A ribozyme that lacks cytidine

Nature

Volumn 402, Issue 6759, 1999, Pages 323-325

  Rogers, Jeff ^a   Joyce, Gerald F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE; DNA; RIBOZYME; RNA LIGASE;

ARTICLE; BIOGENESIS; CATALYSIS; EVOLUTION; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; RNA DEGRADATION; RNA STRUCTURE;

NASA DISCIPLINE EXOBIOLOGY; NON-NASA CENTER;

BASE SEQUENCE; CATALYSIS; CLONING, MOLECULAR; CYTIDINE; DIRECTED MOLECULAR EVOLUTION; LIGASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEIC ACID CONFORMATION; POLYMERASE CHAIN REACTION; RNA, CATALYTIC; VARIATION (GENETICS);

EID: 0033581938     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/46335     Document Type: Article

References (21)

1. Gesteland, R. F., Cech, T. R. & Atkins, J. F. (eds) The RNA World 2nd edn (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1999).
2. Kruger, K. et al. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 31, 147-157 (1982).
3. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N. & Altman, S. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme. Cell 35, 849-857 (1983).
4. Lorsch, J. R. & Szostak, J. W. In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature 371, 31-36 (1994).
5. Ekland, E. H. & Bartel, D. P. RNA-catalysed RNA polymerization using nucleoside triphosphates. Nature 382, 373-376 (1996).
6. Zhang, B. & Cech, T. R. Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features. Chem. Biol. 5, 539-553 (1998).
7. Unrau, P. J. & Bartel, D. P. RNA-catalysed nucleotide synthesis. Nature 395, 260-263 (1998).
8. Levy, M. & Miller, S. L. The stability of the RNA bases: implications for the origin of life. Proc. Natl Acad. Sci. USA 95, 7933-7938 (1998).
9. Bartel, D. P. & Szostak, J. W. Isolation of new ribozymes from a large pool of random sequences. Science 261, 1411-1418 (1993).
10. Ekland, E. H., Szostak, J. W. & Bartel, D. P. Structurally complex and highly active RNA ligases derived from random RNA sequences. Science 269, 364-370 (1995).
11. Wright, M. C. & Joyce, G. F. Continuous in vitro evolution of catalytic function. Science 276, 614-617 (1997).
12. Hayatsu, H., Wataya, Y. & Kai, K. The addition of sodium bisulfite to uracil and to cytosine. J. Am. Chem. Soc. 92, 724-726 (1970).
13. Rohatgi, R., Bartel, D. P. & Szostak, J. W. Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. J. Am. Chem. Soc. 118, 3332-3339 (1996).
14. Yoshida, H., Kumimoto, H. & Okamoto, K. dutA RNA functions as an untranslatable RNA in the development of Dictyostelium discoideum. Nucleic Acids Res. 22, 41-46 (1994).
15. Shu, H., Wise, C. A., Clark-Walker, G. D. & Martin, N. C. A gene required for RNase P activity in Candida (Torulopsis) glabrata mitochondria codes for a 227-nucleotide RNA with homology to bacterial RNase P RNA. Mol Cell. Biol. 11, 1662-1667 (1991).
16. Goodall, G. J. & Filipowicz, W. The A-U rich sequences present in the introns of plant nuclear pre-mRNAs are required for splicing. Cell 58, 473-483 (1989).
17. Crick, F. H. C. The origin of the genetic code. J. Mol. Biol. 38, 367-379 (1968).
18. Vassylyev, D. G. & Morikawa, K. Precluding uracil from DNA. Structure 4, 1381-1385 (1996).
19. Vartanian, J., Henry, M. & Wain-Hobson, S. Hypermutagenic PCR involving all four transitions and a sizeable portion of transversions. Nucleic Acids Res. 24, 2627-2631 (1996).
20. Cadwell, R. C. & Joyce, G. F. Randomization of genes by PCR mutagenesis. PCR Methods Applic. 2, 28-33 (1992).
21. Stern, S., Moazed, D. & Noller, H. F. Analysis of RNA structure using chemical and enzymatic probing monitored by primer extension. Methods Enzymol. 164, 481-489 (1988).