
    • Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation
    • Yang F., Liu X.B., Quinones M., Melby P.C., Ghio A., and Haile D.J. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem 277 (2002) 39786-39791
    • (2002) J Biol Chem , vol.277 , pp. 39786-39791
    • Yang, F.1    Liu, X.B.2    Quinones, M.3    Melby, P.C.4    Ghio, A.5    Haile, D.J.6
  • 77
    • 0035933846 scopus 로고    scopus 로고
    • IRP1 activation by extracellular oxidative stress in the perfused rat liver
    • Mueller S., Pantopoulos K., Hubner C.A., Stremmel W., and Hentze M.W. IRP1 activation by extracellular oxidative stress in the perfused rat liver. J Biol Chem 276 (2001) 23192-23196
    • (2001) J Biol Chem , vol.276 , pp. 23192-23196
    • Mueller, S.1    Pantopoulos, K.2    Hubner, C.A.3    Stremmel, W.4    Hentze, M.W.5
  • 78
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G., and Goodnough L.T. Anemia of chronic disease. N Engl J Med 352 (2005) 1011-1023
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.