CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation

Journal of Immunology

Volumn 176, Issue 3, 2006, Pages 1402-1410

  Ponomarev, Eugene D ^a   Shriver, Leah P ^a,b   Dittel, Bonnie N ^a,b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD40 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BONE MARROW CELL; CELL LINEAGE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CHIMERA; CONTROLLED STUDY; DISEASE COURSE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MICROGLIA; MONOCYTE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SYMPTOMATOLOGY; T LYMPHOCYTE;

EID: 31144457903     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.3.1402     Document Type: Article

References (38)

1. Jack, C., F. Ruffini, A. Bar-Or, and J. P. Antel. 2005. Microglia and multiple sclerosis. J. Neurosci. Res. 81: 363-373.
2. Raivich, G., and R. Banati. 2004. Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease: Brain Res. Rev. 46: 261-281.
3. Sedgwick, J. D., S. Schwender, H. Imrich, R. Dörries, G. W. Butcher, and V. ter Meulen. 1991. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc. Natl. Acad. Sci. USA 88: 7438-7442.
4. Ponomarev, E. D., L. P. Shriver, K. Maresz, and B. N. Dittel. 2005. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res. 81: 374-389.
5. Heppner, F. L., M. Greter, D. Marino, J. Falsig, G. Raivich, N. Hövelmeyer, A. Waisman, T. Rülicke, M. Prinz, J. Priller, et al. 2005. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat. Med. 11: 146-152.
6. D'Aversa, T. G., K. M. Weidenheim, and J. W. Berman. 2002. CD40-CD40L interactions induce chemokine expression by human microglia: implications for human immunodeficiency virus encephalitis and multiple sclerosis. Am. J. Pathol. 160: 559-567.
7. Olson, J. K., A. M. Girvin, and S. D. Miller. 2001. Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus. J. Virol. 75: 9780-9789.
8. Tompkins, S. M., J. Padilla, M. C. Dal Canto, J. P. Ting, L. Van Kaer, and S. D. Miller. 2002. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J. Immunol. 168: 4173-4183.
9. Matyszak, M. K., S. Denis-Donini, S. Citterio, R. Longhi, F. Granucci, and P. Ricciardi-Castagnoli. 1999. Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation. Eur. J. Immunol. 29: 3063-3076.
10. Aloisi, F., R. De Simone, S. Columba-Cabezas, G. Penna, and L. Adorini. 2000. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells. J. Immunol. 164: 1705-1712.
11. Gerritse, K., J. D. Laman, R. J. Noelle, A. Aruffo, J. A. Ledbetter, W. J. Boersma, and E. Claassen. 1996. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl Acad. Sci. USA 93: 2499-2504.
12. van Kooten, C., and J. Banchereau. 2000. CD40-CD40 ligand. J. Leukocyte Biol. 67: 2-17.
13. Stout, R. D., and J. Suttles. 1996. The many roles of CD40 in cell-mediated inflammatory responses. Immunol. Today 17: 487-492.
14. Sospedra, M., and R. Martin. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23: 683-747.
15. Wong, F. S., B. N. Dittel, and C. A. Janeway, Jr. 1999. Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis. Immunol. Rev. 169: 93-104.
16. Chitnis, T., and S. J. Khoury. 2003. Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis. J. Allergy Clin. Immunol. 112: 837-849.
17. Becher, B., B. G. Durell, A. V. Miga, W. F. Hickey, and R. J. Noelle. 2001. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J. Exp. Med. 193: 967-974.
18. Ndhlovu, L. C., N. Ishii, K. Murata, T. Sato, and K. Sugamura. 2001. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J. Immunol. 167: 2991-2999.
19. Hochweller, K., and S. M. Anderton. 2004. Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administration. Eur. J. Immunol. 34: 990-998.
20. Howard, L. M., A. J. Miga, C. L. Vanderlugt, M. C. Dal Canto, J. D. Laman, R. J. Noelle, and S. D. Miller. 1999. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis. J. Clin. Invest. 103: 281-290.
21. Laman, J. D., B. A. 't Hart, H. Brok, M. van Meurs, M. M. Schellekens, A. Kasran, L. Boon, J. Bauer, M. de Boer, and J. Ceuppens. 2002. Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12). Eur. J. Immunol. 32: 2218-2228.
22. 't Hart, B. A., E. L. Blezer, H. P. Brok, L. Boon, M. de Boer, J. Bauer, and J. D. Laman. 2005. Treatment with chimeric anti-human CD40 antibody suppresses MRI-detectable inflammation and enlargement of pre-existing brain lesions in common marmosets affected by MOG-induced EAE. J. Neuroimmunol. 163: 31-39.
23. Ichikawa, H. T., L. P. Williams, and B. M. Segal. 2002. Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease. J. Immunol. 169: 2781-2787.
24. Holländer, G. A., E. Castigli, R. Kulbacki, M. Su, S. J. Burakoff, J. C. Gutierrez-Ramos, and R. S. Geha. 1996. Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice. Proc. Natl. Acad. Sci. USA 93: 4994-4998.
25. Dittel, B. N., R. M. Merchant, and C. A. Janeway, Jr. 1999. Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol. 162: 6392-6400.
26. Ponomarev, E. D., and B. N. Dittel. 2005. γδ T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism. J. Immunol. 174: 4678-4687.
27. Watanabe, T., T. Yamamoto, Y. Abe, N. Saito, T. Kumagai, and H. Kayama. 1999. Differential activation of microglia after experimental spinal cord injury. J. Neurotrauma 16: 255-265.
28. Isaksson, J., M. Farooque, A. Holtz, L. Hillered, and Y. Olsson. 1999. Expression of ICAM-1 and CD11b after experimental spinal cord injury in rats. J. Neurotrauma 16: 165-173.
29. Kreutzberg, G. W. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19: 312-318.
30. Zhang, Z., K. Trautmann, and H. J. Schluesener. 2005. Microglia activation in rat spinal cord by systemic injection of TLR3 and TLR7/8 agonists. J. Neuroimmunol. 164: 154-160.
31. Ponomarev, E. D., M. Novikova, M. Yassai, M. Szczepanik, J. Gorski, and B. N. Dittel. 2004. γδ T cell regulation of IFN-γ production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J. Immunol. 173: 1587-1595.
32. Ford, A. L., E. Foulcher, F. A. Lemckert, and J. D. Sedgwick. 1996. Microglia induce CD4 T lymphocyte final effector function and death. J. Exp. Med. 184: 1737-1745.
33. Ponomarev, E. D., M. Novikova, K. Maresz, L. P. Shriver, and B. N. Dittel. 2005. Development of a culture system that supports adult microglial cell proliferation and maintenance in the resting state. J. Immunol. Methods 300: 32-46.
34. McMahon, E. J., S. L. Bailey, C. V. Castenada, H. Waldner, and S. D. Miller. 2005. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 11: 335-339.
35. Becher, B., B. G. Durell, and R. J. Noelle. 2003. IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J. Clin. Invest 112: 1186-1191.
36. Okuno, T., Y. Nakatsuji, A. Kumanogoh, K. Koguchi, M. Moriya, H. Fujimura, H. Kikutani, and S. Sakoda. 2004. Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway: relevance to amyotrophic lateral sclerosis. J. Neurochem. 91: 404-412.
37. Tan, J., T. Town, T. Mori, D. Obregon, Y. Wu, A. DelleDonne, A. Rojiani, F. Crawford, R. A. Flavell, and M. Mullan. 2002. CD40 is expressed and functional on neuronal cells. EMBO J. 21: 643-652.
38. Aloisi, F., F. Ria, and L. Adorini. 2000. Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol. Today 21: 141-147.