Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3′-5′ phosphodiester bonds

Journal of the American Chemical Society

Volumn 118, Issue 14, 1996, Pages 3340-3344

  Rohatgi, Rajat ^a   Bartel, David P ^a,b   Szostak, Jack W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; IN VITRO STUDY; REACTION ANALYSIS; RNA SYNTHESIS;

NASA DISCIPLINE EXOBIOLOGY; NASA DISCIPLINE NUMBER 52-20; NASA PROGRAM EXOBIOLOGY; NON-NASA CENTER;

BASE SEQUENCE; EVOLUTION, MOLECULAR; HYDROLYSIS; IMIDAZOLES; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; OLIGONUCLEOTIDES; OLIGORIBONUCLEOTIDES; RNA; RNA, CATALYTIC; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPLATES, GENETIC; TIME FACTORS;

EID: 0029915714     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9537134     Document Type: Article

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