Potential risk for infection and atherosclerosis due to iron therapy

Journal of Renal Nutrition

Volumn 15, Issue 1, 2005, Pages 105-110

  Sengoelge, Gürkan ^a   Sunder Plassmann, Gere ^a   Hörl, Walter H ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE;

ARTERY INTIMA PROLIFERATION; BACTERIAL GROWTH; BACTERIAL INFECTION; CARBONYLATION; CELL DAMAGE; CONFERENCE PAPER; CORONARY ARTERY ATHEROSCLEROSIS; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; FATTY ACID OXIDATION; HEMODIALYSIS; HOSPITALIZATION; HUMAN; INFECTION COMPLICATION; INFECTION RISK; IRON OVERLOAD; IRON THERAPY; KIDNEY FAILURE; LEUKOCYTE FUNCTION; LIPID PEROXIDATION; NEUTROPHIL; OXIDATIVE STRESS; PROTEIN DIET; REPERFUSION INJURY; RISK ASSESSMENT; URINARY EXCRETION;

ANIMALS; ATHEROSCLEROSIS; BACTERIAL INFECTIONS; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; FERRITINS; HUMANS; IMMUNITY; INFECTION; IRON; IRON OVERLOAD; KIDNEY FAILURE, CHRONIC; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MEAT; OXIDATIVE STRESS; RENAL DIALYSIS; RISK FACTORS;

BACTERIA (MICROORGANISMS);

EID: 11844298978     PISSN: 10512276     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jrn.2004.09.018     Document Type: Conference Paper

References (83)

1. J.J.M. Marx, R.C. Hider Iron. An essential but potentially harmful nutrient Eur J Clin Invest 32 suppl 1 2000 1 2
2. E. Haugen, K.A. Nath The involvement of oxidative stress in the progression of renal injury Blood Purif 17 1999 58 65
3. S. Klahr Oxygen radicals and renal diseases Miner Electrolyte Metab 23 1997 140 143
4. R.A. Zager, A.C. Johnson, S.Y. Hanson Parenteral iron formulations A comparative toxicologic analysis and mechanisms of cell injury Am J Kidney Dis 40 2002 90 103
5. S.V. Shah Role of iron in progressive renal disease Am J Kidney Dis 37 2003 S30 S33
6. G.J. Handelman, M.F. Walter, R. Adhikarla Elevated plasma F2-isoprostanes in patients on long-term hemodialysis Kidney Int 59 2001 1960 1966
7. M.A. Spittle, N.A. Hoenich, G.J. Handelman Oxidative stress and inflammation in hemodialysis patients Am J Kidney Dis 38 2001 1408 1413
8. A.K. Salahudeen, B. Oliver, J.D. Bower Increase in plasma esterified F2-isoprostanes following intravenous iron infusion in patients on hemodialysis Kidney Int 60 2001 1525 1531
9. J.M. Roob, G. Khoschsorur, A. Tiran Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis J Am Soc Nephrol 11 2000 539 549
10. T. Drüeke, V. Witko-Sarsat, Z. Massy Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease Circulation 106 2002 2212 2217
11. R. Agarwal, N. Vasavada, N.G. Sachs Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease Kidney Int 65 2004 2279 2289
12. T.M. Rooyakkers, E.S. Stroes, M.P. Kooistra Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo Eur J Clin Invest 32 suppl 1 2002 9 16
13. J. Herrera, M. Nava, F. Romero Melatonin prevents oxidative stress resulting from iron and erythropoietin administration Am J Kidney Dis 37 2001 750 757
14. D. Tovbin, D. Mazor, M. Vorobiov Induction of protein oxidation by intravenous iron in hemodialysis patients Role of inflammation Am J Kidney Dis 40 2002 1005 1012
15. S.V. Shah, M.G. Alam Role of iron in atherosclerosis Am J Kidney Dis 41 suppl 1 2003 80 83
16. B.J. Van Lenten, J. Prieve, M. Navab Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo J Clin Invest 95 1995 2104 2110
17. A.J. Matthews, G.M. Vercellotti, H.J. Menchaca Iron and atherosclerosis Inhibition by the iron chelator deferiprone (L1) J Surg Res 73 1997 35 40
18. S.J. Duffy, E.S. Biegelsen, M. Holbrook Iron chelation improves endothelial function in patients with coronary artery disease Circulation 103 2001 2799 2804
19. E. Porreca, S. Ucchino, C. Di Febbo Antiproliferative effect of deferrioxamine on vascular smooth muscle cells in vitro and in vivo Arterioscler Thromb 14 1994 299 304
20. B. Halliwell, J.M.C. Gutteridge Role of free radicals and catalytic metal ions in human disease An overview Methods Enzymol 186 1990 1 85
21. B. De Valk, J.J.M. Marx Iron, atherosclerosis, and ischemic heart disease Arch Intern Med 159 2000 1542 1548
22. E.E. Voest, G. Vreugdenhil, J.J.M. Marx Iron-chelating agents in non-iron overload conditions Ann Intern Med 120 1994 490 499
23. T.M. Rooyakkers, E.S.G. Stroes, M.P. Kooistra Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo Eur J Clin Invest 32 suppl 1 2002 9 16
24. G. Sengoelge, V. Rainer, J. Kletzmayt Dose-dependent of parenteral iron therapy on bleomycin detectable iron in immune apheresis patients Kidney Int 66 2004 295 302
25. M.P. Kooistra, S. Kersting, I. Gosriwatana Nontransferrin-bound iron in tzhe plasma of haemodialysis patients after intravenous iron saccharate infusion Eur J Clin Invest 32 suppl 1 2002 36 41
26. B. Scheiber-Mojdehkar, B. Lutzky, R. Schaufler Non-transferrin-bound iron in the serum of hemodialysis patients who receive ferric saccharate No correlation to peroxide generation J Am Soc Nephrol 15 2004 1648 1655
27. B.P. Esposito, W. Breuer, I. Slotki Labile iron in parenteral iron formulations and its potential for generating plasma nontransferrin-bound iron in dialysis patients Eur J Clin Invest 32 suppl 1 2002 42 49
28. R. Michelis, R. Gery, S. Sela Carbonyl stress induced by intravenous iron during haemodialysis Nephrol Dial Transplant 18 2003 924 930
29. F.L.J. Visseren, M.S.A. Verkerk, T. van der Bruggen Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A Eur J Clin Invest 32 suppl 1 2002 84 90
30. R. Baliga, N. Ueda, S.V. Shah Kidney iron status in passive Heymann nephritis and the effect of iron deficient diet J Am Soc Nephrol 7 2000 337 345
31. R. Baliga, N. Ueda, S.V. Shah Increase in bleomycin-detectable iron in ischemia/reperfusion injury to rat kidneys Biochem J 291 1993 901 905
32. J.A. Araujo, E.L. Romano, B.E. Brito Iron overload augments the development of atherosclerotic lesions in rabbits Arterioscler Thromb Vasc Biol 15 1995 1172 1180
33. H. Van Jaarsfeld, G.F. Pool, H.C. Barnard Dietary iron concentration alters LDL oxidatively. The effect of antioxidants Res Commun Mol Pathol Pharmacol 99 1998 69 80
34. A.J. Dabbagh, G.T. Shwaery, J.F. Keaney Jr Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit Arterioscler Thromb Vasc Biol 17 1997 2638 2645
35. E.A. Kirk, J.W. Heinecke, R.C. LeBoeuf Iron overload diminishes atherosclerosis in apoE-deficient mice J Clin Invest 107 2001 1545 1553
36. S.M. Turbino-Ribeiro, M.E. Silva, D.A. Chianca Jr Iron overload in hypercholesterolemic rats affects iron homeostasis and serum lipids but not blood pressure J Nutr 133 2003 15 20
37. J.T. Salonen, K. Nyyssönen, H. Korpela High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men Circulation 86 1992 803 811
38. S. Kiechl, F. Aichinger, F. Gerstenbrand Body iron stores and presence of carotid atherosclerosis. Results from the Bruneck study Arterioscler Thromb 14 1994 1625 1630
39. H.I. Morrison, R.M. Semenciw, Y. Mao Serum iron and risk of fatal acute myocardial infarction Epidemiology 5 1994 243 246
40. A. Ascherio, W.C. Willett, E.B. Rimm Dietary intake and risk of coronary disease among men Circulation 89 1994 969 974
41. P.S. Gartside, C.J. Glueck The important role of modifiable dietary and behavioral characteristics in the causation and prevention of coronary heart disease hospitalization and mortality The prospective NHANES I follow-up study J Am Coll Nutr 14 1995 71 79
42. M.C. Corti, J.M. Guralnik, M.E. Salive Serum iron level, coronary artery disease, and all-cause mortality in older men and women Am J Cardiol 79 1997 120 127
43. S. Nurko, E. Young Serum ferritin (SF), cardiovascular risk and mortality risk in hemodialysis patients J Am Soc Nephrol 8 1997 206A (abstr)
44. M. Miller, G.M. Hutchins Hemochromatosis, multiorgan hemosiderosis, and coronary artery disease JAMA 272 1994 231 233
45. Q. Yang, S.M. McDonnell, M.J. Khoury Hemochromatosis-associated mortality in the United States from 1979 to 1992 An analysis of multiple-cause mortality data Ann Intern Med 129 1998 946 953
46. A. Besarab, W.K. Bolton, J.K. Browne The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin N Engl J Med 339 1998 584 590
47. P. Williams, E. Griffiths Bacterial transferrin receptors--structure, function and contribution to virulence Med Microbiol Immunol 181 1992 301 322
48. T. Gallant, M.H. Freedman, H. Vellend Yersinia sepsis in patients with iron overload treated with deferoxamine N Engl J Med 314 1986 1643 (letter)
49. T. Walter, S. Arredondo, M. Arévalo Effect of iron therapy on phagocytosis and bacterial activity in neutrophils of iron-deficient infants Am J Clin Nutr 44 1986 877 882
50. H. Murakawa, C.E. Bland, W.T. Willis Iron deficiency and neutrophil function Different rates of correction of the depressions in oxidative burst and myeloperoxidase activity after iron treatment Blood 69 1987 1464 1468
51. M.J. Struelens, G. Mondal, M. Roberts Role of bacterial and host factors in the pathogenesis of Shigella septicemia Eur J Clin Microbiol Infect Dis 9 1990 337 344
52. M.L. Towns, B. Bennett, I.J. Check An improved method for determining the microbial inhibitory activity of serum and its application to the study of patients with leukemia Am J Clin Pathol 92 1989 192 198
53. R.L. Hunter, B. Bennett, M. Towns Transferrin in disease II Defects in the regulation of transferrin saturation with iron contribute to susceptibility to infection Am J Clin Pathol 81 1984 748 753
54. G. Weiss Iron and immunity A double-edged sword Eur J Clin Invest 32 suppl 1 2002 70 78
55. J. Cantinieaux, J. Boelaert, C. Hariga Impaired neutrophil defense against Yersinia enterocolitica in patients with iron overload who are undergoing dialysis J Lab Clin Med 111 1988 524 528
56. S.I. Patruta, R. Edlinger, G. Sunder-Plassmann Neutrophil impairment associated with iron therapy in hemodialysis patients with functional iron deficiency J Am Soc Nephrol 9 1998 655 663
57. National Kidney Foundation NKF-DOQI clinical practice guidelines for the treatment of anemia of chronic renal failure Am J Kidney Dis 30 1997 S192 S237
58. P.M. Harrison, P. Arosio The ferritins Molecular properties, iron storage function and cellular regulation Biochim Biophys Acta 1275 1996 161 203
59. Y. Cui, Z.N. Zhang, R.S. Li Influence of latent iron deficiency on generation of oxagen species in polymorphonuclear leukocytes Chin Med J 103 1990 642 646
60. R.D. Klausner, T.A. Rouault, J.B. Harford Regulating the fate of mRNA The control of cellular iron metabolism Cell 72 1993 19 28
61. A. Bomford, R. Williams Long term results of venesection therapy in idiopathic haemochromatosis Q J Med 45 1976 611 623
62. E.D. Weinberg Iron depletion A defense against intracellular infection and neoplasia Life Sci 50 1992 1289 1297
63. J.H. Brock, T. Mainou-Fowler The role of iron and transferrin in lymphocyte transformation Immunol Today 4 1983 347 351
64. T. Walter, S. Arredondo, M. Arévalo Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron-deficient infants Am J Clin Nutr 44 1986 877 882
65. S.M. Payne Iron and virulence in the family Enterobacteriaceae Crit Rev Microbiol 16 1988 81 111
66. M. Sussman Iron and infection A. Jacobs M. Worwood Iron in Biochemistry and Medicine 1974 Academic Press New York, NY 649 679
67. H.L. Bonkovsky, B.F. Banner, A.L. Rothman Iron and chronic viral hepatitis Hepatology 25 1997 759 768
68. Y. Salhi, D. Costagliola, P. Rebulla Serum ferritin, desferrioxamine, and evolution of HIV-1 infection in thalassemic patients J Acquir Immune Defic Syndr 18 1998 473 478
69. A. Menecacci, E. Cenci, J.R. Bolaert Iron overload alters innate and T helper cell responses to Candida albicans in mice J Infect Dis 175 1997 1467 1476
70. J.R. Boelaert, B.F. Cantinieaux, C.F. Hariga Recombinant erythropoietin in reverses polymorphonuclear granulocyte dysfunction in iron-overloaded dialysis patients Nephrol Dial Transplant 5 1990 504 507
71. B. Hoen, A. Paul-Dauphin, D. Hestin EPIBACDIAL A multicenter prospective study of risk factors for bacteremia in chronic hemodialysis patients J Am Soc Nephrol 9 1998 869 876
72. W.H. Hörl Hemodialysis membranes Interleukins, biocompatibility, and middle molecules J Am Soc Nephrol 13 suppl 1 2002 62 71
73. R. Deicher, F. Ziai, G. Cohen High-dose parenteral iron sucrose depresses neutrophil intracellular killing capacity Kidney Int 64 2003 728 736
74. G. Sengoelge, J. Kletzmayr, I. Ferrara Impairment of transendothelial migration by iron complexes J Am Soc Nephrol 14 2003 2639 2644
75. M. Kessler, B. Hoen, D. Mayeux Bacteremia in patients on chronic hemodialysis Nephron 64 1993 95 100
76. B. Hoen, M. Kessler, D. Hestin Risk factors for bacterial infections in chronic haemodialysis adult patients A multicentre prospective survey Nephrol Dial Transplant 10 1995 377 381
77. A. Seifert, D. von Herrath, K. Schaefer Iron overload, but not treatment with desferrioxamine favours the development of septicemia in patients on maintenance hemodialysis Q J Med 65 1987 1015 1024
78. C.L. Tielemans, C.M. Lenclud, R. Wens Critical role of iron overload in the increased susceptibility of haemodialysis patients to bacterial infections. Beneficial effects of desferrioxamine Nephrol Dial Transplant 4 1989 883 887
79. J.R. Boelaert, R.F. Daneeels, M.L. Schurgers Iron overload in haemodialysis patients increases the risk of bacteraemia A prospective study Nephrol Dial Transplant 5 1990 130 134
80. H.I. Feldman, J. Santanna, W. Guo Iron administration and clinical outcomes in hemodialysis patients J Am Soc Nephrol 13 2002 734 744
81. H.I. Feldman, M. Joffe, B. Robinson Administration of parenteral iron and mortality among hemodialysis patients J Am Soc Nephrol 15 2004 1623 1632
82. K. Kalantar-Zadeh, R. Rodriguez, M.H. Humphreys Serum ferritin is a marker of morbidity and mortality in hemodialysis patients Am J Kidney Dis 37 2001 564 572
83. J. Kletzmayr, W.H. Hörl Iron overload and cardiovascular complications in dialysis patients Nephrol Dial Transplant 17 suppl 2 2002 27 32