Discovery of ligands for Nurr1 by combined use of NMR screening with different isotopic and spin-labeling strategies

Journal of Biomolecular Screening

Volumn 12, Issue 3, 2007, Pages 301-311

  Poppe, Leszek ^a   Harvey, Timothy S ^a   Mohr, Christopher ^a   Zondlo, James ^a   Tegley, Christopher M ^a   Nuanmanee, Opas ^a   Cheetham, Janet ^a  

^a AMGEN INC   (United States)

Author keywords

Fragment based approach; Isotope labeling; NMR screening; Nurr1 ligands; Spin labeling

Indexed keywords

CARBON 13; CYSTEINE; LIGAND; MACROGOL; MERCAPTOETHANOL; NUCLEAR RECEPTOR RELATED FACTOR 1;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; DISSOCIATION CONSTANT; ELECTRON SPIN RESONANCE; ISOTOPE LABELING; MAGNETISM; MOLECULAR PROBE; MOLECULAR SIZE; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SCREENING; SIGNAL TRANSDUCTION; SPIN LABELING; VALIDATION PROCESS;

BINDING SITES; DNA-BINDING PROTEINS; FLUORINE; HUMANS; ISOTOPE LABELING; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; NITROGEN ISOTOPES; REPRODUCIBILITY OF RESULTS; SPIN LABELS; TRANSCRIPTION FACTORS;

EID: 34047156546     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057106299161     Document Type: Article

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