NMR-based techniques in the hit identification and optimisation processes

Expert Opinion on Therapeutic Targets

Volumn 8, Issue 6, 2004, Pages 597-611

  Pellecchia, Maurizio ^a   Becattini, Barbara ^a   Crowell, Kevin J ^a   Fattorusso, Roberto ^a   Forino, Martino ^a   Fragai, Marco ^a   Jung, Dawoon ^a   Mustelin, Tomas ^a   Tautz, Lutz ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

3 FABS; Drug design; Drug discovery; Inter ligand nuclear Overhauser effect (ILOE); NMR; SAR by NMR; Saturation transfer difference (STD); Structure based iterative optimisations (SUBITO); Stucture activity relationships (SAR) by ILOE

Indexed keywords

AMINO ACID; LIGAND; PHOSPHOTRANSFERASE; PROTEINASE;

BINDING SITE; CHEMICAL STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; VALIDATION PROCESS;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ENZYMES; FORECASTING; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11144352156     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.8.6.597     Document Type: Review

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