Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40

EMBO Journal

Volumn 22, Issue 15, 2003, Pages 3855-3864

  Eliopoulos, Aristides G ^a,b   Wang, Chun Chi ^b   Dumitru, Calin D ^b   Tsichlis, Philip N ^b  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

CD40; ERK; Signaling; TNF; Tpl2

Indexed keywords

ANTIBODY; CD40 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN TPL2; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; ENZYME ACTIVATION; IMMUNOGLOBULIN E; MACROPHAGES; MAP KINASE KINASE KINASES; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0042525945     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg386     Document Type: Article

References (52)

1. Afford, S.C., Randhawa, S., Eliopoulos, A.G., Hubscher, S.G., Young, L.S. and Adams, D.H. (1999) CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface Fas ligand expression and amplifies Fas-mediated hepatocyte death during allograft rejection. J. Exp. Med., 189, 441-446.
2. Ahonen, C., Manning, E., Erickson, L.D., O'Connor, B., Lind, E.F., Pullen, S.S., Kehry, M.R. and Noelle, R.J. (2002) The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat. Immunol. 3, 451-456.
3. Allen, R.C. et al. (1993) CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science, 259, 990-993.
4. Armitage, R.J., Macduff, B.M., Spriggs, M.K. and Fanslow, W.C. (1993) Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J. Immunol., 150, 3671-3680.
5. Aruffo, A. et al. (1993) The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell, 72, 291-300.
6. Bacharier, L.B. and Geha, R.S. (2000) Molecular mechanisms of IgE regulation. J. Allergy Clin. Immunol., 105, S547-S558.
7. Basaki, Y., Ikizawa, K., Kajiwara, K. and Yanagihara, Y. (2002) CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line. Arch. Biochem. Biophys., 405, 199-204.
8. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. and Goeddel, D.V. (1996) TRAF6 is a signal transducer for interleukin-1. Nature, 383, 443-446.
9. Ceci, J.D., Patriotis, C.P., Tsatsanis, C., Makris, A.M., Kovatch, R., Swing, D.A., Jenkins, N.A., Tsichlis, P.N. and Copeland, N.G. (1997) Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev., 11, 688-700.
10. Challa, A. et al. (2002) Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells. Blood, 99, 3411-3418.
11. Chung, J.Y., Park, Y.C., Ye, H. and Wu, H. (2002) All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J. Cell Sci., 115, 679-688.
12. DiSanto, J.P., Bonnefoy, J.Y., Gauchat, J.F., Fischer, A. and de Saint Basile, G. (1993) CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM. Nature, 361, 541-543.
13. Dumitru, C.D. et al. (2000) TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell, 103, 1071-1083.
14. Eliopoulos, A.G. et al. (1996) CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr virus-encoded LMPI: involvement of TRAF3 as a common mediator. Oncogene, 13, 2243-2254.
15. Eliopoulos, A.G., Davies, C., Knox, P.G., Gallagher, N.J., Afford, S.C., Adams, D.H. and Young, L.S. (2000) CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol. Cell. Biol., 20, 5503-5515.
16. Eliopoulos, A.G., Dumitru, C.D., Wang, C.-C., Cho, J. and Tsichlis, P.N. (2002a) Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J., 21, 4931-4940.
17. Eliopoulos, A.G., Davies, C., Blake, S.S., Murray, P., Najafipour, S., Tsichlis, P.N. and Young, L.S. (2002b) The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-κB signaling downstream of TRAF2. J. Virol., 76, 4567-4579.
18. Erny, K.M., Peli, J., Lambert, J.F., Muller, V. and Diggelmann, H. (1996) Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis. Oncogene, 13, 2015-2020.
19. Funakoshi, S. et al. (1994) Inhibition of human B-cell lymphoma growth by CD40 stimulation. Blood, 83, 2787-2794.
20. Gauchat, J.F. et al. (1993) Induction of human IgE synthesis in B cells by mast cells and basophils. Nature, 365, 340-343.
21. Grell, M. et al. (1999) Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J., 18, 3034-3043.
22. Grewal, I.S., Xu, J. and Flavell, R.A. (1995) Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature, 378, 617-620.
23. Horwitz, B.H., Zelazowski, P., Shen, Y., Wolcott, K.M., Scott, M.L., Baltimore, D. and Snapper, C.M. (1999) The p65 subunit of NF-κB is redundant with p50 during B cell proliferative responses and is required for germline CH transcription and class switching to IgG3. J. Immunol., 162, 1941-1946.
24. Iciek, L.A., Delphin, S.A. and Stavnezer, J. (1997) CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-κB: synergy with IL-4 induction. J. Immunol., 158, 4769-4779.
25. Inoue, J., Ishida, T., Tsukamoto, N., Kobayashi, N., Naito, A., Azuma, S. and Yamamoto, T. (2000) Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. Exp. Cell Res., 254, 14-24.
26. Ishida, T. et al. (1996) Identification of TRAF6, a novel tumour necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem., 271, 28745-28748.
27. Jabara, H.H., Fu, S.M., Geha, R.S. and Vercelli, D. (1990) CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med., 172, 1861-1864.
28. Jabara, H. et al. (2002) The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity, 17, 265-276.
29. Jupp, O.J., McFarlane, S.M., Anderson, H.M., Littlejohn, A.F., Mohamed, A.A., MacKay, R.H., Vandenabeele, P. and MacEwan, D.J. (2001) Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways. Biochem. J., 359, 525-535.
30. Kashiwada, M., Shirakata, Y., Inoue, J.-I., Nakano, H., Okazaki, K., Okumura, K., Yamamoto, T., Nagaoka, H. and Takemori, T. (1998) Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signalling along a Ras-independent pathway. J. Exp. Med., 187, 237-244.
31. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. and Kikutani, H. (1994) The immune responses in CD40 deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity, 1, 167-178.
32. Kontoyiannis, D. et al. (2002) Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J. Exp. Med., 196, 1563-1574.
33. Korthauer, U. et al. (1993) Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature, 361, 539-541.
34. Leo, E., Zapata, J.M. and Reed, J.C. (1999) CD40-mediated activation of Ig-Cγ1- and Ig-cε germ-line promoters involves multiple TRAF family proteins. Eur. J. Immunol., 29, 3908-3913.
35. Lin, X., Cunningham, E.T., Mu, Y., Geleziunas, R. and Greene, W.C. (1999) The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity, 10, 271-280.
36. Linehan, L.A., Warren, W.D., Thompson, P.A., Grusby, M.J. and Berton, M.T. (1998) STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J. Immunol., 161, 302-310.
37. Lomaga, M.A. et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40 and LPS signaling. Genes Dev., 13, 1015-1024.
38. Patriotis, C., Makris, A., Bear, S.E. and Tsichlis, P.N. (1993) Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc. Natl Acad. Sci. USA, 90, 2251-2255.
39. Patriotis, C., Makris, A., Chernoff, J. and Tsichlis, P.N. (1994) Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc. Natl Acad. Sci. USA, 91, 9755-9759.
40. Purkerson, J. and Isakson, P. (1992) A two-signal model for regulation of immunoglobulin isotype switching. FASEB J., 6, 3245-3252.
41. Reinhard, C., Shamoon, B., Shyamala, V. and Williams, L.T. (1997) Tumour necrosis factor-α-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J., 16, 1080-1092.
42. Ren, H., Schmalstieg, A., Yuan, D. and Gaynor, R.B. (2002) I-κB kinase β is critical for B cell proliferation and antibody response. J. Immunol., 168, 577-587.
43. Salmeron, A., Ahmad, T.B., Carlile, G.W., Pappin, D., Narsimhan, R.P. and Ley, S.C. (1996) Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase. EMBO J., 15, 817-826.
44. Shimoda, K. et al. (1996) Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature, 380, 630-633.
45. Takeda, K. et al. (1996) Essential role of Stat6 in IL-4 signalling. Nature, 380, 627-630.
46. Tsatsanis, C., Patriotis, C., Bear, S.E. and Tsichlis, P.N. (1998a) The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cells. Proc. Natl Acad. Sci. USA, 95, 3827-3832.
47. Tsatsanis, C., Patriotis, C. and Tsichlis, P.N. (1998b) Tpl-2 induces IL-2 expression in T cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB. Oncogene, 17, 2609-2618.
48. Tsukamoto, N., Kobayashi, N., Azuma, S., Yamamoto, T. and Inoue, J.-I. (1999) Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40. Proc. Natl Acad. Sci. USA, 96, 1234-1239.
49. van Kooten, C. and Banchereau, J. (2000) CD40-CD40 ligand. J. Leukoc. Biol., 67, 2-17.
50. Vidalain, P.O., Azocar, O., Servet-Delprat, C., Rabourdin-Combe, C., Gerlier, D. and Manie, S. (2000) CD40 signaling in human dendritic cells is initiated within membrane rafts. EMBO J., 19, 3304-3313.
51. Waterfield, M.R., Zhang, M., Norman, L.P. and Sun, S.C. (2003) NF-κB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol. Cell, 11, 685-694.
52. Xu, J., Foy, T.M., Laman, J.D., Elliot, E.A., Dun, J.J., Waldscmidt, T.J., Elsemore, J., Noelle, R.J. and Flavell, R.A. (1994) Mice deficient for the CD40 ligand. Immunity, 1, 423-431.