Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis

Cancer Biology and Therapy

Volumn 8, Issue 16, 2009, Pages

  Pan, Yu ^a,b   Ren, Kai Huan ^a   He, Hong Wei ^a   Shao, Rong Guang ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Checkpoint abrogation; Chk1; DNA damage; G2 M arrest; LDM; P53

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 2; CASPASE 3; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DOUBLE STRANDED DNA; ENEDIYNE; GAMMA HISTONE H2AX PROTEIN; HISTONE H2AX; LIDAMYCIN; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; ANTIBIOTIC C 1027; ANTINEOPLASTIC ANTIBIOTIC; CASP2 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYSTEINE PROTEINASE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; SENSITIZATION; CELL DIVISION; CELL GROWTH; CELL STRAIN HCT116; COLON TUMOR; DRUG EFFECT; ENZYMOLOGY; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; WESTERN BLOTTING;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CASPASE 2; CASPASE 3; CELL CYCLE PROTEINS; CELL DIVISION; CELL GROWTH PROCESSES; COLONIC NEOPLASMS; CYSTEINE ENDOPEPTIDASES; ENEDIYNES; G2 PHASE; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70349098826     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.16.8955     Document Type: Article

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