The effect of cytidine on the structure and function of an RNA ligase ribozyme

RNA

Volumn 7, Issue 3, 2001, Pages 395-404

  Rogers, Jeff ^a   Joyce, Gerald F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

In vitro evolution; Ribozyme; RNA ligase

Indexed keywords

3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ADENOSINE; CYTIDINE; GUANOSINE; RIBOZYME; RNA LIGASE; URIDINE;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME STRUCTURE; EVOLUTION; IN VITRO STUDY; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; RNA SEQUENCE; RNA STRUCTURE; SEQUENCE ANALYSIS;

BASE SEQUENCE; CYTIDINE; DIRECTED MOLECULAR EVOLUTION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; POLYNUCLEOTIDE LIGASES; RNA, CATALYTIC;

EID: 0035032445     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S135583820100228X     Document Type: Article

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8. The internal equilibrium of the hammerhead ribozyme reaction
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18. Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation
19. Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3′-5′ phosphodiester bonds
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21. Analysis and RNA structure using chemical and enzymatic probing monitored by primer extension
22. Hypermutagenic PCR involving all four transitions and a sizeable portion of transversions
23. Continuous in vitro evolution of catalytic function