Structure-guided engineering of the regioselectivity of RNA ligase ribozymes

Journal of the American Chemical Society

Volumn 131, Issue 10, 2009, Pages 3532-3540

  Pitt, Jason N ^a,b,c   Ferré D'Amaré, Adrian R ^a,b,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLASS II; IN-VITRO; LIGASE RIBOZYME; LIGATION REACTIONS; LOCAL GEOMETRY; PHOSPHODIESTERS; RIBOZYMES; RNA POLYMERASE; RNA SYNTHESIS; RNA WORLD; STRUCTURAL DIFFERENCES; TRIPHOSPHATE;

CRYSTAL STRUCTURE; ESTERS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; REGIOSELECTIVITY; RNA; SUBSTRATES; SYNTHESIS (CHEMICAL);

ENZYMES;

ADENOSINE TRIPHOSPHATE; ALANINE; GLYCINE; OLIGONUCLEOTIDE; PHOSPHATE; PHOSPHODIESTERASE; RIBOZYME; RNA LIGASE; RNA POLYMERASE;

ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CHIMERA; CRYSTAL STRUCTURE; HYPOTHESIS; IN VITRO SELECTION; PROTEIN CROSS LINKING; PROTEIN ENGINEERING; REGIOSELECTIVITY; RNA STRUCTURE; RNA SYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CONFORMATION;

CATALYSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RNA LIGASE (ATP); RNA, CATALYTIC;

EID: 70249111526     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8067325     Document Type: Article

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